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Jayant Rajan, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone628-206-6103
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    I am an infectious diseases physician by training with a background in immunology, epidemiology/biostatistics and computation. My research is largely translational with my primary focus being the use of unbiased serological profiling to understand the humoral immune response to flavivirus infections. I believe that this approach, combined with others can aid us in vaccine design. I am also interested in expanding this technique to other infectious diseases.

    My second area of interest is more computation-focused. In collaboration with other investigators at UCSF, I have developed a gene expression signature that we believe can be an effective tool for TB-screening in people with HIV in TB-endemic areas. This work fits into a larger interest in trying to understand how to more effectively leverage data generated from high throughput assays.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rajan JV, Semitala FC, Mehta T, Seielstad M, Montalvo L, Andama A, Asege L, Nakaye M, Katende J, Mwebe S, Kamya MR, Yoon C, Cattamanchi A. A Novel, 5-Transcript, Whole-blood Gene-expression Signature for Tuberculosis Screening Among People Living With Human Immunodeficiency Virus. Clin Infect Dis. 2018 Nov 20. PMID: 30462176.
      View in: PubMed
    2. Prado TND, Riley LW, Sanchez M, Fregona G, Nóbrega RLP, Possuelo LG, Zandonade E, Locatelli RL, Souza FM, Rajan JV, Maciel ELN. Prevalence and risk factors for latent tuberculosis infection among primary health care workers in Brazil. Cad Saude Publica. 2017 12 18; 33(12):e00154916. PMID: 29267691.
      View in: PubMed
    3. Greenfield BK, Rajan J, McKone TE. A multivariate analysis of CalEnviroScreen: comparing environmental and socioeconomic stressors versus chronic disease. Environ Health. 2017 Dec 13; 16(1):131. PMID: 29237504.
      View in: PubMed
    4. Snyder RE, Rajan JV, Costa F, Lima HCAV, Calcagno JI, Couto RD, Riley LW, Reis MG, Ko AI, Ribeiro GS. Differences in the Prevalence of Non-Communicable Disease between Slum Dwellers and the General Population in a Large Urban Area in Brazil. Trop Med Infect Dis. 2017 Sep 16; 2(3). PMID: 30270904.
      View in: PubMed
    5. Rajan JV, Ferrazoli L, Waldman EA, Simonsen V, Ferreira P, Telles MA, Riley LW. Diabetes increases the risk of recent-transmission tuberculosis in household contacts in São Paulo, Brazil. Int J Tuberc Lung Dis. 2017 08 01; 21(8):916-921. PMID: 28786800.
      View in: PubMed
    6. Prado TN, Rajan JV, Miranda AE, Dias ED, Cosme LB, Possuelo LG, Sanchez MN, Golub JE, Riley LW, Maciel EL. Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis. Braz J Infect Dis. 2017 Mar - Apr; 21(2):162-170. PMID: 27936379.
      View in: PubMed
    7. Rajan JV, Moura J, Gourley G, Kiso K, Sizilio A, Cortez AM, Riley LW, Veras MA, Sarkar U. Understanding the barriers to successful adoption and use of a mobile health information system in a community health center in São Paulo, Brazil: a cohort study. BMC Med Inform Decis Mak. 2016 11 17; 16(1):146. PMID: 27855685.
      View in: PubMed
    8. Inoue M, Williams KL, Oliver T, Vandenabeele P, Rajan JV, Miao EA, Shinohara ML. Interferon-ß therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. Sci Signal. 2012 May 22; 5(225):ra38. PMID: 22623753; PMCID: PMC3509177.
      View in: PubMed, PubMed Central
    9. Miao EA, Rajan JV, Aderem A. Caspase-1-induced pyroptotic cell death. Immunol Rev. 2011 Sep; 243(1):206-14. PMID: 21884178; PMCID: PMC3609431.
      View in: PubMed, PubMed Central
    10. Warren SE, Duong H, Mao DP, Armstrong A, Rajan J, Miao EA, Aderem A. Generation of a Listeria vaccine strain by enhanced caspase-1 activation. Eur J Immunol. 2011 Jul; 41(7):1934-40. PMID: 21538346.
      View in: PubMed
    11. Miao EA, Rajan JV. Salmonella and Caspase-1: A complex Interplay of Detection and Evasion. Front Microbiol. 2011; 2:85. PMID: 21833326; PMCID: PMC3153046.
      View in: PubMed, PubMed Central
    12. Rajan JV, Rodriguez D, Miao EA, Aderem A. The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. J Virol. 2011 May; 85(9):4167-72. PMID: 21289120; PMCID: PMC3126243.
      View in: PubMed, PubMed Central
    13. Rajan JV, Warren SE, Miao EA, Aderem A. Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett. 2010 Nov 19; 584(22):4627-32. PMID: 20971108.
      View in: PubMed
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