Jean Publicover, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-3547
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTPh.D.05/2006Viral Pathogenesis and Vaccine Development
    University of Rochester, Rochester, NYB.S.05/2001MIcrobiology
    Collapse Awards and Honors
    2008UCSF Postdoctoral Research in Hepatology Fellow
    2008  - 2011A.P. Giannini Foundation Fellow
    2008  - 2011NIH LRP Pediatric Research Recipient
    2013  - 2018NIDDK K01 Mentored Research Scientist Development Award
    2015  - 2016UCSF Liver Center Pilot Feasibility Grant Awardee

    Collapse Overview 
    Collapse Overview
    The goal of my research is to identify factors that influence the initiation of effective immune responses to HBV in the liver. Currently, my focus is on understanding the role of the liver as a site of immune priming to hepatotropic pathogens and the influence of commensal bacteria on the liver priming environment. I am also very interested visualizing of immune structures in the liver by immunofluorescent staining of liver tissue.

    Collapse Research 
    Collapse Research Activities and Funding
    Identifying a role for commensal bacteria on the liver immune priming environment
    NIH K01DK099405Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 03 26; 6(57). Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. PMID: 33771888; PMCID: PMC8425767.
      View in: PubMed   Mentions:    Fields:    
    2. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20). Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. PMID: 30333313; PMCID: PMC6237456.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    3. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018 03 21; 10(433). Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. PMID: 29563320; PMCID: PMC6018058.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    4. Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice Are Associated With Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells. Cell Med. 2017; 9(3):117-125. Fomin ME, Beyer AI, Publicover J, Lu K, Bakkour S, Simmons G, Muench MO. PMID: 28713641; PMCID: PMC5509021.
      View in: PubMed   Mentions: 2  
    5. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. PMID: 26457468; PMCID: PMC4806644.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    6. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS One. 2013; 8(10):e77255. Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. PMID: 24167566; PMCID: PMC3805584.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    7. S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241. Publicover PJ, Gaggar GA, Nishimura NS, Van Horn VC, Goodsell GA, Muench MM, Reinhardt RR, van Rooijen vN, Peters PA, Cyster CJ, Erle ED, Rosenthal RP, Avanesyan AL, Spolski SR, Leonard LW, Cooper CS, Baron BJ. .
      View in: Publisher Site   Mentions:
    8. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290; PMCID: PMC3754256.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    9. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul; 18(7):1060-8. Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. PMID: 22706385; PMCID: PMC3478098.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    10. 742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells. Gastroenterology. 2012 May 1; 142(5):s-927. Zeissig ZS, Murata MK, Sweet SL, Publicover PJ, Hu HZ, Kaser KA, Arlt AA, Günther GR, Hampe HJ, Schreiber SS, Baron BJ, Moody MD, Liang LT, Blumberg BR. .
      View in: Publisher Site   Mentions:
    11. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest. 2011 Jul; 121(7):2863-75. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. PMID: 21646718; PMCID: PMC3223836.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    12. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. PMID: 21393863; PMCID: PMC3049376.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    13. Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5839-43. Rose NF, Publicover J, Chattopadhyay A, Rose JK. PMID: 18391206; PMCID: PMC2311333.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin Vaccine Immunol. 2008 May; 15(5):817-24. Liao JB, Publicover J, Rose JK, DiMaio D. PMID: 18337377; PMCID: PMC2394842.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent. J Immunol. 2007 May 15; 178(10):6350-8. Ramsburg EA, Publicover JM, Coppock D, Rose JK. PMID: 17475864.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    16. Replication and propagation of attenuated vesicular stomatitis virus vectors in vivo: vector spread correlates with induction of immune responses and persistence of genomic RNA. J Virol. 2007 Feb; 81(4):2078-82. Simon ID, Publicover J, Rose JK. PMID: 17151110; PMCID: PMC1797556.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis factor alpha. J Virol. 2006 Jul; 80(14):7028-36. Publicover J, Ramsburg E, Robek M, Rose JK. PMID: 16809308; PMCID: PMC1489072.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    18. A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. J Virol. 2005 Dec; 79(24):15043-53. Ramsburg E, Publicover J, Buonocore L, Poholek A, Robek M, Palin A, Rose JK. PMID: 16306575; PMCID: PMC1316007.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCellsPHPublic Health
    19. A single-cycle vaccine vector based on vesicular stomatitis virus can induce immune responses comparable to those generated by a replication-competent vector. J Virol. 2005 Nov; 79(21):13231-8. Publicover J, Ramsburg E, Rose JK. PMID: 16227246; PMCID: PMC1262593.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Characterization of nonpathogenic, live, viral vaccine vectors inducing potent cellular immune responses. J Virol. 2004 Sep; 78(17):9317-24. Publicover J, Ramsburg E, Rose JK. PMID: 15308726; PMCID: PMC506945.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCellsPHPublic Health
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