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Jean Publicover, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-476-3547
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTPh.D.05/2006Viral Pathogenesis and Vaccine Development
    University of Rochester, Rochester, NYB.S.05/2001MIcrobiology
    Collapse Awards and Honors
    2008UCSF Postdoctoral Research in Hepatology Fellow
    2008  - 2011A.P. Giannini Foundation Fellow
    2008  - 2011NIH LRP Pediatric Research Recipient
    2013  - 2018NIDDK K01 Mentored Research Scientist Development Award
    2015  - 2016UCSF Liver Center Pilot Feasibility Grant Awardee

    Collapse Overview 
    Collapse Overview
    The goal of my research is to identify factors that influence the initiation of effective immune responses to HBV in the liver. Currently, my focus is on understanding the role of the liver as a site of immune priming to hepatotropic pathogens and the influence of commensal bacteria on the liver priming environment. I am also very interested visualizing of immune structures in the liver by immunofluorescent staining of liver tissue.

    Collapse Research 
    Collapse Research Activities and Funding
    Identifying a role for commensal bacteria on the liver immune priming environment
    NIH/NIDDK K01DK099405Jul 1, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells. JCI Insight. 2018 10 18; 3(20). PMID: 30333313.
      View in: PubMed
    2. Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018 03 21; 10(433). PMID: 29563320.
      View in: PubMed
    3. Fomin ME, Beyer AI, Publicover J, Lu K, Bakkour S, Simmons G, Muench MO. Higher Serum Alanine Transaminase Levels in Male Urokinase-Type Plasminogen Activator-Transgenic Mice Are Associated With Improved Engraftment of Hepatocytes but not Liver Sinusoidal Endothelial Cells. Cell Med. 2017; 9(3):117-125. PMID: 28713641.
      View in: PubMed
    4. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260. PMID: 26457468.
      View in: PubMed
    5. Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS One. 2013; 8(10):e77255. PMID: 24167566.
      View in: PubMed
    6. Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron. S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241.
      View in: Publisher Site
    7. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. PMID: 23925290.
      View in: PubMed
    8. Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul; 18(7):1060-8. PMID: 22706385.
      View in: PubMed
    9. Sebastian Zeissig, Kazumoto Murata, Lindsay Sweet, Jean Publicover, Zongyi Hu, Arthur Kaser, Alexander Arlt, Rainer Günther, Jochen Hampe, Stefan Schreiber, Jody Baron, D. Branch Moody, T Jake Liang, Richard S. Blumberg. 742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells. Gastroenterology. 2012 May 1; 142(5):s-927.
      View in: Publisher Site
    10. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75. PMID: 21646718.
      View in: PubMed
    11. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62. PMID: 21393863.
      View in: PubMed
    12. Rose NF, Publicover J, Chattopadhyay A, Rose JK. Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5839-43. PMID: 18391206.
      View in: PubMed
    13. Liao JB, Publicover J, Rose JK, DiMaio D. Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin Vaccine Immunol. 2008 May; 15(5):817-24. PMID: 18337377.
      View in: PubMed
    14. Ramsburg EA, Publicover JM, Coppock D, Rose JK. Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent. J Immunol. 2007 May 15; 178(10):6350-8. PMID: 17475864.
      View in: PubMed
    15. Simon ID, Publicover J, Rose JK. Replication and propagation of attenuated vesicular stomatitis virus vectors in vivo: vector spread correlates with induction of immune responses and persistence of genomic RNA. J Virol. 2007 Feb; 81(4):2078-82. PMID: 17151110.
      View in: PubMed
    16. Publicover J, Ramsburg E, Robek M, Rose JK. Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis factor alpha. J Virol. 2006 Jul; 80(14):7028-36. PMID: 16809308.
      View in: PubMed
    17. Ramsburg E, Publicover J, Buonocore L, Poholek A, Robek M, Palin A, Rose JK. A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. J Virol. 2005 Dec; 79(24):15043-53. PMID: 16306575.
      View in: PubMed
    18. Publicover J, Ramsburg E, Rose JK. A single-cycle vaccine vector based on vesicular stomatitis virus can induce immune responses comparable to those generated by a replication-competent vector. J Virol. 2005 Nov; 79(21):13231-8. PMID: 16227246.
      View in: PubMed
    19. Publicover J, Ramsburg E, Rose JK. Characterization of nonpathogenic, live, viral vaccine vectors inducing potent cellular immune responses. J Virol. 2004 Sep; 78(17):9317-24. PMID: 15308726.
      View in: PubMed
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