 Jean Publicover, PhD
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| Title | RES-FY |
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| School | UCSF School of Medicine |
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| Department | Medicine |
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| Address | 513 Parnassus Avenue
San Francisco CA 94117
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| Phone | 415-476-3547 |
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| vCard | Download vCard |
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 Biography | Yale University, New Haven, CT | Ph.D. | 05/2006 | Viral Pathogenesis and Vaccine Development | | University of Rochester, Rochester, NY | B.S. | 05/2001 | MIcrobiology |
| 2008 | | UCSF Postdoctoral Research in Hepatology Fellow | | 2008
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| 2011 | A.P. Giannini Foundation Fellow | | 2008
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| 2011 | NIH LRP Pediatric Research Recipient | | 2013
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| 2018 | NIDDK K01 Mentored Research Scientist Development Award | | 2015
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| 2016 | UCSF Liver Center Pilot Feasibility Grant Awardee |
Overview The goal of my research is to identify factors that influence the initiation of effective immune responses to HBV in the liver. Currently, my focus is on understanding the role of the liver as a site of immune priming to hepatotropic pathogens and the influence of commensal bacteria on the liver priming environment. I am also very interested visualizing of immune structures in the liver by immunofluorescent staining of liver tissue.
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260. PMID: 26457468.
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Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS One. 2013; 8(10):e77255. PMID: 24167566; PMCID: PMC3805584.
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Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. PMID: 23925290; PMCID: PMC3754256.
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Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul; 18(7):1060-8. PMID: 22706385; PMCID: PMC3478098.
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Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75. PMID: 21646718; PMCID: PMC3223836.
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Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62. PMID: 21393863; PMCID: PMC3049376.
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Rose NF, Publicover J, Chattopadhyay A, Rose JK. Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5839-43. PMID: 18391206; PMCID: PMC2311333.
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Liao JB, Publicover J, Rose JK, DiMaio D. Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin Vaccine Immunol. 2008 May; 15(5):817-24. PMID: 18337377; PMCID: PMC2394842.
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Ramsburg EA, Publicover J, Coppock D, Rose JK. Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent. J Immunol. 2007 May 15; 178(10):6350-8. PMID: 17475864.
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Simon ID, Publicover J, Rose JK. Replication and propagation of attenuated vesicular stomatitis virus vectors in vivo: vector spread correlates with induction of immune responses and persistence of genomic RNA. J Virol. 2007 Feb; 81(4):2078-82. PMID: 17151110; PMCID: PMC1797556.
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Publicover J, Ramsburg E, Robek M, Rose JK. Rapid pathogenesis induced by a vesicular stomatitis virus matrix protein mutant: viral pathogenesis is linked to induction of tumor necrosis factor alpha. J Virol. 2006 Jul; 80(14):7028-36. PMID: 16809308; PMCID: PMC1489072.
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Ramsburg E, Publicover J, Buonocore L, Poholek A, Robek M, Palin A, Rose JK. A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. J Virol. 2005 Dec; 79(24):15043-53. PMID: 16306575; PMCID: PMC1316007.
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Publicover J, Ramsburg E, Rose JK. A single-cycle vaccine vector based on vesicular stomatitis virus can induce immune responses comparable to those generated by a replication-competent vector. J Virol. 2005 Nov; 79(21):13231-8. PMID: 16227246; PMCID: PMC1262593.
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Publicover J, Ramsburg E, Rose JK. Characterization of nonpathogenic, live, viral vaccine vectors inducing potent cellular immune responses. J Virol. 2004 Sep; 78(17):9317-24. PMID: 15308726; PMCID: PMC506945.
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