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Jeffrey Gotts, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone415-443-9263
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine - Internal Medicine

    Collapse Overview 
    Collapse Overview
    My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury
    NIH/NHLBI F32HL117549Jan 1, 2014 - Dec 31, 2014
    Role: Principal Investigator
    MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY
    NIH/NIMH F31MH012798Aug 15, 2000
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 Apr; 7(4):e14. PMID: 30926051.
      View in: PubMed
    2. Gotts JE. High-power vaping injures the human lung. Am J Physiol Lung Cell Mol Physiol. 2019 May 01; 316(5):L703-L704. PMID: 30838866.
      View in: PubMed
    3. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 Feb; 7(2):154-162. PMID: 30455077.
      View in: PubMed
    4. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25. PMID: 30158203.
      View in: PubMed
    5. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40. PMID: 30131373.
      View in: PubMed
    6. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 01; 315(1):L25-L40. PMID: 29543040.
      View in: PubMed
    7. Gotts JE, Matthay MA. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 02 01; 197(3):280-281. PMID: 29072926.
      View in: PubMed
    8. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L966-L967. PMID: 29109110.
      View in: PubMed
    9. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039. PMID: 28340238.
      View in: PubMed
    10. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. PMID: 28737769.
      View in: PubMed
    11. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L193-L206. PMID: 28522559.
      View in: PubMed
    12. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. PMID: 27716790.
      View in: PubMed
    13. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615. PMID: 27689795.
      View in: PubMed
    14. Gotts JE, Matthay MA. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585. PMID: 27217054.
      View in: PubMed
    15. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958.
      View in: PubMed
    16. Gotts JE, Matthay MA. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):797-809. PMID: 25453426; PMCID: PMC4254691.
    17. Gotts JE, Abbott J, Matthay MA. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 01; 307(5):L395-406. PMID: 25038188; PMCID: PMC4154253.
    18. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. PMID: 25593740.
      View in: PubMed
    19. Gotts JE, Matthay MA. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5. PMID: 24503258.
      View in: PubMed
    20. Gotts JE, Matthay MA. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-1527. PMID: 23732575.
      View in: PubMed
    21. Gotts JE, Matthay MA. Mesenchymal stem cells and the stem cell niche: a new chapter. Am J Physiol Lung Cell Mol Physiol. 2012 Jun 01; 302(11):L1147-9. PMID: 22505672.
      View in: PubMed
    22. Gotts JE, Matthay MA. Mesenchymal stem cells and acute lung injury. Crit Care Clin. 2011 Jul; 27(3):719-33. PMID: 21742225; PMCID: PMC3134785.
    23. Gotts JE, Chesselet MF. Mechanisms of subventricular zone expansion after focal cortical ischemic injury. J Comp Neurol. 2005 Jul 25; 488(2):201-14. PMID: 15924343.
      View in: PubMed
    24. Gotts JE, Chesselet MF. Vascular changes in the subventricular zone after distal cortical lesions. Exp Neurol. 2005 Jul; 194(1):139-50. PMID: 15899251.
      View in: PubMed
    25. Gotts JE, Chesselet MF. Migration and fate of newly born cells after focal cortical ischemia in adult rats. J Neurosci Res. 2005 Apr 15; 80(2):160-71. PMID: 15751027.
      View in: PubMed
    26. Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther. 2002 Jul; 6(1):73-82. PMID: 12095306.
      View in: PubMed
    27. Gotts JE, Press C, Leasure JL, Schallert T. Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane. J Neurotrauma. 2000 Nov; 17(11):1067-77. PMID: 11101209.
      View in: PubMed
    28. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8179-84. PMID: 9223335.
      View in: PubMed