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Jeffrey Gotts, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-0735
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine - Internal Medicine

    Collapse Overview 
    Collapse Overview
    My focus is to improve the care of critically ill patients through my roles as a practicing intensivist, co-director of the medical ICU, and teacher and mentor of resident and fellow clinical trainees. I also conduct basic science investigations of bacterial and viral pneumonia, focusing on mechanisms of injury and recovery.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Mesenchymal Stem Cell Therapy in Viral-Induced Acute Lung Injury
    NIH/NHLBI F32HL117549Jan 1, 2014 - Dec 31, 2014
    Role: Principal Investigator
    MECHANISMS OF SVZ EXPANSION FOLLOWING CORTICAL INJURY
    NIH/NIMH F31MH012798Aug 15, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate. Am J Respir Cell Mol Biol. 2020 Aug 21. Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE. PMID: 32822237.
      View in: PubMed   Mentions:    Fields:    
    2. The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 01; 319(2):L218-L227. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. PMID: 32519893.
      View in: PubMed   Mentions:
    3. Treatment for severe acute respiratory distress syndrome from COVID-19. Lancet Respir Med. 2020 05; 8(5):433-434. Matthay MA, Aldrich JM, Gotts JE. PMID: 32203709.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCellsPHPublic Health
    4. What are the respiratory effects of e-cigarettes? BMJ. 2019 09 30; 366:l5275. Gotts JE, Jordt SE, McConnell R, Tarran R. PMID: 31570493.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    5. Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L717-L736. Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA. PMID: 31509438.
      View in: PubMed   Mentions:
    6. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. Lancet Respir Med. 2019 04; 7(4):e14. Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. PMID: 30926051.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. High-power vaping injures the human lung. Am J Physiol Lung Cell Mol Physiol. 2019 May 01; 316(5):L703-L704. Gotts JE. PMID: 30838866.
      View in: PubMed   Mentions:
    8. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. Lancet Respir Med. 2019 02; 7(2):154-162. Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. PMID: 30455077.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCTClinical Trials
    9. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 2018 11; 27(Suppl 1):s20-s25. Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. PMID: 30158203.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    10. Possible hepatotoxicity of IQOS. Tob Control. 2018 11; 27(Suppl 1):s39-s40. Chun L, Moazed F, Matthay M, Calfee C, Gotts J. PMID: 30131373.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    11. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. PMID: 29543040.
      View in: PubMed   Mentions:
    12. Cell-based Therapy in Sepsis. A Step Closer. Am J Respir Crit Care Med. 2018 02 01; 197(3):280-281. Gotts JE, Matthay MA. PMID: 29072926.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties". Am J Physiol Lung Cell Mol Physiol. 2017 11 01; 313(5):L966-L967. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 29109110.
      View in: PubMed   Mentions:
    14. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. PMID: 28340238.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    15. Local lung hypoxia determines epithelial fate decisions during alveolar regeneration. Nat Cell Biol. 2017 Aug; 19(8):904-914. Xi Y, Kim T, Brumwell AN, Driver IH, Wei Y, Tan V, Jackson JR, Xu J, Lee DK, Gotts JE, Matthay MA, Shannon JM, Chapman HA, Vaughan AE. PMID: 28737769.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    16. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L193-L206. Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE. PMID: 28522559.
      View in: PubMed   Mentions:
    17. Cathepsin L Helps to Defend Mice from Infection with Influenza A. PLoS One. 2016; 11(10):e0164501. Xu X, Greenland JR, Gotts JE, Matthay MA, Caughey GH. PMID: 27716790.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    18. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016 10; 55(4):613-615. Kanegai CM, Xi Y, Donne ML, Gotts JE, Driver IH, Amidzic G, Lechner AJ, Jones KD, Vaughan AE, Chapman HA, Rock JR. PMID: 27689795.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    19. Sepsis: pathophysiology and clinical management. BMJ. 2016 05 23; 353:i1585. Gotts JE, Matthay MA. PMID: 27217054.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    20. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. PMID: 25533958.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    21. Endogenous and exogenous cell-based pathways for recovery from acute respiratory distress syndrome. Clin Chest Med. 2014 Dec; 35(4):797-809. Gotts JE, Matthay MA. PMID: 25453426.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy. . 2014 Sep 01; 307(5):L395-406. Gotts JE, Abbott J, Matthay MA. PMID: 25038188.
      View in: PubMed   Mentions:
    23. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Ann Intensive Care. 2014; 4:22. Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. PMID: 25593740.
      View in: PubMed   Mentions:
    24. Treating ARDS: new hope for a tough problem. Lancet Respir Med. 2014 Feb; 2(2):84-5. Gotts JE, Matthay MA. PMID: 24503258.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Cell therapy for lung disease: a step forward. Chest. 2013 Jun; 143(6):1525-1527. Gotts JE, Matthay MA. PMID: 23732575.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    26. Mesenchymal stem cells and the stem cell niche: a new chapter. . 2012 Jun 01; 302(11):L1147-9. Gotts JE, Matthay MA. PMID: 22505672.
      View in: PubMed   Mentions:
    27. Mesenchymal stem cells and acute lung injury. Crit Care Clin. 2011 Jul; 27(3):719-33. Gotts JE, Matthay MA. PMID: 21742225.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    28. Mechanisms of subventricular zone expansion after focal cortical ischemic injury. J Comp Neurol. 2005 Jul 25; 488(2):201-14. Gotts JE, Chesselet MF. PMID: 15924343.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    29. Vascular changes in the subventricular zone after distal cortical lesions. Exp Neurol. 2005 Jul; 194(1):139-50. Gotts JE, Chesselet MF. PMID: 15899251.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    30. Migration and fate of newly born cells after focal cortical ischemia in adult rats. J Neurosci Res. 2005 Apr 15; 80(2):160-71. Gotts JE, Chesselet MF. PMID: 15751027.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    31. Noninvasive, repetitive, quantitative measurement of gene expression from a bicistronic message by positron emission tomography, following gene transfer with adenovirus. Mol Ther. 2002 Jul; 6(1):73-82. Liang Q, Gotts J, Satyamurthy N, Barrio J, Phelps ME, Gambhir SS, Herschman HR. PMID: 12095306.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    32. Focal brain injury, FGF-2 and the adverse effects of excessive motor demand on cortical and nigral degeneration: marked protection by delayed intermittent exposure to halothane. J Neurotrauma. 2000 Nov; 17(11):1067-77. Gotts JE, Press C, Leasure JL, Schallert T. PMID: 11101209.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    33. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):8179-84. Kawamata T, Dietrich WD, Schallert T, Gotts JE, Cocke RR, Benowitz LI, Finklestein SP. PMID: 9223335.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells