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Jeffrey Sall, PhD, MD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Phone415-476-0322
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Postdoctoral Studies2007Anesthesia & Perioperative Care
    University of California, San FranciscoResidency 2006Anesthesia & Perioperative Care
    University of Iowa, Iowa CityInternship2003Internal Medicine
    University of Iowa, Iowa CityM.D./Ph.D.2002Medicine/Neuroscience
    University of Nebraska, LincolnB.S.1994Biology

    Collapse Research 
    Collapse Research Activities and Funding
    A Double-blind, Randomized and Placebo-controlled Phase 2 Study to Evaluate the Safety and Efficacy of T89 in Prevention and Treatment of Acute Mountain Sickness During Rapid Ascent
    Tasly Pharmaceutical Dec 1, 2017 - May 31, 2021
    Role: PI
    Prevention of cerebral injury in pediatric diabetic ketoacidosis
    American Diabetes Association May 1, 2017 - Apr 30, 2021
    Role: Sub-Contract
    Testosterone's role in sex-specific outcomes after early anesthesia
    NIH/NIGMS R01GM112831Mar 1, 2015 - Feb 29, 2020
    Role: Principal Investigator
    Volatile anesthetic alteration of neural precursor cell cycle and fate decisions
    NIH/NIGMS K08GM086511Feb 1, 2010 - Jan 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020 May; 124(5):585-593. PMID: 32145876.
      View in: PubMed
    2. Chinn GA, Sasaki Russell JM, Banh ET, Lee SC, Sall JW. Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats. Anesth Analg. 2019 11; 129(5):1365-1373. PMID: 31517674.
      View in: PubMed
    3. Sasaki Russell JM, Hagelstein M, Lee BH, Sall JW. Anesthesia-induced Recognition Deficit is Improved in Postnatally Gonadectomized Male Rats. J Neurosurg Anesthesiol. 2019 Sep 09. PMID: 31503065.
      View in: PubMed
    4. Sasaki Russell JM, Chinn GA, Maharjan D, Eichbaum Y, Sall JW. Female rats are more vulnerable to lasting cognitive impairment after isoflurane exposure on postnatal day 4 than 7. Br J Anaesth. 2019 Apr; 122(4):490-499. PMID: 30857605.
      View in: PubMed
    5. Vutskits L, Sall JW. Targeting Microglia: A New Avenue for Anesthesia Neuroprotection after Brain Injury? Anesthesiology. 2018 08; 129(2):232-234. PMID: 29787387.
      View in: PubMed
    6. Lundeberg J, Feiner JR, Schober A, Sall JW, Eilers H, Bickler PE. Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels. High Alt Med Biol. 2018 Sep; 19(3):249-258. PMID: 29924642.
      View in: PubMed
    7. Vutskits L, Sall JW, Jevtovic-Todorovic V. A poisoned chalice: the heritage of parental anaesthesia exposure. Br J Anaesth. 2018 08; 121(2):337-339. PMID: 30032869.
      View in: PubMed
    8. Southwell DG, Birk HS, Han SJ, Li J, Sall JW, Berger MS. Resection of gliomas deemed inoperable by neurosurgeons based on preoperative imaging studies. J Neurosurg. 2018 09; 129(3):567-575. PMID: 29125414.
      View in: PubMed
    9. Vutskits L, Sall JW. Reproducibility of science and developmental anaesthesia neurotoxicity: a tale of two cities. Br J Anaesth. 2017 09 01; 119(3):451-452. PMID: 28969307.
      View in: PubMed
    10. Glaser N, Sasaki-Russell J, Cohen M, Little C, O'Donnell M, Sall J. Histological and cognitive alterations in adult diabetic rats following an episode of juvenile diabetic ketoacidosis: Evidence of permanent cerebral injury. Neurosci Lett. 2017 05 22; 650:161-167. PMID: 28435047.
      View in: PubMed
    11. J. W. Sall. Anesthesia Kills Brain Cells, But What Does It Mean?. Survey of Anesthesiology. 2017 Apr 1; 61(2):45.
      View in: Publisher Site
    12. Sall JW. Anesthesia Kills Brain Cells, but What Does It Mean? Anesthesiology. 2016 12; 125(6):1090-1091. PMID: 27655217.
      View in: PubMed
    13. Pinyavat T, Warner DO, Flick RP, McCann ME, Andropoulos DB, Hu D, Sall JW, Spann MN, Ing C. Summary of the Update Session on Clinical Neurotoxicity Studies. J Neurosurg Anesthesiol. 2016 Oct; 28(4):356-360. PMID: 27768673.
      View in: PubMed
    14. Chinn GA, Sasaki Russell JM, Sall JW. Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials. Ann Transl Med. 2016 Oct; 4(20):408. PMID: 27867960.
      View in: PubMed
    15. Lee BH, Chan JT, Hazarika O, Vutskits L, Sall JW. Early exposure to volatile anesthetics impairs long-term associative learning and recognition memory. PLoS One. 2014; 9(8):e105340. PMID: 25165850.
      View in: PubMed
    16. Lee BH, Hazarika OD, Quitoriano GR, Lin N, Leong J, Brosnan H, Chan JT, May LD, Yu D, Alkhamisi A, Stratmann G, Sall JW. Effect of combining anesthetics in neonates on long-term cognitive function. Int J Dev Neurosci. 2014 Oct; 37:87-93. PMID: 25003987.
      View in: PubMed
    17. Stratmann G, Lee J, Sall JW, Lee BH, Alvi RS, Shih J, Rowe AM, Ramage TM, Chang FL, Alexander TG, Lempert DK, Lin N, Siu KH, Elphick SA, Wong A, Schnair CI, Vu AF, Chan JT, Zai H, Wong MK, Anthony AM, Barbour KC, Ben-Tzur D, Kazarian NE, Lee JY, Shen JR, Liu E, Behniwal GS, Lammers CR, Quinones Z, Aggarwal A, Cedars E, Yonelinas AP, Ghetti S. Effect of general anesthesia in infancy on long-term recognition memory in humans and rats. Neuropsychopharmacology. 2014 Sep; 39(10):2275-87. PMID: 24910347.
      View in: PubMed
    18. Lee BH, Chan JT, Kraeva E, Peterson K, Sall JW. Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females. Neuropharmacology. 2014 Aug; 83:9-17. PMID: 24704083.
      View in: PubMed
    19. Dubowitz G, Breyer K, Lipnick M, Sall JW, Feiner J, Ikeda K, MacLeod DB, Bickler PE. Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers. Anaesthesia. 2013 Dec; 68(12):1220-3. PMID: 23992483.
      View in: PubMed
    20. Lin N, Moon TS, Stratmann G, Sall JW. Biphasic change of progenitor proliferation in dentate gyrus after single dose of isoflurane in young adult rats. J Neurosurg Anesthesiol. 2013 Jul; 25(3):306-10. PMID: 23752046.
      View in: PubMed
    21. Sall JW, Leong J. Technical communication: stability of propofol in polystyrene-based tissue culture plates. Anesth Analg. 2013 Jul; 117(1):65-7. PMID: 23632056.
      View in: PubMed
    22. Ramage TM, Chang FL, Shih J, Alvi RS, Quitoriano GR, Rau V, Barbour KC, Elphick SA, Kong CL, Tantoco NK, Ben-Tzur D, Kang H, McCreery MS, Huang P, Park A, Uy J, Rossi MJ, Zhao C, Di Geronimo RT, Stratmann G, Sall JW. Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats. Br J Anaesth. 2013 Jun; 110 Suppl 1:i39-46. PMID: 23592692.
      View in: PubMed
    23. Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler PE. Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia. Anesth Analg. 2013 Oct; 117(4):847-58. PMID: 23477959.
      View in: PubMed
    24. Sall JW, Stratmann G, Leong J, Woodward E, Bickler PE. Propofol at clinically relevant concentrations increases neuronal differentiation but is not toxic to hippocampal neural precursor cells in vitro. Anesthesiology. 2012 Nov; 117(5):1080-90. PMID: 23001052.
      View in: PubMed
    25. Shih J, May LD, Gonzalez HE, Lee EW, Alvi RS, Sall JW, Rau V, Bickler PE, Lalchandani GR, Yusupova M, Woodward E, Kang H, Wilk AJ, Carlston CM, Mendoza MV, Guggenheim JN, Schaefer M, Rowe AM, Stratmann G. Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Anesthesiology. 2012 Mar; 116(3):586-602. PMID: 22354242.
      View in: PubMed
    26. Stratmann G, Sall JW, Bell JS, Alvi RS, May Ld, Ku B, Dowlatshahi M, Dai R, Bickler PE, Russell I, Lee MT, Hrubos MW, Chiu C. Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Anesthesiology. 2010 Feb; 112(2):305-15. PMID: 20098132.
      View in: PubMed
    27. Stratmann G, Sall JW, May LD, Loepke AW, Lee MT. Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function. Anesth Analg. 2010 Feb; 110(2):431-7. PMID: 19917621.
      View in: PubMed
    28. Osredkar D, Sall JW, Bickler PE, Ferriero DM. Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis. 2010 May; 38(2):259-65. PMID: 20117210.
      View in: PubMed
    29. Stratmann G, Sall JW, Eger EI, Laster MJ, Bell JS, May LD, Eilers H, Krause M, Heusen Fv, Gonzalez HE. Increasing the duration of isoflurane anesthesia decreases the minimum alveolar anesthetic concentration in 7-day-old but not in 60-day-old rats. Anesth Analg. 2009 Sep; 109(3):801-6. PMID: 19690249.
      View in: PubMed
    30. Stratmann G, May LD, Sall JW, Alvi RS, Bell JS, Ormerod BK, Rau V, Hilton JF, Dai R, Lee MT, Visrodia KH, Ku B, Zusmer EJ, Guggenheim J, Firouzian A. Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. Anesthesiology. 2009 Apr; 110(4):849-61. PMID: 19293696.
      View in: PubMed
    31. Sall JW, Stratmann G, Leong J, McKleroy W, Mason D, Shenoy S, Pleasure SJ, Bickler PE. Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture. Anesthesiology. 2009 Apr; 110(4):826-33. PMID: 19293697.
      View in: PubMed
    32. Stratmann G, Sall JW, May LD, Bell JS, Magnusson KR, Rau V, Visrodia KH, Alvi RS, Ku B, Lee MT, Dai R. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology. 2009 Apr; 110(4):834-48. PMID: 19293705.
      View in: PubMed
    33. J Sall, PE Bickler, G Stratmann, W McKleroy. Isoflurane is toxic to isolated neural progenitor cells from rat hippocampus: possible role of calcium-mediated neurotoxicity. Journal of Neurosurgical Anesthesiology. 2006 Oct 1; 18(4):288.
      View in: Publisher Site
    34. J Sall, PE Bickler, G Stratmann, W McKleroy. Isoflurane is toxic to isolated neural progenitor cells from rat hippocampus: possible role of calcium-mediated neurotoxicity. Journal of Neurosurgical Anesthesiology. 2006 Oct 1; 18(4):288.
      View in: Publisher Site
    35. Sall JW, Klisovic DD, O'Dorisio MS, Katz SE. Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells. Exp Eye Res. 2004 Oct; 79(4):465-76. PMID: 15381031.
      View in: PubMed
    36. Klisovic DD, O'Dorisio MS, Katz SE, Sall JW, Balster D, O'Dorisio TM, Craig E, Lubow M. Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2193-201. PMID: 11527930.
      View in: PubMed
    37. Sall JW, O'Dorisio MS, O'Dorisio TM.Octreotide: The Next Decade. Biology of Neuroendocrine Tumors. 1999; 117-131.
    38. Zera AJ, Sall J, Grudzinski K. Flight-muscle polymorphism in the cricket Gryllus firmus: muscle characteristics and their influence on the evolution of flightlessness. Physiol Zool. 1997 Sep-Oct; 70(5):519-29. PMID: 9279919.
      View in: PubMed
    39. Zera AJ, Sall J, Schwartz R.Arch Insect Biochem Physiol. Artificial selection on JHE activity in Gryllus assimilis: nature of activity differences between lines and effect on JH binding and metabolism. 1996; (32):421-428.
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