Jeffrey Sall, PhD, MD

Title(s)Professor, Anesthesia
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #256C
San Francisco CA 94117
Phone415-476-0322
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Postdoctoral Studies2007Anesthesia & Perioperative Care
    University of California, San FranciscoResidency 2006Anesthesia & Perioperative Care
    University of Iowa, Iowa CityInternship2003Internal Medicine
    University of Iowa, Iowa CityM.D./Ph.D.2002Medicine/Neuroscience
    University of Nebraska, LincolnB.S.1994Biology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Comprehensive analysis of developmental cannabis exposure on brain, immune and sensory systems
    California Bureau of Cannabis Control contract 65325Jan 1, 2022 - Jan 1, 2024
    Role: PI
    A Multicenter, Double-blind, Randomized and Placebo-controlled Pivotal Phase 3 Study to Evaluate the Safety and Efficacy of T89 in Prevention and Treatment of Acute Mountain Sickness (AMS) After Rapid Ascent
    Tasly Pharmaceutical P0552959May 1, 2021 - Apr 30, 2025
    Role: PI
    A PHASE 3/4 RANDOMIZED, DOUBLE-BLIND, DOSE-RANGING STUDY OF THE SAFETY AND EFFICACY OF DEXMEDETOMIDINE (DEX) USED WITH PROPOFOL (PRO) AS NEEDED FOR PROCEDURAL SEDATION OF PEDIATRIC SUBJECTS =1 MONTH TO <17 YEARS OF AGE UNDERGOING MRI SCANS
    Pfizer Jul 30, 2020 - Jul 29, 2022
    Role: PI
    A Double-blind, Randomized and Placebo-controlled Phase 2 Study to Evaluate the Safety and Efficacy of T89 in Prevention and Treatment of Acute Mountain Sickness During Rapid Ascent
    Tasly Pharmaceutical Dec 1, 2017 - May 31, 2021
    Role: PI
    Prevention of cerebral injury in pediatric diabetic ketoacidosis
    American Diabetes Association May 1, 2017 - Apr 30, 2021
    Role: Sub-Contract
    Testosterone's role in sex-specific outcomes after early anesthesia
    NIH R01GM112831Mar 1, 2015 - Feb 28, 2021
    Role: Principal Investigator
    Volatile anesthetic alteration of neural precursor cell cycle and fate decisions
    NIH K08GM086511Feb 1, 2010 - Jan 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Randomized Phase 2 Study to Evaluate Efficacy and Safety of AR36 for Prevention of Acute Mountain Sickness. Wilderness Environ Med. 2023 Nov 01. Schober A, Chinn G, Eichbaum Y, Dudley M, Sall JW, University of California San Francisco AR36 working group. PMID: 37923683.
      View in: PubMed   Mentions:    Fields:    
    2. The Effect of Route of Administration and Vehicle on the Pharmacokinetics of THC and CBD in Adult, Neonate, and Breastfed Sprague-Dawley Rats. Cannabis Cannabinoid Res. 2023 Oct 18. Soni I, Chinn GA, Halifax JC, Lynch KL, Sall JW. PMID: 37852006.
      View in: PubMed   Mentions:    Fields:    
    3. A Spatial Memory Deficit in Male But Not Female Rats After Neonatal Diazepam Exposure: A New Model for Developmental Sedative Neurotoxicity. Anesth Analg. 2023 Jun 22. Chinn GA, Cummins MH, Sall JW. PMID: 37347707.
      View in: PubMed   Mentions:    Fields:    
    4. Anesthesia-induced Recognition Deficit Is Improved in Postnatally Gonadectomized Male Rats. J Neurosurg Anesthesiol. 2021 Jul 01; 33(3):273-280. Sasaki Russell JM, Hagelstein M, Lee BH, Sall JW. PMID: 31503065; PMCID: PMC7061064.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    5. Testosterone is Sufficient to Impart Susceptibility to Isoflurane Neurotoxicity in Female Neonatal Rats. J Neurosurg Anesthesiol. 2022 10 01; 34(4):429-436. Chinn GA, Duong K, Horovitz TR, Sasaki Russell JM, Sall JW. PMID: 34127616; PMCID: PMC8671561.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats. Anesthesiology. 2020 10 01; 133(4):852-866. Chinn GA, Sasaki Russell JM, Yabut NA, Maharjan D, Sall JW. PMID: 32930727; PMCID: PMC7695485.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020 May; 124(5):585-593. Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. PMID: 32145876; PMCID: PMC7424895.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Voluntary Exercise Rescues the Spatial Memory Deficit Associated With Early Life Isoflurane Exposure in Male Rats. Anesth Analg. 2019 11; 129(5):1365-1373. Chinn GA, Sasaki Russell JM, Banh ET, Lee SC, Sall JW. PMID: 31517674; PMCID: PMC6800827.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    9. Female rats are more vulnerable to lasting cognitive impairment after isoflurane exposure on postnatal day 4 than 7. Br J Anaesth. 2019 Apr; 122(4):490-499. Sasaki Russell JM, Chinn GA, Maharjan D, Eichbaum Y, Sall JW. PMID: 30857605; PMCID: PMC6435941.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    10. Targeting Microglia: A New Avenue for Anesthesia Neuroprotection after Brain Injury? Anesthesiology. 2018 08; 129(2):232-234. Vutskits L, Sall JW. PMID: 29787387.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels. High Alt Med Biol. 2018 Sep; 19(3):249-258. Lundeberg J, Feiner JR, Schober A, Sall JW, Eilers H, Bickler PE. PMID: 29924642.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    12. A poisoned chalice: the heritage of parental anaesthesia exposure. Br J Anaesth. 2018 08; 121(2):337-339. Vutskits L, Sall JW, Jevtovic-Todorovic V. PMID: 30032869.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    13. Resection of gliomas deemed inoperable by neurosurgeons based on preoperative imaging studies. J Neurosurg. 2018 09; 129(3):567-575. Southwell DG, Birk HS, Han SJ, Li J, Sall JW, Berger MS. PMID: 29125414.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    14. Reproducibility of science and developmental anaesthesia neurotoxicity: a tale of two cities. Br J Anaesth. 2017 09 01; 119(3):451-452. Vutskits L, Sall JW. PMID: 28969307.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. Histological and cognitive alterations in adult diabetic rats following an episode of juvenile diabetic ketoacidosis: Evidence of permanent cerebral injury. Neurosci Lett. 2017 05 22; 650:161-167. Glaser N, Sasaki-Russell J, Cohen M, Little C, O'Donnell M, Sall J. PMID: 28435047.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Anesthesia Kills Brain Cells, but What Does It Mean? Anesthesiology. 2016 12; 125(6):1090-1091. Sall JW. PMID: 27655217; PMCID: PMC5119529.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Is a short anesthetic exposure in children safe? Time will tell: a focused commentary of the GAS and PANDA trials. Ann Transl Med. 2016 Oct; 4(20):408. Chinn GA, Sasaki Russell JM, Sall JW. PMID: 27867960; PMCID: PMC5107408.
      View in: PubMed   Mentions: 9  
    18. Summary of the Update Session on Clinical Neurotoxicity Studies. J Neurosurg Anesthesiol. 2016 Oct; 28(4):356-360. Pinyavat T, Warner DO, Flick RP, McCann ME, Andropoulos DB, Hu D, Sall JW, Spann MN, Ing C. PMID: 27768673; PMCID: PMC5077165.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Early exposure to volatile anesthetics impairs long-term associative learning and recognition memory. PLoS One. 2014; 9(8):e105340. Lee BH, Chan JT, Hazarika O, Vutskits L, Sall JW. PMID: 25165850; PMCID: PMC4148240.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    20. Effect of combining anesthetics in neonates on long-term cognitive function. Int J Dev Neurosci. 2014 Oct; 37:87-93. Lee BH, Hazarika OD, Quitoriano GR, Lin N, Leong J, Brosnan H, Chan JT, May LD, Yu D, Alkhamisi A, Stratmann G, Sall JW. PMID: 25003987; PMCID: PMC4144805.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    21. Effect of general anesthesia in infancy on long-term recognition memory in humans and rats. Neuropsychopharmacology. 2014 Sep; 39(10):2275-87. Stratmann G, Lee J, Sall JW, Lee BH, Alvi RS, Shih J, Rowe AM, Ramage TM, Chang FL, Alexander TG, Lempert DK, Lin N, Siu KH, Elphick SA, Wong A, Schnair CI, Vu AF, Chan JT, Zai H, Wong MK, Anthony AM, Barbour KC, Ben-Tzur D, Kazarian NE, Lee JY, Shen JR, Liu E, Behniwal GS, Lammers CR, Quinones Z, Aggarwal A, Cedars E, Yonelinas AP, Ghetti S. PMID: 24910347; PMCID: PMC4168665.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    22. Isoflurane exposure in newborn rats induces long-term cognitive dysfunction in males but not females. Neuropharmacology. 2014 Aug; 83:9-17. Lee BH, Chan JT, Kraeva E, Peterson K, Sall JW. PMID: 24704083; PMCID: PMC4077337.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    23. Accuracy of the Lifebox pulse oximeter during hypoxia in healthy volunteers. Anaesthesia. 2013 Dec; 68(12):1220-3. Dubowitz G, Breyer K, Lipnick M, Sall JW, Feiner J, Ikeda K, MacLeod DB, Bickler PE. PMID: 23992483.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    24. Biphasic change of progenitor proliferation in dentate gyrus after single dose of isoflurane in young adult rats. J Neurosurg Anesthesiol. 2013 Jul; 25(3):306-10. Lin N, Moon TS, Stratmann G, Sall JW. PMID: 23752046; PMCID: PMC3682229.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Technical communication: stability of propofol in polystyrene-based tissue culture plates. Anesth Analg. 2013 Jul; 117(1):65-7. Sall JW, Leong J. PMID: 23632056; PMCID: PMC3690162.
      View in: PubMed   Mentions: 3     Fields:    
    26. Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats. Br J Anaesth. 2013 Jun; 110 Suppl 1:i39-46. Ramage TM, Chang FL, Shih J, Alvi RS, Quitoriano GR, Rau V, Barbour KC, Elphick SA, Kong CL, Tantoco NK, Ben-Tzur D, Kang H, McCreery MS, Huang P, Park A, Uy J, Rossi MJ, Zhao C, Di Geronimo RT, Stratmann G, Sall JW. PMID: 23592692; PMCID: PMC3695640.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    27. Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia. Anesth Analg. 2013 Oct; 117(4):847-858. Feiner JR, Rollins MD, Sall JW, Eilers H, Au P, Bickler PE. PMID: 23477959; PMCID: PMC4476500.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    28. Propofol at clinically relevant concentrations increases neuronal differentiation but is not toxic to hippocampal neural precursor cells in vitro. Anesthesiology. 2012 Nov; 117(5):1080-90. Sall JW, Stratmann G, Leong J, Woodward E, Bickler PE. PMID: 23001052; PMCID: PMC3483886.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. Delayed environmental enrichment reverses sevoflurane-induced memory impairment in rats. Anesthesiology. 2012 Mar; 116(3):586-602. Shih J, May LD, Gonzalez HE, Lee EW, Alvi RS, Sall JW, Rau V, Bickler PE, Lalchandani GR, Yusupova M, Woodward E, Kang H, Wilk AJ, Carlston CM, Mendoza MV, Guggenheim JN, Schaefer M, Rowe AM, Stratmann G. PMID: 22354242; PMCID: PMC4146425.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    30. Isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome in aged rats. Anesthesiology. 2010 Feb; 112(2):305-15. Stratmann G, Sall JW, Bell JS, Alvi RS, May Ld, Ku B, Dowlatshahi M, Dai R, Bickler PE, Russell I, Lee MT, Hrubos MW, Chiu C. PMID: 20098132; PMCID: PMC5214622.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    31. Beyond anesthetic properties: the effects of isoflurane on brain cell death, neurogenesis, and long-term neurocognitive function. Anesth Analg. 2010 Feb; 110(2):431-7. Stratmann G, Sall JW, May LD, Loepke AW, Lee MT. PMID: 19917621.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    32. Erythropoietin promotes hippocampal neurogenesis in in vitro models of neonatal stroke. Neurobiol Dis. 2010 May; 38(2):259-65. Osredkar D, Sall JW, Bickler PE, Ferriero DM. PMID: 20117210; PMCID: PMC2854222.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    33. Increasing the duration of isoflurane anesthesia decreases the minimum alveolar anesthetic concentration in 7-day-old but not in 60-day-old rats. Anesth Analg. 2009 Sep; 109(3):801-6. Stratmann G, Sall JW, Eger EI, Laster MJ, Bell JS, May LD, Eilers H, Krause M, Heusen Fv, Gonzalez HE. PMID: 19690249.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    34. Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. Anesthesiology. 2009 Apr; 110(4):849-61. Stratmann G, May LD, Sall JW, Alvi RS, Bell JS, Ormerod BK, Rau V, Hilton JF, Dai R, Lee MT, Visrodia KH, Ku B, Zusmer EJ, Guggenheim J, Firouzian A. PMID: 19293696.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    35. Isoflurane inhibits growth but does not cause cell death in hippocampal neural precursor cells grown in culture. Anesthesiology. 2009 Apr; 110(4):826-33. Sall JW, Stratmann G, Leong J, McKleroy W, Mason D, Shenoy S, Pleasure SJ, Bickler PE. PMID: 19293697; PMCID: PMC2747751.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    36. Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. Anesthesiology. 2009 Apr; 110(4):834-48. Stratmann G, Sall JW, May LD, Bell JS, Magnusson KR, Rau V, Visrodia KH, Alvi RS, Ku B, Lee MT, Dai R. PMID: 19293705.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    37. Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells. Exp Eye Res. 2004 Oct; 79(4):465-76. Sall JW, Klisovic DD, O'Dorisio MS, Katz SE. PMID: 15381031.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    38. Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2193-201. Klisovic DD, O'Dorisio MS, Katz SE, Sall JW, Balster D, O'Dorisio TM, Craig E, Lubow M. PMID: 11527930.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    39. Octreotide: The Next Decade. Biology of Neuroendocrine Tumors. 1999; 117-131. Sall JW, O'Dorisio MS, O'Dorisio TM.
    40. Flight-muscle polymorphism in the cricket Gryllus firmus: muscle characteristics and their influence on the evolution of flightlessness. Physiol Zool. 1997 Sep-Oct; 70(5):519-29. Zera AJ, Sall J, Grudzinski K. PMID: 9279919.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    41. Arch Insect Biochem Physiol. Artificial selection on JHE activity in Gryllus assimilis: nature of activity differences between lines and effect on JH binding and metabolism. 1996; (32):421-428. Zera AJ, Sall J, Schwartz R.
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