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Jennifer Whistler, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-7236
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    Collapse Research 
    Collapse Research Activities and Funding
    Genetic Variation in the Neuropeptide S Receptor and Opioid Abuse Liability
    NIH/NIDA R21DA043816Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Molecular and circuit mechanisms of antipsychotics
    NIH/NIMH R01MH112729Apr 10, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    Dopamine receptor trafficking in drug sensitization and behavioral flexibility
    NIH/NIDA R01DA037963Sep 15, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Neuropeptide S receptors in ethanol abuse and anxiety
    NIH/NIAAA R21AA023231Sep 10, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Receptor trafficking profiles of clinically important dopaminergic drugs
    NIH/NIMH R21MH096058Mar 1, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Selectively targeting delta opioid receptor subtypes to control drinking behavior
    NIH/NIAAA R01AA020401Aug 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Selectively Targeting Opioid Receptor Heterodimers
    NIH/NIDA R21DA031574Feb 15, 2011 - Jan 31, 2014
    Role: Principal Investigator
    Role of opioid receptor trafficking in tolerance and dependence
    NIH/NIDA R01DA019958May 1, 2007 - Mar 31, 2014
    Role: Principal Investigator
    GASP and Trafficking of the Dopamine Receptors
    NIH/NIMH R01MH068442Jul 1, 2003 - Apr 30, 2009
    Role: Principal Investigator
    Trafficking and signaling of opioid receptor subtypes and heterodimers
    NIH/NIDA R01DA015232Apr 1, 2002 - Jul 31, 2011
    Role: Principal Investigator
    REGULATION OF OPIOID RECEPTOR FUNCTION
    NIH/NIDA F32DA005844Mar 25, 1998
    Role: Principal Investigator

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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Luo SX, Timbang L, Kim JI, Shang Y, Sandoval K, Tang AA, Whistler J, Ding JB, Huang EJ. TGF-ß Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning. Cell Rep. 2016 Dec 20; 17(12):3233-3245. PMID: 28009292.
      View in: PubMed
    2. Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambo E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler J. Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins. ACS Chem Neurosci. 2017 Mar 15; 8(3):473-485. PMID: 27744679.
      View in: PubMed
    3. Mei F, Mayoral SR, Nobuta H, Wang F, Desponts C, Lorrain DS, Xiao L, Green AJ, Rowitch D, Whistler J, Chan JR. Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination. J Neurosci. 2016 Jul 27; 36(30):7925-35. PMID: 27466337; PMCID: PMC4961778 [Available on 01/27/17].
    4. Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler J, Bender KJ. ß-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Rep. 2016 Aug 09; 16(6):1518-1526. PMID: 27452469.
      View in: PubMed
    5. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler J, Bruchas MR, Kash TL. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016 Mar 29; 14(12):2774-83. PMID: 26997280; PMCID: PMC4814306.
    6. Roed SN, Wismann P, Underwood CR, Kulahin N, Iversen H, Cappelen KA, Schäffer L, Lehtonen J, Hecksher-Soerensen J, Secher A, Mathiesen JM, Bräuner-Osborne H, Whistler J, Knudsen SM, Waldhoer M. Real-time trafficking and signaling of the glucagon-like peptide-1 receptor. Mol Cell Endocrinol. 2014 Feb 15; 382(2):938-49. PMID: 24275181.
      View in: PubMed
    7. He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler J, Levine B. Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism. Cell. 2013 Aug 29; 154(5):1085-99. PMID: 23954414; PMCID: PMC4231430.
    8. Madhavan A, Argilli E, Bonci A, Whistler J. Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area. J Neurosci. 2013 Jul 24; 33(30):12329-36. PMID: 23884939; PMCID: PMC3721842.
    9. van Rijn RM, Defriel JN, Whistler J. Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology (Berl). 2013 Jul; 228(1):1-18. PMID: 23649885; PMCID: PMC3679311.
    10. Milan-Lobo L, Enquist J, van Rijn RM, Whistler J. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One. 2013; 8(3):e58362. PMID: 23554887; PMCID: PMC3598907.
    11. Goldsmith JR, Perez-Chanona E, Yadav PN, Whistler J, Roth B, Jobin C. Intestinal epithelial cell-derived µ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling. Am J Pathol. 2013 Mar; 182(3):776-85. PMID: 23291213; PMCID: PMC3589074.
    12. Harvey JH, van Rijn RM, Whistler J. A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods Mol Biol. 2013; 995:43-54. PMID: 23494371.
      View in: PubMed
    13. van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler J. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. J Pharmacol Exp Ther. 2013 Jan; 344(1):179-88. PMID: 23097213; PMCID: PMC3533407.
    14. Harvey JH, Long DH, England PM, Whistler J. Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. ACS Med Chem Lett. 2012 Aug 09; 3(8):640-644. PMID: 23585918.
      View in: PubMed
    15. Enquist J, Ferwerda M, Madhavan A, Hok D, Whistler J. Chronic ethanol potentiates the effect of neuropeptide s in the basolateral amygdala and shows increased anxiolytic and anti-depressive effects. Neuropsychopharmacology. 2012 Oct; 37(11):2436-45. PMID: 22739468; PMCID: PMC3445991.
    16. Albada HB, Wieberneit F, Dijkgraaf I, Harvey JH, Whistler J, Stoll R, Metzler-Nolte N, Fish RH. The chemoselective reactions of tyrosine-containing G-protein-coupled receptor peptides with [Cp*Rh(H2O)3](OTf)2, including 2D NMR structures and the biological consequences. J Am Chem Soc. 2012 Jun 27; 134(25):10321-4. PMID: 22671299.
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    17. Kargl J, Balenga NA, Platzer W, Martini L, Whistler J, Waldhoer M. The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55. Br J Pharmacol. 2012 Apr; 165(8):2611-9. PMID: 21718301; PMCID: PMC3366063.
    18. Schröder R, Xue L, Konya V, Martini L, Kampitsch N, Whistler J, Ulven T, Heinemann A, Pettipher R, Kostenis E. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2. PLoS One. 2012; 7(3):e33329. PMID: 22442685; PMCID: PMC3307725.
    19. Whistler J. Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology. Drug Alcohol Depend. 2012 Mar 01; 121(3):189-204. PMID: 22226706; PMCID: PMC4224378.
    20. Brissett DI, Whistler J, van Rijn RM. Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes. Eur J Pain. 2012 Mar; 16(3):327-37. PMID: 22337177; PMCID: PMC4086711.
    21. Enquist J, Ferwerda M, Milan-Lobo L, Whistler J. Chronic methadone treatment shows a better cost/benefit ratio than chronic morphine in mice. J Pharmacol Exp Ther. 2012 Feb; 340(2):386-92. PMID: 22062352; PMCID: PMC3263965.
    22. Kühhorn J, Götz A, Hübner H, Thompson D, Whistler J, Gmeiner P. Development of a bivalent dopamine D2 receptor agonist. J Med Chem. 2011 Nov 24; 54(22):7911-9. PMID: 21999579.
      View in: PubMed
    23. van Rijn RM, Brissett DI, Whistler J. Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug Alcohol Depend. 2012 Apr 01; 122(1-2):156-9. PMID: 22018601; PMCID: PMC3279630.
    24. van Rijn RM, Brissett DI, Whistler J. Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biol Psychiatry. 2012 Feb 01; 71(3):232-8. PMID: 21889123; PMCID: PMC4086708.
    25. Berger AC, Whistler J. Morphine-induced mu opioid receptor trafficking enhances reward yet prevents compulsive drug use. EMBO Mol Med. 2011 Jul; 3(7):385-97. PMID: 21656686; PMCID: PMC3394511.
    26. He L, Whistler J. Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. PLoS One. 2011; 6(5):e19372. PMID: 21602922; PMCID: PMC3094338.
    27. Enquist J, Kim JA, Bartlett S, Ferwerda M, Whistler J. A novel knock-in mouse reveals mechanistically distinct forms of morphine tolerance. J Pharmacol Exp Ther. 2011 Aug; 338(2):633-40. PMID: 21562138; PMCID: PMC3141896.
    28. Thompson D, Whistler J. Trafficking properties of the D5 dopamine receptor. Traffic. 2011 May; 12(5):644-56. PMID: 21348911.
      View in: PubMed
    29. Milan-Lobo L, Whistler J. Heteromerization of the µ- and d-opioid receptors produces ligand-biased antagonism and alters µ-receptor trafficking. J Pharmacol Exp Ther. 2011 Jun; 337(3):868-75. PMID: 21422164; PMCID: PMC3097170.
    30. Tschammer N, Elsner J, Goetz A, Ehrlich K, Schuster S, Ruberg M, Kühhorn J, Thompson D, Whistler J, Hübner H, Gmeiner P. Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. J Med Chem. 2011 Apr 14; 54(7):2477-91. PMID: 21388142.
      View in: PubMed
    31. Thompson D, Whistler J. Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1. J Biol Chem. 2011 Jan 14; 286(2):1598-608. PMID: 21030592; PMCID: PMC3020768.
    32. Madhavan A, Bonci A, Whistler J. Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area. J Neurosci. 2010 Oct 20; 30(42):14029-35. PMID: 20962224; PMCID: PMC3637958.
    33. van Rijn RM, Brissett DI, Whistler J. Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. J Pharmacol Exp Ther. 2010 Oct; 335(1):133-9. PMID: 20605909; PMCID: PMC2957775.
    34. Moser E, Kargl J, Whistler J, Waldhoer M, Tschische P. G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology. 2010; 86(1):22-9. PMID: 20693822; PMCID: PMC2919430.
    35. Thompson D, Martini L, Whistler J. Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One. 2010 Jun 09; 5(6):e11038. PMID: 20543951; PMCID: PMC2882949.
    36. Berger AC, Whistler J. How to design an opioid drug that causes reduced tolerance and dependence. Ann Neurol. 2010 May; 67(5):559-69. PMID: 20437553; PMCID: PMC2943346.
    37. Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler J, Waldhoer M. The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28. Traffic. 2010 May; 11(5):660-74. PMID: 20102549; PMCID: PMC2974616.
    38. Bonde MM, Yao R, Ma JN, Madabushi S, Haunsø S, Burstein ES, Whistler J, Sheikh SP, Lichtarge O, Hansen JL. An angiotensin II type 1 receptor activation switch patch revealed through evolutionary trace analysis. Biochem Pharmacol. 2010 Jul 01; 80(1):86-94. PMID: 20227396; PMCID: PMC2864232.
    39. Madhavan A, He L, Stuber GD, Bonci A, Whistler J. micro-Opioid receptor endocytosis prevents adaptations in ventral tegmental area GABA transmission induced during naloxone-precipitated morphine withdrawal. J Neurosci. 2010 Mar 03; 30(9):3276-86. PMID: 20203187; PMCID: PMC2943338.
    40. Martini L, Thompson D, Kharazia V, Whistler J. Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1. Neuropsychopharmacology. 2010 May; 35(6):1363-73. PMID: 20164830; PMCID: PMC2953419.
    41. Henstridge CM, Balenga NA, Schröder R, Kargl JK, Platzer W, Martini L, Arthur S, Penman J, Whistler J, Kostenis E, Waldhoer M, Irving AJ. GPR55 ligands promote receptor coupling to multiple signalling pathways. Br J Pharmacol. 2010 Jun; 160(3):604-14. PMID: 20136841; PMCID: PMC2931561.
    42. van Rijn RM, Whistler J, Waldhoer M. Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol. 2010 Feb; 10(1):73-9. PMID: 19846340; PMCID: PMC2900797.
    43. He L, Kim JA, Whistler J. Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant mu-opioid receptor. FASEB J. 2009 Dec; 23(12):4327-34. PMID: 19679639; PMCID: PMC2812043.
    44. van Rijn RM, Whistler J. The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol Psychiatry. 2009 Oct 15; 66(8):777-84. PMID: 19576572; PMCID: PMC2757485.
    45. Ravindranathan A, Joslyn G, Robertson M, Schuckit MA, Whistler J, White RL. Functional characterization of human variants of the mu-opioid receptor gene. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10811-6. PMID: 19528663; PMCID: PMC2705556.
    46. He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler J. Methadone antinociception is dependent on peripheral opioid receptors. J Pain. 2009 Apr; 10(4):369-79. PMID: 19327642; PMCID: PMC2952445.
    47. Wallace MJ, Newton PM, McMahon T, Connolly J, Huibers A, Whistler J, Messing RO. PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2. Neuropsychopharmacology. 2009 Jun; 34(7):1733-42. PMID: 19158669; PMCID: PMC2680927.
    48. van Rijn RM, Whistler J. The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? Mol Interv. 2008 Dec; 8(6):277-80. PMID: 19144899.
      View in: PubMed
    49. Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E. The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J Biol Chem. 2009 Jan 09; 284(2):1324-36. PMID: 19010788.
      View in: PubMed
    50. Kim JA, Bartlett S, He L, Nielsen CK, Chang AM, Kharazia V, Waldhoer M, Ou CJ, Taylor S, Ferwerda M, Cado D, Whistler J. Morphine-induced receptor endocytosis in a novel knockin mouse reduces tolerance and dependence. Curr Biol. 2008 Jan 22; 18(2):129-35. PMID: 18207746; PMCID: PMC2997702.
    51. Martini L, Whistler J. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr Opin Neurobiol. 2007 Oct; 17(5):556-64. PMID: 18068348.
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    52. Thompson D, Pusch M, Whistler J. Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors. J Biol Chem. 2007 Oct 05; 282(40):29178-85. PMID: 17635908.
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    53. Xia YF, He L, Whistler J, Hjelmstad GO. Acute amphetamine exposure selectively desensitizes kappa-opioid receptors in the nucleus accumbens. Neuropsychopharmacology. 2008 Mar; 33(4):892-900. PMID: 17551543; PMCID: PMC2268619.
    54. Tappe-Theodor A, Agarwal N, Katona I, Rubino T, Martini L, Swiercz J, Mackie K, Monyer H, Parolaro D, Whistler J, Kuner T, Kuner R. A molecular basis of analgesic tolerance to cannabinoids. J Neurosci. 2007 Apr 11; 27(15):4165-77. PMID: 17428994.
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    55. Lasek AW, Janak PH, He L, Whistler J, Heberlein U. Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain Behav. 2007 Nov; 6(8):728-35. PMID: 17428267.
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    56. He L, Whistler J. The biochemical analysis of methadone modulation on morphine-induced tolerance and dependence in the rat brain. Pharmacology. 2007; 79(4):193-202. PMID: 17356311.
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    57. Martini L, Waldhoer M, Pusch M, Kharazia V, Fong J, Lee JH, Freissmuth C, Whistler J. Ligand-induced down-regulation of the cannabinoid 1 receptor is mediated by the G-protein-coupled receptor-associated sorting protein GASP1. FASEB J. 2007 Mar; 21(3):802-11. PMID: 17197383.
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    58. Enquist J, Skröder C, Whistler J, Leeb-Lundberg LM. Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor endocytosis. Mol Pharmacol. 2007 Feb; 71(2):494-507. PMID: 17110500.
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    59. Bartlett SE, Enquist J, Hopf FW, Lee JH, Gladher F, Kharazia V, Waldhoer M, Mailliard WS, Armstrong R, Bonci A, Whistler J. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proc Natl Acad Sci U S A. 2005 Aug 09; 102(32):11521-6. PMID: 16049099; PMCID: PMC1183554.
    60. He L, Whistler J. An opiate cocktail that reduces morphine tolerance and dependence. Curr Biol. 2005 Jun 07; 15(11):1028-33. PMID: 15936273.
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    61. Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler J. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):9050-5. PMID: 15932946; PMCID: PMC1157030.
    62. Kostenis E, Martini L, Ellis J, Waldhoer M, Heydorn A, Rosenkilde MM, Norregaard PK, Jorgensen R, Whistler J, Milligan G. A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity. J Pharmacol Exp Ther. 2005 Apr; 313(1):78-87. PMID: 15615862.
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    63. Heydorn A, Søndergaard BP, Ersbøll B, Holst B, Nielsen FC, Haft CR, Whistler J, Schwartz TW. A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP). J Biol Chem. 2004 Dec 24; 279(52):54291-303. PMID: 15452121.
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    64. Waldhoer M, Bartlett SE, Whistler J. Opioid receptors. Annu Rev Biochem. 2004; 73:953-90. PMID: 15189164.
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    65. Waldhoer M, Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler J, Schwartz TW. The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biol Chem. 2003 May 23; 278(21):19473-82. PMID: 12646575.
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    66. Whistler J, Gerber BO, Meng EC, Baranski TJ, von Zastrow M, Bourne HR. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic. 2002 Dec; 3(12):866-77. PMID: 12453150.
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    67. Whistler J, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M. Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26; 297(5581):615-20. PMID: 12142540.
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    68. Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler J, Von Zastrow M, Grandy DK, Williams JT. mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. J Neurosci. 2002 Jul 01; 22(13):5769-76. PMID: 12097530.
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    69. Bartlett SE, Whistler J. The near-death experience of delta opioid receptors leads to new drug targets. Mol Interv. 2002 Jun; 2(3):134-6. PMID: 14993372.
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    70. He L, Fong J, von Zastrow M, Whistler J. Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell. 2002 Jan 25; 108(2):271-82. PMID: 11832216.
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    71. Finn AK, Whistler J. Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron. 2001 Dec 06; 32(5):829-39. PMID: 11738029.
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    72. Whistler J, Tsao P, von Zastrow M. A phosphorylation-regulated brake mechanism controls the initial endocytosis of opioid receptors but is not required for post-endocytic sorting to lysosomes. J Biol Chem. 2001 Sep 07; 276(36):34331-8. PMID: 11443128.
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    73. Ungless MA, Whistler J, Malenka RC, Bonci A. Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons. Nature. 2001 May 31; 411(6837):583-7. PMID: 11385572.
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    74. Whistler J, Beattie E, von Zastrow M. Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway. Sci STKE. 2000 Aug 29; 2000(47):pe1. PMID: 11752604.
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    75. Whistler J, von Zastrow M. Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction. J Biol Chem. 1999 Aug 27; 274(35):24575-8. PMID: 10455121.
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    76. Whistler J, Chuang HH, Chu P, Jan LY, von Zastrow M. Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron. 1999 Aug; 23(4):737-46. PMID: 10482240.
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    77. Whistler J, von Zastrow M. Morphine-activated opioid receptors elude desensitization by beta-arrestin. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9914-9. PMID: 9707575; PMCID: PMC21436.
    78. Whistler J, Rine J. Ras2 and Ras1 protein phosphorylation in Saccharomyces cerevisiae. J Biol Chem. 1997 Jul 25; 272(30):18790-800. PMID: 9228053.
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