Jeoung-Sook Shin, PhD

Address513 Parnassus Ave
San Francisco CA 94143
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    Dendritic cells play important roles in inducing immunity against microbial antigens while developing tolerance against self or innocuous foreign antigens. Our laboratory is interested in identifying the specific mechanism by which dendritic cells mediate regulatory T cell (Treg) development and defining the biological impact that dendritic cells make on immune suppressive function of Treg. Our recent study implicates the role of Membrane-Associated RING finger CH 1 (MARCH1) ubiquitin ligase in dendritic cell selection of natural Treg. Current research focuses on defining the molecular mechanism by which MARCH1 mediates Treg development and determining functional specialization of Treg generated in this MARCH1-dependent manner.

    Our laboratory is also interested in understanding how dendritic cells participate in IgE-mediated asthma pathogenesis. Asthma represents a serious inflammatory airway disease affecting hundred millions of adults and children in the world. IgE is one of the most important pathologic players in this disease, however the underlying mechanism is not completely understood. Our recent study indicates that dendritic cells constitutively internalize circulating IgE via the high affinity IgE receptor (FceRI) and promote serum IgE clearance, which implicates dendritic cells in IgE turnover. In asthma however, dendritic cells accumulate IgE at their surface and infiltrate airway epithelium, suggesting functional alteration and contribution of dendritic cells to this disease. Current research aims to identify the molecular mechanism by which FceRI mediates internalization of IgE in dendritic cells and determine the specific contribution that these cells make to asthma.

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    Role of MARCH1 E3 ubiquitin ligase in thymic dendritic cell function
    NIH R01GM105800Sep 5, 2013 - May 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Oh J, Shin J. Molecular mechanism and cellular function of MHCII ubiquitination. Immunol Rev. 2015 Jul; 266(1):134-44. PMID: 26085212; PMCID: PMC4677682.
    2. Oh J, Shin J. The Role of Dendritic Cells in Central Tolerance. Immune Netw. 2015 Jun; 15(3):111-20. PMID: 26140042; PMCID: PMC4486773.
    3. Shin J, Greer AM. The role of FceRI expressed in dendritic cells and monocytes. Cell Mol Life Sci. 2015 Jun; 72(12):2349-60. PMID: 25715742; PMCID: PMC4479177.
    4. Greer AM, Matthay MA, Kukreja J, Bhakta NR, Nguyen CP, Wolters PJ, Woodruff PG, Fahy JV, Shin J. Accumulation of BDCA1? dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma. PLoS One. 2014; 9(6):e99084. PMID: 24915147; PMCID: PMC4051692.
    5. Eggel A, Baravalle G, Hobi G, Kim B, Buschor P, Forrer P, Shin J, Vogel M, Stadler BM, Dahinden CA, Jardetzky TS. Accelerated dissociation of IgE-FceRI complexes by disruptive inhibitors actively desensitizes allergic effector cells. J Allergy Clin Immunol. 2014 Jun; 133(6):1709-19.e8. PMID: 24642143; PMCID: PMC4083100.
    6. Baravalle G, Greer AM, LaFlam TN, Shin J. Antigen-conjugated human IgE induces antigen-specific T cell tolerance in a humanized mouse model. J Immunol. 2014 Apr 01; 192(7):3280-8. PMID: 24610015; PMCID: PMC4472313.
    7. Greer AM, Wu N, Putnam AL, Woodruff PG, Wolters P, Kinet JP, Shin J. Serum IgE clearance is facilitated by human FceRI internalization. J Clin Invest. 2014 Mar; 124(3):1187-98. PMID: 24569373; PMCID: PMC3938266.
    8. Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin J. MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med. 2013 Jun 03; 210(6):1069-77. PMID: 23712430; PMCID: PMC3674695.
    9. Ma JK, Platt MY, Eastham-Anderson J, Shin J, Mellman I. MHC class II distribution in dendritic cells and B cells is determined by ubiquitin chain length. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):8820-7. PMID: 22566640; PMCID: PMC3384207.
    10. Baravalle G, Park H, McSweeney M, Ohmura-Hoshino M, Matsuki Y, Ishido S, Shin J. Ubiquitination of CD86 is a key mechanism in regulating antigen presentation by dendritic cells. J Immunol. 2011 Sep 15; 187(6):2966-73. PMID: 21849678; PMCID: PMC4496154.
    11. Bloom O, Unternaehrer JJ, Jiang A, Shin J, Delamarre L, Allen P, Mellman I. Spinophilin participates in information transfer at immunological synapses. J Cell Biol. 2008 Apr 21; 181(2):203-11. PMID: 18411312; PMCID: PMC2315669.
    12. Shin J, Shelburne CP, Jin C, LeFurgey EA, Abraham SN. Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. J Immunol. 2006 Nov 01; 177(9):5791-800. PMID: 17056503.
      View in: PubMed
    13. Shin J, Ebersold M, Pypaert M, Delamarre L, Hartley A, Mellman I. Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination. Nature. 2006 Nov 02; 444(7115):115-8. PMID: 17051151.
      View in: PubMed
    14. Duncan MJ, Li G, Shin J, Carson JL, Abraham SN. Bacterial penetration of bladder epithelium through lipid rafts. J Biol Chem. 2004 Apr 30; 279(18):18944-51. PMID: 14976212.
      View in: PubMed
    15. Duncan MJ, Shin J, Abraham SN. Microbial entry through caveolae: variations on a theme. Cell Microbiol. 2002 Dec; 4(12):783-91. PMID: 12464009.
      View in: PubMed
    16. Shin J, Abraham SN. Cell biology. Caveolae--not just craters in the cellular landscape. Science. 2001 Aug 24; 293(5534):1447-8. PMID: 11520975.
      View in: PubMed
    17. Shin J, Abraham SN. Caveolae as portals of entry for microbes. Microbes Infect. 2001 Jul; 3(9):755-61. PMID: 11489424.
      View in: PubMed
    18. Shin J, Abraham SN. Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis. FEMS Microbiol Lett. 2001 Apr 13; 197(2):131-8. PMID: 11313125.
      View in: PubMed
    19. Abraham S, Shin J, Malaviya R. Type 1 fimbriated Escherichia coli-mast cell interactions in cystitis. J Infect Dis. 2001 Mar 01; 183 Suppl 1:S51-5. PMID: 11171015.
      View in: PubMed
    20. Shin J, Abraham SN. Co-option of endocytic functions of cellular caveolae by pathogens. Immunology. 2001 Jan; 102(1):2-7. PMID: 11168630; PMCID: PMC1783146.
    21. Shin J, Gao Z, Abraham SN. Involvement of cellular caveolae in bacterial entry into mast cells. Science. 2000 Aug 04; 289(5480):785-8. PMID: 10926542.
      View in: PubMed
    22. Shin J, Gao Z, Abraham SN. Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. Biosci Rep. 1999 Oct; 19(5):421-32. PMID: 10763810.
      View in: PubMed
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