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Jeroen Roose, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-476-3977
ORCID ORCID Icon0000-0003-4746-2811 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    University of UtrechtPhDImmunology
    Collapse Awards and Honors
    University of Utrecht, The Netherlands1999  - 1999PhD award summa cum laude
    Dutch Sientific Organization NWO1999  - 2000Postdoctoral Award TALENT
    Dutch Cancer Society KWF2000  - 2003Postdoctoral Award
    Arthritis Foundation2006  - 2010Arthritis Investigator Award
    NIH - NCI2006  - 2011K01 Howard Temin career development Award
    Sydney Kimmel Foundation 2008  - 2010Kimmel Scholar Award
    Gabrielle's Angel Foundation 2012  - 2015Junior Investigator
    UCSF PSA (Postdoctoral Scholar’s Association)2013  - 20132013 Outstanding Faculty Mentor Award
    Alex Lemonade Stand Foundation 2015  - 2017Innovator Award

    Collapse Overview 
    Collapse Overview
    Research Interests:

    Our laboratory is interested in genetic lesions that lead to abnormal Ras signal transduction events and development of diseases such as autoimmunity and cancer. Active Ras communicates to many downstream targets and affects many cell biological responses. Our goal is to understand the mechanism of activation of the small GTPase Ras by Ras exchange factors and its role in normal physiology as well as understand how alterations in Ras-kinase signals underlie pathology. http://rooselab.ucsf.edu/

    Collapse Research 
    Collapse Research Activities and Funding
    Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
    NIH/NIAID P01AI091580May 18, 2020 - Jun 30, 2021
    Role: Co-Investigator
    Balanced signaling cues to guide cell transitions in the blood lineage continuum
    NIH/NHLBI R01HL120724Aug 15, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Molecular understanding of cytokine-Ras signals in leukemic bone marrow
    NIH/NCI R01CA187318Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants
    NIH/NIAID R01AI104789Mar 1, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Mechanistic Studies of Ras-MAPK Signals: Specialzed Cues for the T cell Lineage?
    NIH/NIAID R56AI095292Sep 1, 2011 - Aug 31, 2012
    Role: Principal Investigator
    The role of tonic signal-input in stable gene profiles
    NIH/NCI K01CA113367Aug 1, 2009 - Jul 31, 2011
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Cell Stem Cell. 2020 Aug 14. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. PMID: 32818433.
      View in: PubMed   Mentions:    Fields:    
    2. Protocol for Comprehensive Synthetic Lethality Screens. . 2020 Jun 1; 1(1):100016. Damia Romero-Moya, Jeroen P. Roose. .
      View in: Publisher Site   Mentions:
    3. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. Cancers (Basel). 2019 Sep 24; 11(10). Samocha A, Doh H, Kessenbrock K, Roose JP. PMID: 31554261.
      View in: PubMed   Mentions:
    4. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science. 2019 10 04; 366(6461):109-115. Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J. PMID: 31604311.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. mTOR and other effector kinase signals that impact T cell function and activity. Immunol Rev. 2019 09; 291(1):134-153. Myers DR, Wheeler B, Roose JP. PMID: 31402496.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation. Sci Signal. 2019 07 23; 12(591). Jun JE, Kulhanek KR, Chen H, Chakraborty A, Roose JP. PMID: 31337738.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. JCI Insight. 2019 06 25; 5. Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P. PMID: 31237864.
      View in: PubMed   Mentions: 1     Fields:    
    8. Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells. Cell Rep. 2019 05 07; 27(6):1858-1874.e6. Myers DR, Norlin E, Vercoulen Y, Roose JP. PMID: 31067469.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    9. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019 04 09; 27(2):631-647.e5. Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. PMID: 30970263.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. PLoS One. 2018; 13(5):e0193849. Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. PMID: 29799846.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 09 27; 6. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. PMID: 28952923.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Tonic Signals: Why Do Lymphocytes Bother? Trends Immunol. 2017 11; 38(11):844-857. Myers DR, Zikherman J, Roose JP. PMID: 28754596.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017 05 23; 19(8):1558-1571. Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. PMID: 28538176.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017 05 08; 31(5):685-696.e6. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC. PMID: 28486107.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    15. Lost GRP on cytotoxicity? Nat Immunol. 2016 11 16; 17(12):1339-1340. Roose JP. PMID: 27849207.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nat Struct Mol Biol. 2016 09; 23(9):838-46. Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT. PMID: 27501536.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle. Small GTPases. 2017 01 02; 8(1):20-25. Mues M, Roose JP. PMID: 27159504.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    18. Suppressive signals in colorectal cancer: RasGRP1 a new marker for anti-EGFR therapy?. Journal of Clinical Oncology. 2016 Feb 1; 34(4_suppl):625-625. Jeroen Roose, Philippe Depeille, Robert S. Warren. .
      View in: Publisher Site   Mentions:
    19. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. PMID: 26740656.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. Kinase and Phosphatase Effector Pathways in T Cells. Encyclopedia of Immunobiology. 2016 Jan 1; 25-37. Darienne R. Myers, Jeroen P. Roose. .
      View in: Publisher Site   Mentions:
    21. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene. 2016 07 14; 35(28):3658-68. Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP. PMID: 26549032.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    22. Unexpected insights for anti-EGFR cancer therapy. Oncotarget. 2015 Aug 07; 6(22):18746-7. Depeille P, Warren RS, Roose JP. PMID: 26300054.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    23. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. PMID: 26005835.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    24. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol. 2015 Jul 01; 195(1):31-5. Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD. PMID: 26002977.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    25. Editorial overview: lymphocyte development and activation: lymphocytes, integrators of information. Curr Opin Immunol. 2015 Apr; 33:v-vii. Roose J, Fagarasan S. PMID: 25776004.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    26. Flavors of EGFR-Ras signals impacting intestinal homeostasis. Cell Cycle. 2015; 14(20):3205-6. Depeille P, Roose JP. PMID: 26292152.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    27. Protein kinase Cd promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. PMID: 24515435.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios? T cells and autoantibodies. Elife. 2013 Dec 12; 2:e01020. Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP. PMID: 24336796.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    29. PLC-? and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PMID: 24300897.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    30. RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing). 2013 Oct 01; 8(5):508-532. Ksionda O, Limnander A, Roose JP. PMID: 24744772.
      View in: PubMed   Mentions:
    31. Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells. Front Immunol. 2013 Sep 04; 4:239. Jun JE, Rubio I, Roose JP. PMID: 24027568.
      View in: PubMed   Mentions: 21     Fields:    
    32. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife. 2013 Jul 30; 2:e00813. Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J. PMID: 23908768.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    33. Biochemical heterogeneity and developmental varieties in T-cell leukemia. Cell Cycle. 2013 May 15; 12(10):1480-1. Chakraborty AK, Roose JP. PMID: 23652920.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS. Mol Cell Biol. 2013 Jun; 33(12):2470-84. Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP. PMID: 23589333.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal. 2013 Mar 26; 6(268):ra21. Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP. PMID: 23532335.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    36. A phospholipase C-?1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. J Immunol. 2013 Jan 01; 190(1):147-58. Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. PMID: 23209318.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B. 2012 Mar 22; 116(11):3630-40. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. PMID: 22332778.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    38. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRa gene expression. PLoS One. 2011; 6(9):e25540. Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. PMID: 21966541.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    39. STIM1, PKC-d and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol. 2011 May; 12(5):425-33. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. PMID: 21441934.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    40. PI3 Kinase, Phospholipase C (PLC)-?, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells. Blood. 2009 Nov 20; 114(22):2512-2512. Ernesto Diaz-Flores, Hana Leah Goldschmidt, Philippe Depeille, Victor Ng, Jeroen Roose, Kevan Shokat, Benjamin S. Braun, Kevin Shannon. .
      View in: Publisher Site   Mentions:
    41. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature. 2009 Sep 17; 461(7262):411-4. Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K. PMID: 19727076.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    42. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal. 2009 Apr 14; 2(66):pt2. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. PMID: 19366993.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    43. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell. 2009 Jan 23; 136(2):337-51. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. PMID: 19167334.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    44. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):528-33. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. PMID: 19098101.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    45. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol. 2007 Apr; 27(7):2732-45. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. PMID: 17283063.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    46. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J Exp Med. 2006 Jul 10; 203(7):1733-44. Nirula A, Ho M, Phee H, Roose J, Weiss A. PMID: 16785309.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    47. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005 Jun; 25(11):4426-41. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. PMID: 15899849.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    48. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol Cell Biol. 2005 Jun; 25(12):4924-33. Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A. PMID: 15923611.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    49. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 2003 Nov; 1(2):E53. Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. PMID: 14624253.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    50. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res. 2001 Apr 01; 29(7):1410-9. Brantjes H, Roose J, van De Wetering M, Clevers H. PMID: 11266540.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    51. T cells: getting a GRP on Ras. Nat Immunol. 2000 Oct; 1(4):275-6. Roose J, Weiss A. PMID: 11017094.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    52. dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila. Int J Dev Biol. 2000 Oct; 44(7):749-56. Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias AM. PMID: 11128568.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mech Dev. 2000 Mar 01; 91(1-2):311-5. Molenaar M, Brian E, Roose J, Clevers H, Destrée O. PMID: 10704855.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    54. TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta. 1999 Oct 29; 1424(2-3):M23-37. Roose J, Clevers H. PMID: 10528152.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    55. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 1999 Sep 17; 285(5435):1923-6. Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H. PMID: 10489374.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    56. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Genomics. 1999 Apr 15; 57(2):301-5. Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H. PMID: 10198172.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    57. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 1998 Oct 08; 395(6702):604-8. Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A. PMID: 9783586.
      View in: PubMed   Mentions: 204     Fields:    Translation:AnimalsCells
    58. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 1998 Oct 08; 395(6702):608-12. Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destrée O, Clevers H. PMID: 9783587.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    59. Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development. Mech Dev. 1998 Jul; 75(1-2):151-4. Molenaar M, Roose J, Peterson J, Venanzi S, Clevers H, Destrée O. PMID: 9739131.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    60. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar; 18(3):1248-56. Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H. PMID: 9488439.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    61. High expression of the HMG box factor sox-13 in arterial walls during embryonic development. Nucleic Acids Res. 1998 Jan 15; 26(2):469-76. Roose J, Korver W, Oving E, Wilson A, Wagenaar G, Markman M, Lamers W, Clevers H. PMID: 9421502.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    62. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics. 1997 Dec 15; 46(3):435-42. Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H. PMID: 9441747.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    63. The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes. Immunobiology. 1997 Dec; 198(1-3):157-61. Korver W, Roose J, Wilson A, Clevers H. PMID: 9442387.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    64. The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 01; 25(9):1715-9. Korver W, Roose J, Clevers H. PMID: 9108152.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    65. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell. 1996 Aug 09; 86(3):391-9. Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destrée O, Clevers H. PMID: 8756721.
      View in: PubMed   Mentions: 510     Fields:    Translation:AnimalsCells
    66. Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva. J Immunol. 1995 Aug 01; 155(3):1370-81. Toye PG, Metzelaar MJ, Wijngaard PL, Nene V, Iams K, Roose J, Nyanjui JK, Gobright E, Musoke AJ, Clevers HC. PMID: 7636202.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    67. Synthetic protease inhibitors: promising compounds to arrest pathobiologic processes. J Lab Clin Med. 1995 Apr; 125(4):433-41. Roose JP, Van Noorden CJ. PMID: 7706897.
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