Jeroen Roose, PhD

Title(s)Professor, Anatomy
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW, #1325
San Francisco CA 94143
ORCID ORCID Icon0000-0003-4746-2811 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division
    University of UtrechtPhDImmunology
    Collapse Awards and Honors
    Alex Lemonade Stand Foundation 2015  - 2017Innovator Award
    UCSF PSA (Postdoctoral Scholar’s Association)2013  - 20132013 Outstanding Faculty Mentor Award
    Gabrielle's Angel Foundation 2012  - 2015Junior Investigator
    Sydney Kimmel Foundation 2008  - 2010Kimmel Scholar Award
    NIH - NCI2006  - 2011K01 Howard Temin career development Award
    Arthritis Foundation2006  - 2010Arthritis Investigator Award
    Dutch Cancer Society KWF2000  - 2003Postdoctoral Award
    Dutch Sientific Organization NWO1999  - 2000Postdoctoral Award TALENT
    University of Utrecht, The Netherlands1999  - 1999PhD award summa cum laude

    Collapse Overview 
    Collapse Overview
    Research Interests:

    Our laboratory focuses on understanding cell fate decisions driven by cell-cell interactions and signaling pathways, in the context of immunology, cancer, and stem cell biology. We have a very international team that embraces DEI. Post docs in my lab go off to start their own academic labs or secure exciting positions in industry.

    In addition to running our lab, I enjoy setting up large collaborative research programs so that my team members (and everyone else) can benefit. In 2018, I co-founded ImmunoX. Also in 2018, I started an Organoid disease to biology (D2B) unit. I co-lead the UCSF Endeavor Program that focuses on cancer metastasis and co-lead the UCSF AutoImmunoProfiler Initiative.

    Collapse Research 
    Collapse Research Activities and Funding
    Roles for Intracellular pH dynamics in cancer
    NIH/NCI 2 R01 CA197855Apr 1, 2023 - Mar 31, 2028
    Role: PI
    Defining and re-engineering the DTC and metastatic cell surface to prevent lethal breast cancer metastasis
    DoD W81XWH-22-2-0007 (BC210386P4)Aug 1, 2022 - Jul 30, 2026
    Role: PI
    Defining the unique properties of the distinct signaling machinery used by the TCR
    NIH/NIAID 3P01 AI091580May 1, 2022 - Apr 30, 2027
    Role: Co-Lead/PI
    Molecular understanding of leukemic bone marrow cytokine-Ras signals and metabolic dependence
    NIH/NCI 2R01 CA187318Jan 1, 2022 - Dec 30, 2026
    Role: PI
    Understand and Eliminate Metastatic Cancer
    Mark Foundation for Cancer Research A136299Dec 1, 2020 - Nov 30, 2023
    Role: Co-Lead/PI
    Balanced signaling cues to guide cell transitions in the blood lineage continuum
    NIH R01HL120724Aug 15, 2015 - Apr 30, 2021
    Role: Principal Investigator
    Molecular understanding of cytokine-Ras signals in leukemic bone marrow
    NIH R01CA187318Jul 1, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants
    NIH R56AI104789Mar 1, 2014 - May 31, 2022
    Role: Principal Investigator
    Loss of Intrinsic Control in Autoimmune T Helper Cells with Signaling Variants
    NIH R01AI104789Mar 1, 2014 - Feb 28, 2019
    Role: Principal Investigator
    Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR
    NIH P01AI091580Jul 15, 2011 - Jun 30, 2021
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Abstract 7465: Leukemia inhibitory factor creates an immune suppressive tumor microenvironment and fosters tumor growth in KRAS-driven pancreatic ductal adenocarcinoma. Cancer Research. 2024 Mar 22; 84(6_Supplement):7465-7465. Miller-Phillips ML, Hanafi HI, Combes CA, Bano BS, Hysenaj HL, Roose RJ, Olshen OA, Kiemen KA, Umetsu US, Wang WM, Collisson CE. .
      View in: Publisher Site   Mentions:
    2. Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma. Cancer Research. 2024 Jan 16; 84(2_Supplement):a046-a046. Hendley HA, Urano UA, Peng PX, Ashe AS, Phu PT, Ng NM, Kerper KN, Berrios BD, Lee LJ, Jin JD, Jang JG, Gbenedio GO, Roose RJ, Yeh YJ, Gallinger GS, Biankin BA, Ntranos NV, Chang CD, Dawson DD, Kim KG, Weaver WV, Raffai RR, Hebrok HM. .
      View in: Publisher Site   Mentions:
    3. Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions. bioRxiv. 2023 Dec 20. Karra L, Finger AM, Shechtman L, Krush M, Huang RM, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. PMID: 38187679; PMCID: PMC10769276.
      View in: PubMed   Mentions:
    4. Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling. J Immunol. 2023 09 15; 211(6):917-922. Chang Y, Manivannan P, Doosti A, Lapinski PE, Chen D, Roose JP, King PD. PMID: 37566514; PMCID: PMC10529702.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression. Cancer Cell. 2023 05 08; 41(5):853-870.e13. Jana S, Brahma S, Arora S, Wladyka CL, Hoang P, Blinka S, Hough R, Horn JL, Liu Y, Wang LJ, Depeille P, Smith E, Montgomery RB, Lee JK, Haffner MC, Vakar-Lopez F, Grivas P, Wright JL, Lam HM, Black PC, Roose JP, Ryazanov AG, Subramaniam AR, Henikoff S, Hsieh AC. PMID: 37084735; PMCID: PMC10208629.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants. Stem Cell Reports. 2023 03 14; 18(3):636-653. Hysenaj L, Little S, Kulhanek K, Magnen M, Bahl K, Gbenedio OM, Prinz M, Rodriguez L, Andersen C, Rao AA, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Mick E, Khalid MM, Taha TY, Kumar R, Li JZ, Ding VW, Matsumoto S, Maishan M, Sreekumar B, Simoneau C, Nazarenko I, Tomlinson MG, Khan K, von Gottberg A, Sigal A, Looney MR, Fragiadakis GK, Jablons DM, Langelier CR, Matthay M, Krummel M, Erle DJ, Combes AJ, Sil A, Ott M, Kratz JR, Roose JP. PMID: 36827975; PMCID: PMC9948283.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Abstract IA022: Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment. Cancer Research. 2023 Jan 15; 83(2_Supplement_2):ia022-ia022. Gonzalez GH, Mei MW, Robles RI, Hagerling HC, Allen AB, Okholm OT, Nanjaraj NA, Verbeek VT, Kalavacherla KS, Gogh GM, Georgiou GS, Daras DM, Phillips PJ, Spitzer SM, Roose RJ, Werb WZ. .
      View in: Publisher Site   Mentions:
    8. NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. bioRxiv. 2022 Aug 02. Simoneau CR, Chen PY, Xing GK, Khalid MM, Meyers NL, Hayashi JM, Taha TY, Leon KE, Ashuach T, Fontaine KA, Rodriguez L, Joehnk B, Walcott K, Vasudevan S, Fang X, Maishan M, Schultz S, Roose J, Matthay MA, Sil A, Arjomandi M, Yosef N, Ott M. PMID: 35982664; PMCID: PMC9387123.
      View in: PubMed   Mentions: 1  
    9. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. PMID: 35611333; PMCID: PMC9128787.
      View in: PubMed   Mentions:
    10. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. PMID: 35592107; PMCID: PMC9119017.
      View in: PubMed   Mentions:
    11. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in NrasQ61R/+ mice. Leukemia. 2022 04; 36(4):1167-1170. Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J. PMID: 35082403; PMCID: PMC8983511.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Cellular architecture of human brain metastases. Cell. 2022 02 17; 185(4):729-745.e20. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. PMID: 35063085; PMCID: PMC8857062.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    13. Editorial overview: Communities in immune cell signaling. Curr Opin Immunol. 2021 12; 73:iii-iv. Roose J, Barton G. PMID: 34863507; PMCID: PMC8634753.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. 603 Autoreactivity drives increased metabolism in T cells from SLE patients?. Lupus Science & Medicine. 2021 Nov 1; 8(Suppl 2):a22-a23. Bahl BK, Myers MD, Roose RJ. .
      View in: Publisher Site   Mentions:
    15. Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors. Blood. 2021 06 10; 137(23):3259-3271. Wen Z, Yun G, Hebert A, Kong G, Ranheim EA, Finn R, Rajagoplan A, Li S, Zhou Y, Yu M, Damnernsawad A, Roose JP, Coon JJ, Wen R, Wang D, Zhang J. PMID: 33512434; PMCID: PMC8351901.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    16. SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator. bioRxiv. 2021 Jun 02. Hysenaj L, Little S, Kulhanek K, Gbenedio OM, Rodriguez L, Shen A, Lone JC, Lupin-Jimenez LC, Bonser LR, Serwas NK, Bahl K, Mick E, Li JZ, Ding VW, Matsumoto S, Maishan M, Simoneau C, Fragiadakis G, Jablons DM, Langelier CR, Matthay M, Ott M, Krummel M, Combes AJ, Sil A, Erle DJ, Kratz JR, Roose JP. PMID: 34100012; PMCID: PMC8183007.
      View in: PubMed   Mentions: 1  
    17. T cells: a dedicated effector kinase pathways for every trait? Biochem J. 2021 03 26; 478(6):1303-1307. Bahl K, Roose JP. PMID: 33755101.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    18. Investigating increased hematopoietic stem cell fitness in a novel mouse model. Small GTPases. 2022 Jan; 13(1):7-13. Karra L, Roose JP. PMID: 33517841; PMCID: PMC9707538.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    19. Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models. Cancers (Basel). 2021 Feb 09; 13(4). Li PJ, Roose JP, Jablons DM, Kratz JR. PMID: 33572297; PMCID: PMC7915264.
      View in: PubMed   Mentions: 2  
    20. Regulation of the Small GTPase Ras and Its Relevance to Human Disease. Methods Mol Biol. 2021; 2262:19-43. Kulhanek KR, Roose JP, Rubio I. PMID: 33977469.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity. Eur J Immunol. 2021 02; 51(2):471-482. Baars MJD, Douma T, Simeonov DR, Myers DR, Kulhanek K, Banerjee S, Zwakenberg S, Baltissen MP, Amini M, de Roock S, van Wijk F, Vermeulen M, Marson A, Roose JP, Vercoulen Y. PMID: 33065764; PMCID: PMC7894479.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis. Oncogene. 2020 11; 39(45):6920-6934. Karra L, Romero-Moya D, Ksionda O, Krush M, Gu Z, Mues M, Depeille P, Mullighan C, Roose JP. PMID: 32989257; PMCID: PMC7655557.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    23. Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo. Cell Stem Cell. 2020 11 05; 27(5):840-851.e6. Miao Y, Ha A, de Lau W, Yuki K, Santos AJM, You C, Geurts MH, Puschhof J, Pleguezuelos-Manzano C, Peng WC, Senlice R, Piani C, Buikema JW, Gbenedio OM, Vallon M, Yuan J, de Haan S, Hemrika W, Rösch K, Dang LT, Baker D, Ott M, Depeille P, Wu SM, Drost J, Nusse R, Roose JP, Piehler J, Boj SF, Janda CY, Clevers H, Kuo CJ, Garcia KC. PMID: 32818433; PMCID: PMC7655723.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    24. Protocol for Barcoding T Cells Combined with Timed Stimulations. STAR Protoc. 2020 09 18; 1(2):100067. Kulhanek KR, Myers DR, Ksionda O, Vercoulen Y, Romero-Moya D, Roose JP. PMID: 33111105; PMCID: PMC7580249.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. Protocol for Comprehensive Synthetic Lethality Screens. STAR Protoc. 2020 06 19; 1(1). Romero-Moya D, Roose JP. PMID: 32984851; PMCID: PMC7518629.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. Cancers (Basel). 2019 Sep 24; 11(10). Samocha A, Doh H, Kessenbrock K, Roose JP. PMID: 31554261; PMCID: PMC6826786.
      View in: PubMed   Mentions: 4  
    27. Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science. 2019 10 04; 366(6461):109-115. Kondo Y, Ognjenovic J, Banerjee S, Karandur D, Merk A, Kulhanek K, Wong K, Roose JP, Subramaniam S, Kuriyan J. PMID: 31604311; PMCID: PMC7007921.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    28. mTOR and other effector kinase signals that impact T cell function and activity. Immunol Rev. 2019 09; 291(1):134-153. Myers DR, Wheeler B, Roose JP. PMID: 31402496; PMCID: PMC6697425.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    29. Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation. Sci Signal. 2019 07 23; 12(591). Jun JE, Kulhanek KR, Chen H, Chakraborty A, Roose JP. PMID: 31337738; PMCID: PMC7340343.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer. JCI Insight. 2019 06 25; 5. Gbenedio OM, Bonnans C, Grun D, Wang CY, Hatch AJ, Mahoney MR, Barras D, Matli M, Miao Y, Garcia KC, Tejpar S, Delorenzi M, Venook AP, Nixon AB, Warren RS, Roose JP, Depeille P. PMID: 31237864; PMCID: PMC6693836.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    31. Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells. Cell Rep. 2019 05 07; 27(6):1858-1874.e6. Myers DR, Norlin E, Vercoulen Y, Roose JP. PMID: 31067469; PMCID: PMC6593126.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep. 2019 04 09; 27(2):631-647.e5. Mues M, Karra L, Romero-Moya D, Wandler A, Hangauer MJ, Ksionda O, Thus Y, Lindenbergh M, Shannon K, McManus MT, Roose JP. PMID: 30970263; PMCID: PMC6690758.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. PLoS One. 2018; 13(5):e0193849. Ksionda O, Mues M, Wandler AM, Donker L, Tenhagen M, Jun J, Ducker GS, Matlawska-Wasowska K, Shannon K, Shokat KM, Roose JP. PMID: 29799846; PMCID: PMC5969748.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    34. A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife. 2017 09 27; 6. Vercoulen Y, Kondo Y, Iwig JS, Janssen AB, White KA, Amini M, Barber DL, Kuriyan J, Roose JP. PMID: 28952923; PMCID: PMC5643099.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    35. Tonic Signals: Why Do Lymphocytes Bother? Trends Immunol. 2017 11; 38(11):844-857. Myers DR, Zikherman J, Roose JP. PMID: 28754596; PMCID: PMC5669999.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    36. Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. Cell Rep. 2017 05 23; 19(8):1558-1571. Myers DR, Lau T, Markegard E, Lim HW, Kasler H, Zhu M, Barczak A, Huizar JP, Zikherman J, Erle DJ, Zhang W, Verdin E, Roose JP. PMID: 28538176; PMCID: PMC5587137.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    37. RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell. 2017 05 08; 31(5):685-696.e6. Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC. PMID: 28486107; PMCID: PMC5499527.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    38. Lost GRP on cytotoxicity? Nat Immunol. 2016 11 16; 17(12):1339-1340. Roose JP. PMID: 27849207.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    39. One-way membrane trafficking of SOS in receptor-triggered Ras activation. Nat Struct Mol Biol. 2016 09; 23(9):838-46. Christensen SM, Tu HL, Jun JE, Alvarez S, Triplet MG, Iwig JS, Yadav KK, Bar-Sagi D, Roose JP, Groves JT. PMID: 27501536; PMCID: PMC5016256.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    40. Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle. Small GTPases. 2017 01 02; 8(1):20-25. Mues M, Roose JP. PMID: 27159504; PMCID: PMC5331899.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    41. Suppressive signals in colorectal cancer: RasGRP1 a new marker for anti-EGFR therapy?. Journal of Clinical Oncology. 2016 Feb 1; 34(4_suppl):625-625. Roose RJ, Depeille DP, Warren WR. .
      View in: Publisher Site   Mentions:
    42. Abstract B22: Screening and validation of combination therapy in T cell leukemia. Technologies Used in Basic Cancer Research. 2016 Feb 1; b22-b22. Mues MM, Lindenbergh LM, McManus MM, Roose RJ. .
      View in: Publisher Site   Mentions:
    43. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 06; 36(1):142-52. Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM. PMID: 26740656; PMCID: PMC4701956.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    44. Kinase and Phosphatase Effector Pathways in T Cells. Encyclopedia of Immunobiology. 2016 Jan 1; 25-37. Myers MD, Roose RJ. .
      View in: Publisher Site   Mentions:
    45. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene. 2016 07 14; 35(28):3658-68. Ksionda O, Melton AA, Bache J, Tenhagen M, Bakker J, Harvey R, Winter SS, Rubio I, Roose JP. PMID: 26549032; PMCID: PMC4868787.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    46. Unexpected insights for anti-EGFR cancer therapy. Oncotarget. 2015 Aug 07; 6(22):18746-7. Depeille P, Warren RS, Roose JP. PMID: 26300054; PMCID: PMC4662453.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    47. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. PMID: 26005835; PMCID: PMC4652934.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    48. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia. J Immunol. 2015 Jul 01; 195(1):31-5. Lubeck BA, Lapinski PE, Oliver JA, Ksionda O, Parada LF, Zhu Y, Maillard I, Chiang M, Roose J, King PD. PMID: 26002977; PMCID: PMC4475412.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    49. Editorial overview: lymphocyte development and activation: lymphocytes, integrators of information. Curr Opin Immunol. 2015 Apr; 33:v-vii. Roose J, Fagarasan S. PMID: 25776004; PMCID: PMC4868092.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    50. Flavors of EGFR-Ras signals impacting intestinal homeostasis. Cell Cycle. 2015; 14(20):3205-6. Depeille P, Roose JP. PMID: 26292152; PMCID: PMC4825600.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    51. Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance. Mol Cell Biol. 2014 Apr; 34(8):1474-85. Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP. PMID: 24515435; PMCID: PMC3993585.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies. Elife. 2013 Dec 12; 2:e01020. Daley SR, Coakley KM, Hu DY, Randall KL, Jenne CN, Limnander A, Myers DR, Polakos NK, Enders A, Roots C, Balakishnan B, Miosge LA, Sjollema G, Bertram EM, Field MA, Shao Y, Andrews TD, Whittle B, Barnes SW, Walker JR, Cyster JG, Goodnow CC, Roose JP. PMID: 24336796; PMCID: PMC3858598.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    53. PLC-γ and PI3K link cytokines to ERK activation in hematopoietic cells with normal and oncogenic Kras. Sci Signal. 2013 Dec 03; 6(304):ra105. Diaz-Flores E, Goldschmidt H, Depeille P, Ng V, Akutagawa J, Krisman K, Crone M, Burgess MR, Williams O, Houseman B, Shokat K, Sampath D, Bollag G, Roose JP, Braun BS, Shannon K. PMID: 24300897; PMCID: PMC4117477.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    54. RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing). 2013 Oct 01; 8(5):508-532. Ksionda O, Limnander A, Roose JP. PMID: 24744772; PMCID: PMC3987922.
      View in: PubMed   Mentions: 35  
    55. Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells. Front Immunol. 2013 Sep 04; 4:239. Jun JE, Rubio I, Roose JP. PMID: 24027568; PMCID: PMC3762125.
      View in: PubMed   Mentions: 37     Fields:    
    56. Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife. 2013 Jul 30; 2:e00813. Iwig JS, Vercoulen Y, Das R, Barros T, Limnander A, Che Y, Pelton JG, Wemmer DE, Roose JP, Kuriyan J. PMID: 23908768; PMCID: PMC3728621.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    57. Biochemical heterogeneity and developmental varieties in T-cell leukemia. Cell Cycle. 2013 May 15; 12(10):1480-1. Chakraborty AK, Roose JP. PMID: 23652920; PMCID: PMC3680523.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    58. Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS. Mol Cell Biol. 2013 Jun; 33(12):2470-84. Jun JE, Yang M, Chen H, Chakraborty AK, Roose JP. PMID: 23589333; PMCID: PMC3700092.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    59. Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis. Sci Signal. 2013 Mar 26; 6(268):ra21. Hartzell C, Ksionda O, Lemmens E, Coakley K, Yang M, Dail M, Harvey RC, Govern C, Bakker J, Lenstra TL, Ammon K, Boeter A, Winter SS, Loh M, Shannon K, Chakraborty AK, Wabl M, Roose JP. PMID: 23532335; PMCID: PMC3737252.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    60. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. J Immunol. 2013 Jan 01; 190(1):147-58. Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL. PMID: 23209318; PMCID: PMC3529846.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    61. The membrane environment can promote or suppress bistability in cell signaling networks. J Phys Chem B. 2012 Mar 22; 116(11):3630-40. Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK. PMID: 22332778; PMCID: PMC3321252.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    62. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. PLoS One. 2011; 6(9):e25540. Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP. PMID: 21966541; PMCID: PMC3180458.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    63. Stim1, PKCd and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (109.6). The Journal of Immunology. 2011 Apr 1; 186(1_Supplement):109.6-109.6. Limnander LA, Depeille DP, Freedman FT, Liou LJ, Leitges LM, Kurosaki KT, Roose RJ, Weiss WA. .
      View in: Publisher Site   Mentions:
    64. STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol. 2011 May; 12(5):425-33. Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A. PMID: 21441934; PMCID: PMC3623929.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    65. Abstract 3837: PI-3 kinase acts upstream of oncogenic Ras in hematopoietic cells through a cytokine-PLC?-RasGRP pathway. Cellular and Molecular Biology. 2010 Apr 15; 3837-3837. Diaz-Flores DE, Goldschmidt GH, Depeille DP, Ng NV, Roose RJ, Shokat SK, Braun BB, Shannon SK. .
      View in: Publisher Site   Mentions:
    66. PI3 Kinase, Phospholipase C (PLC)-?, and RasGRPs Act Cooperatively to Activate the Ras-Extracellular-Related Kinase (ERK) Pathway in Response to Cytokines in Normal and Kras Mutant Myeloid Cells. Blood. 2009 Nov 20; 114(22):2512-2512. Diaz-Flores DE, Goldschmidt GH, Depeille DP, Ng NV, Roose RJ, Shokat SK, Braun BB, Shannon SK. .
      View in: Publisher Site   Mentions:
    67. Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature. 2009 Sep 17; 461(7262):411-4. Lauchle JO, Kim D, Le DT, Akagi K, Crone M, Krisman K, Warner K, Bonifas JM, Li Q, Coakley KM, Diaz-Flores E, Gorman M, Przybranowski S, Tran M, Kogan SC, Roose JP, Copeland NG, Jenkins NA, Parada L, Wolff L, Sebolt-Leopold J, Shannon K. PMID: 19727076; PMCID: PMC4119783.
      View in: PubMed   Mentions: 82     Fields:    Translation:Animals
    68. Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes. Sci Signal. 2009 Apr 14; 2(66):pt2. Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J. PMID: 19366993; PMCID: PMC2755093.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    69. Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell. 2009 Jan 23; 136(2):337-51. Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP. PMID: 19167334; PMCID: PMC2662698.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    70. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):528-33. Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK. PMID: 19098101; PMCID: PMC2626737.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    71. Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol. 2007 Apr; 27(7):2732-45. Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A. PMID: 17283063; PMCID: PMC1899892.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    72. Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4. J Exp Med. 2006 Jul 10; 203(7):1733-44. Nirula A, Ho M, Phee H, Roose J, Weiss A. PMID: 16785309; PMCID: PMC2118337.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    73. A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol. 2005 Jun; 25(11):4426-41. Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A. PMID: 15899849; PMCID: PMC1140631.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    74. Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. Mol Cell Biol. 2005 Jun; 25(12):4924-33. Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A. PMID: 15923611; PMCID: PMC1140569.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    75. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 2003 Nov; 1(2):E53. Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. PMID: 14624253; PMCID: PMC261890.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    76. All Tcf HMG box transcription factors interact with Groucho-related co-repressors. Nucleic Acids Res. 2001 Apr 01; 29(7):1410-9. Brantjes H, Roose J, van De Wetering M, Clevers H. PMID: 11266540; PMCID: PMC31284.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    77. T cells: getting a GRP on Ras. Nat Immunol. 2000 Oct; 1(4):275-6. Roose J, Weiss A. PMID: 11017094.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    78. dTcf antagonises Wingless signalling during the development and patterning of the wing in Drosophila. Int J Dev Biol. 2000 Oct; 44(7):749-56. Lawrence N, Dearden P, Hartley D, Roose J, Clevers H, Arias AM. PMID: 11128568.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    79. Differential expression of the Groucho-related genes 4 and 5 during early development of Xenopus laevis. Mech Dev. 2000 Mar 01; 91(1-2):311-5. Molenaar M, Brian E, Roose J, Clevers H, Destrée O. PMID: 10704855.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    80. TCF transcription factors: molecular switches in carcinogenesis. Biochim Biophys Acta. 1999 Oct 29; 1424(2-3):M23-37. Roose J, Clevers H. PMID: 10528152.
      View in: PubMed   Mentions: 105     Fields:    Translation:HumansAnimalsCells
    81. Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. Science. 1999 Sep 17; 285(5435):1923-6. Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T, Clevers H. PMID: 10489374.
      View in: PubMed   Mentions: 174     Fields:    Translation:HumansAnimalsCells
    82. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Genomics. 1999 Apr 15; 57(2):301-5. Roose J, Korver W, de Boer R, Kuipers J, Hurenkamp J, Clevers H. PMID: 10198172.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    83. Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 1998 Oct 08; 395(6702):604-8. Cavallo RA, Cox RT, Moline MM, Roose J, Polevoy GA, Clevers H, Peifer M, Bejsovec A. PMID: 9783586.
      View in: PubMed   Mentions: 250     Fields:    Translation:AnimalsCells
    84. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. Nature. 1998 Oct 08; 395(6702):608-12. Roose J, Molenaar M, Peterson J, Hurenkamp J, Brantjes H, Moerer P, van de Wetering M, Destrée O, Clevers H. PMID: 9783587.
      View in: PubMed   Mentions: 243     Fields:    Translation:AnimalsCells
    85. Differential expression of the HMG box transcription factors XTcf-3 and XLef-1 during early xenopus development. Mech Dev. 1998 Jul; 75(1-2):151-4. Molenaar M, Roose J, Peterson J, Venanzi S, Clevers H, Destrée O. PMID: 9739131.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    86. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar; 18(3):1248-56. Korinek V, Barker N, Willert K, Molenaar M, Roose J, Wagenaar G, Markman M, Lamers W, Destree O, Clevers H. PMID: 9488439; PMCID: PMC108837.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    87. High expression of the HMG box factor sox-13 in arterial walls during embryonic development. Nucleic Acids Res. 1998 Jan 15; 26(2):469-76. Roose J, Korver W, Oving E, Wilson A, Wagenaar G, Markman M, Lamers W, Clevers H. PMID: 9421502; PMCID: PMC147262.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    88. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics. 1997 Dec 15; 46(3):435-42. Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H. PMID: 9441747.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    89. The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes. Immunobiology. 1997 Dec; 198(1-3):157-61. Korver W, Roose J, Wilson A, Clevers H. PMID: 9442387.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    90. The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 1997 May 01; 25(9):1715-9. Korver W, Roose J, Clevers H. PMID: 9108152; PMCID: PMC146663.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    91. XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell. 1996 Aug 09; 86(3):391-9. Molenaar M, van de Wetering M, Oosterwegel M, Peterson-Maduro J, Godsave S, Korinek V, Roose J, Destrée O, Clevers H. PMID: 8756721.
      View in: PubMed   Mentions: 616     Fields:    Translation:AnimalsCells
    92. Characterization of the gene encoding the polymorphic immunodominant molecule, a neutralizing antigen of Theileria parva. J Immunol. 1995 Aug 01; 155(3):1370-81. Toye PG, Metzelaar MJ, Wijngaard PL, Nene V, Iams K, Roose J, Nyanjui JK, Gobright E, Musoke AJ, Clevers HC. PMID: 7636202.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    93. Synthetic protease inhibitors: promising compounds to arrest pathobiologic processes. J Lab Clin Med. 1995 Apr; 125(4):433-41. Roose JP, Van Noorden CJ. PMID: 7706897.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
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