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Joanna Hellmuth, MD, MHS

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
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    Dr. Joanna Hellmuth is neurologist with sub-specialty training in cognitive and behavioral neurology. She practices at the UCSF Memory and Aging Center, where she evaluates and manages patients with mild cognitive impairment; neurodegenerative disorders such as Alzheimer's disease, Lewy body disease, frontotemporal dementia, vascular dementia; and patients with HIV-related cognitive changes. Dr. Hellmuth completed her bachelor's degree at the Johns Hopkins University, a master's degree from Johns Hopkins School of Public Health, and her medical degree from the University of Vermont College of Medicine. She completed her neurology residency at the University of California, San Francisco and later joined the Memory and Aging Center for fellowship training in neurodegenerative disorders prior to joining the faculty in the department of Neurology. Dr. Hellmuth's research interests are unraveling the neuroimmunologic mechanisms of HIV-associated neurocognitive disorder (HAND) to develop effective treatments and interventions.

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    Defining the clinical utility of CSF biomarkers of neurodegeneration in HIV+ elders
    NIH/NIMH K23MH114724Jul 18, 2017 - Jun 30, 2021
    Role: PI

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hellmuth J, Rabinovici GD, Miller BL. The Rise of Pseudomedicine for Dementia and Brain Health. JAMA. 2019 Jan 25. PMID: 30681701.
      View in: PubMed
    2. Hellmuth J, Slike BM, Sacdalan C, Best J, Kroon E, Phanuphak N, Fletcher JLK, Prueksakaew P, Jagodzinski LL, Valcour V, Robb M, Ananworanich J, Allen IE, Krebs SJ, Spudich S. Very early ART initiation during acute HIV infection is associated with normalization of cerebrospinal fluid but not plasma markers of immune activation. J Infect Dis. 2019 Jan 21. PMID: 30668739.
      View in: PubMed
    3. Narvid J, McCoy D, Dupont SM, Callen A, Tosun D, Hellmuth J, Valcour V. Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling. AJNR Am J Neuroradiol. 2018 Dec; 39(12):2211-2217. PMID: 30467218.
      View in: PubMed
    4. Hellmuth J, Milanini B, Masliah E, Tartaglia MC, Dunlop MB, Moore DJ, Javandel S, DeVaughn S, Valcour V. A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder. Neurocase. 2018 Aug; 24(4):213-219. PMID: 30304986.
      View in: PubMed
    5. Chan P, Patel P, Hellmuth J, Colby DJ, Kroon E, Sacdalan C, Pinyakorn S, Jagodzinski L, Krebs S, Ananworanich J, Valcour V, Spudich S. Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV. J Infect Dis. 2018 Aug 14; 218(6):937-945. PMID: 29741638.
      View in: PubMed
    6. Samboju V, Philippi CL, Chan P, Cobigo Y, Fletcher JLK, Robb M, Hellmuth J, Benjapornpong K, Dumrongpisutikul N, Pothisri M, Paul R, Ananworanich J, Spudich S, Valcour V. Structural and functional brain imaging in acute HIV. Neuroimage Clin. 2018; 20:327-335. PMID: 30101063.
      View in: PubMed
    7. Chan P, Hellmuth J, Colby D, Kroon E, Sacdalan C, Fletcher J, Patel P, Pinyakorn S, Valcour V, Ananworanich J, Spudich S. Safety of lumbar puncture procedure in an international research setting during acute HIV infection. J Virus Erad. 2018 Jan 01; 4(1):16-20. PMID: 29568548.
      View in: PubMed
    8. Hellmuth J, Colby D, Valcour V, Suttichom D, Spudich S, Ananworanich J, Prueksakaew P, Sailasuta N, Allen I, Jagodzinski LL, Slike B, Ochi D, Paul R. Depression and Anxiety are Common in Acute HIV Infection and Associate with Plasma Immune Activation. AIDS Behav. 2017 Nov; 21(11):3238-3246. PMID: 28484888.
      View in: PubMed
    9. Clifford KM, Samboju V, Cobigo Y, Milanini B, Marx GA, Hellmuth JM, Rosen HJ, Kramer JH, Allen IE, Valcour VG. Progressive Brain Atrophy Despite Persistent Viral Suppression in HIV Patients Older Than 60 Years. J Acquir Immune Defic Syndr. 2017 11 01; 76(3):289-297. PMID: 28650401.
      View in: PubMed
    10. Kessing CF, Spudich S, Valcour V, Cartwright P, Chalermchai T, Fletcher JL, Takata H, Nichols C, Josey BJ, Slike B, Krebs SJ, Sailsuta N, Lerdlum S, Jagodzinski L, Tipsuk S, Suttichom D, Rattanamanee S, Zetterberg H, Hellmuth J, Phanuphak N, Robb ML, Michael NL, Ananworanich J, Trautmann L. High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection. J Acquir Immune Defic Syndr. 2017 05 01; 75(1):108-117. PMID: 28177966.
      View in: PubMed
    11. Peluso MJ, Valcour V, Phanuphak N, Ananworanich J, Fletcher JL, Chalermchai T, Krebs SJ, Robb ML, Hellmuth J, Gisslén M, Zetterberg H, Spudich S. Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. AIDS. 2017 01 14; 31(2):247-252. PMID: 27819802.
      View in: PubMed
    12. Kamtchum-Tatuene J, Wan Sulaiman WA, Lekoubou A, Hellmuth J, Valcour V, Spudich S. Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016 Nov 29; 87(22):2386. PMID: 27895248.
      View in: PubMed
    13. Chan P, Hellmuth J, Spudich S, Valcour V. Cognitive Impairment and Persistent CNS Injury in Treated HIV. Curr HIV/AIDS Rep. 2016 08; 13(4):209-17. PMID: 27188299.
      View in: PubMed
    14. Hellmuth J, Fletcher JL, Valcour V, Kroon E, Ananworanich J, Intasan J, Lerdlum S, Narvid J, Pothisri M, Allen I, Krebs SJ, Slike B, Prueksakaew P, Jagodzinski LL, Puttamaswin S, Phanuphak N, Spudich S. Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016 Jul 12; 87(2):148-54. PMID: 27287217; PMCID: PMC4940060 [Available on 07/12/17].
    15. Valcour VG, Spudich SS, Sailasuta N, Phanuphak N, Lerdlum S, Fletcher JL, Kroon ED, Jagodzinski LL, Allen IE, Adams CL, Prueksakaew P, Slike BM, Hellmuth JM, Kim JH, Ananworanich J. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV. PLoS One. 2015; 10(11):e0142600. PMID: 26555069; PMCID: PMC4640512.
    16. Hellmuth J, Valcour V, Spudich S. CNS reservoirs for HIV: implications for eradication. J Virus Erad. 2015 Apr; 1(2):67-71. PMID: 26430703.
      View in: PubMed
    17. Hellmuth J, Milanini B, Valcour V. Interactions between ageing and NeuroAIDS. Curr Opin HIV AIDS. 2014 Nov; 9(6):527-32. PMID: 25203641; PMCID: PMC4296966.
    18. Hellmuth J, Mirsky J, Heuer HW, Matlin A, Jafari A, Garbutt S, Widmeyer M, Berhel A, Sinha L, Miller BL, Kramer JH, Boxer AL. Multicenter validation of a bedside antisaccade task as a measure of executive function. Neurology. 2012 Jun 05; 78(23):1824-31. PMID: 22573640; PMCID: PMC3369520.
    19. Boxer AL, Garbutt S, Seeley WW, Jafari A, Heuer HW, Mirsky J, Hellmuth J, Trojanowski JQ, Huang E, DeArmond S, Neuhaus J, Miller BL. Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease. Arch Neurol. 2012 Apr; 69(4):509-17. PMID: 22491196; PMCID: PMC3423186.
    20. Garbutt S, Matlin A, Hellmuth J, Schenk AK, Johnson JK, Rosen H, Dean D, Kramer J, Neuhaus J, Miller BL, Lisberger SG, Boxer AL. Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's disease. Brain. 2008 May; 131(Pt 5):1268-81. PMID: 18362099; PMCID: PMC2367697.
    21. Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ. Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci. 2007 Jan; 10(1):77-86. PMID: 17159989; PMCID: PMC3578579.
    22. Boxer AL, Garbutt S, Rankin KP, Hellmuth J, Neuhaus J, Miller BL, Lisberger SG. Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degeneration. J Neurosci. 2006 Jun 07; 26(23):6354-63. PMID: 16763044; PMCID: PMC2551317.