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Structure-based discovery of nonopioid analgesics acting through the a2A-adrenergic receptor. Science. 2022 09 30; 377(6614):eabn7065.
Fink EA, Xu J, H?bner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P. PMID: 36173843.
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3 Fields:
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HumansAnimals
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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons. Elife. 2022 08 15; 11.
Yue WWS, Yuan L, Braz JM, Basbaum AI, Julius D. PMID: 35968676; PMCID: PMC9377796.
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1 Fields:
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HumansAnimalsCells
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Intraspinal Transplantation of Precursors of Cortical GABAergic Interneurons to Treat Neuropathic Pain. . 2022 May 27; 178:159-170.
Braz BJ, Basbaum BA. .
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ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans. Pain. 2023 01 01; 164(1):43-58.
Yu X, Ton AN, Niu Z, Morales BM, Chen J, Braz J, Lai MH, Barruet E, Liu H, Cheung K, Ali S, Chan T, Bigay K, Ho J, Nikolli I, Hansberry S, Wentworth K, Kriegstein A, Basbaum A, Hsiao EC. PMID: 35442931; PMCID: PMC9582048.
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HumansCells
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Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor. J Med Chem. 2022 03 10; 65(5):4201-4217.
Levit Kaplan A, Strachan RT, Braz JM, Craik V, Slocum S, Mangano T, Amabo V, O'Donnell H, Lak P, Basbaum AI, Roth BL, Shoichet BK. PMID: 35195401; PMCID: PMC9116900.
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3 Fields:
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Humans
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Structures of the s2 receptor enable docking for bioactive ligand discovery. Nature. 2021 Dec; 600(7890):759-764.
Alon A, Lyu J, Braz JM, Tummino TA, Craik V, O'Meara MJ, Webb CM, Radchenko DS, Moroz YS, Huang XP, Liu Y, Roth BL, Irwin JJ, Basbaum AI, Shoichet BK, Kruse AC. PMID: 34880501; PMCID: PMC8867396.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice. Elife. 2021 10 15; 10.
Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI. PMID: 34652270; PMCID: PMC8639143.
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PubMed Mentions:
12 Fields:
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AnimalsCells
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LB722 IL-31/IL31RA negatively regulate IL-4 production and cutaneous M2-like macrophage accumulation. Journal of Investigative Dermatology. 2021 Sep 1; 141(9):b5.
Fassett FM, Braz BJ, Castellanos CC, Schroeder SA, Sadeghi SM, Mar MD, Zhou ZC, Shin SJ, Basbaum BA, Ansel AK. .
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Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons. Proc Natl Acad Sci U S A. 2021 07 13; 118(28).
Wercberger R, Braz JM, Weinrich JA, Basbaum AI. PMID: 34234018; PMCID: PMC8285968.
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8 Fields:
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AnimalsCells
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Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity. Elife. 2021 06 01; 10.
L?ken LS, Braz JM, Etlin A, Sadeghi M, Bernstein M, Jewell M, Steyert M, Kuhn J, Hamel K, Llewellyn-Smith IJ, Basbaum A. PMID: 34061020; PMCID: PMC8245130.
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PubMed Mentions:
8 Fields:
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AnimalsCells
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Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness. Proc Natl Acad Sci U S A. 2021 02 23; 118(8).
Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI. PMID: 33602818; PMCID: PMC7923356.
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PubMed Mentions:
6 Fields:
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AnimalsCells
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Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain. Nat Commun. 2020 01 14; 11(1):264.
Yu X, Liu H, Hamel KA, Morvan MG, Yu S, Leff J, Guan Z, Braz JM, Basbaum AI. PMID: 31937758; PMCID: PMC6959328.
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121 Fields:
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AnimalsCells
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Ablation of spinal cord estrogen receptor a-expressing interneurons reduces chemically induced modalities of pain and itch. J Comp Neurol. 2020 07; 528(10):1629-1643.
Tran M, Braz JM, Hamel K, Kuhn J, Todd AJ, Basbaum AI. PMID: 31872868; PMCID: PMC7317200.
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PubMed Mentions:
3 Fields:
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AnimalsCells
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GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness. Brain. 2019 09 01; 142(9):2655-2669.
Juarez-Salinas DL, Braz JM, Etlin A, Gee S, Sohal V, Basbaum AI. PMID: 31321411; PMCID: PMC6752168.
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20 Fields:
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AnimalsCells
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Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion. Neuron. 2019 06 05; 102(5):944-959.e3.
Meda KS, Patel T, Braz JM, Malik R, Turner ML, Seifikar H, Basbaum AI, Sohal VS. PMID: 31030955; PMCID: PMC6554049.
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PubMed Mentions:
38 Fields:
Translation:
Animals
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Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn. Pain. 2019 Feb; 160(2):442-462.
Dickie AC, Bell AM, Iwagaki N, Polg?r E, Gutierrez-Mecinas M, Kelly R, Lyon H, Turnbull K, West SJ, Etlin A, Braz J, Watanabe M, Bennett DLH, Basbaum AI, Riddell JS, Todd AJ. PMID: 30247267; PMCID: PMC6330098.
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32 Fields:
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AnimalsCells
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Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls. Pain Rep. 2018 Jul-Aug; 3(4):e659.
Juarez-Salinas DL, Braz JM, Hamel KA, Basbaum AI. PMID: 30123855; PMCID: PMC6085145.
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8
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NaV1.1 inhibition can reduce visceral hypersensitivity. JCI Insight. 2018 06 07; 3(11).
Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F. PMID: 29875317; PMCID: PMC6124407.
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17 Fields:
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HumansAnimalsCells
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Synergistic antipruritic effects of gamma aminobutyric acid A�and B agonists in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2017 Aug; 140(2):454-464.e2.
Cevikbas F, Braz JM, Wang X, Solorzano C, Sulk M, Buhl T, Steinhoff M, Basbaum AI. PMID: 28232084; PMCID: PMC5546982.
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13 Fields:
Translation:
AnimalsCells
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Rebuilding CNS inhibitory circuits to control chronic neuropathic pain and itch. Prog Brain Res. 2017; 231:87-105.
Braz JM, Etlin A, Juarez-Salinas D, Llewellyn-Smith IJ, Basbaum AI. PMID: 28554402.
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PubMed Mentions:
7 Fields:
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HumansAnimalsCells
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Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE. Exp Neurol. 2016 09; 283(Pt A):224-34.
Frezel N, Sohet F, Daneman R, Basbaum AI, Braz JM. PMID: 27343802; PMCID: PMC5500277.
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14 Fields:
Translation:
AnimalsCells
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Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101.
Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. PMID: 26642091; PMCID: PMC4703328.
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PubMed Mentions:
200 Fields:
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AnimalsCells
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Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury. Cell Rep. 2015 Nov 10; 13(6):1246-1257.
Petitjean H, Pawlowski SA, Fraine SL, Sharif B, Hamad D, Fatima T, Berg J, Brown CM, Jan LY, Ribeiro-da-Silva A, Braz JM, Basbaum AI, Sharif-Naeini R. PMID: 26527000; PMCID: PMC6038918.
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134 Fields:
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AnimalsCells
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CT-guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine. Sci Transl Med. 2015 Sep 16; 7(305):305ra145.
Brown JD, Saeed M, Do L, Braz J, Basbaum AI, Iadarola MJ, Wilson DM, Dillon WP. PMID: 26378245; PMCID: PMC4854290.
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25 Fields:
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AnimalsCells
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Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch. J Clin Invest. 2014 Aug; 124(8):3612-6.
Braz JM, Juarez-Salinas D, Ross SE, Basbaum AI. PMID: 25003193; PMCID: PMC4109547.
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22 Fields:
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AnimalsCells
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Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control. Neuron. 2014 Jun 1; 82(6):1407.
Braz BJ, Solorzano SC, Wang WX, Basbaum BA. .
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Sciatic nerve transection triggers release and intercellular transfer of a genetically expressed macromolecular tracer in dorsal root ganglia. J Comp Neurol. 2011 Sep 01; 519(13):2648-57.
Br?z JM, Ackerman L, Basbaum AI. PMID: 21484801; PMCID: PMC3864657.
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6 Fields:
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HumansAnimalsCells
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Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons. J Neurosci. 2011 Jul 13; 31(28):10119-27.
Cavanaugh DJ, Chesler AT, Br?z JM, Shah NM, Julius D, Basbaum AI. PMID: 21752988; PMCID: PMC3147010.
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PubMed Mentions:
136 Fields:
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AnimalsCells
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Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli. Pain. 2010 Aug; 150(2):290-301.
Br?z JM, Basbaum AI. PMID: 20605331; PMCID: PMC2922479.
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76 Fields:
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AnimalsCells
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320 DIFFERENTIAL ATF3 EXPRESSION REVEALS THE PROFILE OF DORSAL ROOT GANGLION (DRG) NEURONS ACTIVATED BY DIVERSE NOXIOUS CHEMICAL STIMULI. European Journal of Pain. 2009 Sep 1; 13(S1):s98a-s98.
Braz BJ, Basbaum BA. .
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Triggering genetically-expressed transneuronal tracers by peripheral axotomy reveals convergent and segregated sensory neuron-spinal cord connectivity. Neuroscience. 2009 Nov 10; 163(4):1220-32.
Bráz JM, Basbaum AI. PMID: 19647044; PMCID: PMC2760676.
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26 Fields:
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AnimalsCells
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Inputs to serotonergic neurons revealed by conditional viral transneuronal tracing. J Comp Neurol. 2009 May 10; 514(2):145-60.
Braz JM, Enquist LW, Basbaum AI. PMID: 19274668; PMCID: PMC2696271.
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31 Fields:
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AnimalsCells
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Chapter 22 The Endogenous Neuromodulation System. Neuromodulation. 2009 Jan 1; 303-312.
Basbaum BA, Braz BJ, Ossipov OM, Porreca PF. .
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Innocuous, not noxious, input activates PKCgamma interneurons of the spinal dorsal horn via myelinated afferent fibers. J Neurosci. 2008 Aug 06; 28(32):7936-44.
Neumann S, Braz JM, Skinner K, Llewellyn-Smith IJ, Basbaum AI. PMID: 18685019; PMCID: PMC3844752.
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93 Fields:
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AnimalsCells
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Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits. J Comp Neurol. 2008 Apr 20; 507(6):1990-2003.
Braz JM, Basbaum AI. PMID: 18273889; PMCID: PMC4947410.
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26 Fields:
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AnimalsCells
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Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor. Neuron. 2005 Sep 15; 47(6):787-93.
Braz JM, Nassar MA, Wood JN, Basbaum AI. PMID: 16157274.
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136 Fields:
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AnimalsCells
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[From inflammation to pain: experimental gene therapy]. Med Sci (Paris). 2004 Mar; 20(3):325-30.
Meunier A, Braz J, Cesselin F, Hamon M, Pohl M. PMID: 15067578.
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HumansAnimals
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Gene therapy of chronic pain. Curr Gene Ther. 2003 Jun; 3(3):223-38.
Pohl M, Meunier A, Hamon M, Braz J. PMID: 12762481.
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3 Fields:
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HumansAnimals
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Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15148-53.
Braz JM, Rico B, Basbaum AI. PMID: 12391304; PMCID: PMC137558.
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47 Fields:
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AnimalsCells
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The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord. J Neurochem. 2002 May; 81(3):659-62.
Ballet S, Braz J, Mauborgne A, Bourgoin S, Zajac JM, Hamon M, Cesselin F. PMID: 12065675.
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Animals
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Gene therapy of pain: emerging strategies and future directions. Eur J Pharmacol. 2001 Oct 19; 429(1-3):39-48.
Pohl M, Braz J. PMID: 11698025.
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9 Fields:
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HumansAnimals
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Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons. J Neurosci. 2001 Oct 15; 21(20):7881-8.
Braz J, Beaufour C, Coutaux A, Epstein AL, Cesselin F, Hamon M, Pohl M. PMID: 11588161; PMCID: PMC6763863.
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46 Fields:
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AnimalsCells
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Effets analgésiques des morphiniques et systèmes opioïdergiques dans les douleurs chroniques: confrontation des données cliniques et des données expérimentales chez l’animal. Douleur et Analgésie. 2001 Mar 1; 14(1):49-58.
Braz BJ, Coutaux CA. .
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Met-enkephalin is preferentially transported into the peripheral processes of primary afferent fibres in both control and HSV1-driven proenkephalin A overexpressing rats. Neuroscience. 2001; 103(4):1073-83.
Antunes bras J, Becker C, Bourgoin S, Lombard M, Cesselin F, Hamon M, Pohl M. PMID: 11301214.
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15 Fields:
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AnimalsCells
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Effects of peripheral axotomy on cholecystokinin neurotransmission in the rat spinal cord. J Neurochem. 1999 Feb; 72(2):858-67.
Antunes Bras JM, Laporte AM, Benoliel JJ, Bourgoin S, Mauborgne A, Hamon M, Cesselin F, Pohl M. PMID: 9930763.
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7 Fields:
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AnimalsCells
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Herpes simplex virus 1-mediated transfer of preproenkephalin A in rat dorsal root ganglia. J Neurochem. 1998 Mar; 70(3):1299-303.
Antunes Bras JM, Epstein AL, Bourgoin S, Hamon M, Cesselin F, Pohl M. PMID: 9489753.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells