Joel Babdor, PhD

Title(s)Postdoctoral Scholar, Otolaryngology
SchoolSchool of Medicine
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    Paris Descartes University, ParisPhD.Cell and molecular biology of dendritic cells

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    Joel Babdor, PhD, is a postdoctoral researcher in the Spitzer lab. He uses high-throughput, high-dimensional technologies and computational methods to study the interactions between the human immune system and the microbiome at the systems level. He focuses on human research in healthy populations and in pathological settings where the immune system plays an important role (cancer, autoimmunity and organ transplantation).

    One of the main projects Joel has developed in the Spitzer lab is the ImmunoMicrobiome Study, an IRB-approved human research protocol, which successfully enrolled 111 healthy individuals, to perform a comprehensive analysis of the peripheral immune system, the gut/oral/skin microbiome, and the metabolome. His study is designed to assess variations of the immune system and the microbiome across time and explore the interactions between these biological compartments. As "it takes a village", Joel is collaboratively developing novel, integrative computational strategies to analyze the ImmunoMicrobiome multi-OMIC dataset.

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    ImmunoMicrobiome: Longitudinal integrative analysis of systems-level immunity and the microbiome in a healthy population
    Bakar ImmunoX - CoProject
    Role: Researcher
    Development of Tissue MicroArray-MIBI-Analysis for Topological Characterization of the Immune Landscape in Synchronous Primary and Metastatic Colorectal Cancers
    Bakar ImmunoX - CoPilot
    Role: Researcher

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC. Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy. Cell Rep. 2019 Jul 16; 28(3):819-831.e4. PMID: 31315057.
      View in: PubMed
    2. Weimershaus M, Mauvais FX, Saveanu L, Adiko C, Babdor J, Abramova A, Montealegre S, Lawand M, Evnouchidou I, Huber KJ, Chadt A, Zwick M, Vargas P, Dussiot M, Lennon-Dumenil AM, Brocker T, Al-Hasani H, van Endert P. Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation. Cell Rep. 2018 09 25; 24(13):3568-3581. PMID: 30257216.
      View in: PubMed
    3. Coman T, Rossignol J, D'Aveni M, Fabiani B, Dussiot M, Rignault R, Babdor J, Bouillé M, Herbelin A, Coté F, Moura IC, Hermine O, Rubio MT. Human CD4- invariant NKT lymphocytes regulate graft versus host disease. Oncoimmunology. 2018; 7(11):e1470735. PMID: 30377560.
      View in: PubMed
    4. Drecourt A, Babdor J, Dussiot M, Petit F, Goudin N, Garfa-Traoré M, Habarou F, Bole-Feysot C, Nitschké P, Ottolenghi C, Metodiev MD, Serre V, Desguerre I, Boddaert N, Hermine O, Munnich A, Rötig A. Impaired Transferrin Receptor Palmitoylation and Recycling in Neurodegeneration with Brain Iron Accumulation. Am J Hum Genet. 2018 02 01; 102(2):266-277. PMID: 29395073.
      View in: PubMed
    5. Babdor J, Descamps D, Adiko AC, Tohmé M, Maschalidi S, Evnouchidou I, Vasconcellos LR, De Luca M, Mauvais FX, Garfa-Traore M, Brinkmann MM, Chignard M, Manoury B, Saveanu L. IRAP+ endosomes restrict TLR9 activation and signaling. Nat Immunol. 2017 05; 18(5):509-518. PMID: 28319098.
      View in: PubMed
    6. Trias E, Ibarburu S, Barreto-Núñez R, Babdor J, Maciel TT, Guillo M, Gros L, Dubreuil P, Díaz-Amarilla P, Cassina P, Martínez-Palma L, Moura IC, Beckman JS, Hermine O, Barbeito L. Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis. J Neuroinflammation. 2016 07 11; 13(1):177. PMID: 27400786.
      View in: PubMed
    7. Adiko AC, Babdor J, Gutiérrez-Martínez E, Guermonprez P, Saveanu L. Intracellular Transport Routes for MHC I and Their Relevance for Antigen Cross-Presentation. Front Immunol. 2015; 6:335. PMID: 26191062.
      View in: PubMed
    8. Saveanu L, Babdor J, Lawand M, van Endert P. Insulin-regulated aminopeptidase and its compartment in dendritic cells. Mol Immunol. 2013 Sep; 55(2):153-5. PMID: 23123036.
      View in: PubMed
    9. Loredana Saveanu, Joel Babdor, Mira Tohme, Sophia Maschalidi, Benedicte Manoury, Peter van Endert. Irap is required for normal phagosome and endosome maturation in dendritic cells. Molecular Immunology. 2012 May 1; 51(1):34.
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