Joel Karliner, MD

TitleProfessor Emeritus
InstitutionUniversity of California San Francisco
Address550 16th. Street
San Francisco CA 94158
Phone415-221-4810 ext. 3171
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship School of Medicine - Cardiology

    Collapse Research 
    Collapse Research Activities and Funding
    Immune Modulation and Cardiac Remodeling
    VA I01BX002994Oct 1, 2016 - Sep 30, 2020
    Role: Co-Principal Investigator
    Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    VA I01BX000324Apr 1, 2009 - Mar 31, 2013
    Role: Principal Investigator
    Sphingosine 1-phosphate and cardioprotection
    NIH/NHLBI R01HL090606Mar 16, 2009 - Feb 28, 2014
    Role: Principal Investigator
    Mechanisms of Cardioprotection in Ischemia and Failure
    NIH/NHLBI P01HL068738Aug 1, 2002 - Jul 31, 2008
    Role: Principal Investigator
    Protection From Cardiac Reperfusion Injury by Ethanol
    NIH/NIAAA R01AA011135Sep 30, 1996 - Jun 30, 2008
    Role: Co-Principal Investigator
    Diet-Induced Insulin Resistance and Myocardial Ischemia in Pigs
    NIH/NHLBI R01HL049944Feb 1, 1994 - May 31, 2014
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Goetzl EJ, Goetzl L, Karliner JS, Tang N, Pulliam L. Human plasma platelet-derived exosomes: effects of aspirin. FASEB J. 2016 05; 30(5):2058-63. PMID: 26873936; PMCID: PMC4836374 [Available on 05/01/17].
    2. Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL. Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis. J Cardiovasc Pharmacol. 2016 Jan; 67(1):47-56. PMID: 26322923; PMCID: PMC4703534 [Available on 01/01/17].
    3. Yeghiazarians Y, Honbo N, Imhof I, Woods B, Aguilera V, Ye J, Boyle AJ, Karliner JS. IL-15: a novel prosurvival signaling pathway in cardiomyocytes. J Cardiovasc Pharmacol. 2014 May; 63(5):406-11. PMID: 24805144; PMCID: PMC4115639.
    4. Karliner JS. Arsonists and firefighters: the perpetual inflammatory civil war for survival. Circulation. 2014 Jun 10; 129(23):2368-70. PMID: 24710031; PMCID: PMC4061904.
    5. Wang G, Kim RY, Imhof I, Honbo N, Luk FS, Li K, Kumar N, Zhu BQ, Eberlé D, Ching D, Karliner JS, Raffai RL. The immunosuppressant FTY720 prolongs survival in a mouse model of diet-induced coronary atherosclerosis and myocardial infarction. J Cardiovasc Pharmacol. 2014 Feb; 63(2):132-143. PMID: 24508946; PMCID: PMC4574629.
    6. Karliner JS. Selected aspects of cellular responses in heart failure. J Cardiovasc Pharmacol. 2014 Feb; 63(2):83-4. PMID: 24390177.
      View in: PubMed
    7. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PLoS One. 2013; 8(7):e68154. PMID: 23874529; PMCID: PMC3712965.
    8. Kawabori M, Kacimi R, Karliner JS, Yenari MA. Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets. World J Cardiol. 2013 Apr 26; 5(4):75-86. PMID: 23675553; PMCID: PMC3653015.
    9. Vessey DA, Li L, Imhof I, Honbo N, Karliner JS. FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. Med Sci Monit Basic Res. 2013 Apr 09; 19:126-32. PMID: 23567658; PMCID: PMC3659128.
    10. Karliner JS. Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. Biochim Biophys Acta. 2013 Jan; 1831(1):203-12. PMID: 22735359; PMCID: PMC3479372.
    11. Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS. A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS One. 2012; 7(4):e34177. PMID: 22509276; PMCID: PMC3317925.
    12. Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB. Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. PLoS One. 2011; 6(7):e21779. PMID: 21814553; PMCID: PMC3140972.
    13. Vessey DA, Li L, Jin ZQ, Kelley M, Honbo N, Zhang J, Karliner JS. A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. Oxid Med Cell Longev. 2011; 2011:961059. PMID: 21904650; PMCID: PMC3166792.
    14. Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1753-61. PMID: 21335477; PMCID: PMC3094087.
    15. Tao R, Kim SH, Honbo N, Karliner JS, Alano CC. Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol. 2010 Dec; 56(6):659-68. PMID: 20881608; PMCID: PMC3064957.
    16. Dahi S, Karliner JS, Sarkar R, Lovett DH. Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia. Int J Exp Pathol. 2011 Feb; 92(1):50-6. PMID: 21039989; PMCID: PMC3052756.
    17. Zhang J, Chatterjee K, Alano CC, Kalinowski MA, Honbo N, Karliner JS. Vincristine attenuates N-methyl-N'-nitro-N-nitrosoguanidine-induced poly-(ADP) ribose polymerase activity in cardiomyocytes. J Cardiovasc Pharmacol. 2010 Mar; 55(3):219-26. PMID: 20375713; PMCID: PMC2865187.
    18. Tao R, Hoover HE, Honbo N, Kalinowski M, Alano CC, Karliner JS, Raffai R. High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. Am J Physiol Heart Circ Physiol. 2010 Mar; 298(3):H1022-8. PMID: 20061542; PMCID: PMC2838562.
    19. Kotlyar AB, Randazzo A, Honbo N, Jin ZQ, Karliner JS, Cecchini G. Cardioprotective activity of a novel and potent competitive inhibitor of lactate dehydrogenase. FEBS Lett. 2010 Jan 04; 584(1):159-65. PMID: 19913538; PMCID: PMC2794998.
    20. Chatterjee K, Zhang J, Honbo N, Karliner JS. Doxorubicin cardiomyopathy. Cardiology. 2010; 115(2):155-62. PMID: 20016174; PMCID: PMC2848530.
    21. Karliner JS. Lessons from the besotted heart. J Am Coll Cardiol. 2009 Dec 01; 54(23):2197-8. PMID: 19942092.
      View in: PubMed
    22. Vessey DA, Li L, Honbo N, Karliner JS. Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning. Am J Physiol Heart Circ Physiol. 2009 Oct; 297(4):H1429-35. PMID: 19648253; PMCID: PMC2770755.
    23. Tao R, Hoover HE, Zhang J, Honbo N, Alano CC, Karliner JS. Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization. J Cardiovasc Pharmacol. 2009 Jun; 53(6):486-94. PMID: 19433984; PMCID: PMC2835551.
    24. Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N, Wisneski A, Cha J, Karliner JS, Mann MJ. Myocardial survival signaling in response to stem cell transplantation. J Am Coll Surg. 2009 Apr; 208(4):607-13. PMID: 19476797; PMCID: PMC2817986.
    25. Karliner JS, Brown JH. Lipid signalling in cardiovascular pathophysiology. Cardiovasc Res. 2009 May 01; 82(2):171-4. PMID: 19297369.
      View in: PubMed
    26. Karliner JS. Sphingosine kinase and sphingosine 1-phosphate in cardioprotection. J Cardiovasc Pharmacol. 2009 Mar; 53(3):189-97. PMID: 19247197; PMCID: PMC2835544.
    27. Yeh CC, Li H, Malhotra D, Huang MC, Zhu BQ, Goetzl EJ, Vessey DA, Karliner JS, Mann MJ. Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol. 2009 Apr; 296(4):H1193-9. PMID: 19234089; PMCID: PMC2670694.
    28. Karliner JS. Sphingosine kinase regulation and cardioprotection. Cardiovasc Res. 2009 May 01; 82(2):184-92. PMID: 19017750; PMCID: PMC2721648.
    29. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Cardiovasc Pathol. 2009 Sep-Oct; 18(5):253-61. PMID: 18835790; PMCID: PMC3367668.
    30. Vessey DA, Li L, Kelley M, Karliner JS. Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):425-9. PMID: 18706887; PMCID: PMC3402379.
    31. Chatterjee K, Zhang J, Tao R, Honbo N, Karliner JS. Vincristine attenuates doxorubicin cardiotoxicity. Biochem Biophys Res Commun. 2008 Sep 05; 373(4):555-60. PMID: 18590705; PMCID: PMC2846088.
    32. Jin ZQ, Karliner JS, Vessey DA. Ischaemic postconditioning protects isolated mouse hearts against ischaemia/reperfusion injury via sphingosine kinase isoform-1 activation. Cardiovasc Res. 2008 Jul 01; 79(1):134-40. PMID: 18334546.
      View in: PubMed
    33. Vessey DA, Li L, Kelley M, Zhang J, Karliner JS. Sphingosine can pre- and post-condition heart and utilizes a different mechanism from sphingosine 1-phosphate. J Biochem Mol Toxicol. 2008 Mar-Apr; 22(2):113-8. PMID: 18418901.
      View in: PubMed
    34. Alano CC, Tran A, Tao R, Ying W, Karliner JS, Swanson RA. Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes. J Neurosci Res. 2007 Nov 15; 85(15):3378-85. PMID: 17853438.
      View in: PubMed
    35. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H205-12. PMID: 17965283; PMCID: PMC3372085.
    36. Zhang J, Honbo N, Goetzl EJ, Chatterjee K, Karliner JS, Gray MO. Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3150-8. PMID: 17766476.
      View in: PubMed
    37. Grivennikova VG, Kotlyar AB, Karliner JS, Cecchini G, Vinogradov AD. Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I. Biochemistry. 2007 Sep 25; 46(38):10971-8. PMID: 17760425; PMCID: PMC2258335.
    38. Tao R, Karliner JS, Simonis U, Zheng J, Zhang J, Honbo N, Alano CC. Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes. Biochem Biophys Res Commun. 2007 Nov 16; 363(2):257-62. PMID: 17880922; PMCID: PMC2844438.
    39. Bao X, Lu CM, Liu F, Gu Y, Dalton ND, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J, Simpson PC, Ziegler MG. Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse. Circulation. 2007 Aug 28; 116(9):1024-31. PMID: 17698731.
      View in: PubMed
    40. Chatterjee K, Zhang J, Honbo N, Simonis U, Shaw R, Karliner JS. Acute vincristine pretreatment protects adult mouse cardiac myocytes from oxidative stress. J Mol Cell Cardiol. 2007 Sep; 43(3):327-36. PMID: 17662302.
      View in: PubMed
    41. Jin ZQ, Zhang J, Huang Y, Hoover HE, Vessey DA, Karliner JS. A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. Cardiovasc Res. 2007 Oct 01; 76(1):41-50. PMID: 17610857.
      View in: PubMed
    42. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):189-95. PMID: 17475219; PMCID: PMC3423089.
    43. Kacimi R, Vessey DA, Honbo N, Karliner JS. Adult cardiac fibroblasts null for sphingosine kinase-1 exhibit growth dysregulation and an enhanced proinflammatory response. J Mol Cell Cardiol. 2007 Jul; 43(1):85-91. PMID: 17512943.
      View in: PubMed
    44. Tao R, Zhang J, Vessey DA, Honbo N, Karliner JS. Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. Cardiovasc Res. 2007 Apr 01; 74(1):56-63. PMID: 17320845.
      View in: PubMed
    45. Vessey DA, Kelley M, Zhang J, Li L, Tao R, Karliner JS. Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. J Biochem Mol Toxicol. 2007; 21(5):273-9. PMID: 17912702.
      View in: PubMed
    46. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1847-60. PMID: 17158653.
      View in: PubMed
    47. Vessey DA, Kelley M, Li L, Huang Y, Zhou HZ, Zhu BQ, Karliner JS. Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury. Med Sci Monit. 2006 Oct; 12(10):BR318-24. PMID: 17006394.
      View in: PubMed
    48. Karliner JS. Toward solving the riddle: the enigma becomes less mysterious. Circ Res. 2006 Sep 01; 99(5):465-7. PMID: 16946142.
      View in: PubMed
    49. Jin ZQ, Karliner JS. Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. Cardiovasc Res. 2006 Sep 01; 71(4):725-34. PMID: 16831409.
      View in: PubMed
    50. Zhu BQ, Simonis U, Cecchini G, Zhou HZ, Li L, Teerlink JR, Karliner JS. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006 Jun; 11(2):119-28. PMID: 16891289.
      View in: PubMed
    51. Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1838-46. PMID: 16699069.
      View in: PubMed
    52. Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol. 2006 Mar; 290(3):H1103-9. PMID: 16243914.
      View in: PubMed
    53. Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Cardiovasc Res. 2006 Feb 15; 69(3):688-96. PMID: 16183043.
      View in: PubMed
    54. Kotlyar AB, Karliner JS, Cecchini G. A novel strong competitive inhibitor of complex I. FEBS Lett. 2005 Aug 29; 579(21):4861-6. PMID: 16107251.
      View in: PubMed
    55. Karliner JS. Off the shelf but not mass produced. Chem Biol. 2005 Jun; 12(6):614-5. PMID: 15975506.
      View in: PubMed
    56. Karliner JS. Symbols within words: have we neglected the AdeNOsine A2 receptor? Cardiovasc Res. 2005 Mar 01; 65(4):763-5. PMID: 15721853.
      View in: PubMed
    57. Vessey DA, Kelley M, Karliner JS. A rapid radioassay for sphingosine kinase. Anal Biochem. 2005 Feb 01; 337(1):136-42. PMID: 15649386.
      View in: PubMed
    58. Jin ZQ, Zhou HZ, Cecchini G, Gray MO, Karliner JS. MnSOD in mouse heart: acute responses to ischemic preconditioning and ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005 Jun; 288(6):H2986-94. PMID: 15681709.
      View in: PubMed
    59. Zhu BQ, Zhou HZ, Teerlink JR, Karliner JS. Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion. Cardiovasc Drugs Ther. 2004 Nov; 18(6):421-31. PMID: 15770429.
      View in: PubMed
    60. Jin ZQ, Goetzl EJ, Karliner JS. Sphingosine kinase activation mediates ischemic preconditioning in murine heart. Circulation. 2004 Oct 05; 110(14):1980-9. PMID: 15451787.
      View in: PubMed
    61. Karliner JS. Mechanisms of cardioprotection by lysophospholipids. J Cell Biochem. 2004 Aug 15; 92(6):1095-103. PMID: 15258895.
      View in: PubMed
    62. Chi NC, Karliner JS. Molecular determinants of responses to myocardial ischemia/reperfusion injury: focus on hypoxia-inducible and heat shock factors. Cardiovasc Res. 2004 Feb 15; 61(3):437-47. PMID: 14962475.
      View in: PubMed
    63. Maklashina E, Kotlyar AB, Karliner JS, Cecchini G. Effect of oxygen on activation state of complex I and lack of oxaloacetate inhibition of complex II in Langendorff perfused rat heart. FEBS Lett. 2004 Jan 02; 556(1-3):64-8. PMID: 14706827.
      View in: PubMed
    64. Zhu BQ, Heeschen C, Sievers RE, Karliner JS, Parmley WW, Glantz SA, Cooke JP. Second hand smoke stimulates tumor angiogenesis and growth. Cancer Cell. 2003 Sep; 4(3):191-6. PMID: 14522253.
      View in: PubMed
    65. Graeler MH, Kong Y, Karliner JS, Goetzl EJ. Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes. J Biol Chem. 2003 Jul 25; 278(30):27737-41. PMID: 12782628.
      View in: PubMed
    66. Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. J Renin Angiotensin Aldosterone Syst. 2003 Mar; 4(1):31-7. PMID: 12692751.
      View in: PubMed
    67. Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Biochem J. 2003 Feb 01; 369(Pt 3):485-96. PMID: 12371906; PMCID: PMC1223099.
    68. Maklashina E, Sher Y, Zhou HZ, Gray MO, Karliner JS, Cecchini G. Effect of anoxia/reperfusion on the reversible active/de-active transition of NADH-ubiquinone oxidoreductase (complex I) in rat heart. Biochim Biophys Acta. 2002 Oct 03; 1556(1):6-12. PMID: 12351213.
      View in: PubMed
    69. Zhou HZ, Karliner JS, Gray MO. Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H165-74. PMID: 12063287.
      View in: PubMed
    70. Jin ZQ, Zhou HZ, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO. Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H1970-7. PMID: 12003800.
      View in: PubMed
    71. Karliner JS. Lysophospholipids and the cardiovascular system. Biochim Biophys Acta. 2002 May 23; 1582(1-3):216-21. PMID: 12069831.
      View in: PubMed