John Gilchrist, PhD

Title(s)Postdoctoral Scholar, Physiology
SchoolSchool of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 Mar 07; 97(5):1063-1077.e4. PMID: 29478917.
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    2. Gilchrist J, Bosmans F. Using voltage-sensor toxins and their molecular targets to investigate NaV 1.8 gating. J Physiol. 2018 May 15; 596(10):1863-1872. PMID: 29193176.
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    3. Early M, Schroeder WG, Unnithan R, Gilchrist JM, Muller WA, Schenkel A. Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses. PeerJ. 2017; 5:e3555. PMID: 28713655.
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    4. Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. The tarantula toxin ß/d-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Sci Rep. 2017 04 20; 7(1):974. PMID: 28428547.
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    5. Ikonomopoulou MP, Smith JJ, Herzig V, Pineda SS, Dziemborowicz S, Er SY, Durek T, Gilchrist J, Alewood PF, Nicholson GM, Bosmans F, King GF. Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix. Toxicon. 2016 Dec 01; 123:62-70. PMID: 27793656.
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    6. Herzig V, Ikonomopoulou M, Smith JJ, Dziemborowicz S, Gilchrist J, Kuhn-Nentwig L, Rezende FO, Moreira LA, Nicholson GM, Bosmans F, King GF. Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami. Sci Rep. 2016 07 07; 6:29538. PMID: 27383378.
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    7. Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 06 23; 534(7608):494-9. PMID: 27281198.
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    8. Das S, Gilchrist J, Bosmans F, Van Petegem F. Binary architecture of the Nav1.2-ß2 signaling complex. Elife. 2016 Feb 19; 5. PMID: 26894959; PMCID: PMC4769172.
    9. Bende NS, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Wagner J, Nicholson GM, King GF, Bosmans F. A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a. Nat Commun. 2014 Jul 11; 5:4350. PMID: 25014760; PMCID: PMC4115291.
    10. Lishnevsky M, Young LC, Woods SJ, Groshong SD, Basaraba RJ, Gilchrist JM, Higgins DM, Gonzalez-Juarrero M, Bass TA, Muller WA, Schenkel AR. Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice. Exp Mol Pathol. 2014 Aug; 97(1):128-36. PMID: 24972347; PMCID: PMC4414406.
    11. Gilchrist J, Dutton S, Diaz-Bustamante M, McPherson A, Olivares N, Kalia J, Escayg A, Bosmans F. Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents. ACS Chem Biol. 2014 May 16; 9(5):1204-12. PMID: 24635129; PMCID: PMC4027953.
    12. Gilchrist J, Olivera BM, Bosmans F. Animal toxins influence voltage-gated sodium channel function. Handb Exp Pharmacol. 2014; 221:203-29. PMID: 24737238.
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    13. Gilchrist J, Das S, Van Petegem F, Bosmans F. Crystallographic insights into sodium-channel modulation by the ß4 subunit. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E5016-24. PMID: 24297919; PMCID: PMC3870679.
    14. Gilchrist J, Bosmans F. Animal toxins can alter the function of Nav1.8 and Nav1.9. Toxins (Basel). 2012 08; 4(8):620-32. PMID: 23012651; PMCID: PMC3446747.
    15. Early MA, Lishnevsky M, Gilchrist JM, Higgins DM, Orme IM, Muller WA, Gonzalez-Juarerro M, Schenkel AR. Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry. Exp Mol Pathol. 2009 Oct; 87(2):152-8. PMID: 19646434; PMCID: PMC2753694.
    16. Schroeder WG, Mitrescu LM, Hart ML, Unnithan R, Gilchrist JM, Smith EE, Shanley C, Benedict KM, Taraba L, Volckens J, Basaraba RJ, Schenkel AR. Flexible low-cost system for small animal aerosol inhalation exposure to drugs, proteins, inflammatory agents, and infectious agents. Biotechniques. 2009 Mar; 46(3 Suppl):Piii-Pviii. PMID: 19317668.
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