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John Houde, PhD

Title(s)Professor, Otolaryngology
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-6888
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    John F. Houde, PhD, is a Professor in Residence and he is the Director of the Speech Neuroscience Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his Electrical Engineering undergraduate degree from the California Institute of Technology in Pasadena, and he obtained his MS in Computer Science from Duke University, Durham, North Carolina. Dr. Houde earned his PhD in Brain and Cognitive Science from MIT, and this was followed by a fellowship in Medicine from UCSF.

    Dr. Houde’s research focuses on understanding the role of auditory feedback in speech and the neural mechanisms supporting auditory feedback. His research projects include computational modeling, psychophysical investigations, and functional neuroimaging that examine auditory feedback's role in the learning and maintenance of speech, as well as the online control of speech. A major focus of Dr. Houde’s lab is determining the role of auditory feedback in speaking by examining how speakers respond to realtime alterations of their audio feedback. Another major focus is using functional neuroimaging, especially magnetoencephalography (MEG), as well as electrocorticography (ECoG) to study how auditory feedback is processed during speaking.

    Dr. Houde also studies how feedback processing in speech production is compromised in various clinical conditions, such as Alzheimer’s disease and spasmodic dysphonia.

    Dr. Houde is a member of the Cognitive Neuroscience Society, the Society of Neuroscience, and the Society for the Neuroscience Language. He has contributed to 24 peer-reviewed articles, 2 patents, and over 50 abstracts.

    Specialty:
    The neuroscience of speech production

    Expertise:
    Research in cognitive neuroscience

    Professional Interests:
    Speech, hearing, neuroscience, cognitive science, acoustics, auditory feedback, motor control

    Education and Training:
    • BS: California Institute of Technology – Electrical Engineering
    • MS: Duke University – Computer Science
    • PhD: Massachusetts Institute of Technology, Cambridge – Brain and Cognitive Science
    • Postdoctoral Training: University of California, San Francisco

    Collapse Research 
    Collapse Research Activities and Funding
    The role of the cerebellum in speech
    NIH/NIDCD R01DC017091Dec 25, 2018 - Nov 30, 2023
    Role: Principal Investigator
    CRCNS: Modeling the role of auditory feedback in speech motor control
    NIH/NIDCD R01DC017696Sep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Dynamic Brain Imaging of Speech in Primary Progressive Aphasia
    NIH/NINDS R01NS100440Sep 15, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Timing of Neural activity in Spasmodic Dysphonia
    NIH/NIDCD R21DC014525Apr 2, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Imaging sensorimotor adaptation and compensation of speech
    NIH/NIDCD R01DC013979Jul 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Neuroimaging of Speech Motor Control
    NIH/NIDCD R01DC010145Jun 28, 2010 - May 31, 2015
    Role: Principal Investigator
    The Neural Substrates of Impaired Feedback Control in P*
    NIH/NIDCD R21DC005582Apr 10, 2002 - Mar 31, 2005
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Taking the sublexical route: brain dynamics of reading in the semantic variant of primary progressive aphasia. Brain. 2020 Aug 01; 143(8):2545-2560. Borghesani V, Hinkley LBN, Ranasinghe KG, Thompson MMC, Shwe W, Mizuiri D, Lauricella M, Europa E, Honma S, Miller Z, Miller B, Vossel K, Henry MML, Houde JF, Gorno-Tempini ML, Nagarajan SS. PMID: 32789455.
      View in: PubMed   Mentions:    Fields:    
    2. The Visual Word Form Area compensates for auditory working memory dysfunction in schizophrenia. Sci Rep. 2020 06 01; 10(1):8881. Herman AB, Brown EG, Dale CL, Hinkley LB, Subramaniam K, Houde JF, Fisher M, Vinogradov S, Nagarajan SS. PMID: 32483253.
      View in: PubMed   Mentions:    Fields:    
    3. Optimizing Magnetoencephalographic Imaging Estimation of Language Lateralization for Simpler Language Tasks. Front Hum Neurosci. 2020; 14:105. Hinkley LBN, De Witte E, Cahill-Thompson M, Mizuiri D, Garrett C, Honma S, Findlay A, Gorno-Tempini ML, Tarapore P, Kirsch HE, Mariën P, Houde JF, Berger M, Nagarajan SS. PMID: 32499685.
      View in: PubMed   Mentions:
    4. Learning and adaptation in speech production without a vocal tract. Sci Rep. 2019 09 19; 9(1):13582. Thompson MMC, Houde JF, Nagarajan SS. PMID: 31537824.
      View in: PubMed   Mentions:    Fields:    
    5. The FACTS model of speech motor control: Fusing state estimation and task-based control. PLoS Comput Biol. 2019 09; 15(9):e1007321. Parrell B, Ramanarayanan V, Nagarajan S, Houde J. PMID: 31479444.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    6. Modeling the Role of Sensory Feedback in Speech Motor Control and Learning. J Speech Lang Hear Res. 2019 08 29; 62(8S):2963-2985. Parrell B, Houde J. PMID: 31465712.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Cortical-Basal Ganglia-Cerebellar Networks in Unilateral Vocal Fold Paralysis: A Pilot Study. Laryngoscope. 2020 02; 130(2):460-464. Perez PL, Cueva KL, Rosen CA, Young VN, Naunheim ML, Yung KC, Schneider SL, Mizuiri D, Klein DJ, Houde JF, Hinkley LB, Nagarajan SS, Cheung SW. PMID: 31070785.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy. Sci Rep. 2019 05 02; 9(1):6814. Subramaniam K, Hinkley LBN, Mizuiri D, Kothare H, Cai C, Garrett C, Findlay A, Houde JF, Nagarajan SS. PMID: 31048735.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Abnormally increased vocal responses to pitch feedback perturbations in patients with cerebellar degeneration. J Acoust Soc Am. 2019 05; 145(5):EL372. Houde JF, Gill JS, Agnew Z, Kothare H, Hickok G, Parrell B, Ivry RB, Nagarajan SS. PMID: 31153297.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Sci Rep. 2019 04 05; 9(1):5686. Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS. PMID: 30952883.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Cortical networks for speech motor control in unilateral vocal fold paralysis. Laryngoscope. 2019 09; 129(9):2125-2130. Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Hinkley LB, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW. PMID: 30570142.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Vocal motor control and central auditory impairments in unilateral vocal fold paralysis. Laryngoscope. 2019 09; 129(9):2112-2117. Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW. PMID: 30484858.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. Online Adaptation to Altered Auditory Feedback Is Predicted by Auditory Acuity and Not by Domain-General Executive Control Resources. Front Hum Neurosci. 2018; 12:91. Martin CD, Niziolek CA, Duñabeitia JA, Perez A, Hernandez D, Carreiras M, Houde JF. PMID: 29593516.
      View in: PubMed   Mentions:
    14. Reality Monitoring and Feedback Control of Speech Production Are Related Through Self-Agency. Front Hum Neurosci. 2018; 12:82. Subramaniam K, Kothare H, Mizuiri D, Nagarajan SS, Houde JF. PMID: 29559903.
      View in: PubMed   Mentions:
    15. Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions. Sci Rep. 2018 01 19; 8(1):1274. Demopoulos C, Kothare H, Mizuiri D, Henderson-Sabes J, Fregeau B, Tjernagel J, Houde JF, Sherr EH, Nagarajan SS. PMID: 29352208.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    16. Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants. Brain. 2017 Oct 01; 140(10):2737-2751. Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS. PMID: 28969381.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration. J Neurosci. 2017 09 20; 37(38):9249-9258. Parrell B, Agnew Z, Nagarajan S, Houde J, Ivry RB. PMID: 28842410.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    18. Sensorimotor adaptation affects perceptual compensation for coarticulation. J Acoust Soc Am. 2017 04; 141(4):2693. Schuerman WL, Nagarajan S, McQueen JM, Houde J. PMID: 28464681.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease. Neurobiol Aging. 2017 04; 52:71-80. Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Nagarajan SS, Houde JF. PMID: 28131013.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Bihemispheric network dynamics coordinating vocal feedback control. Hum Brain Mapp. 2016 Apr; 37(4):1474-85. Kort NS, Cuesta P, Houde JF, Nagarajan SS. PMID: 26917046.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    21. The cortical computations underlying feedback control in vocal production. Curr Opin Neurobiol. 2015 Aug; 33:174-81. Houde JF, Chang EF. PMID: 25989242.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    22. Vowel generation for children with cerebral palsy using myocontrol of a speech synthesizer. Front Hum Neurosci. 2014; 8:1077. Niu CM, Lee K, Houde JF, Sanger TD. PMID: 25657622.
      View in: PubMed   Mentions:
    23. Optimal timing of pulse onset for language mapping with navigated repetitive transcranial magnetic stimulation. Neuroimage. 2014 Oct 15; 100:219-36. Krieg SM, Tarapore PE, Picht T, Tanigawa N, Houde J, Sollmann N, Meyer B, Vajkoczy P, Berger MS, Ringel F, Nagarajan S. PMID: 24945663.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    24. Simulating a state feedback model of speaking. Proceedings of the 10th International Seminar on Speech Production. 2014; 202-5. Houde JF, Niziolek C, Kort N, Agnew Z, & Nagarajan SS.
    25. Auditory cortex processes variation in our own speech. PLoS One. 2013; 8(12):e82925. Sitek KR, Mathalon DH, Roach BJ, Houde JF, Niziolek CA, Ford JM. PMID: 24349399.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    26. What does motor efference copy represent? Evidence from speech production. J Neurosci. 2013 Oct 09; 33(41):16110-6. Niziolek CA, Nagarajan SS, Houde JF. PMID: 24107944.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    27. A bilateral cortical network responds to pitch perturbations in speech feedback. Neuroimage. 2014 Feb 01; 86:525-35. Kort NS, Nagarajan SS, Houde JF. PMID: 24076223.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    28. Language mapping with navigated repetitive TMS: proof of technique and validation. Neuroimage. 2013 Nov 15; 82:260-72. Tarapore PE, Findlay AM, Honma SM, Mizuiri D, Houde JF, Berger MS, Nagarajan SS. PMID: 23702420.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    29. Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction. J Neurosci. 2013 Mar 27; 33(13):5439-53. Herman AB, Houde JF, Vinogradov S, Nagarajan SS. PMID: 23536060.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    30. Human cortical sensorimotor network underlying feedback control of vocal pitch. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):2653-8. Chang EF, Niziolek CA, Knight RT, Nagarajan SS, Houde JF. PMID: 23345447.
      View in: PubMed   Mentions: 68     Fields:    Translation:Humans
    31. A right-lateralized cortical network drives error correction to voice pitch feedback perturbation . Journal of the Acoustical Society of America. 2013; 134(5):4234. Kort N, Nagarajan SS, & Houde JF ..
    32. Feedback-driven corrective movements in speech in the absence of altered feedback . Journal of the Acoustical Society of America. 2013; 134(5):4167. Niziolek CA, Nagarajan SS, & Houde JF ..
    33. Neural evidence for state feedback control of speaking. Proceedings of Meetings on Acoustics. 2013; 19(1). Houde JF, Kort NS, Niziolek CA, Chang EF, & Nagarajan SS.View Publication.
    34. Partial compensation for altered auditory feedback: a tradeoff with somatosensory feedback? Lang Speech. 2012 Jun; 55(Pt 2):295-308. Katseff S, Houde J, Johnson K. PMID: 22783636.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    35. Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Ann Neurol. 2012 May; 71(5):668-86. Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde JF, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE. PMID: 22522481.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    36. Speech production as state feedback control. Front Hum Neurosci. 2011; 5:82. Houde JF, Nagarajan SS. PMID: 22046152.
      View in: PubMed   Mentions:
    37. Sensorimotor integration in speech processing: computational basis and neural organization. Neuron. 2011 Feb 10; 69(3):407-22. Hickok G, Houde J, Rong F. PMID: 21315253.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimals
    38. There's more to speech perception than meets the ear. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20139-40. Houde JF. PMID: 19934047.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    39. Speech target modulates speaking induced suppression in auditory cortex. BMC Neurosci. 2009 Jun 13; 10:58. Ventura MI, Nagarajan SS, Houde JF. PMID: 19523234.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    40. Autism overflows with syntheses. Neuropsychol Rev. 2009 Jun; 19(2):273-4. Belmonte MK, Bonneh YS, Adini Y, Iversen PE, Akshoomoff NA, Kenet T, Moore CI, Simon HJ, Houde JF, Merzenich MM. PMID: 19449104.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Motor-induced suppression of the auditory cortex. J Cogn Neurosci. 2009 Apr; 21(4):791-802. Aliu SO, Houde JF, Nagarajan SS. PMID: 18593265.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    42. Cross-modal extinction in a boy with severely autistic behaviour and high verbal intelligence. Cogn Neuropsychol. 2008 Jul; 25(5):635-52. Bonneh YS, Belmonte MK, Pei F, Iversen PE, Kenet T, Akshoomoff N, Adini Y, Simon HJ, Moore CI, Houde JF, Merzenich MM. PMID: 18651259.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    43. Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations. Arch Gen Psychiatry. 2007 Mar; 64(3):286-96. Heinks-Maldonado TH, Mathalon DH, Houde JF, Gray M, Faustman WO, Ford JM. PMID: 17339517.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    44. Dynamic cortical imaging of speech compensation for auditory feedback perturbations. Journal of the Acoustical Society of America. 2007; 121:3045. Houde JF, Nagarajan SS, & Heinks-Maldonado, T.
    45. How is auditory feedback processed during speaking?. Journal of the Acoustical Society of America. 2007; 122:3087. Houde JF, & Nagarajan SS.
    46. Magnetoencephalographic evidence for a precise forward model in speech production. Neuroreport. 2006 Sep 18; 17(13):1375-9. Heinks-Maldonado TH, Nagarajan SS, Houde JF. PMID: 16932142.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    47. Compensatory responses to brief perturbations of speech amplitude. Acoustics Research Letters Online. 2005; 6(3):131-7. Heinks-Maldonado TH, & Houde JF..
    48. The effect of spectral manipulations on the identification of affective and linguistic prosody. Brain Lang. 2003 Feb; 84(2):250-63. Lakshminarayanan K, Ben Shalom D, van Wassenhove V, Orbelo D, Houde J, Poeppel D. PMID: 12590914.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    49. Modulation of the auditory cortex during speech: an MEG study. J Cogn Neurosci. 2002 Nov 15; 14(8):1125-38. Houde JF, Nagarajan SS, Sekihara K, Merzenich MM. PMID: 12495520.
      View in: PubMed   Mentions: 148     Fields:    Translation:Humans
    50. Sensorimotor adaptation of speech I: Compensation and adaptation. J Speech Lang Hear Res. 2002 Apr; 45(2):295-310. Houde JF, Jordan MI. PMID: 12003512.
      View in: PubMed   Mentions: 65     Fields:    Translation:Humans
    51. Magnetic field responses of auditory cortex to produced speech. Journal of the Acoustical Society of America. 1999; 106:2207. Nagarajan SS, Houde JF, & Merzenich MM.
    52. Sensorimotor adaptation in speech production. Science. 1998 Feb 20; 279(5354):1213-6. Houde JF, Jordan MI. PMID: 9469813.
      View in: PubMed   Mentions: 214     Fields:    Translation:Humans
    53. Adaptation in speech motor control. In Jordan MI, Kearns MJ, and Solla SA (Eds.), Adavances in Neural Information Processing Systems (NIPS) 10. 1998. Houde JF, & Jordan MI.
    54. Adaptation in speech production to transformed auditory feedback. Journal of the Acoustical Society of America. 1995; 97:3243. Houde JF, & Jordan MI.
    55. The complete pattern of ocular dominance stripes in the striate cortex and visual field of the macaque monkey. J Neurosci. 1985 Feb; 5(2):486-501. LeVay S, Connolly M, Houde J, Van Essen DC. PMID: 3973679.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
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