John Houde, PhD

Title(s)Associate Professor, Otolaryngology
SchoolSchool of Medicine
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    John F. Houde, PhD, is an Associate Professor in Residence and he is the Director of the Speech Neuroscience Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his Electrical Engineering undergraduate degree from the California Institute of Technology in Pasadena, and he obtained his MS in Computer Science from Duke University, Durham, North Carolina. Dr. Houde earned his PhD in Brain and Cognitive Science from MIT, and this was followed by a fellowship in Medicine from UCSF.

    Dr. Houde’s research focuses on understanding the role of auditory feedback in speech and the neural mechanisms supporting auditory feedback. His research projects include computational modeling, psychophysical investigations, and functional neuroimaging that examine auditory feedback's role in the learning and maintenance of speech, as well as the online control of speech. A major focus of Dr. Houde’s lab is determining the role of auditory feedback in speaking by examining how speakers respond to realtime alterations of their audio feedback. Another major focus is using functional neuroimaging, especially magnetoencephalography (MEG), as well as electrocorticography (ECoG) to study how auditory feedback is processed during speaking.

    Dr. Houde also studies how feedback processing in speech production is compromised in various clinical conditions, such as Alzheimer’s disease and spasmodic dysphonia.

    Dr. Houde is a member of the Cognitive Neuroscience Society, the Society of Neuroscience, and the Society for the Neuroscience Language. He has contributed to 24 peer-reviewed articles, 2 patents, and over 50 abstracts.

    The neuroscience of speech production

    Research in cognitive neuroscience

    Professional Interests:
    Speech, hearing, neuroscience, cognitive science, acoustics, auditory feedback, motor control

    Education and Training:
    • BS: California Institute of Technology – Electrical Engineering
    • MS: Duke University – Computer Science
    • PhD: Massachusetts Institute of Technology, Cambridge – Brain and Cognitive Science
    • Postdoctoral Training: University of California, San Francisco

    Collapse Research 
    Collapse Research Activities and Funding
    The role of the cerebellum in speech
    NIH/NIDCD R01DC017091Dec 25, 2018 - Nov 30, 2023
    Role: Principal Investigator
    CRCNS: Modeling the role of auditory feedback in speech motor control
    NIH/NIDCD R01DC017696Sep 1, 2018 - Aug 31, 2021
    Role: Principal Investigator
    Dynamic Brain Imaging of Speech in Primary Progressive Aphasia
    NIH/NINDS R01NS100440Sep 15, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Timing of Neural activity in Spasmodic Dysphonia
    NIH/NIDCD R21DC014525Apr 2, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Imaging sensorimotor adaptation and compensation of speech
    NIH/NIDCD R01DC013979Jul 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Neuroimaging of Speech Motor Control
    NIH/NIDCD R01DC010145Jun 28, 2010 - May 31, 2015
    Role: Principal Investigator
    The Neural Substrates of Impaired Feedback Control in P*
    NIH/NIDCD R21DC005582Apr 10, 2002 - Mar 31, 2005
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Perez PL, Cueva KL, Rosen CA, Young VN, Naunheim ML, Yung KC, Schneider SL, Mizuiri D, Klein DJ, Houde JF, Hinkley LB, Nagarajan SS, Cheung SW. Cortical-Basal Ganglia-Cerebellar Networks in Unilateral Vocal Fold Paralysis: A Pilot Study. Laryngoscope. 2019 May 09. PMID: 31070785.
      View in: PubMed
    2. Subramaniam K, Hinkley LBN, Mizuiri D, Kothare H, Cai C, Garrett C, Findlay A, Houde JF, Nagarajan SS. Beta-band activity in medial prefrontal cortex predicts source memory encoding and retrieval accuracy. Sci Rep. 2019 May 02; 9(1):6814. PMID: 31048735.
      View in: PubMed
    3. Houde JF, Gill JS, Agnew Z, Kothare H, Hickok G, Parrell B, Ivry RB, Nagarajan SS. Abnormally increased vocal responses to pitch feedback perturbations in patients with cerebellar degeneration. J Acoust Soc Am. 2019 May; 145(5):EL372. PMID: 31153297.
      View in: PubMed
    4. Ranasinghe KG, Kothare H, Kort N, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Lee R, Miller BL, Gorno-Tempini ML, Vossel KA, Houde JF, Nagarajan SS. Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease. Sci Rep. 2019 Apr 05; 9(1):5686. PMID: 30952883.
      View in: PubMed
    5. Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Hinkley LB, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW. Cortical networks for speech motor control in unilateral vocal fold paralysis. Laryngoscope. 2018 Dec 20. PMID: 30570142.
      View in: PubMed
    6. Naunheim ML, Yung KC, Schneider SL, Henderson-Sabes J, Kothare H, Mizuiri D, Klein DJ, Houde JF, Nagarajan SS, Cheung SW. Vocal motor control and central auditory impairments in unilateral vocal fold paralysis. Laryngoscope. 2018 Nov 28. PMID: 30484858.
      View in: PubMed
    7. Martin CD, Niziolek CA, Duñabeitia JA, Perez A, Hernandez D, Carreiras M, Houde JF. Online Adaptation to Altered Auditory Feedback Is Predicted by Auditory Acuity and Not by Domain-General Executive Control Resources. Front Hum Neurosci. 2018; 12:91. PMID: 29593516.
      View in: PubMed
    8. Subramaniam K, Kothare H, Mizuiri D, Nagarajan SS, Houde JF. Reality Monitoring and Feedback Control of Speech Production Are Related Through Self-Agency. Front Hum Neurosci. 2018; 12:82. PMID: 29559903.
      View in: PubMed
    9. Demopoulos C, Kothare H, Mizuiri D, Henderson-Sabes J, Fregeau B, Tjernagel J, Houde JF, Sherr EH, Nagarajan SS. Abnormal Speech Motor Control in Individuals with 16p11.2 Deletions. Sci Rep. 2018 01 19; 8(1):1274. PMID: 29352208.
      View in: PubMed
    10. Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS. Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants. Brain. 2017 Oct 01; 140(10):2737-2751. PMID: 28969381.
      View in: PubMed
    11. Parrell B, Agnew Z, Nagarajan S, Houde J, Ivry RB. Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration. J Neurosci. 2017 09 20; 37(38):9249-9258. PMID: 28842410.
      View in: PubMed
    12. Schuerman WL, Nagarajan S, McQueen JM, Houde J. Sensorimotor adaptation affects perceptual compensation for coarticulation. J Acoust Soc Am. 2017 Apr; 141(4):2693. PMID: 28464681.
      View in: PubMed
    13. Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Nagarajan SS, Houde JF. Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease. Neurobiol Aging. 2017 04; 52:71-80. PMID: 28131013.
      View in: PubMed
    14. Kort NS, Cuesta P, Houde JF, Nagarajan SS. Bihemispheric network dynamics coordinating vocal feedback control. Hum Brain Mapp. 2016 Apr; 37(4):1474-85. PMID: 26917046.
      View in: PubMed
    15. Houde JF, Chang EF. The cortical computations underlying feedback control in vocal production. Curr Opin Neurobiol. 2015 Aug; 33:174-81. PMID: 25989242.
      View in: PubMed
    16. Niu CM, Lee K, Houde JF, Sanger TD. Vowel generation for children with cerebral palsy using myocontrol of a speech synthesizer. Front Hum Neurosci. 2014; 8:1077. PMID: 25657622; PMCID: PMC4302943.
    17. Krieg SM, Tarapore PE, Picht T, Tanigawa N, Houde J, Sollmann N, Meyer B, Vajkoczy P, Berger MS, Ringel F, Nagarajan S. Optimal timing of pulse onset for language mapping with navigated repetitive transcranial magnetic stimulation. Neuroimage. 2014 Oct 15; 100:219-36. PMID: 24945663.
      View in: PubMed
    18. Houde JF, Niziolek C, Kort N, Agnew Z, & Nagarajan SS.Simulating a state feedback model of speaking. Proceedings of the 10th International Seminar on Speech Production. 2014; 202-5.
    19. Sitek KR, Mathalon DH, Roach BJ, Houde JF, Niziolek CA, Ford JM. Auditory cortex processes variation in our own speech. PLoS One. 2013; 8(12):e82925. PMID: 24349399; PMCID: PMC3862760.
    20. Niziolek CA, Nagarajan SS, Houde JF. What does motor efference copy represent? Evidence from speech production. J Neurosci. 2013 Oct 09; 33(41):16110-6. PMID: 24107944; PMCID: PMC3792453.
    21. Kort NS, Nagarajan SS, Houde JF. A bilateral cortical network responds to pitch perturbations in speech feedback. Neuroimage. 2014 Feb 01; 86:525-35. PMID: 24076223.
      View in: PubMed
    22. Tarapore PE, Findlay AM, Honma SM, Mizuiri D, Houde JF, Berger MS, Nagarajan SS. Language mapping with navigated repetitive TMS: proof of technique and validation. Neuroimage. 2013 Nov 15; 82:260-72. PMID: 23702420; PMCID: PMC3759608.
    23. Herman AB, Houde JF, Vinogradov S, Nagarajan SS. Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction. J Neurosci. 2013 Mar 27; 33(13):5439-53. PMID: 23536060; PMCID: PMC3711632.
    24. Chang EF, Niziolek CA, Knight RT, Nagarajan SS, Houde JF. Human cortical sensorimotor network underlying feedback control of vocal pitch. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):2653-8. PMID: 23345447; PMCID: PMC3574939.
    25. Niziolek CA, Nagarajan SS, & Houde JF .Feedback-driven corrective movements in speech in the absence of altered feedback . Journal of the Acoustical Society of America. 2013; 134(5):4167.
    26. Houde JF, Kort NS, Niziolek CA, Chang EF, & Nagarajan SS.Neural evidence for state feedback control of speaking. Proceedings of Meetings on Acoustics. 2013; 19(1).
    27. Kort N, Nagarajan SS, & Houde JF .A right-lateralized cortical network drives error correction to voice pitch feedback perturbation . Journal of the Acoustical Society of America. 2013; 134(5):4234.
    28. Katseff S, Houde J, Johnson K. Partial compensation for altered auditory feedback: a tradeoff with somatosensory feedback? Lang Speech. 2012 Jun; 55(Pt 2):295-308. PMID: 22783636.
      View in: PubMed
    29. Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde JF, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE. Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Ann Neurol. 2012 May; 71(5):668-86. PMID: 22522481; PMCID: PMC3380661.
    30. Houde JF, Nagarajan SS. Speech production as state feedback control. Front Hum Neurosci. 2011; 5:82. PMID: 22046152.
      View in: PubMed
    31. Hickok G, Houde J, Rong F. Sensorimotor integration in speech processing: computational basis and neural organization. Neuron. 2011 Feb 10; 69(3):407-22. PMID: 21315253; PMCID: PMC3057382.
    32. Houde JF. There's more to speech perception than meets the ear. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20139-40. PMID: 19934047; PMCID: PMC2787137.
    33. Ventura MI, Nagarajan SS, Houde JF. Speech target modulates speaking induced suppression in auditory cortex. BMC Neurosci. 2009 Jun 13; 10:58. PMID: 19523234; PMCID: PMC2703647.
    34. Belmonte MK, Bonneh YS, Adini Y, Iversen PE, Akshoomoff NA, Kenet T, Moore CI, Simon HJ, Houde JF, Merzenich MM. Autism overflows with syntheses. Neuropsychol Rev. 2009 Jun; 19(2):273-4. PMID: 19449104.
      View in: PubMed
    35. Aliu SO, Houde JF, Nagarajan SS. Motor-induced suppression of the auditory cortex. J Cogn Neurosci. 2009 Apr; 21(4):791-802. PMID: 18593265; PMCID: PMC2944400.
    36. Bonneh YS, Belmonte MK, Pei F, Iversen PE, Kenet T, Akshoomoff N, Adini Y, Simon HJ, Moore CI, Houde JF, Merzenich MM. Cross-modal extinction in a boy with severely autistic behaviour and high verbal intelligence. Cogn Neuropsychol. 2008 Jul; 25(5):635-52. PMID: 18651259.
      View in: PubMed
    37. Heinks-Maldonado TH, Mathalon DH, Houde JF, Gray M, Faustman WO, Ford JM. Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations. Arch Gen Psychiatry. 2007 Mar; 64(3):286-96. PMID: 17339517.
      View in: PubMed
    38. Houde JF, Nagarajan SS, & Heinks-Maldonado, T.Dynamic cortical imaging of speech compensation for auditory feedback perturbations. Journal of the Acoustical Society of America. 2007; 121:3045.
    39. Houde JF, & Nagarajan SS.How is auditory feedback processed during speaking?. Journal of the Acoustical Society of America. 2007; 122:3087.
    40. Heinks-Maldonado TH, Nagarajan SS, Houde JF. Magnetoencephalographic evidence for a precise forward model in speech production. Neuroreport. 2006 Sep 18; 17(13):1375-9. PMID: 16932142; PMCID: PMC4060597.
    41. Heinks-Maldonado TH, & Houde JF.Compensatory responses to brief perturbations of speech amplitude. Acoustics Research Letters Online. 2005; 6(3):131-7.
    42. Lakshminarayanan K, Ben Shalom D, van Wassenhove V, Orbelo D, Houde J, Poeppel D. The effect of spectral manipulations on the identification of affective and linguistic prosody. Brain Lang. 2003 Feb; 84(2):250-63. PMID: 12590914.
      View in: PubMed
    43. Houde JF, Nagarajan SS, Sekihara K, Merzenich MM. Modulation of the auditory cortex during speech: an MEG study. J Cogn Neurosci. 2002 Nov 15; 14(8):1125-38. PMID: 12495520.
      View in: PubMed
    44. Houde JF, Jordan MI. Sensorimotor adaptation of speech I: Compensation and adaptation. J Speech Lang Hear Res. 2002 Apr; 45(2):295-310. PMID: 12003512.
      View in: PubMed
    45. Nagarajan SS, Houde JF, & Merzenich MM.Magnetic field responses of auditory cortex to produced speech. Journal of the Acoustical Society of America. 1999; 106:2207.
    46. Houde JF, Jordan MI. Sensorimotor adaptation in speech production. Science. 1998 Feb 20; 279(5354):1213-6. PMID: 9469813.
      View in: PubMed
    47. Houde JF, & Jordan MI.Adaptation in speech motor control. In Jordan MI, Kearns MJ, and Solla SA (Eds.), Adavances in Neural Information Processing Systems (NIPS) 10. 1998.
    48. Houde JF, & Jordan MI.Adaptation in speech production to transformed auditory feedback. Journal of the Acoustical Society of America. 1995; 97:3243.
    49. LeVay S, Connolly M, Houde J, Van Essen DC. The complete pattern of ocular dominance stripes in the striate cortex and visual field of the macaque monkey. J Neurosci. 1985 Feb; 5(2):486-501. PMID: 3973679.
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