John Houde, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Overview
    John F. Houde, PhD, is an Associate Professor in Residence and he is the Director of the Speech Neuroscience Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his Electrical Engineering undergraduate degree from the California Institute of Technology in Pasadena, and he obtained his MS in Computer Science from Duke University, Durham, North Carolina. Dr. Houde earned his PhD in Brain and Cognitive Science from MIT, and this was followed by a fellowship in Medicine from UCSF.

    Dr. Houde’s research focuses on understanding the role of auditory feedback in speech and the neural mechanisms supporting auditory feedback. His research projects include computational modeling, psychophysical investigations, and functional neuroimaging that examine auditory feedback's role in the learning and maintenance of speech, as well as the online control of speech. A major focus of Dr. Houde’s lab is determining the role of auditory feedback in speaking by examining how speakers respond to realtime alterations of their audio feedback. Another major focus is using functional neuroimaging, especially magnetoencephalography (MEG), as well as electrocorticography (ECoG) to study how auditory feedback is processed during speaking.

    Dr. Houde also studies how feedback processing in speech production is compromised in various clinical conditions, such as Alzheimer’s disease and spasmodic dysphonia.

    Dr. Houde is a member of the Cognitive Neuroscience Society, the Society of Neuroscience, and the Society for the Neuroscience Language. He has contributed to 24 peer-reviewed articles, 2 patents, and over 50 abstracts.

    The neuroscience of speech production

    Research in cognitive neuroscience

    Professional Interests:
    Speech, hearing, neuroscience, cognitive science, acoustics, auditory feedback, motor control

    Education and Training:
    • BS: California Institute of Technology – Electrical Engineering
    • MS: Duke University – Computer Science
    • PhD: Massachusetts Institute of Technology, Cambridge – Brain and Cognitive Science
    • Postdoctoral Training: University of California, San Francisco

    Collapse Research 
    Collapse Research Activities and Funding
    Dynamic Brain Imaging of Speech in Primary Progressive Aphasia
    NIH/NINDS R01NS100440Sep 15, 2017 - Aug 31, 2022
    Role: Co-Principal Investigator
    Timing of Neural activity in Spasmodic Dysphonia
    NIH/NIDCD R21DC014525Apr 2, 2015 - Mar 31, 2017
    Role: Principal Investigator
    Imaging sensorimotor adaptation and compensation of speech
    NIH/NIDCD R01DC013979Jul 1, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    Neuroimaging of Speech Motor Control
    NIH/NIDCD R01DC010145Jun 28, 2010 - May 31, 2015
    Role: Principal Investigator
    The Neural Substrates of Impaired Feedback Control in P*
    NIH/NIDCD R21DC005582Apr 10, 2002 - Mar 31, 2005
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde J, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS. Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants. Brain. 2017 Oct 01; 140(10):2737-2751. PMID: 28969381.
      View in: PubMed
    2. Parrell B, Agnew Z, Nagarajan S, Houde J, Ivry RB. Impaired Feedforward Control and Enhanced Feedback Control of Speech in Patients with Cerebellar Degeneration. J Neurosci. 2017 Sep 20; 37(38):9249-9258. PMID: 28842410.
      View in: PubMed
    3. Schuerman WL, Nagarajan S, McQueen JM, Houde J. Sensorimotor adaptation affects perceptual compensation for coarticulation. J Acoust Soc Am. 2017 Apr; 141(4):2693. PMID: 28464681.
      View in: PubMed
    4. Ranasinghe KG, Gill JS, Kothare H, Beagle AJ, Mizuiri D, Honma SM, Gorno-Tempini ML, Miller BL, Vossel KA, Nagarajan SS, Houde J. Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease. Neurobiol Aging. 2017 Apr; 52:71-80. PMID: 28131013.
      View in: PubMed
    5. Kort NS, Cuesta P, Houde J, Nagarajan SS. Bihemispheric network dynamics coordinating vocal feedback control. Hum Brain Mapp. 2016 Apr; 37(4):1474-85. PMID: 26917046.
      View in: PubMed
    6. Houde J, Chang EF. The cortical computations underlying feedback control in vocal production. Curr Opin Neurobiol. 2015 Aug; 33:174-81. PMID: 25989242; PMCID: PMC4628828.
    7. Niu CM, Lee K, Houde J, Sanger TD. Vowel generation for children with cerebral palsy using myocontrol of a speech synthesizer. Front Hum Neurosci. 2014; 8:1077. PMID: 25657622; PMCID: PMC4302943.
    8. Krieg SM, Tarapore PE, Picht T, Tanigawa N, Houde J, Sollmann N, Meyer B, Vajkoczy P, Berger MS, Ringel F, Nagarajan S. Optimal timing of pulse onset for language mapping with navigated repetitive transcranial magnetic stimulation. Neuroimage. 2014 Oct 15; 100:219-36. PMID: 24945663.
      View in: PubMed
    9. Houde J, Niziolek C, Kort N, Agnew Z, & Nagarajan SS. Simulating a state feedback model of speaking. Proceedings of the 10th International Seminar on Speech Production. 2014; 202-5.
    10. Sitek KR, Mathalon DH, Roach BJ, Houde J, Niziolek CA, Ford JM. Auditory cortex processes variation in our own speech. PLoS One. 2013; 8(12):e82925. PMID: 24349399; PMCID: PMC3862760.
    11. Niziolek CA, Nagarajan SS, Houde J. What does motor efference copy represent? Evidence from speech production. J Neurosci. 2013 Oct 09; 33(41):16110-6. PMID: 24107944; PMCID: PMC3792453.
    12. Kort NS, Nagarajan SS, Houde J. A bilateral cortical network responds to pitch perturbations in speech feedback. Neuroimage. 2014 Feb 01; 86:525-35. PMID: 24076223; PMCID: PMC4063684.
    13. Tarapore PE, Findlay AM, Honma SM, Mizuiri D, Houde J, Berger MS, Nagarajan SS. Language mapping with navigated repetitive TMS: proof of technique and validation. Neuroimage. 2013 Nov 15; 82:260-72. PMID: 23702420; PMCID: PMC3759608.
    14. Herman AB, Houde J, Vinogradov S, Nagarajan SS. Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction. J Neurosci. 2013 Mar 27; 33(13):5439-53. PMID: 23536060; PMCID: PMC3711632.
    15. Chang EF, Niziolek CA, Knight RT, Nagarajan SS, Houde J. Human cortical sensorimotor network underlying feedback control of vocal pitch. Proc Natl Acad Sci U S A. 2013 Feb 12; 110(7):2653-8. PMID: 23345447; PMCID: PMC3574939.
    16. Houde J, Kort NS, Niziolek CA, Chang EF, & Nagarajan SS. Neural evidence for state feedback control of speaking. Proceedings of Meetings on Acoustics. 2013; 19(1).
    17. Kort N, Nagarajan SS, & Houde JF . A right-lateralized cortical network drives error correction to voice pitch feedback perturbation . Journal of the Acoustical Society of America. 2013; 134(5):4234.
    18. Niziolek CA, Nagarajan SS, & Houde JF . Feedback-driven corrective movements in speech in the absence of altered feedback . Journal of the Acoustical Society of America. 2013; 134(5):4167.
    19. Katseff S, Houde J, Johnson K. Partial compensation for altered auditory feedback: a tradeoff with somatosensory feedback? Lang Speech. 2012 Jun; 55(Pt 2):295-308. PMID: 22783636.
      View in: PubMed
    20. Findlay AM, Ambrose JB, Cahn-Weiner DA, Houde J, Honma S, Hinkley LB, Berger MS, Nagarajan SS, Kirsch HE. Dynamics of hemispheric dominance for language assessed by magnetoencephalographic imaging. Ann Neurol. 2012 May; 71(5):668-86. PMID: 22522481; PMCID: PMC3380661.
    21. Houde J, Nagarajan SS. Speech production as state feedback control. Front Hum Neurosci. 2011; 5:82. PMID: 22046152; PMCID: PMC3200525.
    22. Hickok G, Houde J, Rong F. Sensorimotor integration in speech processing: computational basis and neural organization. Neuron. 2011 Feb 10; 69(3):407-22. PMID: 21315253; PMCID: PMC3057382.
    23. Houde J. There's more to speech perception than meets the ear. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20139-40. PMID: 19934047; PMCID: PMC2787137.
    24. Ventura MI, Nagarajan SS, Houde J. Speech target modulates speaking induced suppression in auditory cortex. BMC Neurosci. 2009 Jun 13; 10:58. PMID: 19523234; PMCID: PMC2703647.
    25. Belmonte MK, Bonneh YS, Adini Y, Iversen PE, Akshoomoff NA, Kenet T, Moore CI, Simon HJ, Houde J, Merzenich MM. Autism overflows with syntheses. Neuropsychol Rev. 2009 Jun; 19(2):273-4. PMID: 19449104.
      View in: PubMed
    26. Aliu SO, Houde J, Nagarajan SS. Motor-induced suppression of the auditory cortex. J Cogn Neurosci. 2009 Apr; 21(4):791-802. PMID: 18593265; PMCID: PMC2944400.
    27. Bonneh YS, Belmonte MK, Pei F, Iversen PE, Kenet T, Akshoomoff N, Adini Y, Simon HJ, Moore CI, Houde J, Merzenich MM. Cross-modal extinction in a boy with severely autistic behaviour and high verbal intelligence. Cogn Neuropsychol. 2008 Jul; 25(5):635-52. PMID: 18651259.
      View in: PubMed
    28. Heinks-Maldonado TH, Mathalon DH, Houde J, Gray M, Faustman WO, Ford JM. Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations. Arch Gen Psychiatry. 2007 Mar; 64(3):286-96. PMID: 17339517.
      View in: PubMed
    29. Houde J, & Nagarajan SS. How is auditory feedback processed during speaking?. Journal of the Acoustical Society of America. 2007; 122:3087.
    30. Houde J, Nagarajan SS, & Heinks-Maldonado, T. Dynamic cortical imaging of speech compensation for auditory feedback perturbations. Journal of the Acoustical Society of America. 2007; 121:3045.
    31. Heinks-Maldonado TH, Nagarajan SS, Houde J. Magnetoencephalographic evidence for a precise forward model in speech production. Neuroreport. 2006 Sep 18; 17(13):1375-9. PMID: 16932142; PMCID: PMC4060597.
    32. Heinks-Maldonado TH, & Houde JF. Compensatory responses to brief perturbations of speech amplitude. Acoustics Research Letters Online. 2005; 6(3):131-7.
    33. Lakshminarayanan K, Ben Shalom D, van Wassenhove V, Orbelo D, Houde J, Poeppel D. The effect of spectral manipulations on the identification of affective and linguistic prosody. Brain Lang. 2003 Feb; 84(2):250-63. PMID: 12590914.
      View in: PubMed
    34. Houde J, Nagarajan SS, Sekihara K, Merzenich MM. Modulation of the auditory cortex during speech: an MEG study. J Cogn Neurosci. 2002 Nov 15; 14(8):1125-38. PMID: 12495520.
      View in: PubMed
    35. Houde J, Jordan MI. Sensorimotor adaptation of speech I: Compensation and adaptation. J Speech Lang Hear Res. 2002 Apr; 45(2):295-310. PMID: 12003512.
      View in: PubMed
    36. Nagarajan SS, Houde J, & Merzenich MM. Magnetic field responses of auditory cortex to produced speech. Journal of the Acoustical Society of America. 1999; 106:2207.
    37. Houde J, Jordan MI. Sensorimotor adaptation in speech production. Science. 1998 Feb 20; 279(5354):1213-6. PMID: 9469813.
      View in: PubMed
    38. Houde J, & Jordan MI. Adaptation in speech motor control. In Jordan MI, Kearns MJ, and Solla SA (Eds.), Adavances in Neural Information Processing Systems (NIPS) 10. 1998.
    39. Houde J, & Jordan MI. Adaptation in speech production to transformed auditory feedback. Journal of the Acoustical Society of America. 1995; 97:3243.
    40. LeVay S, Connolly M, Houde J, Van Essen DC. The complete pattern of ocular dominance stripes in the striate cortex and visual field of the macaque monkey. J Neurosci. 1985 Feb; 5(2):486-501. PMID: 3973679.
      View in: PubMed
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