John Watson | UCSF Profiles

John Watson, PhD

Title	Professor
Institution	University of California San Francisco
Department	Dean's Office
Address	1855 Folsom Street San Francisco CA 94103
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Research

Research Activities and Funding

UCSF CC/SFSU Collaborative--Cancer Research and Training
NIH/NCI P20CA091430May 1, 2001 - Apr 30, 2004
Role: Principal Investigator

DIPTERA MEVALONIC ACID METABOLISM AND REGULATION
NIH/NIGMS R01GM052623Sep 30, 1994 - Aug 31, 1998
Role: Principal Investigator

STEROL DEPENDENT REGULATION OF MEVALONATE SYNTHESIS
NIH/NHLBI R01HL040445Apr 1, 1988 - Mar 31, 1992
Role: Principal Investigator

STEROL INDEPENDENT REGULATION OF HMG-COA REDUCTASE
NIH/NHLBI R01HL031156Jul 1, 1983 - Sep 30, 1991
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

Plemenitas A, Watson J. Down-regulation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with highly purified liposomal cholesterol. Eur J Biochem. 1999 Dec; 266(2):317-26. PMID: 10561571.

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Erickson SK, Cooper AD, Barnard GF, Havel CM, Watson J, Feingold KR, Moser AH, Hughes-Fulford M, Siperstein MD. Regulation of cholesterol metabolism in a slow-growing hepatoma in vivo. Biochim Biophys Acta. 1988 May 22; 960(2):131-8. PMID: 2835108.

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Havel C, Rector ER, Watson J. Isopentenoid synthesis in isolated embryonic Drosophila cells. Possible regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by shunted mevalonate carbon. J Biol Chem. 1986 Aug 05; 261(22):10150-6. PMID: 3733706.

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Cabrera JA, Bolds J, Shields PE, Havel CM, Watson J. Isoprenoid synthesis in Halobacterium halobium. Modulation of 3-hydroxy-3-methylglutaryl coenzyme a concentration in response to mevalonate availability. J Biol Chem. 1986 Mar 15; 261(8):3578-83. PMID: 3633268.

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Watson J, Havel CM, Lobos DV, Baker FC, Morrow CJ. Isoprenoid synthesis in isolated embryonic Drosophila cells. Sterol-independent regulatory signal molecule is distal to isopentenyl 1-pyrophosphates. J Biol Chem. 1985 Nov 15; 260(26):14083-91. PMID: 4055772.

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Silberkang M, Havel CM, Friend DS, McCarthy BJ, Watson J. Isoprene synthesis in isolated embryonic Drosophila cells. I. Sterol-deficient eukaryotic cells. J Biol Chem. 1983 Jul 10; 258(13):8503-11. PMID: 6863298.

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Brown K, Havel CM, Watson J. Isoprene synthesis in isolated embryonic Drosophila cells. II. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. J Biol Chem. 1983 Jul 10; 258(13):8512-8. PMID: 6863299.

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Havel C, Hansbury E, Scallen TJ, Watson J. Regulation of cholesterol synthesis in primary rat hepatocyte culture cells. Possible regulatory site at sterol demethylation. J Biol Chem. 1979 Oct 10; 254(19):9573-82. PMID: 489551.

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Beirne OR, Heller R, Watson J. Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase in minimal deviation hepatoma 7288C. Immunological measurements in hepatoma tissue culture cells. J Biol Chem. 1977 Feb 10; 252(3):950-4. PMID: 190221.

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Beirne OR, Watson J. Comparison of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma cells grown in vivo and in vitro. Proc Natl Acad Sci U S A. 1976 Aug; 73(8):2735-9. PMID: 183207; PMCID: PMC430723.

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Bell JJ, Sargeant TE, Watson J. Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives. Evidence supporting two distinct mechanisms.20l. J Biol Chem. 1976 Mar 25; 251(6):1745-58. PMID: 176160.

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Kirsten ES, Watson J. Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in hepatoma tissue culture cells by serum lipoproteins. J Biol Chem. 1974 Oct 10; 249(19):6104-9. PMID: 4371188.

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