Johnathon Lakins, PhD

Title(s)Specialist, Surgery
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSE, #550
San Francisco CA 94143
Phone415-476-3973
PronounsHe/Him/His
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2024 Mar; 30(3):908. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 38017076.
      View in: PubMed   Mentions: 1     Fields:    
    2. Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci. 2023 10 15; 136(20). Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. PMID: 37855733.
      View in: PubMed   Mentions:    Fields:    
    3. Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells. bioRxiv. 2023 Jul 15. Ayad NME, Lakins JN, Ghagre A, Ehrlicher AJ, Weaver VM. PMID: 37503095; PMCID: PMC10370032.
      View in: PubMed   Mentions:
    4. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer. Nat Commun. 2023 06 15; 14(1):3561. Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM. PMID: 37322009; PMCID: PMC10272194.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    5. Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer. J Exp Med. 2021 05 03; 218(5). Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM. PMID: 33822843; PMCID: PMC8025243.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    6. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. Nat Mater. 2021 04; 20(4):548-559. Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, Nasir A, Bjarnadottir O, Werb Z, Kabos P, Chen YY, Hwang ES, Park M, Coussens LM, Nelson AC, Hansen KC, Weaver VM. PMID: 33257795; PMCID: PMC8005404.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansCells
    7. Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells. Dev Cell. 2020 12 21; 55(6):679-694.e11. Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM. PMID: 33207224; PMCID: PMC7755684.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    8. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics. J Vis Exp. 2019 09 28; (151). Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM. PMID: 31609314; PMCID: PMC9359695.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. Controlled modelling of human epiblast and amnion development using stem cells. Nature. 2019 09; 573(7774):421-425. Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J. PMID: 31511693; PMCID: PMC8106232.
      View in: PubMed   Mentions: 204     Fields:    Translation:HumansCells
    10. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. 2016 10 06; 19(4):462-475. Przybyla L, Lakins JN, Weaver VM. PMID: 27452175; PMCID: PMC5336327.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    11. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 05; 22(5):497-505. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. PMID: 27089513; PMCID: PMC4860133.
      View in: PubMed   Mentions: 309     Fields:    Translation:HumansAnimalsCells
    12. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. J Biotechnol. 2015 Jan 10; 193:66-9. Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM. PMID: 25435379; PMCID: PMC4454500.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    13. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nat Med. 2014 Apr; 20(4):360-7. Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. PMID: 24633304; PMCID: PMC3981899.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansAnimalsCells
    14. A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep. 2013; 3:1449. Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH. PMID: 23618955; PMCID: PMC3636513.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    15. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods Mol Biol. 2012; 916:317-50. Lakins JN, Chin AR, Weaver VM. PMID: 22914951.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    16. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest. 2010 May; 120(5):1535-50. Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. PMID: 20389018; PMCID: PMC2860938.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimals
    17. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009 Nov 25; 139(5):891-906. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. PMID: 19931152; PMCID: PMC2788004.
      View in: PubMed   Mentions: 1965     Fields:    Translation:HumansAnimalsCells
    18. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci. 2007 Oct 15; 120(Pt 20):3700-12. Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. PMID: 17911169.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    19. Tensional homeostasis and the malignant phenotype. Cancer Cell. 2005 Sep; 8(3):241-54. Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. PMID: 16169468.
      View in: PubMed   Mentions: 1840     Fields:    Translation:AnimalsCells
    20. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. J Cell Biol. 2003 Dec 22; 163(6):1397-407. Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM. PMID: 14691145; PMCID: PMC2173718.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    21. beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002 Sep; 2(3):205-16. Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JC, Giancotti F, Werb Z, Bissell MJ. PMID: 12242153; PMCID: PMC2788997.
      View in: PubMed   Mentions: 336     Fields:    Translation:HumansCells
    22. Evidence that clusterin has discrete chaperone and ligand binding sites. Biochemistry. 2002 Jan 08; 41(1):282-91. Lakins JN, Poon S, Easterbrook-Smith SB, Carver JA, Tenniswood MP, Wilson MR. PMID: 11772027.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
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