Joline Fan, MD, MS

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #1451
San Francisco CA 94143
Phone415-353-2273
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse education and training
    Princeton UniversityB.S.E.Chemical and Biological Engineering
    Stanford UniversityM.S.Bioengineering
    University of California San FranciscoM.D.Medicine
    University of California San FranciscoResidencyNeurology
    University of California San FranciscoFellowshipEpilepsy
    Collapse awards and honors
    American Epilepsy Society (AES)2022AES Young Investigator Award
    University of California San Francisco2024Chen Scholar Award

    Collapse Overview 
    Collapse overview
    Joline Fan, MD, MS, is an Assistant Professor at UCSF in the Departments of Neurology (Division of Epilepsy) and Psychiatry & Behavioral Sciences. Her research focuses on developing innovative neurostimulation technologies for neuropsychiatric disorders and exploring the complex relationship between sleep and epilepsy through multimodal neuroimaging. As an epileptologist, Dr. Fan specializes in invasive recording methods, including intracranial responsive neurostimulation and stimulation mapping. She is also investigating personalized, non-invasive, low-intensity focused ultrasound methods for treating neuropsychiatric disorders like depression and epilepsy.
    Collapse Mentoring

    Collapse Research 
    Collapse research activities and funding
    Mapping Corticolimbic Circuitry of Arousal Using Intracranial Electrophysiology
    Brain & Behavior Research Foundation NARSAD Young Investigator Grant 31207Jul 15, 2023 - Jul 14, 2025
    Network dynamics of sleep-wake states in epilepsy
    NIH/NINDS 1K23NS125123Jan 15, 2023 - Dec 31, 2027
    Doris Duke Charitable Foundation (Physician Scientist Fellowship) 2021090Jun 1, 2021 - Jun 30, 2023
    CTSI TL1 Post-doctoral Fellowship Training Program 5TL1TR001871Jul 1, 2020 - Jun 30, 2021

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 35. Personalized Stimulation Targets for Closed-Loop Deep Brain Stimulation for Major Depressive Disorder. Biological Psychiatry. 2025 May 1; 97(9):s89. Sellers SK, Maya MD, Tremblay-McGaw TA, Stapper SN, Henderson HC, Choi CI, Mergenthaler MJ, Becker BN, Kunwar KE, Allawala AA, Hamlat HE, Woodworth WK, Fan FJ, Khambhati KA, Rao RV, Sugrue SL, Cohen CJ, Scangos SK, Chang CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    2. 303. Decoding Multiday Rhythms in Mood in Human Treatment-Resistant Depression. Biological Psychiatry. 2025 May 1; 97(9):s221. Nandini NP, Fan FJ, Sellers SK, Maya MD, Tremblay-McGaw TA, Becker BN, Allawala AA, Sugrue SL, Rao RV, Krystal KA, Chang CE, Khambhati KA. .
      View in: Publisher Site   Mentions:
    3. 287. Modulation of Human Intracranial Circuit Physiology and Personalized Neural Biomarkers Associated With Symptom State in Treatment-Resistant Depression. Biological Psychiatry. 2025 May 1; 97(9):s214. Allawala AA, Khambhati KA, Sellers SK, Maya MD, Tremblay-McGaw TA, Stapper SN, Kunwar KE, Woodworth WK, Choi CI, Mergenthaler MJ, Fan FJ, Rao RV, Sugrue SL, Scangos SK, Chang CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    4. Invasive Brain Mapping Identifies Personalized Therapeutic Neuromodulation Targets for Obsessive-Compulsive Disorder. medRxiv. 2025 Mar 17. Lee AM, Kist A, Alvarez J, Sellers KK, Khambhati AN, Sugrue LP, Reid LB, Kadlec K, Fan JM, Allawala AB, Racine CA, Norbu T, Astudillo D, Tremblay-McGaw AG, Becker N, Alhourani A, Starr PA, Chang EF, Krystal AD. PMID: 40166548; PMCID: PMC11957075.
      View in: PubMed   Mentions:
    5. Influences of electrode density on intracranial seizure localisation: a single-blinded randomised crossover study. EBioMedicine. 2025 Mar; 113:105606. Chinedu-Eneh EO, Chiang S, Andrews JP, Tadayon E, Fan JM, Garcia PA, Gonzalez-Giraldo E, Hegde M, Hullett P, Rao VR, Knowlton RC, Chang EF, Kleen JK. PMID: 40037091; PMCID: PMC11925122.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Mapping between fMRI and electrophysiological networks encoding depressive symptoms. Brain Stimulation. 2025 Jan 1; 18(1):566-567. Alvarez AJ, Sabetfakhri SN, Kist KA, Slepneva SN, Fan FJ, Motzkin MJ, Morrison MM, Sugrue SL, Sellers SK, Chang CE, Krystal KA, Lee LA. .
      View in: Publisher Site   Mentions:
    7. Thalamic transcranial ultrasound stimulation in treatment resistant depression. Brain Stimul. 2024 Sep-Oct; 17(5):1001-1004. Fan JM, Woodworth K, Murphy KR, Hinkley L, Cohen JL, Yoshimura J, Choi I, Tremblay-McGaw AG, Mergenthaler J, Good CH, Pellionisz PA, Lee AM, Di Ianni T, Sugrue LP, Krystal AD. PMID: 39173737; PMCID: PMC11531731.
      View in: PubMed   Mentions: 6     Fields:    
    8. 15. Mapping Between fMRI and Electrophysiological Networks Encoding Depressive Symptoms. Biological Psychiatry. 2024 May 1; 95(10):s80. Alvarez AJ, Sabetfakhri SN, Fan FJ, Slepneva SN, Motzkin MJ, Morrison MM, Sugrue SL, Sellers SK, Krystal KA, Lee LA. .
      View in: Publisher Site   Mentions:
    9. Preprocessing Electrophysiological Data: EEG, iEEG, and MEG Data. Statistical Methods in Epilepsy. 2024 Mar 25; 25-50. Sellers SK, Fan FJ, Hinkley HL, Kirsch KH. .
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    10. Intracranial beta activity is a biomarker of circadian and stimulation-induced arousal in obsessive compulsive disorder. Brain Stimul. 2024 Jan-Feb; 17(1):29-31. Fan JM, De B, Frank AC, Basich-Pease G, Norbu T, Morrison MA, Larson P, Starr PA, Krystal AD, Lee AM. PMID: 38097012; PMCID: PMC11539915.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Cortical Synchrony and Information Flow during Transition from Wakefulness to Light Non-Rapid Eye Movement Sleep. J Neurosci. 2023 11 29; 43(48):8157-8171. Fan JM, Kudo K, Verma P, Ranasinghe KG, Morise H, Findlay AM, Vossel K, Kirsch HE, Raj A, Krystal AD, Nagarajan SS. PMID: 37788939; PMCID: PMC10697405.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    12. Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder. J Vis Exp. 2023 07 07; (197). Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 37486114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    13. Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans. Brain Stimul. 2023 Jul-Aug; 16(4):1072-1082. Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD. PMID: 37385540; PMCID: PMC10634663.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    14. Closed-loop neurostimulation for the treatment of psychiatric disorders. Neuropsychopharmacology. 2024 Jan; 49(1):163-178. Sellers KK, Cohen JL, Khambhati AN, Fan JM, Lee AM, Chang EF, Krystal AD. PMID: 37369777; PMCID: PMC10700557.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. 468. Correspondence Between fMRI and Electrophysiological Functional Connectivity in Treatment-Resistant Depression. Biological Psychiatry. 2023 May 1; 93(9):s284. Sabetfakhri SN, Fan FJ, Slepneva SN, Motzkin MJ, Morrison MM, Sugrue SL, Sellers SK, Krystal KA, Lee LA. .
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    16. 46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression. Biological Psychiatry. 2023 May 1; 93(9):s112-s113. Cohen CJ, Fan FJ, Sellers SK, Khambhati KA, Dawes DH, Scangos SK, Rao RV, Sugrue SL, Starr SP, Chang CE, Krystal KA. .
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    17. Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations. Brain Stimul. 2023 Mar-Apr; 16(2):462-465. Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD. PMID: 36773780; PMCID: PMC10627048.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Changes in intracranial neurophysiology associated with acute COVID-19 infection. Clin Neurophysiol. 2023 04; 148:29-31. Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 36791656; PMCID: PMC9896881.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    19. BNST beta power is associated with diurnal variations in wakefulness and DBS-induced arousal in patients with severe OCD. Brain Stimulation. 2023 Jan 1; 16(1):378. De DB, Fan FJ, Lee LA. .
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    20. Correspondence in network connectivity assessed using fMRI and intracranial recordings in patients with severe refractory depression. Brain Stimulation. 2023 Jan 1; 16(1):373-374. Sabetfakhri SN, Fan FJ, Slepneva SN, Motkzin MJ, Morrison MM, Sugrue SL, Krystal KA, Lee LA. .
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    21. Modern intracranial electroencephalography for epilepsy localization with combined subdural grid and depth electrodes with low and improved hemorrhagic complication rates. J Neurosurg. 2023 03 01; 138(3):821-827. Lee AT, Nichols NM, Speidel BA, Fan JM, Cajigas I, Knowlton RC, Chang EF. PMID: 35901681.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. Network connectivity predicts effectiveness of responsive neurostimulation in focal epilepsy. Brain Commun. 2022; 4(3):fcac104. Fan JM, Lee AT, Kudo K, Ranasinghe KG, Morise H, Findlay AM, Kirsch HE, Chang EF, Nagarajan SS, Rao VR. PMID: 35611310; PMCID: PMC9123848.
      View in: PubMed   Mentions: 16  
    23. Management of Status Epilepticus and Indications for Inpatient Electroencephalography Monitoring. Neurol Clin. 2022 02; 40(1):1-16. Fan JM, Singhal NS, Guterman EL. PMID: 34798964.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    24. Bilateral temporal lobe epilepsy: How many seizures are required in chronic ambulatory electrocorticography to estimate the laterality ratio? Epilepsia. 2022 01; 63(1):199-208. Chiang S, Fan JM, Rao VR. PMID: 34723396; PMCID: PMC9056258.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    25. 073 Whole-brain network analysis of neural oscillations during light sleep. Sleep. 2021 May 3; 44(Supplement_2):a30-a31. Fan FJ, Kudo KK, Ranasinghe RK, Morise MH, Findlay FA, Kirsch KH, Krystal KA, Nagarajan NS. .
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    26. Seizure Cycles in Focal Epilepsy. JAMA Neurol. 2021 04 01; 78(4):454-463. Leguia MG, Andrzejak RG, Rummel C, Fan JM, Mirro EA, Tcheng TK, Rao VR, Baud MO. PMID: 33555292; PMCID: PMC7871210.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    27. Evidence for long memory in focal seizure duration. Epilepsia Open. 2021 03; 6(1):140-148. Fan JM, Chiang S, Rao VR. PMID: 33681657; PMCID: PMC7918332.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    28. Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time. Front Neurol. 2020; 11:616764. Fan JM, Gorno-Tempini ML, Dronkers NF, Miller BL, Berger MS, Chang EF. PMID: 33447252; PMCID: PMC7801263.
      View in: PubMed   Mentions: 1  
    29. Balancing Hemorrhage Risk with Electrode Coverage. Neurosurgery. 2020 Dec 1; 67(Supplement_1). Lee LA, Nichols NN, Speidel SB, Fan FJ, Knowlton KR, Chang CE. .
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    30. Catastrophic stroke burden in a patient with uncontrolled psoriasis and psoriatic arthritis: a case report. BMC Neurol. 2020 Mar 21; 20(1):106. Fan JM, Solomon DA, López GY, Hofmann JW, Colorado RA, Kim AS, Meisel K, Halabi C. PMID: 32199449; PMCID: PMC7085172.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Characterization of Multidien Rhythms in Patients with Epilepsy (S36.007). Neurology. 2019 Apr 9; 92(15_supplement). Fan FJ, Baud BM, Rao RV. .
      View in: Publisher Site   Mentions:
    32. Performance sustaining intracortical neural prostheses. J Neural Eng. 2014 Dec; 11(6):066003. Nuyujukian P, Kao JC, Fan JM, Stavisky SD, Ryu SI, Shenoy KV. PMID: 25307561.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    33. A high-performance keyboard neural prosthesis enabled by task optimization. IEEE Trans Biomed Eng. 2015 Jan; 62(1):21-29. Nuyujukian P, Fan JM, Kao JC, Ryu SI, Shenoy KV. PMID: 25203982; PMCID: PMC4418192.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    34. Intention estimation in brain-machine interfaces. J Neural Eng. 2014 Feb; 11(1):016004. Fan JM, Nuyujukian P, Kao JC, Chestek CA, Ryu SI, Shenoy KV. PMID: 24654266; PMCID: PMC4105020.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    35. A high-performance neural prosthesis enabled by control algorithm design. Nat Neurosci. 2012 Dec; 15(12):1752-7. Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Churchland MM, Kaufman MT, Kao JC, Ryu SI, Shenoy KV. PMID: 23160043; PMCID: PMC3638087.
      View in: PubMed   Mentions: 173     Fields:    Translation:Animals
    36. A recurrent neural network for closed-loop intracortical brain-machine interface decoders. J Neural Eng. 2012 Apr; 9(2):026027. Sussillo D, Nuyujukian P, Fan JM, Kao JC, Stavisky SD, Ryu S, Shenoy K. PMID: 22427488; PMCID: PMC3638090.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    37. A brain machine interface control algorithm designed from a feedback control perspective. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:1318-22. Gilja V, Nuyujukian P, Chestek CA, Cunningham JP, Yu BM, Fan JM, Ryu SI, Shenoy KV. PMID: 23366141.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    38. Characterizing tumor heterogeneity with functional imaging and quantifying high-risk tumor volume for early prediction of treatment outcome: cervical cancer as a model. Int J Radiat Oncol Biol Phys. 2012 Jul 01; 83(3):972-9. Mayr NA, Huang Z, Wang JZ, Lo SS, Fan JM, Grecula JC, Sammet S, Sammet CL, Jia G, Zhang J, Knopp MV, Yuh WT. PMID: 22208967; PMCID: PMC4373343.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    39. Therapy Outcome Prediction of Cervical Cancer with the Regression Rate of Physiologic High-risk Tumor Subvolume Assessed by DCE MRI. International Journal of Radiation Oncology • Biology • Physics. 2011 Oct 1; 81(2):s47. Mayr MN, Huang HZ, Lo LS, Jia JG, Grecula GJ, Zhang ZJ, Fan FJ, Knopp KM, Yuh YW. .
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    40. Long-term stability of neural prosthetic control signals from silicon cortical arrays in rhesus macaque motor cortex. J Neural Eng. 2011 Aug; 8(4):045005. Chestek CA, Gilja V, Nuyujukian P, Foster JD, Fan JM, Kaufman MT, Churchland MM, Rivera-Alvidrez Z, Cunningham JP, Ryu SI, Shenoy KV. PMID: 21775782; PMCID: PMC3644617.
      View in: PubMed   Mentions: 138     Fields:    
    41. Monkey models for brain-machine interfaces: the need for maintaining diversity. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1301-5. Nuyujukian P, Fan JM, Gilja V, Kalanithi PS, Chestek CA, Shenoy KV. PMID: 22254555.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    42. Quantifying Absolute Functional Risk Volume with Functional Tumor Imaging for Treatment Outcome Prediction in Cervical Cancer. International Journal of Radiation Oncology • Biology • Physics. 2010 Nov 1; 78(3):s142-s143. Mayr MN, Wang WJ, Huang HZ, Lo LS, Fan FJ, Grecula GJ, Sammet SS, Tosti TC, Knopp KM, Yuh YW. .
      View in: Publisher Site   Mentions:
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