Juan Irwin, MD, PhD

Title(s)Recall NFA, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #1620
San Francisco CA 94143
Phone415-476-2039
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Identifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach. iScience. 2024 Apr 19; 27(4):109388. Oskotsky TT, Bhoja A, Bunis D, Le BL, Tang AS, Kosti I, Li C, Houshdaran S, Sen S, Vallvé-Juanico J, Wang W, Arthurs E, Govil A, Mahoney L, Lang L, Gaudilliere B, Stevenson DK, Irwin JC, Giudice LC, McAllister SL, Sirota M. PMID: 38510116; PMCID: PMC10952035.
      View in: PubMed   Mentions:
    2. ENDOMETRIAL SUBCELLULAR ALTERATIONS IN ENDOMETRIOSIS IDENTIFIED BY SINGLE-CELL ANALYSIS ACROSS THE MENSTRUAL CYCLE. Fertility and Sterility. 2023 Oct 1; 120(4):e61-e62. Almonte AA, Wang WW, Flynn FE, Houshdaran HS, Vallvé-Juanico VJ, Irwin IJ, Kushnoor KD, Combes CA, Fragiadakis FG, Sirota SM, Giudice GL. .
      View in: Publisher Site   Mentions:
    3. Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function. Commun Biol. 2023 08 16; 6(1):780. Mortlock S, Houshdaran S, Kosti I, Rahmioglu N, Nezhat C, Vitonis AF, Andrews SV, Grosjean P, Paranjpe M, Horne AW, Jacoby A, Lager J, Opoku-Anane J, Vo KC, Manvelyan E, Sen S, Ghukasyan Z, Collins F, Santamaria X, Saunders P, Kober K, McRae AF, Terry KL, Vallvé-Juanico J, Becker C, Rogers PAW, Irwin JC, Zondervan K, Montgomery GW, Missmer S, Sirota M, Giudice L. PMID: 37587191; PMCID: PMC10432557.
      View in: PubMed   Mentions: 2  Translation:HumansCells
    4. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet. 2023 03; 55(3):423-436. Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Slomka M, Smith BH, Smolarz B, Szaflik T, Szyllo K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI, DBDS Genomic Consortium, FinnGen Study, FinnGen Endometriosis Taskforce, Celmatix Research Team, 23andMe Research Team, Adachi S, Buring JE, Ridker PM, D'Hooghe T, Goulielmos GN, Hapangama DK, Hayward C, Horne AW, Low SK, Martikainen H, Chasman DI, Rogers PAW, Saunders PT, Sirota M, Spector T, Strapagiel D, Tung JY, Whiteman DC, Giudice LC, Velez-Edwards DR, Uimari O, Kraft P, Salumets A, Nyholt DR, Mägi R, Stefansson K, Becker CM, Yurttas-Beim P, Steinthorsdottir V, Nyegaard M, Missmer SA, Montgomery GW, Morris AP, Zondervan KT. PMID: 36914876; PMCID: PMC10042257.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    5. Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis. Reprod Biomed Online. 2022 09; 45(3):519-530. Zhai J, Li S, Sen S, Vallvé-Juanico J, Irwin JC, Vo KC, Wan J, Du Y, Chen ZJ, Giudice LC. PMID: 35773139; PMCID: PMC9976941.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kong W, Kumar ME, Kuo AH, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, Olivieri JE, Park M, Ravikumar N, Stanley G, Tan W, Tarashansky AJ, Vanheusden R, Wang P, Wang S, Xing G, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Leylek R, Liu S, Maltzman JS, Metzger RJ, Phansalkar R, Sasagawa K, Sinha R, Song H, Swarup A, Trimm E, Veizades S, Wang B, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Kuo CS, Nguyen P, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wu A, Wu SM, Wyss-Coray T. PMID: 35549404; PMCID: PMC9812260.
      View in: PubMed   Mentions: 185     Fields:    Translation:HumansCells
    7. Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood. BMC Med. 2022 04 15; 20(1):158. Vallvé-Juanico J, George AF, Sen S, Thomas R, Shin MG, Kushnoor D, Vásquez JJ, Vo KC, Irwin JC, Roan NR, Combes AJ, Giudice LC. PMID: 35421980; PMCID: PMC9011995.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    8. Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis. Front Immunol. 2021; 12:788315. Bunis DG, Wang W, Vallvé-Juanico J, Houshdaran S, Sen S, Ben Soltane I, Kosti I, Vo KC, Irwin JC, Giudice LC, Sirota M. PMID: 35069565; PMCID: PMC8766492.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    9. Patterns of sex hormone receptor expression in stimulated endometrium from oocyte donors. Hum Fertil (Camb). 2022 Oct; 25(4):662-669. Manvelyan E, Houshdaran S, Irwin JC, Giudice LC, Aghajanova L. PMID: 33464141.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. Int J Mol Sci. 2020 Apr 09; 21(7). Houshdaran S, Chen JC, Vallvé-Juanico J, Balayan S, Vo KC, Smith-McCune K, Greenblatt RM, Irwin JC, Giudice LC. PMID: 32283828; PMCID: PMC7177488.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. A Pilot Cancer-Phenome Biobanking System in a Low-Resource Southeast Asian Setting: The Philippine General Hospital Biobank Experience. Biopreserv Biobank. 2020 Jun; 18(3):180-188. Sajo MEJV, Teves JMY, Corachea AJM, Diaz LA, Chan AFO, Valparaiso AP, Dy Echo AVV, Macalindong SS, Uy GLB, Dofitas RB, Habana MAE, Gerona RR, Irwin JC, Giudice LC, Velarde MC. PMID: 32202927.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. In vitro evidence that platelet-rich plasma stimulates cellular processes involved in endometrial regeneration. J Assist Reprod Genet. 2018 May; 35(5):757-770. Aghajanova L, Houshdaran S, Balayan S, Manvelyan E, Irwin JC, Huddleston HG, Giudice LC. PMID: 29404863; PMCID: PMC5984879.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    13. Effects of noncavity-distorting fibroids on endometrial gene expression and function. Biol Reprod. 2017 Oct 01; 97(4):564-576. Aghajanova L, Houshdaran S, Irwin JC, Giudice LC. PMID: 29025102; PMCID: PMC6279121.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Stromal fibroblasts from perimenopausal endometrium exhibit a different transcriptome than those from the premenopausal endometrium. Biol Reprod. 2017 Sep 01; 97(3):387-399. Erikson DW, Barragan F, Piltonen TT, Chen JC, Balayan S, Irwin JC, Giudice LC. PMID: 29024986; PMCID: PMC5803759.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Estrogen and progesterone receptors show distinct patterns in differentendometrial cells of oocyte donors after ovarian stimulation. Fertility and Sterility. 2017 Sep 1; 108(3):e234. Manvelyan ME, Aghajanova AL, Houshdaran HS, Irwin IJ, Giudice GL. .
      View in: Publisher Site   Mentions:
    16. Platelets for endometrial regeneration: a novel approach. Fertility and Sterility. 2016 Sep 1; 106(3):e82. Aghajanova AL, Houshdaran HS, Balayan BS, Irwin IJ, Huddleston HH, Giudice GL. .
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    17. Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis. Biol Reprod. 2016 11; 95(5):93. Houshdaran S, Nezhat CR, Vo KC, Zelenko Z, Irwin JC, Giudice LC. PMID: 27535958; PMCID: PMC5178151.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    18. Human Endometrial Fibroblasts Derived from Mesenchymal Progenitors Inherit Progesterone Resistance and Acquire an Inflammatory Phenotype in the Endometrial Niche in Endometriosis. Biol Reprod. 2016 05; 94(5):118. Barragan F, Irwin JC, Balayan S, Erikson DW, Chen JC, Houshdaran S, Piltonen TT, Spitzer TL, George A, Rabban JT, Nezhat C, Giudice LC. PMID: 27075616; PMCID: PMC4939744.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    19. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-10.e1. Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC. PMID: 26515378; PMCID: PMC4744114.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    20. Mid-secretory eutopic endometrium in intramural fibroids and severe endometriosis: relevance to fertility. Fertility and Sterility. 2015 Sep 1; 104(3):e344. Aghajanova AL, Irwin IJ, Giudice GL. .
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    21. Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: A Randomized Crossover Study. PLoS One. 2015; 10(7):e0129769. Smith-McCune K, Chen JC, Greenblatt RM, Shanmugasundaram U, Shacklett BL, Hilton JF, Johnson B, Irwin JC, Giudice LC. PMID: 26177352; PMCID: PMC4503751.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    22. Progestin-Containing Contraceptives Alter Expression of Host Defense-Related Genes of the Endometrium and Cervix. Reprod Sci. 2015 Jul; 22(7):814-28. Goldfien GA, Barragan F, Chen J, Takeda M, Irwin JC, Perry J, Greenblatt RM, Smith-McCune KK, Giudice LC. PMID: 25634912; PMCID: PMC4565478.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    23. Unexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract. AIDS Research and Human Retroviruses. 2014 Oct 1; 30(S1):a238-a238. Smith-McCune SK, Chen CJ, Greenblatt GR, Shacklett SB, Shanmugasundaram SU, Hilton HJ, Johnson JB, Barragan BF, Irwin IJ, Takeda TM, Pannell PJ, Perry PJ, Giudice GL. .
      View in: Publisher Site   Mentions:
    24. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014 Dec; 155(12):4986-99. Tamaresis JS, Irwin JC, Goldfien GA, Rabban JT, Burney RO, Nezhat C, DePaolo LV, Giudice LC. PMID: 25243856; PMCID: PMC4239429.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    25. Ovarian hormones induce differential DNA methylome in decidualizing versus non-decidualizing fibroblasts in patients with endometriosis. Fertility and Sterility. 2014 Sep 1; 102(3):e79. Houshdaran HS, Irwin IJ, Giudice GL. .
      View in: Publisher Site   Mentions:
    26. Human endometrial DNA methylome is cycle-dependent and is associated with gene expression regulation. Mol Endocrinol. 2014 Jul; 28(7):1118-35. Houshdaran S, Zelenko Z, Irwin JC, Giudice LC. PMID: 24877562; PMCID: PMC4075160.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    27. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014 Jun; 29(6):1255-70. Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, Kohgadai N, Irwin JC, Greene WC, Giudice LC, Roan NR. PMID: 24626806; PMCID: PMC4017943.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    28. Inhibition of epidermal growth factor receptor restores decidualization markers in stromal fibroblasts from women with endometriosis. Journal of Endometriosis and Pelvic Pain Disorders. 2014 Jan 1; 6(4):196-211. Erikson ED, Chen CJ, Piltonen PT, Conti CM, Irwin IJ, Giudice GL. .
      View in: Publisher Site   Mentions:
    29. Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production. Fertil Steril. 2013 Oct; 100(4):1132-43. Chen JC, Erikson DW, Piltonen TT, Meyer MR, Barragan F, McIntire RH, Tamaresis JS, Vo KC, Giudice LC, Irwin JC. PMID: 23849844; PMCID: PMC3820417.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Human endometrial co-culture system reveals novel cell-specific effects of nonoxynol-9 on endometrial transcriptome and chemokine secretion. Fertility and Sterility. 2012 Sep 1; 98(3):s27. Chen CJ, Erikson ED, Barragan BF, Irwin IJ, Greene GW, Giudice GL. .
      View in: Publisher Site   Mentions:
    31. Aberrant steroid hormone response and increased pro-inflammatory cytokine secretion in endometrial stromal fibroblasts from women with PCOS. Fertility and Sterility. 2012 Sep 1; 98(3):s26. Piltonen PT, Chen CJ, Spitzer ST, Irwin IJ, Giudice GL. .
      View in: Publisher Site   Mentions:
    32. Pro-inflammatory effects of seminal plasma on human endometrium: implications for implantation and human immunodeficiency virus (HIV) transmission. Fertility and Sterility. 2012 Sep 1; 98(3):s221. Johnson JB, Chen CJ, Roan RN, Barragan BF, Irwin IJ, Giudice GL. .
      View in: Publisher Site   Mentions:
    33. Perivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotype. Biol Reprod. 2012 Feb; 86(2):58. Spitzer TL, Rojas A, Zelenko Z, Aghajanova L, Erikson DW, Barragan F, Meyer M, Tamaresis JS, Hamilton AE, Irwin JC, Giudice LC. PMID: 22075475; PMCID: PMC3290674.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    34. Comparative transcriptome analysis of human trophectoderm and embryonic stem cell-derived trophoblasts reveal key participants in early implantation. Biol Reprod. 2012 Jan; 86(1):1-21. Aghajanova L, Shen S, Rojas AM, Fisher SJ, Irwin JC, Giudice LC. PMID: 21865555.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    35. Effects of Nonoxynol-9 on Endometrial Cytokine Secretion Using an In Vitro Co-Culture System in HIV-Negative Women. Biology of Reproduction. 2011 Jul 1; 85(Suppl_1):41-41. Chen CJ, Irwin IJ, Meyer MM, McIntire MR, Zelenko ZZ, Tamaresis TJ, Vo VK, Giudice GL. .
      View in: Publisher Site   Mentions:
    36. Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development. Fertil Steril. 2011 May; 95(6):2120-2, 2122.e1-12. Sheldon E, Vo KC, McIntire RA, Aghajanova L, Zelenko Z, Irwin JC, Giudice LC. PMID: 21371706; PMCID: PMC3080464.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
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