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A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlation with MYC-overexpression. Journal of Clinical Oncology. 2020 May 20; 38(15_suppl):1076-1076.
Amy Jo Chien, Amelia S Gliwa, Siti Rahmaputri, Heidi F Dittrich, Melanie Catherine Majure, Hope S. Rugo, Michelle E. Melisko, Pamela N. Munster, John W. Park, Mark M. Moasser, Mehrdad Matloubian, Tasha Lea, Julia Rohrberg, Gregor Krings, Andrei Goga. .
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MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 03 10; 30(10):3368-3382.e7.
Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A. PMID: 32160543.
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5 Fields:
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HumansAnimalsCells
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Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118.
Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. PMID: 30478424.
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51 Fields:
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HumansAnimalsCells
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The Plasticity of the Hsp90 Co-chaperone System. Mol Cell. 2017 Sep 21; 67(6):947-961.e5.
Sahasrabudhe P, Rohrberg J, Biebl MM, Rutz DA, Buchner J. PMID: 28890336.
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28 Fields:
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AnimalsCells
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PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329.
Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PMID: 27775705.
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63 Fields:
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367: Elucidating the synthetic lethal effect of CDK inhibition in triple negative breast cancer. European Journal of Cancer. 2014 Jul 1; 50:s88.
J. Rohrberg, A. Corella, L. Starnes, A. Goga. .
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Regulated structural transitions unleash the chaperone activity of aB-crystallin. Proc Natl Acad Sci U S A. 2013 Oct 01; 110(40):E3780-9.
Peschek J, Braun N, Rohrberg J, Back KC, Kriehuber T, Kastenmüller A, Weinkauf S, Buchner J. PMID: 24043785.
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68 Fields:
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The chaperone Hsp90: changing partners for demanding clients. Trends Biochem Sci. 2013 May; 38(5):253-62.
Röhl A, Rohrberg J, Buchner J. PMID: 23507089.
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104 Fields:
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The regulatory domain stabilizes the p53 tetramer by intersubunit contacts with the DNA binding domain. J Mol Biol. 2013 Jan 09; 425(1):144-55.
Retzlaff M, Rohrberg J, Küpper NJ, Lagleder S, Bepperling A, Manzenrieder F, Peschek J, Kessler H, Buchner J. PMID: 23103206.
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11 Fields:
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Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53. Nat Struct Mol Biol. 2011 Sep 04; 18(10):1086-93.
Hagn F, Lagleder S, Retzlaff M, Rohrberg J, Demmer O, Richter K, Buchner J, Kessler H. PMID: 21892170.
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43 Fields:
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HumansCells
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Monitoring fibril formation of the N-terminal domain of PABPN1 carrying an alanine repeat by tryptophan fluorescence and real-time NMR. FEBS Lett. 2008 May 14; 582(11):1587-92.
Rohrberg J, Sachs R, Lodderstedt G, Sackewitz M, Balbach J, Schwarz E. PMID: 18406354.
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4 Fields:
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HumansCells