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Julie Saba, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins University, Baltimore, MDB.S. 05/1981Natural Sciences
    University of Maryland School of Medicine, Baltimore, MDM.D.05/1985Medicine
    Johns Hopkins University, Baltimore, MDM.A.05/1986Creative Writing
    Duke University Medical Center, Durham, NCResidency07/1989Pediatrics
    Duke University Medical Center, Durham, NCPediatric Fellowship07/1993Hematology/Oncology
    Duke University, Durham, NCPh.D.05/1996Biochemistry/Cell Biology
    Collapse Awards and Honors
    Children's Hospital and Research Center Oakland2012John and Edna Beck Chair in Pediatric Cancer Research
    Children's Hospital and Research Center Oakland2015Director, Swim Across America National Laboratory

    Collapse Overview 
    Collapse Overview
    Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome characterized by defects of kidney, adrenal gland, neurological system, skin and immune system.

    Collapse Research 
    Collapse Research Activities and Funding
    Endogenous and Dietary Sphingolipids as Modulators in Inflammatory Bowel Disease
    NIH/NIDDK R01DK115669Jun 15, 2018 - May 31, 2022
    Role: Principal Investigator
    Agilent 6490 Triple Quadrupole Mass Spectrometer
    NIH S10OD018070Jun 1, 2014 - May 31, 2015
    Role: Principal Investigator
    IVIS Spectrum small animal imaging system
    NIH S10OD010335Jun 15, 2013 - Jun 14, 2014
    Role: Principal Investigator
    FASEB SRC on Lysophospholipd Mediators in Health and Disease
    NIH/NCI R13CA162835Aug 12, 2011 - Aug 11, 2012
    Role: Principal Investigator
    Soy sphingadienes and related compounds in colon cancer chemoprevention and treat
    NIH/NCCIH R21AT005336Sep 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Endogenous sphingosine-1-phosphate as a radioprotector of intestinal tissues
    NIH/NIAID RC1AI078516Aug 1, 2009 - Jan 31, 2011
    Role: Principal Investigator
    S1P Lyase in colon cancer
    NIH/NCI R01CA129438Aug 1, 2007 - Jun 30, 2015
    Role: Principal Investigator
    Sphingolipid Metabolism in Drosophila Development
    NIH/NIGMS R01GM066954Sep 1, 2003 - Feb 28, 2014
    Role: Principal Investigator
    Sphingosine Phosphate:Regulation and Role in Cancer
    NIH/NCI R01CA077528Sep 1, 1998 - Mar 31, 2010
    Role: Principal Investigator
    CERAMIDE MEDIATED SIGNAL TRANSDUCTION IN YEAST
    NIH/NCI K11CA059656Jul 1, 1993 - Jun 30, 1998
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MRI Spectrum of Brain Involvement in Sphingosine-1-Phosphate Lyase Insufficiency Syndrome. AJNR Am J Neuroradiol. 2020 Aug 27. Martin KW, Weaver N, Alhasan K, Gumus E, Sullivan BR, Zenker M, Hildebrandt F, Saba JD. PMID: 32855188.
      View in: PubMed   Mentions:    Fields:    
    2. Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation. J Inherit Metab Dis. 2020 Mar 31. Zhao P, Liu ID, Hodgin JB, Benke PI, Selva J, Torta F, Wenk MR, Endrizzi JA, West O, Ou W, Tang E, Goh DL, Tay SK, Yap HK, Loh A, Weaver N, Sullivan B, Larson A, Cooper MA, Alhasan K, Alangari AA, Salim S, Gumus E, Chen K, Zenker M, Hildebrandt F, Saba JD. PMID: 32233035.
      View in: PubMed   Mentions:    Fields:    
    3. Correction to: Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway. Invest New Drugs. 2019 Dec; 37(6):1309. Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD. PMID: 31032525.
      View in: PubMed   Mentions:    Fields:    
    4. Unraveling the ß-amyloid clearance by astrocytes: Involvement of metabotropic glutamate receptor 3, sAPPa, and class-A scavenger receptor. Neurochem Int. 2019 12; 131:104547. Durand D, Turati J, Rudi MJ, Ramírez D, Saba J, Caruso C, Carniglia L, von Bernhardi R, Lasaga M. PMID: 31536785.
      View in: PubMed   Mentions:    Fields:    
    5. Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease. J Lipid Res. 2019 03; 60(3):456-463. Saba JD. PMID: 30635364.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    6. Sphingosine phosphate lyase insufficiency syndrome (SPLIS): A novel inborn error of sphingolipid metabolism. Adv Biol Regul. 2019 01; 71:128-140. Choi YJ, Saba JD. PMID: 30274713.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. Astrocyte truncated tropomyosin receptor kinase B mediates brain-derived neurotrophic factor anti-apoptotic effect leading to neuroprotection. J Neurochem. 2018 09; 146(6):686-702. Saba J, Turati J, Ramírez D, Carniglia L, Durand D, Lasaga M, Caruso C. PMID: 29851427.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study. Inflamm Bowel Dis. 2018 05 18; 24(6):1321-1334. Suh JH, Degagné É, Gleghorn EE, Setty M, Rodriguez A, Park KT, Verstraete SG, Heyman MB, Patel AS, Irek M, Gildengorin GL, Hubbard NE, Borowsky AD, Saba JD. PMID: 29788359.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway. Invest New Drugs. 2018 10; 36(5):743-754. Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba JD. PMID: 29335887.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Sphingosine-1-Phosphate. Encyclopedia of Signaling Molecules. 2018 Jan 1; 5128-5137. Ashok Kumar, Julie D. Saba. .
      View in: Publisher Site   Mentions:
    11. The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress. J Immunol Sci. 2017; 1(1):1-8. Saba JD. PMID: 30740601.
      View in: PubMed   Mentions:
    12. S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling. Mediators Inflamm. 2017; 2017:7685142. Kumar A, Zamora-Pineda J, Degagné E, Saba JD. PMID: 29333002.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    13. Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity. J Biol Chem. 2017 12 08; 292(49):20292-20304. Hahn C, Tyka K, Saba JD, Lenzen S, Gurgul-Convey E. PMID: 29070677.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. An LC/MS/MS method for quantitation of chemopreventive sphingadienes in food products and biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 01; 1061-1062:292-299. Suh JH, Makarova AM, Gomez JM, Paul LA, Saba JD. PMID: 28772225.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy. 2017 May 04; 13(5):885-899. Mitroi DN, Karunakaran I, Gräler M, Saba JD, Ehninger D, Ledesma MD, van Echten-Deckert G. PMID: 28521611.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    16. Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia. Clin Case Rep. 2017 06; 5(6):891-893. Saba J, Logan AC. PMID: 28588833.
      View in: PubMed   Mentions:
    17. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017 Mar 01; 127(3):912-928. Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba JD, Hildebrandt F. PMID: 28165339.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    18. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. Mediators Inflamm. 2017; 2017:5048616. Carniglia L, Ramírez D, Durand D, Saba J, Turati J, Caruso C, Scimonelli TN, Lasaga M. PMID: 28154473.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism. Sci Rep. 2016 11 24; 6:37064. Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G. PMID: 27883090.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. J Exp Med. 2016 11 14; 213(12):2773-2791. Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba JD. PMID: 27810923.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    21. Sphingosine-1-Phosphate. Encyclopedia of Signaling Molecules. 2016 Jan 1; 1-10. Ashok Kumar, Julie D. Saba. .
      View in: Publisher Site   Mentions:
    22. Regulation of Immune Cell Migration by Sphingosine-1-Phosphate. Cell Mol Biol (OMICS). 2015; 61(2). Kumar A, Saba JD. PMID: 30294722.
      View in: PubMed   Mentions:
    23. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire. Transl Cancer Res. 2015 Oct 01; 4(5):469-483. Suh JH, Saba JD. PMID: 27011900.
      View in: PubMed   Mentions:
    24. A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity. Chem Phys Lipids. 2016 Jan; 194:101-9. Suh JH, Eltanawy A, Rangan A, Saba JD. PMID: 26408264.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. A B cell-dependent mechanism restrains T cell transendothelial migration. Nat Med. 2015 May; 21(5):424-6. Saba JD. PMID: 25951526.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    26. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014 Dec; 124(12):5368-84. Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba JD. PMID: 25347472.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    27. Tracking hippo in the cancer jungle. Chem Biol. 2014 Jul 17; 21(7):803-4. Suh JH, Saba JD. PMID: 25036773.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    28. S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. Clin Exp Gastroenterol. 2014; 7:205-14. Degagné E, Saba JD. PMID: 25061328.
      View in: PubMed   Mentions:
    29. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. FASEB J. 2014 Jan; 28(1):506-19. de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba JD. PMID: 24158395.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    30. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013 Jun 24; 3(3):351-368. Smith GS, Kumar A, Saba JD. PMID: 24619572.
      View in: PubMed   Mentions: 8     Fields:    
    31. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 2013 Feb; 33(4):752-62. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. PMID: 23230267.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development. Gene Expr Patterns. 2013 Jan-Feb; 13(1-2):21-9. Newbigging S, Zhang M, Saba JD. PMID: 23041657.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    33. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9):1920-31. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba JD. PMID: 22781001.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    34. S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. Biochim Biophys Acta. 2013 Jan; 1831(1):167-75. Saba JD, de la Garza-Rodea AS. PMID: 22750505.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    35. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochem Biophys Res Commun. 2012 Jul 20; 424(1):18-21. Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba JD, Hecht SS. PMID: 22727907.
      View in: PubMed   Mentions: 7     Fields:    
    36. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One. 2012; 7(5):e37218. Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba JD. PMID: 22606352.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    37. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3ß pathway in colon cancer. Carcinogenesis. 2012 Sep; 33(9):1726-35. Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba JD. PMID: 22581840.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    38. Sphingosine-1-Phosphate. Encyclopedia of Signaling Molecules. 2012 Jan 1; 1771-1778. Brian R. Dempsey, Anne C. Rintala-Dempsey, Gary S. Shaw, Yuan Xiao Zhu, A. Keith Stewart, Jaime O. Claudio, Constance E. Runyan, H. William Schnaper, Philip D. King, Matthew D. Blunt, Stephen G. Ward, Annegret Reinhold, Burkhart L. Schraven, Mitsunori Fukuda, Jong Ran Lee, Julia Strebovsky, Alexander H. Dalpke, Barbara Mariniello, Kaitlyn Ryan, Chin Chiang, Ashok Kumar, Julie D. Saba, David A. Jans, Gurpreet Kaur, Marc J. Tetel, Pui Man Rosalind Lai, Pradeep Kurup, Jian Xu, Susan Goebel-Goody, Surojit Paul, Paul Lombroso, Pia Ragno, Robert R. Bowers, Danyelle M. Townsend, Kenneth D. Tew, Payel Sen, Nilanjana Chatterjee, Blaine Bartholomew, Arie Horowitz. .
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    39. Corrigendum to “The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner” [Cell. Signal. 23(7) (2011) 1144-1152]. Cellular Signalling. 2012 Jan 1; 24(1):351. Ashok Kumar, Hoe-Sup Byun, Robert Bittman, Julie D. Saba. .
      View in: Publisher Site   Mentions:
    40. Truth and consequences of sphingosine-1-phosphate lyase. Adv Biol Regul. 2012 Jan; 52(1):17-30. Aguilar A, Saba JD. PMID: 21946005.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    41. Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. Anticancer Agents Med Chem. 2011 Nov; 11(9):782-93. Loh KC, Baldwin D, Saba JD. PMID: 21707493.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS One. 2011; 6(11):e26993. McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba JD, Nusse R. PMID: 22069480.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity. PLoS One. 2011; 6(9):e25220. Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, Birklé S. PMID: 21966461.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    44. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul; 23(7):1144-52. Kumar A, Byun HS, Bittman R, Saba JD. PMID: 21385609.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    45. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1753-61. Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba JD. PMID: 21335477.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    46. S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism. Cell Death Dis. 2011 Feb 10; 2:e119. Kumar A, Oskouian B, Fyrst H, Zhang M, Paris F, Saba JD. PMID: 21368890.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    47. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem. 2011 Mar 04; 286(9):7348-58. Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba JD, Proia RL. PMID: 21173151.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    48. Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):426-35. Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba JD, Garcia JG, Natarajan V. PMID: 21148740.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    49. Erratum: An update on sphingosine-1-phosphate and other sphingolipid mediators. Nature Chemical Biology. 2010 Sep 1; 6(9):689-689. Henrik Fyrst, Julie D Saba. .
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    50. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol. 2010 Jul; 6(7):489-97. Fyrst H, Saba JD. PMID: 20559316.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimals
    51. S1P metabolism in cancer and other pathological conditions. Biochimie. 2010 Jun; 92(6):716-23. Leong WI, Saba JD. PMID: 20167244.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    52. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res. 2010 Feb; 173(2):245-53. Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba JD, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC. PMID: 20095857.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansPHPublic Health
    53. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem. 2010 Apr 02; 285(14):10880-9. Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba JD, Proia RL. PMID: 20097939.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    54. Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol. 2010; 688:185-205. Oskouian B, Saba JD. PMID: 20919655.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    55. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Res. 2009 Dec 15; 69(24):9457-64. Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba JD. PMID: 19934323.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    56. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010; 50(1):349-62. Serra M, Saba JD. PMID: 19914275.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    57. Normalization of diabetic wound healing. Surgery. 2010 Mar; 147(3):446-9. Francis-Goforth KN, Harken AH, Saba JD. PMID: 19703697.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    58. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets. 2009 Aug; 13(8):1013-25. Kumar A, Saba JD. PMID: 19534571.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    59. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):366-70. Bandhuvula P, Li Z, Bittman R, Saba JD. PMID: 19250638.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    60. Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res. 2008 Nov 07; 103(10):1164-72. Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D. PMID: 18849324.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    61. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim Biophys Acta. 2008 Sep; 1781(9):448-58. Fyrst H, Saba JD. PMID: 18558101.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    62. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. J Lipid Res. 2008 Mar; 49(3):597-606. Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba JD. PMID: 18156591.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    63. A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity. J Lipid Res. 2007 Dec; 48(12):2769-78. Bandhuvula P, Fyrst H, Saba JD. PMID: 17872591.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. Dev Biol. 2007 Sep 15; 309(2):329-41. Phan VH, Herr DR, Panton D, Fyrst H, Saba JD, Harris GL. PMID: 17706961.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    65. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends Mol Med. 2007 May; 13(5):210-7. Bandhuvula P, Saba JD. PMID: 17416206.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    66. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. Cell Cycle. 2007 Mar 01; 6(5):522-7. Oskouian B, Saba J. PMID: 17361098.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    67. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21; 26(4):1094-104. Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba JD, Turk J, Beverley SM. PMID: 17290222.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    68. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17384-9. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD. PMID: 17090686.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    69. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. 2006 Oct; 26(19):7211-23. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba JD, Proia RL, Hla T. PMID: 16980623.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    70. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 2006 Mar; 54(3):742-53. Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba JD, Tam YY. PMID: 16508938.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    71. Sphingosine-1-Phosphate Lyase. Sphingolipid Biology. 2006 Jan 1; 219-230. Julie D. Saba. .
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    72. Directed Donor Cord Blood Transplantation for Hematological Disorders. Blood. 2005 Nov 16; 106(11):2035-2035. Mark C. Walters, Lynn Quirolo, Sandie Edwards, Joanna Lee, Shanda Robertson, Julie D. Saba, Elizabeth Trachtenberg, Keith C. Quirolo, Bert Lubin. .
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    73. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J Biol Chem. 2005 Oct 07; 280(40):33697-700. Bandhuvula P, Tam YY, Oskouian B, Saba JD. PMID: 16118221.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    74. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. J Biol Chem. 2005 May 06; 280(18):18403-10. Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba JD. PMID: 15734735.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    75. Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program. Ann N Y Acad Sci. 2005; 1054:206-13. Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B. PMID: 16339667.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    76. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17825-30. Jiang Q, Wong J, Fyrst H, Saba JD, Ames BN. PMID: 15596715.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    77. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. Semin Cell Dev Biol. 2004 Oct; 15(5):529-40. Oskouian B, Saba JD. PMID: 15271298.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    78. Lysophospholipids in development: Miles apart and edging in. J Cell Biochem. 2004 Aug 01; 92(5):967-92. Saba JD. PMID: 15258919.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    79. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res. 2004 Apr 02; 94(6):724-34. Saba JD, Hla T. PMID: 15059942.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    80. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. J Biol Chem. 2004 Mar 26; 279(13):12685-94. Herr DR, Fyrst H, Creason MB, Phan VH, Saba JD, Harris GL. PMID: 14722126.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    81. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004 Jan 09; 279(2):1281-90. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba JD. PMID: 14570870.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    82. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster. J Lipid Res. 2004 Jan; 45(1):54-62. Fyrst H, Herr DR, Harris GL, Saba JD. PMID: 13130120.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    83. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. Development. 2003 Jun; 130(11):2443-53. Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba JD. PMID: 12702658.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    84. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J Biol Chem. 2003 Jun 20; 278(25):22341-9. Mendel J, Heinecke K, Fyrst H, Saba JD. PMID: 12682045.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    85. Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease. Blood. 2003 Jan 01; 101(1):351-7. Reed W, Smith R, Dekovic F, Lee JY, Saba JD, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH. PMID: 12393579.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    86. Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. J Biol Chem. 2001 Apr 13; 276(15):11712-8. Birchwood CJ, Saba JD, Dickson RC, Cunningham KW. PMID: 11278643.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    87. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics. 2000 Dec; 156(4):1519-29. Kim S, Fyrst H, Saba J. PMID: 11102354.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    88. Molecular cloning - and functional characterization of the human sphingosine-1 -phosphate lyase gene. Journal of Pediatric Hematology/Oncology. 2000 Jul 1; 22(4):382. J. Zhou, U. Reiss, J. D. Saba. .
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    89. A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. Anal Biochem. 2000 May 15; 281(1):36-44. Caligan TB, Peters K, Ou J, Wang E, Saba J, Merrill AH. PMID: 10847608.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    90. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochemical Journal. 1999 Sep 15; 342(3):667-675. MAO Cungui, Julie D. SABA, Lina M. OBEID. .
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    91. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem J. 1999 Sep 15; 342 Pt 3:667-75. Mao C, Saba JD, Obeid LM. PMID: 10477278.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    92. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Biochemistry. 1999 May 04; 38(18):5864-71. Fyrst H, Oskouian B, Kuypers FA, Saba JD. PMID: 10231538.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    93. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. Mol Cell Biol Res Commun. 1999 Apr; 1(1):66-71. Gottlieb D, Heideman W, Saba JD. PMID: 10329480.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    94. YAP1 confers resistance to the fatty acid synthase inhibitor cerulenin through the transporter Flr1p in Saccharomyces cerevisiae. Mol Gen Genet. 1999 Mar; 261(2):346-53. Oskouian B, Saba JD. PMID: 10102370.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    95. Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem J. 1998 Jun 01; 332 ( Pt 2):525-31. Lanterman MM, Saba JD. PMID: 9601083.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    96. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem Biophys Res Commun. 1998 Jan 26; 242(3):502-7. Zhou J, Saba JD. PMID: 9464245.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    97. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem. 1997 Oct 17; 272(42):26087-90. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. PMID: 9334171.
      View in: PubMed   Mentions: 69     Fields:    Translation:Animals
    98. Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):233-40; discussion 240-1. Saba JD, Obeid LM, Hannun YA. PMID: 8650271.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    99. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61. Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA. PMID: 8387486.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    100. A seven-month-old infant with fever and neutrophilic leukocytosis. J Pediatr. 1992 May; 120(5):819-24. Fishbein JD, Bruggers CS, Friedman NJ, Graham ML, Kurtzberg J. PMID: 1578323.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    101. Large-cell lymphoma presenting with a distinctive inflammatory dermatosis. J Am Acad Dermatol. 1991 Nov; 25(5 Pt 2):912-5. Tope WD, Fishbein JD, White PF, Prose NS. PMID: 1761769.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    102. Pelger-Huet anomaly in an infant with multiple congenital anomalies. Am J Hematol. 1991 Nov; 38(3):240-2. Fishbein JD, Falletta JM. PMID: 1951327.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    103. A piece of my mind. The poetry of medicine. JAMA. 1990 Dec 19; 264(23):2999. Fishbein J. PMID: 2243427.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    104. Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion. Pediatr Infect Dis J. 1990 Sep; 9(9):676-8. Fishbein JD, Friedman HS, Bennett BB, Falletta JM. PMID: 2235195.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    105. Indicator enzyme assays. II. Adenylate kinase: application to human muscle biopsies and blood cells. Biochem Med. 1980 Oct; 24(2):130-42. Fishbein WN, Davis JI, Winkert JW, Fishbein JD. PMID: 6257235.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    106. Journal of Immunological Sciences. The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress. in press. Saba JD..
    107. Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study. in press. Suh JH Degagné E Gleghorn EE Setty M Rodriguez A Park KT Verstraete SG Heyman MB Patel AS Irek M Gildengorin GL Hubbard NE Borowsky AD Saba JD..
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