Julie Saba, MD, PhD

InstitutionUniversity of California San Francisco
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins University, Baltimore, MDB.S. 05/1981Natural Sciences
    University of Maryland School of Medicine, Baltimore, MDM.D.05/1985Medicine
    Johns Hopkins University, Baltimore, MDM.A.05/1986Creative Writing
    Duke University Medical Center, Durham, NCResidency07/1989Pediatrics
    Duke University Medical Center, Durham, NCPediatric Fellowship07/1993Hematology/Oncology
    Duke University, Durham, NCPh.D.05/1996Biochemistry/Cell Biology
    Collapse Awards and Honors
    Children's Hospital and Research Center Oakland2012John and Edna Beck Chair in Pediatric Cancer Research
    Children's Hospital and Research Center Oakland2015Director, Swim Across America National Laboratory

    Collapse Overview 
    Collapse Overview
    Sphingosine-1-phosphate (S1P) is a bioactive lipid that plays important roles in development, vascular biology, immune cell trafficking, carcinogenesis and other physiological processes. S1P mediates its actions primarily by signaling through a family of G protein-coupled receptors. Our research group is investigating the role of S1P metabolism and signaling in development and disease using cellular and animal models, translational approaches and metabolomics profiling. Our recent findings demonstrate that defects in S1P metabolism underlie a novel childhood syndrome characterized by defects of kidney, adrenal gland, neurological system, skin and immune system.

    Collapse Research 
    Collapse Research Activities and Funding
    Endogenous and Dietary Sphingolipids as Modulators of Inflammatory Bowel Disease
    NIH/NIDDK R01DK115669Jun 15, 2018 - May 31, 2022
    Role: Principal Investigator
    Agilent 6490 Triple Quadrupole Mass Spectrometer
    NIH S10OD018070Jun 1, 2014 - May 31, 2015
    Role: Principal Investigator
    IVIS Spectrum small animal imaging system
    NIH S10OD010335Jun 15, 2013 - Jun 14, 2014
    Role: Principal Investigator
    FASEB SRC on Lysophospholipd Mediators in Health and Disease
    NIH/NCI R13CA162835Aug 12, 2011 - Aug 11, 2012
    Role: Principal Investigator
    Soy sphingadienes and related compounds in colon cancer chemoprevention and treat
    NIH/NCCIH R21AT005336Sep 1, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Endogenous sphingosine-1-phosphate as a radioprotector of intestinal tissues
    NIH/NIAID RC1AI078516Sep 1, 2007 - Feb 28, 2011
    Role: Principal Investigator
    S1P Lyase in colon cancer
    NIH/NCI R01CA129438Jul 1, 2007 - Jan 31, 2018
    Role: Principal Investigator
    Sphingolipid Metabolism in Drosophila Development
    NIH/NIGMS R01GM066954Sep 1, 2003 - Feb 28, 2014
    Role: Principal Investigator
    Sphingosine Phosphate:Regulation and Role in Cancer
    NIH/NCI R01CA077528Sep 1, 1998 - Feb 28, 2011
    Role: Principal Investigator
    NIH/NCI K11CA059656Jul 1, 1993 - Jun 30, 1998
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Suh JH, Degagné É, Gleghorn EE, Setty M, Rodriguez A, Park KT, Verstraete SG, Heyman MB, Patel AS, Irek M, Gildengorin GL, Hubbard NE, Borowsky AD, Saba J. Sphingosine-1-Phosphate Signaling and Metabolism Gene Signature in Pediatric Inflammatory Bowel Disease: A Matched-case Control Pilot Study. Inflamm Bowel Dis. 2018 May 18; 24(6):1321-1334. PMID: 29788359.
      View in: PubMed
    2. Zhao P, Aguilar AE, Lee JY, Paul LA, Suh JH, Puri L, Zhang M, Beckstead J, Witkowski A, Ryan RO, Saba J. Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway. Invest New Drugs. 2018 Jan 16. PMID: 29335887.
      View in: PubMed
    3. Kumar A, Zamora-Pineda J, Degagné E, Saba J. S1P Lyase Regulation of Thymic Egress and Oncogenic Inflammatory Signaling. Mediators Inflamm. 2017; 2017:7685142. PMID: 29333002.
      View in: PubMed
    4. Hahn C, Tyka K, Saba J, Lenzen S, Gurgul-Convey E. Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity. J Biol Chem. 2017 12 08; 292(49):20292-20304. PMID: 29070677.
      View in: PubMed
    5. Mitroi DN, Karunakaran I, Gräler M, Saba J, Ehninger D, Ledesma MD, van Echten-Deckert G. SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. Autophagy. 2017 May 04; 13(5):885-899. PMID: 28521611.
      View in: PubMed
    6. Saba J, Logan AC. Obinutuzumab-induced serum sickness following salvage therapy for chronic lymphocytic leukemia. Clin Case Rep. 2017 Jun; 5(6):891-893. PMID: 28588833.
      View in: PubMed
    7. Lovric S, Goncalves S, Gee HY, Oskouian B, Srinivas H, Choi WI, Shril S, Ashraf S, Tan W, Rao J, Airik M, Schapiro D, Braun DA, Sadowski CE, Widmeier E, Jobst-Schwan T, Schmidt JM, Girik V, Capitani G, Suh JH, Lachaussée N, Arrondel C, Patat J, Gribouval O, Furlano M, Boyer O, Schmitt A, Vuiblet V, Hashmi S, Wilcken R, Bernier FP, Innes AM, Parboosingh JS, Lamont RE, Midgley JP, Wright N, Majewski J, Zenker M, Schaefer F, Kuss N, Greil J, Giese T, Schwarz K, Catheline V, Schanze D, Franke I, Sznajer Y, Truant AS, Adams B, Désir J, Biemann R, Pei Y, Ars E, Lloberas N, Madrid A, Dharnidharka VR, Connolly AM, Willing MC, Cooper MA, Lifton RP, Simons M, Riezman H, Antignac C, Saba J, Hildebrandt F. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017 Mar 01; 127(3):912-928. PMID: 28165339.
      View in: PubMed
    8. Carniglia L, Ramírez D, Durand D, Saba J, Turati J, Caruso C, Scimonelli TN, Lasaga M. Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases. Mediators Inflamm. 2017; 2017:5048616. PMID: 28154473.
      View in: PubMed
    9. Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M, Ehninger D, Sopova E, Shupliakov O, Swandulla D, van Echten-Deckert G. Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism. Sci Rep. 2016 11 24; 6:37064. PMID: 27883090.
      View in: PubMed
    10. Zamora-Pineda J, Kumar A, Suh JH, Zhang M, Saba J. Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. J Exp Med. 2016 Nov 14; 213(12):2773-2791. PMID: 27810923.
      View in: PubMed
    11. Suh JH, Saba J. Sphingosine-1-phosphate in inflammatory bowel disease and colitis-associated colon cancer: the fat's in the fire. Transl Cancer Res. 2015 Oct 01; 4(5):469-483. PMID: 27011900.
      View in: PubMed
    12. Suh JH, Eltanawy A, Rangan A, Saba J. A facile stable-isotope dilution method for determination of sphingosine phosphate lyase activity. Chem Phys Lipids. 2016 Jan; 194:101-9. PMID: 26408264; PMCID: PMC4718852 [Available on 01/01/17].
    13. Saba J. A B cell-dependent mechanism restrains T cell transendothelial migration. Nat Med. 2015 May; 21(5):424-6. PMID: 25951526.
      View in: PubMed
    14. Degagné E, Pandurangan A, Bandhuvula P, Kumar A, Eltanawy A, Zhang M, Yoshinaga Y, Nefedov M, de Jong PJ, Fong LG, Young SG, Bittman R, Ahmedi Y, Saba J. Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. J Clin Invest. 2014 Dec; 124(12):5368-84. PMID: 25347472; PMCID: PMC4348973.
    15. Suh JH, Saba J. Tracking hippo in the cancer jungle. Chem Biol. 2014 Jul 17; 21(7):803-4. PMID: 25036773.
      View in: PubMed
    16. Degagné E, Saba J. S1pping fire: Sphingosine-1-phosphate signaling as an emerging target in inflammatory bowel disease and colitis-associated cancer. Clin Exp Gastroenterol. 2014; 7:205-14. PMID: 25061328; PMCID: PMC4085325.
    17. de la Garza-Rodea AS, Baldwin DM, Oskouian B, Place RF, Bandhuvula P, Kumar A, Saba J. Sphingosine phosphate lyase regulates myogenic differentiation via S1P receptor-mediated effects on myogenic microRNA expression. FASEB J. 2014 Jan; 28(1):506-19. PMID: 24158395; PMCID: PMC3868843.
    18. Smith GS, Kumar A, Saba J. Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway. Biomolecules. 2013 Jun 24; 3(3):351-368. PMID: 24619572.
      View in: PubMed
    19. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 2013 Feb; 33(4):752-62. PMID: 23230267; PMCID: PMC3571353.
    20. Newbigging S, Zhang M, Saba J. Immunohistochemical analysis of sphingosine phosphate lyase expression during murine development. Gene Expr Patterns. 2013 Jan-Feb; 13(1-2):21-9. PMID: 23041657; PMCID: PMC3562366.
    21. Borowsky AD, Bandhuvula P, Kumar A, Yoshinaga Y, Nefedov M, Fong LG, Zhang M, Baridon B, Dillard L, de Jong P, Young SG, West DB, Saba J. Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res. 2012 Sep; 53(9):1920-31. PMID: 22781001; PMCID: PMC3413231.
    22. Saba J, de la Garza-Rodea AS. S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. Biochim Biophys Acta. 2013 Jan; 1831(1):167-75. PMID: 22750505; PMCID: PMC3609719.
    23. Upadhyaya P, Kumar A, Byun HS, Bittman R, Saba J, Hecht SS. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. Biochem Biophys Res Commun. 2012 Jul 20; 424(1):18-21. PMID: 22727907; PMCID: PMC3402648.
    24. Loh KC, Leong WI, Carlson ME, Oskouian B, Kumar A, Fyrst H, Zhang M, Proia RL, Hoffman EP, Saba J. Sphingosine-1-phosphate enhances satellite cell activation in dystrophic muscles through a S1PR2/STAT3 signaling pathway. PLoS One. 2012; 7(5):e37218. PMID: 22606352; PMCID: PMC3351440.
    25. Kumar A, Pandurangan AK, Lu F, Fyrst H, Zhang M, Byun HS, Bittman R, Saba J. Chemopreventive sphingadienes downregulate Wnt signaling via a PP2A/Akt/GSK3ß pathway in colon cancer. Carcinogenesis. 2012 Sep; 33(9):1726-35. PMID: 22581840; PMCID: PMC3514901.
    26. Aguilar A, Saba J. Truth and consequences of sphingosine-1-phosphate lyase. Adv Biol Regul. 2012 Jan; 52(1):17-30. PMID: 21946005; PMCID: PMC3560305.
    27. McElwain MA, Ko DC, Gordon MD, Fyrst H, Saba J, Nusse R. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS One. 2011; 6(11):e26993. PMID: 22069480; PMCID: PMC3206050.
    28. Loh KC, Baldwin D, Saba J. Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond. Anticancer Agents Med Chem. 2011 Nov; 11(9):782-93. PMID: 21707493; PMCID: PMC3259192.
    29. Alvarez-Rueda N, Desselle A, Cochonneau D, Chaumette T, Clemenceau B, Leprieur S, Bougras G, Supiot S, Mussini JM, Barbet J, Saba J, Paris F, Aubry J, Birklé S. A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity. PLoS One. 2011; 6(9):e25220. PMID: 21966461; PMCID: PMC3178631.
    30. Kumar A, Byun HS, Bittman R, Saba J. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul; 23(7):1144-52. PMID: 21385609; PMCID: PMC3086202.
    31. Bandhuvula P, Honbo N, Wang GY, Jin ZQ, Fyrst H, Zhang M, Borowsky AD, Dillard L, Karliner JS, Saba J. S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol. 2011 May; 300(5):H1753-61. PMID: 21335477; PMCID: PMC3094087.
    32. Allende ML, Bektas M, Lee BG, Bonifacino E, Kang J, Tuymetova G, Chen W, Saba J, Proia RL. Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking. J Biol Chem. 2011 Mar 04; 286(9):7348-58. PMID: 21173151; PMCID: PMC3044991.
    33. Zhao Y, Gorshkova IA, Berdyshev E, He D, Fu P, Ma W, Su Y, Usatyuk PV, Pendyala S, Oskouian B, Saba J, Garcia JG, Natarajan V. Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):426-35. PMID: 21148740; PMCID: PMC3175568.
    34. Fyrst H, Saba J. An update on sphingosine-1-phosphate and other sphingolipid mediators. Nat Chem Biol. 2010 Jul; 6(7):489-97. PMID: 20559316; PMCID: PMC3001344.
    35. Leong WI, Saba J. S1P metabolism in cancer and other pathological conditions. Biochimie. 2010 Jun; 92(6):716-23. PMID: 20167244; PMCID: PMC2878883.
    36. Prasanna PG, Blakely WF, Bertho JM, Chute JP, Cohen EP, Goans RE, Grace MB, Lillis-Hearne PK, Lloyd DC, Lutgens LC, Meineke V, Ossetrova NI, Romanyukha A, Saba J, Weisdorf DJ, Wojcik A, Yukihara EG, Pellmar TC. Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. Radiat Res. 2010 Feb; 173(2):245-53. PMID: 20095857.
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    37. Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, Remaley AT, Saba J, Proia RL. Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver. J Biol Chem. 2010 Apr 02; 285(14):10880-9. PMID: 20097939; PMCID: PMC2856294.
    38. Oskouian B, Saba J. Cancer treatment strategies targeting sphingolipid metabolism. Adv Exp Med Biol. 2010; 688:185-205. PMID: 20919655; PMCID: PMC3076281.
    39. Fyrst H, Oskouian B, Bandhuvula P, Gong Y, Byun HS, Bittman R, Lee AR, Saba J. Natural sphingadienes inhibit Akt-dependent signaling and prevent intestinal tumorigenesis. Cancer Res. 2009 Dec 15; 69(24):9457-64. PMID: 19934323; PMCID: PMC2795098.
    40. Serra M, Saba J. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010; 50(1):349-62. PMID: 19914275; PMCID: PMC2862839.
    41. Francis-Goforth KN, Harken AH, Saba J. Normalization of diabetic wound healing. Surgery. 2010 Mar; 147(3):446-9. PMID: 19703697; PMCID: PMC2827630.
    42. Kumar A, Saba J. Lyase to live by: sphingosine phosphate lyase as a therapeutic target. Expert Opin Ther Targets. 2009 Aug; 13(8):1013-25. PMID: 19534571; PMCID: PMC2774446.
    43. Bandhuvula P, Li Z, Bittman R, Saba J. Sphingosine 1-phosphate lyase enzyme assay using a BODIPY-labeled substrate. Biochem Biophys Res Commun. 2009 Mar 06; 380(2):366-70. PMID: 19250638; PMCID: PMC2790368.
    44. Tauseef M, Kini V, Knezevic N, Brannan M, Ramchandaran R, Fyrst H, Saba J, Vogel SM, Malik AB, Mehta D. Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res. 2008 Nov 07; 103(10):1164-72. PMID: 18849324.
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    45. Fyrst H, Saba J. Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight. Biochim Biophys Acta. 2008 Sep; 1781(9):448-58. PMID: 18558101; PMCID: PMC2749932.
    46. Fyrst H, Zhang X, Herr DR, Byun HS, Bittman R, Phan VH, Harris GL, Saba J. Identification and characterization by electrospray mass spectrometry of endogenous Drosophila sphingadienes. J Lipid Res. 2008 Mar; 49(3):597-606. PMID: 18156591.
      View in: PubMed
    47. Bandhuvula P, Fyrst H, Saba J. A rapid fluorescence assay for sphingosine-1-phosphate lyase enzyme activity. J Lipid Res. 2007 Dec; 48(12):2769-78. PMID: 17872591.
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    48. Phan VH, Herr DR, Panton D, Fyrst H, Saba J, Harris GL. Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. Dev Biol. 2007 Sep 15; 309(2):329-41. PMID: 17706961; PMCID: PMC2094363.
    49. Bandhuvula P, Saba J. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends Mol Med. 2007 May; 13(5):210-7. PMID: 17416206.
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    50. Oskouian B, Saba J. Sphingosine-1-phosphate metabolism and intestinal tumorigenesis: lipid signaling strikes again. Cell Cycle. 2007 Mar 01; 6(5):522-7. PMID: 17361098.
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    51. Zhang K, Pompey JM, Hsu FF, Key P, Bandhuvula P, Saba J, Turk J, Beverley SM. Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania. EMBO J. 2007 Feb 21; 26(4):1094-104. PMID: 17290222; PMCID: PMC1852826.
    52. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba J. Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17384-9. PMID: 17090686; PMCID: PMC1859938.
    53. Kohno M, Momoi M, Oo ML, Paik JH, Lee YM, Venkataraman K, Ai Y, Ristimaki AP, Fyrst H, Sano H, Rosenberg D, Saba J, Proia RL, Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. 2006 Oct; 26(19):7211-23. PMID: 16980623; PMCID: PMC1592880.
    54. Kitano M, Hla T, Sekiguchi M, Kawahito Y, Yoshimura R, Miyazawa K, Iwasaki T, Sano H, Saba J, Tam YY. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. 2006 Mar; 54(3):742-53. PMID: 16508938.
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    55. Bandhuvula P, Tam YY, Oskouian B, Saba J. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J Biol Chem. 2005 Oct 07; 280(40):33697-700. PMID: 16118221.
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    56. Oskouian B, Mendel J, Shocron E, Lee MA, Fyrst H, Saba J. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. J Biol Chem. 2005 May 06; 280(18):18403-10. PMID: 15734735.
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    57. Walters MC, Quirolo L, Trachtenberg ET, Edwards S, Hale L, Lee J, Morton-Wiley J, Quirolo K, Robertson S, Saba J, Lubin B. Sibling donor cord blood transplantation for thalassemia major: Experience of the Sibling Donor Cord Blood Program. Ann N Y Acad Sci. 2005; 1054:206-13. PMID: 16339667.
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    58. Jiang Q, Wong J, Fyrst H, Saba J, Ames BN. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. Proc Natl Acad Sci U S A. 2004 Dec 21; 101(51):17825-30. PMID: 15596715; PMCID: PMC535585.
    59. Oskouian B, Saba J. Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. Semin Cell Dev Biol. 2004 Oct; 15(5):529-40. PMID: 15271298.
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    60. Saba J. Lysophospholipids in development: Miles apart and edging in. J Cell Biochem. 2004 Aug 01; 92(5):967-92. PMID: 15258919.
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    61. Saba J, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res. 2004 Apr 02; 94(6):724-34. PMID: 15059942.
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    62. Herr DR, Fyrst H, Creason MB, Phan VH, Saba J, Harris GL. Characterization of the Drosophila sphingosine kinases and requirement for Sk2 in normal reproductive function. J Biol Chem. 2004 Mar 26; 279(13):12685-94. PMID: 14722126.
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    63. Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH, Saba J. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004 Jan 09; 279(2):1281-90. PMID: 14570870.
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    64. Fyrst H, Herr DR, Harris GL, Saba J. Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster. J Lipid Res. 2004 Jan; 45(1):54-62. PMID: 13130120.
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    65. Herr DR, Fyrst H, Phan V, Heinecke K, Georges R, Harris GL, Saba J. Sply regulation of sphingolipid signaling molecules is essential for Drosophila development. Development. 2003 Jun; 130(11):2443-53. PMID: 12702658.
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    66. Mendel J, Heinecke K, Fyrst H, Saba J. Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans. J Biol Chem. 2003 Jun 20; 278(25):22341-9. PMID: 12682045.
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    67. Reed W, Smith R, Dekovic F, Lee JY, Saba J, Trachtenberg E, Epstein J, Haaz S, Walters MC, Lubin BH. Comprehensive banking of sibling donor cord blood for children with malignant and nonmalignant disease. Blood. 2003 Jan 01; 101(1):351-7. PMID: 12393579.
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    68. Kim S, Fyrst H, Saba J. Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae. Genetics. 2000 Dec; 156(4):1519-29. PMID: 11102354; PMCID: PMC1461366.
    69. Caligan TB, Peters K, Ou J, Wang E, Saba J, Merrill AH. A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. Anal Biochem. 2000 May 15; 281(1):36-44. PMID: 10847608.
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    70. Saba J, Obeid LM, Hannun YA. Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):233-40; discussion 240-1. PMID: 8650271.
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    71. Fishbein JD, Dobrowsky RT, Bielawska A, Garrett S, Hannun YA. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61. PMID: 8387486.
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    72. Fishbein JD, Bruggers CS, Friedman NJ, Graham ML, Kurtzberg J. A seven-month-old infant with fever and neutrophilic leukocytosis. J Pediatr. 1992 May; 120(5):819-24. PMID: 1578323.
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    73. Tope WD, Fishbein JD, White PF, Prose NS. Large-cell lymphoma presenting with a distinctive inflammatory dermatosis. J Am Acad Dermatol. 1991 Nov; 25(5 Pt 2):912-5. PMID: 1761769.
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    74. Fishbein JD, Falletta JM. Pelger-Huet anomaly in an infant with multiple congenital anomalies. Am J Hematol. 1991 Nov; 38(3):240-2. PMID: 1951327.
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    75. Fishbein J. A piece of my mind. The poetry of medicine. JAMA. 1990 Dec 19; 264(23):2999. PMID: 2243427.
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    76. Fishbein JD, Friedman HS, Bennett BB, Falletta JM. Catheter-related sepsis refractory to antibiotics treated successfully with adjunctive urokinase infusion. Pediatr Infect Dis J. 1990 Sep; 9(9):676-8. PMID: 2235195.
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    77. Fishbein WN, Davis JI, Winkert JW, Fishbein JD. Indicator enzyme assays. II. Adenylate kinase: application to human muscle biopsies and blood cells. Biochem Med. 1980 Oct; 24(2):130-42. PMID: 6257235.
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    78. Suh JH Degagné E Gleghorn EE Setty M Rodriguez A Park KT Verstraete SG Heyman MB Patel AS Irek M Gildengorin GL Hubbard NE Borowsky AD Saba JD.Sphingosine-1-phosphate signaling and metabolism gene signature in pediatric inflammatory bowel disease: a matched-case control pilot study. in press.
    79. Saba J. Journal of Immunological Sciences. The low down on sphingosine-1-phosphate lyase as a regulator of thymic egress. in press.
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