Kara Lynch, PhD

Title(s)Professor, Laboratory Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-5477
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    Collapse Biography 
    Collapse Education and Training
    Butler UniversityBachelor of Science2002Chemistry and Biology Departments
    University of WisconsinDoctorate2007Biochemistry Department
    University of California, San FranciscoPostdoctoral Studies2009Graduate Division

    Collapse Overview 
    Collapse Overview
    Dr. Lynch is the Co-Director of the Core Clinical Laboratory at San Francisco General Hospital overseeing Chemistry and Toxicology. She is also the Director of Chemistry at UCSF Children's Hospital Oakland. Her research laboratory primarily focuses on identifying and quantifying endogenous and exogenous compounds in biological specimens using novel diagnostic technologies, such as mass spectrometry and biolayer interferometry, and correlating the findings with clinical pathologies. They are involved in translational research studies aimed at the clinical evaluation of novel biomarkers or biomarker panels to diagnosis, treat and monitor disease. The Lynch lab has developed numerous liquid-chromatography tandem mass spectrometry (LC-MS/MS), liquid-chromatography quadrupole time-of-flight (LC-QTOF) mass spectrometry, and label-free immunoassay methods for the detection and quantitation of small molecules and proteins in biological specimens. The methods they develop are used to investigate perturbations in metabolic pathways caused by disease and toxicological exposure. They aim to translate results into information that can be used in clinical practice bridging laboratory research and clinical research through multidisciplinary collaboration and methodologies.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation. Cell. 2022 Apr 29. Wei TT, Chandy M, Nishiga M, Zhang A, Kumar KK, Thomas D, Manhas A, Rhee S, Justesen JM, Chen IY, Wo HT, Khanamiri S, Yang JY, Seidl FJ, Burns NZ, Liu C, Sayed N, Shie JJ, Yeh CF, Yang KC, Lau E, Lynch KL, Rivas M, Kobilka BK, Wu JC. PMID: 35489334.
      View in: PubMed   Mentions:
    2. Establishment of a High-Resolution Liquid Chromatography-Mass Spectrometry Spectral Library for Screening Toxic Natural Products. J Anal Toxicol. 2022 Mar 21; 46(3):303-321. Luo YR, Goodnough R, Yun C, Wu AHB, Lynch KL, Luo YR, Goodnough R, Yun C, Wu AHB, Lynch KL. PMID: 33506876.
      View in: PubMed   Mentions:    Fields:    
    3. Rate of Serum SARS-CoV-2 Antibody Decline for Two mRNA Vaccines. J Appl Lab Med. 2022 03 02; 7(2):625-627. Wu AHB, Nguyen ED, Ong CM, Yun C, Lynch KL, Wu AHB, Nguyen ED, Ong CM, Yun C, Lynch KL. PMID: 34648027; PMCID: PMC8524641.
      View in: PubMed   Mentions:    Fields:    
    4. Adequate Antibody Response to COVID-19 Vaccine in Patients with Monoclonal Gammopathies and Light Chain Amyloidosis. Lab Med. 2022 Jan 13. Wu AHB, Wang CC, Ong CM, Lynch KL. PMID: 35026018; PMCID: PMC8807219.
      View in: PubMed   Mentions:
    5. Evaluation of neutralizing antibodies against SARS-CoV-2 variants after infection and vaccination using a multiplexed surrogate virus neutralization test. Clin Chem. 2022 Jan 09. Lynch KL, Zhou S, Kaul R, Walker R, Wu AH. PMID: 35018416; PMCID: PMC8755391.
      View in: PubMed   Mentions:
    6. Development of an LC-MS/MS Method for Measurement of Irinotecan and Its Major Metabolites in Plasma: Technical Considerations. Lab Med. 2022 Jan 06; 53(1):47-52. Aoullay Z, Van Wijk XMR, Yanhui M, Meddah B, Lynch KL, Cherrah Y, Wu AHB. PMID: 34351422.
      View in: PubMed   Mentions:    Fields:    
    7. Development of a high-throughput differential mobility separation-tandem mass spectrometry (DMS-MS/MS) method for clinical urine drug testing. J Mass Spectrom Adv Clin Lab. 2022 Jan; 23:50-57. Hooshfar S, Tchu S, Yun C, Lynch KL. PMID: 35036987; PMCID: PMC8753179.
      View in: PubMed   Mentions:
    8. Diagnostic Value of Nucleocapsid Protein in Blood for SARS-CoV-2 Infection. Clin Chem. 2021 12 30; 68(1):240-248. Zhang Y, Ong CM, Yun C, Mo W, Whitman JD, Lynch KL, Wu AHB, Zhang Y, Ong CM, Yun C, Whitman JD, Lynch KL, Wu AHB. PMID: 34358289; PMCID: PMC8436384.
      View in: PubMed   Mentions:    Fields:    
    9. Evaluation of transplacental transfer of mRNA vaccine products and functional antibodies during pregnancy and early infancy. medRxiv. 2021 Dec 13. Prahl M, Golan Y, Cassidy AG, Matsui Y, Li L, Alvarenga B, Chen H, Jigmeddagva U, Lin CY, Gonzalez VJ, Chidboy MA, Warrier L, Buarpung S, Murtha AP, Flaherman VJ, Greene WC, Wu AHB, Lynch KL, Rajan J, Gaw SL. PMID: 34931197; PMCID: PMC8687468.
      View in: PubMed   Mentions:
    10. Differences in Post-mRNA Vaccination SARS-CoV-2 IgG Concentrations and Surrogate Virus Neutralization Test Response by HIV Status and Type of Vaccine: a Matched Case-Control Observational Study. Clin Infect Dis. 2021 Dec 05. Spinelli MA, Peluso MJ, Lynch KL, Yun C, Glidden DV, Henrich TJ, Deeks SG, Gandhi M. PMID: 34864962; PMCID: PMC8689738.
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    11. LB8. Lower SARS-CoV-2 IgG and Pseudovirus Neutralization Titers Post-mRNA Vaccination among People Living with HIV. Open Forum Infectious Diseases. 2021 Dec 4; 8(Suppl 1):s805-s805. Spinelli SM, Peluso PM, Lynch LK, Yun YC, Glidden GD, Henrich HT, Deeks DS, Gandhi GM. .
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    12. Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Avidity Maturation and Association with Disease Severity. Clin Infect Dis. 2021 11 02; 73(9):e3095-e3097. Luo YR, Chakraborty I, Yun C, Wu AHB, Lynch KL, Luo YR, Chakraborty I, Yun C, Wu AHB, Lynch KL. PMID: 32927483; PMCID: PMC7543300.
      View in: PubMed   Mentions: 8     Fields:    
    13. The Reference Range for the Anion Gap Is Dependent on the Instrument's Electrolyte Assay. J Appl Lab Med. 2021 11 01; 6(6):1697-1699. Wu AHB, Jankowski T, Zhang Y, Lynch KL. PMID: 34534316.
      View in: PubMed   Mentions:    Fields:    
    14. SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy. bioRxiv. 2021 Oct 13. Ryu JK, Sozmen EG, Dixit K, Montano M, Matsui Y, Liu Y, Helmy E, Deerinck TJ, Yan Z, Schuck R, Acevedo RM, Spencer CM, Thomas R, Pico AR, Zamvil SS, Lynch KL, Ellisman MH, Greene WC, Akassoglou K. PMID: 34671772; PMCID: PMC8528086.
      View in: PubMed   Mentions:
    15. Ongoing tobacco use in women who experience homelessness and unstable housing: A prospective study to inform tobacco cessation interventions and policies. Addictive Behaviors. 2021 Sep 1; 107125. Riley RE, Delucchi DK, Rubin RS, Weiser WS, Vijayaraghavan VM, Lynch LK, Tsoh TJ. .
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    16. Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Sci Transl Med. 2021 Sep 22; 13(612):eabh2624. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ, UCSF COMET consortium. PMID: 34429372; PMCID: PMC8601717.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease. Open Forum Infect Dis. 2021 Aug; 8(8):ofab393. Peluso MJ, Munter SE, Lynch KL, Yun C, Torres L, Iyer NS, Donatelli J, Ryan L, Deitchman AN, Deeks SG, Rutishauser RL, Henrich TJ. PMID: 34395717; PMCID: PMC8344490.
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    18. Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019. Open Forum Infect Dis. 2021 Aug; 8(8):ofab385. Bainbridge ED, Hsue PY, Esensten JH, Lynch KL, Hendrickson CM, Doernberg SB, Fung M, Chin-Hong P, Di Germanio C, Norris PJ, Simmons G, Glidden DV, Luetkemeyer AF. PMID: 34405093; PMCID: PMC8344822.
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    19. Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19. Cell Rep. 2021 07 20; 36(3):109414. Neidleman J, Luo X, George AF, McGregor M, Yang J, Yun C, Murray V, Gill G, Greene WC, Vasquez J, Lee SA, Ghosn E, Lynch KL, Roan NR. PMID: 34260965; PMCID: PMC8238659.
      View in: PubMed   Mentions: 1     Fields:    
    20. A SARS-CoV-2 Label-Free Surrogate Virus Neutralization Test and a Longitudinal Study of Antibody Characteristics in COVID-19 Patients. J Clin Microbiol. 2021 06 18; 59(7):e0019321. Luo YR, Yun C, Chakraborty I, Wu AHB, Lynch KL. PMID: 33827900; PMCID: PMC8218741.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Citywide serosurveillance of the initial SARS-CoV-2 outbreak in San Francisco using electronic health records. Nat Commun. 2021 06 11; 12(1):3566. Routledge I, Epstein A, Takahashi S, Janson O, Hakim J, Duarte E, Turcios K, Vinden J, Sujishi K, Rangel J, Coh M, Besana L, Ho WK, Oon CY, Ong CM, Yun C, Lynch K, Wu AHB, Wu W, Karlon W, Thornborrow E, Peluso MJ, Henrich TJ, Pak JE, Briggs J, Greenhouse B, Rodriguez-Barraquer I. PMID: 34117227; PMCID: PMC8195995.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    22. Lacosamide induced Brugada I morphology in the setting of septicemia: A case report. Medicine (Baltimore). 2021 May 07; 100(18):e25577. Goodnough R, Badea A, Geier C, Lynch KL, LeSaint KT. PMID: 33950934; PMCID: PMC8104292.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. SARS-CoV-2 seroprevalence, and IgG concentration and pseudovirus neutralising antibody titres after infection, compared by HIV status: a matched case-control observational study. Lancet HIV. 2021 06; 8(6):e334-e341. Spinelli MA, Lynch KL, Yun C, Glidden DV, Peluso MJ, Henrich TJ, Gandhi M, Brown LB. PMID: 33933189; PMCID: PMC8084354.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    24. Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. J Appl Lab Med. 2021 04 29; 6(3):592-605. van Wijk XMR, Yun C, Lynch KL. PMID: 33382901.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Hospital-Based Donor Recruitment and Predonation Serologic Testing for COVID-19 Convalescent Plasma. Am J Clin Pathol. 2021 Mar 15; 155(4):515-521. Balcerek J, Trejo E, Levine K, Couey P, Kornberg ZV, Rogine C, Young C, Li PJ, Shy BR, Taylor JE, Bakhtary S, Friedlander T, Lynch KL, Bern C, Esensten JH. PMID: 33399201; PMCID: PMC7929413.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Lack of Cross-Reactivity of Tianeptine with Tricyclic Antidepressant Immunoassays. J Anal Toxicol. 2021 Mar 12; 45(3):e8-e9. Badea A, Ghosh R, Lynch KL, Wu AHB. PMID: 33410462.
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    27. Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv. 2021 Mar 10. van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Voyer TL, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, UCSF COMET consortium, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ. PMID: 33758859; PMCID: PMC7987018.
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    28. Cocaine Use and White Matter Hyperintensities in Homeless and Unstably Housed Women. J Stroke Cerebrovasc Dis. 2021 May; 30(5):105675. Riley ED, Chow FC, Josephson SA, Dilworth SE, Lynch KL, Wade AN, Braun C, Hess CP. PMID: 33677311; PMCID: PMC8415496.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    29. Magnitude and Kinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses and Their Relationship to Disease Severity. Clin Infect Dis. 2021 01 27; 72(2):301-308. Lynch KL, Whitman JD, Lacanienta NP, Beckerdite EW, Kastner SA, Shy BR, Goldgof GM, Levine AG, Bapat SP, Stramer SL, Esensten JH, Hightower AW, Bern C, Wu AHB. PMID: 33501951; PMCID: PMC7454426.
      View in: PubMed   Mentions: 71     Fields:    Translation:Humans
    30. Development of Label-Free Immunoassays as Novel Solutions for the Measurement of Monoclonal Antibody Drugs and Antidrug Antibodies. Clin Chem. 2020 10 01; 66(10):1319-1328. Luo YR, Chakraborty I, Lazar-Molnar E, Wu AHB, Lynch KL. PMID: 32918468.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    31. Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women. Drug Alcohol Depend. 2020 12 01; 217:108252. Riley ED, Vittinghoff E, Wu AHB, Coffin PO, Hsue PY, Kazi DS, Wade A, Braun C, Lynch KL. PMID: 32919207; PMCID: PMC7873814.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547; PMCID: PMC7740072.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCellsPHPublic Health
    33. Magnitude and kinetics of anti-SARS-CoV-2 antibody responses and their relationship to disease severity. Clin Infect Dis. 2020 Jul 14. Lynch KL, Whitman JD, Lacanienta NP, Beckerdite EW, Kastner SA, Shy BR, Goldgof GM, Levine AG, Bapat SP, Stramer SL, Esensten JH, Hightower AW, Bern C, Wu AHB. PMID: 32663256; PMCID: PMC7454426.
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    34. Challenges of High-Resolution Mass Spectrometry For Detecting Designer Drugs. Clin Chem. 2020 07 01; 66(7):868-874. Strathmann FG, Lynch KL, Krotulski A, Negri P, Cichelli J, Meyer MR. PMID: 32628756.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    35. Upper reference limits and percent measurable concentrations using a universal sample bank for high sensitivity cardiac troponin I using a point-of-care assay. Clin Biochem. 2020 09; 83:89-91. Wu AHB, Lynch K, Sexter A, Apple FS. PMID: 32461099.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497; PMCID: PMC7273265.
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    37. AACC Guidance Document on Biotin Interference in Laboratory Tests. J Appl Lab Med. 2020 05 01; 5(3):575-587. Li D, Ferguson A, Cervinski MA, Lynch KL, Kyle PB. PMID: 32445355.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    38. A case of unexplained duodenal ulcer and massive gastrointestinal bleed. Clin Chim Acta. 2020 Jul; 506:188-190. Luo YR, Goodnough R, Menza R, Badea A, Luu HY, Kornblith LZ, Lynch KL. PMID: 32234495.
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    39. Addressing overdose risk among unstably housed women in San Francisco, California: an examination of potential fentanyl contamination of multiple substances. Harm Reduct J. 2020 03 10; 17(1):17. Meacham MC, Lynch KL, Coffin PO, Wade A, Wheeler E, Riley ED. PMID: 32156289; PMCID: PMC7063812.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    40. Real-time comprehensive toxicology testing in the clinical management of accidental pediatric capecitabine ingestion. J Oncol Pharm Pract. 2020 Oct; 26(7):1759-1761. Gintjee TJ, Goodnough R, Li K, Badea A, Lynch KL, Garcia E, Repplinger D. PMID: 32089072.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    41. A thin-film interferometry-based label-free immunoassay for the detection of daratumumab interference in serum protein electrophoresis. Clin Chim Acta. 2020 Mar; 502:128-132. Luo YR, Chakraborty I, Zuk RF, Lynch KL, Wu AHB. PMID: 31883925.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    42. Quantitative biochemical screening for marijuana use and concordance with tobacco use in urban adolescents. Drug Alcohol Depend. 2019 12 01; 205:107583. Benowitz N, Nardone N, St Helen G, Addo N, Jacob P, Liakoni E, Jain S, Hooshfar S, Lynch K. PMID: 31600618; PMCID: PMC6893148.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    43. Notes from the Field: Unintentional Fentanyl Overdoses Among Persons Who Thought They Were Snorting Cocaine - Fresno, California, January 7, 2019. MMWR Morb Mortal Wkly Rep. 2019 08 09; 68(31):687-688. Armenian P, Whitman JD, Badea A, Johnson W, Drake C, Dhillon SS, Rivera M, Brandehoff N, Lynch KL. PMID: 31393864; PMCID: PMC6687194.
      View in: PubMed   Mentions: 5     Fields:    
    44. Correlation of Breath and Blood Δ9-Tetrahydrocannabinol Concentrations and Release Kinetics Following Controlled Administration of Smoked Cannabis. Clin Chem. 2019 09; 65(9):1171-1179. Lynch KL, Luo YR, Hooshfar S, Yun C. PMID: 31296552.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    45. Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I. Clin Biochem. 2019 Nov; 73:35-43. van Wijk XMR, Claassen S, Enea NS, Li P, Yang S, Brouwer MA, Cramer GE, Zuk R, Lynch KL, Wu AHB. PMID: 31247187.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    46. Quantitation of Cannabinoids in Breath Samples Using a Novel Derivatization LC-MS/MS Assay with Ultra-High Sensitivity. J Anal Toxicol. 2019 Jun 01; 43(5):331-339. Luo YR, Yun C, Lynch KL. PMID: 30951168.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    47. A fatal ranolazine overdose after an intentional ingestion. Clin Toxicol (Phila). 2020 03; 58(3):213-214. Goodnough R, Kim-Katz S, Badea A, Lynch KL, Cotter LE, Smollin CG. PMID: 31119956.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. A Liquid-Chromatography High-Resolution Mass Spectrometry Method for Non-FDA Approved Benzodiazepines. J Anal Toxicol. 2019 May 01; 43(4):316-320. van Wijk XMR, Yun C, Hooshfar S, Arens AM, Lung D, Wu AHB, Lynch KL. PMID: 30462225.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    49. Optimization and Comparison of Information-Dependent Acquisition (IDA) to Sequential Window Acquisition of All Theoretical Fragment Ion Spectra (SWATH) for High-Resolution Mass Spectrometry in Clinical Toxicology. Clin Chem. 2019 07; 65(7):862-870. Whitman JD, Lynch KL. PMID: 30996055.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    50. Azo coupling-based derivatization method for high-sensitivity liquid chromatography-tandem mass spectrometry analysis of tetrahydrocannabinol and other aromatic compounds. J Chromatogr A. 2019 Jul 19; 1597:109-118. Luo YR, Han J, Yun C, Lynch KL. PMID: 30910385.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    51. Loperamide associated torsades de pointes, in the setting of complete heart block at marginally supratherapeutic dosing (20mg/day). Clin Toxicol (Phila). 2019 11; 57(11):1123-1124. Goodnough R, Nomura M, Badea A, Lynch KL, Benowitz NL, Tsutaoka B. PMID: 30777457.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Drug Screening Using Liquid Chromatography Quadrupole Time-of-Flight (LC-QqTOF) Mass Spectrometry. Methods Mol Biol. 2019; 1872:181-190. Colby JM, Lynch KL. PMID: 30350290.
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    53. Case of brodifacoum-contaminated synthetic cannabinoid. Clin Toxicol (Phila). 2019 02; 57(2):143-144. Riley SB, Sochat M, Moser K, Lynch KL, Tochtrop R, Isbell TS, Scalzo A. PMID: 30148410.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    54. Accreditation and Quality Assurance for Clinical Liquid Chromatography-Mass Spectrometry Laboratories. Clin Lab Med. 2018 09; 38(3):515-526. Lynch KL. PMID: 30115395.
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    55. Notes from the Field: Toxic Leukoencephalopathy Associated with Tianeptine Misuse - California, 2017. MMWR Morb Mortal Wkly Rep. 2018 Jul 13; 67(27):769-770. Goodnough R, Li K, Fouladkou F, Lynch KL, Shah M, Smollin CG, Blanc PD. PMID: 30001559; PMCID: PMC6047469.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    56. Suspect Screening Using LC-QqTOF Is a Useful Tool for Detecting Drugs in Biological Samples. J Anal Toxicol. 2018 May 01; 42(4):207-213. Colby JM, Thoren KL, Lynch KL. PMID: 29309651.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    57. Evaluation of Intraosseous Fluid as an Alternative Biological Specimen in Postmortem Toxicology. J Anal Toxicol. 2018 Apr 01; 42(3):163-169. Rodda LN, Volk JA, Moffat E, Williams CM, Lynch KL, Wu AHB. PMID: 29272445.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    58. Reproducibility Assessment for a Broad Spectrum Drug Screening Method from Urine using Liquid Chromatography Time-of-Flight Mass Spectrometry. Clinical Mass Spectrometry. 2018 Apr 1; 8(Anal Bioanal Chem. 388 2007):1-7. Metushi MI, Wakefield WM, Lynch LK, Stone SJ, Fitzgerald FR. .
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    59. Quantitation of Infliximab and Detection of Antidrug Antibodies in Serum by Use of Surface Plasmon Resonance. J Appl Lab Med. 2018 Mar 01; 2(5):725-736. Thoren KL, Pasi B, Delgado JC, Wu AHB, Lynch KL. PMID: 33636867.
      View in: PubMed   Mentions: 1     Fields:    
    60. Specimen Validity Testing: Is it "Valid" for Drug Testing in Pain Management? J Appl Lab Med. 2018 Jan 01; 2(4):478-480. Lynch KL. PMID: 33636891.
      View in: PubMed   Mentions:    Fields:    
    61. Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol. Ann Emerg Med. 2018 Mar; 71(3):306-313. Vo KT, Horng H, Li K, Ho RY, Wu AHB, Lynch KL, Smollin CG. PMID: 29103798.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    62. Fentanyl, fentanyl analogs and novel synthetic opioids: A comprehensive review. Neuropharmacology. 2018 05 15; 134(Pt A):121-132. Armenian P, Vo KT, Barr-Walker J, Lynch KL. PMID: 29042317.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    63. Commentary. Clin Chem. 2017 06; 63(6):1072-1073. Lynch KL. PMID: 28550125.
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    64. Anticholinergic toxicity associated with ingestion of water containing lupini bean extract. Clin Toxicol (Phila). 2017 08; 55(7):687-688. Li K, van Wijk XMR, Hayashi S, Lynch KL, Wu AHB, Smollin CG. PMID: 28443353.
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    65. Cocaine use is associated with a higher prevalence of elevated ST2 concentrations. Clin Biochem. 2017 Sep; 50(13-14):791-793. van Wijk XMR, Vittinghoff E, Wu AHB, Lynch KL, Riley ED. PMID: 28442257; PMCID: PMC5638657.
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    66. ASSOCIATION OF COCAINE AND AMPHETAMINE USE WITH TROPONIN I CONCENTRATIONS. Journal of the American College of Cardiology. 2017 Mar 1; 69(11):281. Moore MP, Lynch LK, Wu WA, Ma MY, Scherzer SR, Li LD, Riley RE. .
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    67. Multiple Fentanyl Overdoses - New Haven, Connecticut, June 23, 2016. MMWR Morb Mortal Wkly Rep. 2017 Feb 03; 66(4):107-111. Tomassoni AJ, Hawk KF, Jubanyik K, Nogee DP, Durant T, Lynch KL, Patel R, Dinh D, Ulrich A, D'Onofrio G. PMID: 28151928; PMCID: PMC5657834.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    68. Higher prevalence of detectable troponin I among cocaine-users without known cardiovascular disease. Drug Alcohol Depend. 2017 Mar 01; 172:88-93. Riley ED, Hsue PY, Vittinghoff E, Wu AH, Coffin PO, Moore PK, Lynch KL. PMID: 28157591; PMCID: PMC5464776.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    69. Chapter 6 Toxicology: liquid chromatography mass spectrometry. Mass Spectrometry for the Clinical Laboratory. 2017 Jan 1; 109-130. Lynch LK. .
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    70. Improvement of drug identification in urine by LC-QqTOF using a probability-based library search algorithm. Clinical Mass Spectrometry. 2017 Jan 1; 3:7-12. Colby CJ, Rivera RJ, Burton BL, Cox CD, Lynch LK. .
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    71. Synthetic agents off the darknet: a case of U-47700 and phenazepam abuse. Clin Toxicol (Phila). 2017 Jan; 55(1):71-72. Vo KT, van Wijk XM, Wu AH, Lynch KL, Ho RY. PMID: 27736261.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    72. A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase. Clin Chim Acta. 2016 Dec 01; 463:1-3. van Wijk XMR, Magee CA, Wu AHB, Tana MM, Lynch KL. PMID: 27732874.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Optimization and Validation of High-Resolution Mass Spectrometry Data Analysis Parameters. J Anal Toxicol. 2017 Jan; 41(1):1-5. Colby JM, Thoren KL, Lynch KL. PMID: 28130542.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    74. Adverse Effects From Counterfeit Alprazolam Tablets. JAMA Intern Med. 2016 10 01; 176(10):1554-1555. Arens AM, van Wijk XM, Vo KT, Lynch KL, Wu AH, Smollin CG. PMID: 27532131.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    75. Collaboration at the Heart of Innovation. Clinical Chemistry. 2016 Sep 1; 62(9):1284-1284. Lynch LK. .
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    76. A two-week pilot study of intranasal oxytocin for cocaine-dependent individuals receiving methadone maintenance treatment for opioid use disorder. Addict Res Theory. 2016; 24(6):490-498. Stauffer CS, Musinipally V, Suen A, Lynch KL, Shapiro B, Woolley JD. PMID: 28503120; PMCID: PMC5424696.
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    77. Levamisole-Contaminated Cocaine Use in HIV-Infected and Uninfected Unstably Housed Women. J Womens Health (Larchmt). 2016 09; 25(9):936-43. Riley ED, Kral AH, Cohen J, Dilworth SE, Shumway M, Lynch KL. PMID: 27203838; PMCID: PMC5311463.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    78. Counterfeit Norco Poisoning Outbreak - San Francisco Bay Area, California, March 25-April 5, 2016. MMWR Morb Mortal Wkly Rep. 2016 Apr 29; 65(16):420-3. Vo KT, van Wijk XM, Lynch KL, Wu AH, Smollin CG. PMID: 27123589.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    79. Development and Validation of a Novel LC-MS/MS Opioid Confirmation Assay: Evaluation of β-glucuronidase Enzymes and Sample Cleanup Methods. J Anal Toxicol. 2016 Jun; 40(5):323-9. Yang HS, Wu AH, Lynch KL. PMID: 27121711.
      View in: PubMed   Mentions:    Fields:    Translation:PHPublic Health
    80. Development and validation of an LC-MS/MS sulfonylurea assay for hypoglycemia cases in the emergency department. Clin Chim Acta. 2016 Feb 15; 454:130-4. Yang HS, Wu AH, Johnson-Davis KL, Lynch KL. PMID: 26790752.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    81. Clenbuterol causing non-ST-segment elevation myocardial infarction in a teenage female desiring to lose weight: case and brief literature review. Am J Emerg Med. 2016 Aug; 34(8):1739.e5-7. Quinley KE, Chen HY, Yang HS, Lynch KL, Olson KR. PMID: 26873408.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    82. Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening. Clin Chem. 2016 Jan; 62(1):170-8. Thoren KL, Colby JM, Shugarts SB, Wu AH, Lynch KL. PMID: 26453698.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    83. CLSI C62-A: A New Standard for Clinical Mass Spectrometry. Clin Chem. 2016 Jan; 62(1):24-9. Lynch KL. PMID: 26430075.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    84. Analysis of codeine positivity in urine of pain management patients. J Anal Toxicol. 2015 Jun; 39(5):407-10. Colby JM, Wu AH, Lynch KL. PMID: 25840440.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    85. Promethazine use among chronic pain patients. Drug Alcohol Depend. 2015 May 01; 150:92-7. Lynch KL, Shapiro BJ, Coffa D, Novak SP, Kral AH. PMID: 25754939; PMCID: PMC4389782.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    86. Cross-reactivity of acetylfentanyl and risperidone with a fentanyl immunoassay. J Anal Toxicol. 2014 Nov-Dec; 38(9):672-5. Wang BT, Colby JM, Wu AH, Lynch KL. PMID: 25248490.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    87. Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin Chim Acta. 2014 Mar 20; 430:43-7. Wu AH, Ruan W, Todd J, Lynch KL. PMID: 24394292.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    88. Multi-wavelength spectrophotometric analysis for detection of xanthochromia in cerebrospinal fluid and accuracy for the diagnosis of subarachnoid hemorrhage. Clin Chim Acta. 2013 Sep 23; 424:231-6. Smith A, Wu AH, Lynch KL, Ko N, Grenache DG. PMID: 23800427.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    89. Prolonged ceftriaxone-induced immune thrombocytopenia due to impaired drug clearance: a case report. Transfusion. 2013 Nov; 53(11):2715-21. Jacquot C, Moayeri M, Kim B, Shugarts S, Lynch KL, Leavitt AD. PMID: 23451879.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    90. Promethazine misuse among methadone maintenance patients and community-based injection drug users. J Addict Med. 2013 Mar-Apr; 7(2):96-101. Shapiro BJ, Lynch KL, Toochinda T, Lutnick A, Cheng HY, Kral AH. PMID: 23385449; PMCID: PMC3618500.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    91. Cross-reactivity studies and predictive modeling of "Bath Salts" and other amphetamine-type stimulants with amphetamine screening immunoassays. Clin Toxicol (Phila). 2013 Feb; 51(2):83-91. Petrie M, Lynch KL, Ekins S, Chang JS, Goetz RJ, Wu AH, Krasowski MD. PMID: 23387345.
      View in: PubMed   Mentions: 9     Fields:    Translation:CellsPHPublic Health
    92. Prescription compliance or illicit designer drug abuse? Clin Chem. 2012 Dec; 58(12):1631-4. Petrie MS, Lynch KL, Wu AH, Steinhardt AA, Horowitz GL. PMID: 23193148.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    93. Prevalence and clinical significance of circulating autoantibodies in idiopathic pulmonary fibrosis. Respir Med. 2013 Feb; 107(2):249-55. Lee JS, Kim EJ, Lynch KL, Elicker B, Ryerson CJ, Katsumoto TR, Shum AK, Wolters PJ, Cerri S, Richeldi L, Jones KD, King TE, Collard HR. PMID: 23186614; PMCID: PMC3543473.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    94. Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology. Clin Toxicol (Phila). 2012 Sep; 50(8):733-42. Wu AH, Gerona R, Armenian P, French D, Petrie M, Lynch KL. PMID: 22888997.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    95. Multifocal inflammatory leukoencephalopathy associated with cocaine abuse: is levamisole responsible? Clin Toxicol (Phila). 2012 Jul; 50(6):534-5; author reply 536. Blanc PD, Chin C, Lynch KL. PMID: 22702903.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansPHPublic Health
    96. Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity score. Breast Cancer Res Treat. 2012 Jun; 133(2):677-83. Wu AH, Lorizio W, Tchu S, Lynch K, Gerona R, Ji W, Ruan W, Ruddy KJ, Desantis SD, Burstein HJ, Ziv E. PMID: 22294487; PMCID: PMC5739025.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    97. Therapeutic drug monitoring of tamoxifen using LC-MS/MS. Methods Mol Biol. 2012; 902:211-22. Tchu SM, Lynch KL, Wu AH. PMID: 22767121.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    98. Therapeutic Drug Monitoring to Support Clinical Pharmacogenomics. LC-MS in Drug Bioanalysis. 2012 Jan 1; 127-141. Wu WA, Lynch LK. .
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    99. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Arthritis Rheum. 2011 Dec; 63(12):3998-4001. Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J. PMID: 22127712.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansPHPublic Health
    100. Hydrophilic interaction LC-MS/MS analysis of opioids in urine: significance of glucuronide metabolites. Bioanalysis. 2011 Dec; 3(23):2603-12. French D, Wu A, Lynch K. PMID: 22136049.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    101. Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity. Tissue Antigens. 2011 Jul; 78(1):11-20. Kostenko L, Kjer-Nielsen L, Nicholson I, Hudson F, Lucas A, Foley B, Chen K, Lynch K, Nguyen J, Wu AH, Tait BD, Holdsworth R, Mallal S, Rossjohn J, Bharadwaj M, McCluskey J. PMID: 21501118.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    102. Detection of levamisole exposure in cocaine users by liquid chromatography-tandem mass spectrometry. J Anal Toxicol. 2011 Apr; 35(3):176-8. Lynch KL, Dominy SS, Graf J, Kral AH. PMID: 21439154.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansPHPublic Health
    103. Images in emergency medicine. Adult female with rash on lower extremities. Vasculopathic purpura and neutropenia caused by levamisole-contaminated cocaine. Ann Emerg Med. 2011 Mar; 57(3):307, 311. Lung D, Lynch K, Agrawal S, Armenian P, Banh K. PMID: 21353913.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    104. Vitamin D status of county hospital patients assessed by the DiaSorin LIAISON® 25-hydroxyvitamin D assay. Clin Chim Acta. 2011 Jan 30; 412(3-4):258-62. French D, Gorgi AW, Ihenetu KU, Weeks MA, Lynch KL, Wu AH. PMID: 20965160.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    105. Performance evaluation of three liquid chromatography mass spectrometry methods for broad spectrum drug screening. Clin Chim Acta. 2010 Oct 09; 411(19-20):1474-81. Lynch KL, Breaud AR, Vandenberghe H, Wu AH, Clarke W. PMID: 20540936; PMCID: PMC2914548.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    106. Synaptotagmin-1 utilizes membrane bending and SNARE binding to drive fusion pore expansion. Mol Biol Cell. 2008 Dec; 19(12):5093-103. Lynch KL, Gerona RR, Kielar DM, Martens S, McMahon HT, Martin TF. PMID: 18799625; PMCID: PMC2592635.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    107. Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis. Mol Biol Cell. 2007 Dec; 18(12):4957-68. Lynch KL, Gerona RR, Larsen EC, Marcia RF, Mitchell JC, Martin TF. PMID: 17914059; PMCID: PMC2096586.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    108. Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells. J Cell Sci. 2007 Feb 15; 120(Pt 4):617-27. Lynch KL, Martin TF. PMID: 17264148.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    109. A second SNARE role for exocytic SNAP25 in endosome fusion. Mol Biol Cell. 2006 May; 17(5):2113-24. Aikawa Y, Lynch KL, Boswell KL, Martin TF. PMID: 16481393; PMCID: PMC1446080.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    110. Toward artificial developmental regulators. J Am Chem Soc. 2003 Nov 05; 125(44):13322-3. Arndt HD, Hauschild KE, Sullivan DP, Lake K, Dervan PB, Ansari AZ. PMID: 14583004.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
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