Katherine Scangos, MD, PhD

Title(s)Assistant Professor, Psychiatry
SchoolSchool of Medicine
Address675 18th Street, #1356
San Francisco CA 94107
Phone--
ORCID ORCID Icon0000-0001-7983-7767 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Research 
    Collapse Research Activities and Funding
    Deciphering principles of network dynamics underlying depression symptom severity from multi-day intracranial recordings in patients with major depression
    NIH R21MH124759Jan 1, 2021 - Dec 31, 2022
    Role: Principal Investigator
    Distributed networks underlying depression in epilepsy: a computational circuit-based approach to biomarker development
    NIH K23NS110962Sep 15, 2019 - Aug 31, 2024
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deep brain stimulation for refractory major depressive disorder: a comprehensive review. Mol Psychiatry. 2024 Jan 30. Johnson KA, Okun MS, Scangos KW, Mayberg HS, de Hemptinne C. PMID: 38287101.
      View in: PubMed   Mentions:    Fields:    
    2. Closed-Loop Neurostimulation for Biomarker-Driven, Personalized Treatment of Major Depressive Disorder. J Vis Exp. 2023 07 07; (197). Sellers KK, Khambhati AN, Stapper N, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 37486114.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Intracranial electrical stimulation of corticolimbic sites modulates arousal in humans. Brain Stimul. 2023 Jul-Aug; 16(4):1072-1082. Fan JM, Lee AM, Sellers KK, Woodworth K, Makhoul GS, Liu TX, Henderson C, Astudillo Maya DA, Martinez R, Zamanian H, Speidel BA, Khambhati AN, Rao VR, Sugrue LP, Scangos KW, Chang EF, Krystal AD. PMID: 37385540; PMCID: PMC10634663.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. 46. Amygdala-Hippocampus Coherence is a Biomarker of Predominant Symptom Sets in Patients With Depression. Biological Psychiatry. 2023 May 1; 93(9):s112-s113. Cohen CJ, Fan FJ, Sellers SK, Khambhati KA, Dawes DH, Scangos SK, Rao RV, Sugrue SL, Starr SP, Chang CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    5. New and emerging approaches to treat psychiatric disorders. Nat Med. 2023 02; 29(2):317-333. Scangos KW, State MW, Miller AH, Baker JT, Williams LM. PMID: 36797480.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    6. Epileptiform discharges triggered with direct electrical stimulation for treatment-resistant depression: Factors that modulate risk and treatment considerations. Brain Stimul. 2023 Mar-Apr; 16(2):462-465. Fan JM, Khambhati AN, Sellers KK, Stapper N, Maya DA, Kunwar E, Henderson C, Sugrue LP, Scangos KW, Chang EF, Rao VR, Krystal AD. PMID: 36773780; PMCID: PMC10627048.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Changes in intracranial neurophysiology associated with acute COVID-19 infection. Clin Neurophysiol. 2023 04; 148:29-31. Sellers KK, Stapper N, Astudillo Maya DA, Henderson C, Khambhati AN, Fan JM, Rao VR, Scangos KW, Chang EF, Krystal AD. PMID: 36791656; PMCID: PMC9896881.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Identification of a personalized intracranial biomarker of depression and response to DBS therapy. Brain Stimulation. 2023 Jan 1; 16(1):383. Frank FA, Scangos SK, Larson LP, Norbu NT, Lee LA, Lee LA. .
      View in: Publisher Site   Mentions:
    9. Publisher Correction: State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med. 2022 Oct; 28(10):2218. Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD. PMID: 35941379.
      View in: PubMed   Mentions:    Fields:    
    10. Identification of a Personalized Intracranial Biomarker of Depression and Response to DBS Therapy. Brain Stimulation. 2021 Nov 1; 14(6):1591. Frank FA, Scangos SK, Larson LP, Norbu NT, Lee LA, Lee LM. .
      View in: Publisher Site   Mentions:
    11. Distributed Subnetworks of Depression Defined by Direct Intracranial Neurophysiology. Front Hum Neurosci. 2021; 15:746499. Scangos KW, Khambhati AN, Daly PM, Owen LW, Manning JR, Ambrose JB, Austin E, Dawes HE, Krystal AD, Chang EF. PMID: 34744662; PMCID: PMC8566975.
      View in: PubMed   Mentions: 6  
    12. Closed-loop neuromodulation in an individual with treatment-resistant depression. Nat Med. 2021 10; 27(10):1696-1700. Scangos KW, Khambhati AN, Daly PM, Makhoul GS, Sugrue LP, Zamanian H, Liu TX, Rao VR, Sellers KK, Dawes HE, Starr PA, Krystal AD, Chang EF. PMID: 34608328.
      View in: PubMed   Mentions: 93     Fields:    Translation:Humans
    13. Corrigendum: Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021; 15:765150. Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. PMID: 34658825; PMCID: PMC8517517.
      View in: PubMed   Mentions: 2  
    14. 2 Personalized closed-loop neurostimulation for depression. Journal of Neurology Neurosurgery & Psychiatry. 2021 Jul 16; 92(8):a1-a1. Scangos SK. .
      View in: Publisher Site   Mentions:
    15. Identification of a personalized intracranial biomarker of depression and response to DBS therapy. Brain Stimul. 2021 Jul-Aug; 14(4):1002-1004. Frank AC, Scangos KW, Larson PS, Norbu T, Lee AT, Lee AM. PMID: 34175247; PMCID: PMC8880609.
      View in: PubMed   Mentions: 7     Fields:    
    16. Proceedings of the Eighth Annual Deep Brain Stimulation Think Tank: Advances in Optogenetics, Ethical Issues Affecting DBS Research, Neuromodulatory Approaches for Depression, Adaptive Neurostimulation, and Emerging DBS Technologies. Front Hum Neurosci. 2021; 15:644593. Vedam-Mai V, Deisseroth K, Giordano J, Lazaro-Munoz G, Chiong W, Suthana N, Langevin JP, Gill J, Goodman W, Provenza NR, Halpern CH, Shivacharan RS, Cunningham TN, Sheth SA, Pouratian N, Scangos KW, Mayberg HS, Horn A, Johnson KA, Butson CR, Gilron R, de Hemptinne C, Wilt R, Yaroshinsky M, Little S, Starr P, Worrell G, Shirvalkar P, Chang E, Volkmann J, Muthuraman M, Groppa S, Kühn AA, Li L, Johnson M, Otto KJ, Raike R, Goetz S, Wu C, Silburn P, Cheeran B, Pathak YJ, Malekmohammadi M, Gunduz A, Wong JK, Cernera S, Hu W, Wagle Shukla A, Ramirez-Zamora A, Deeb W, Patterson A, Foote KD, Okun MS. PMID: 33953663; PMCID: PMC8092047.
      View in: PubMed   Mentions: 17  
    17. State-dependent responses to intracranial brain stimulation in a patient with depression. Nat Med. 2021 02; 27(2):229-231. Scangos KW, Makhoul GS, Sugrue LP, Chang EF, Krystal AD. PMID: 33462446; PMCID: PMC8284979.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    18. A Gaussian Process Model of Human Electrocorticographic Data. Cereb Cortex. 2020 09 03; 30(10):5333-5345. Owen LLW, Muntianu TA, Heusser AC, Daly PM, Scangos KW, Manning JR. PMID: 32495832; PMCID: PMC7472198.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    19. Using prefrontal transcranial direct current stimulation (tDCS) to enhance proactive cognitive control in schizophrenia. Neuropsychopharmacology. 2020 10; 45(11):1877-1883. Boudewyn MA, Scangos K, Ranganath C, Carter CS. PMID: 32604401; PMCID: PMC7608454.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Corticocortical Evoked Potentials and Patient Response Reveal Networks Underlying Depression. Biological Psychiatry. 2020 May 1; 87(9):s157. Scangos SK, Makhoul MG, Khambhati KA, Sellers SK, Chang CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    21. Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology. Front Hum Neurosci. 2020; 14:54. Ramirez-Zamora A, Giordano J, Gunduz A, Alcantara J, Cagle JN, Cernera S, Difuntorum P, Eisinger RS, Gomez J, Long S, Parks B, Wong JK, Chiu S, Patel B, Grill WM, Walker HC, Little SJ, Gilron R, Tinkhauser G, Thevathasan W, Sinclair NC, Lozano AM, Foltynie T, Fasano A, Sheth SA, Scangos K, Sanger TD, Miller J, Brumback AC, Rajasethupathy P, McIntyre C, Schlachter L, Suthana N, Kubu C, Sankary LR, Herrera-Ferrá K, Goetz S, Cheeran B, Steinke GK, Hess C, Almeida L, Deeb W, Foote KD, Okun MS. PMID: 32292333; PMCID: PMC7134196.
      View in: PubMed   Mentions: 16  
    22. Pilot Study of An Intracranial Electroencephalography Biomarker of Depressive Symptoms in Epilepsy. J Neuropsychiatry Clin Neurosci. 2020; 32(2):185-190. Scangos KW, Ahmad HS, Shafi A, Sellers KK, Dawes HE, Krystal A, Chang EF. PMID: 31394989; PMCID: PMC7429560.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. An Electrophysiological Biomarker That May Predict Treatment Response to ECT. J ECT. 2019 Jun; 35(2):95-102. Scangos KW, Weiner RD, Coffey EC, Krystal AD. PMID: 30531398; PMCID: PMC6538443.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. O20. Resting State Whole Brain Network Activity in Depression From Intracranial EEG Signals. Biological Psychiatry. 2019 May 1; 85(10):s113-s114. Scangos SK, Khambhati KA, Daly DP, Shafi SA, Dawes DH, Krystal KA, Chang CE. .
      View in: Publisher Site   Mentions:
    25. Effects of acute and subacute stimulation of ventral subthalamic nucleus on cognition and perceptual decision-making in patients with Parkinson’s disease. Brain Stimulation. 2019 Mar 1; 12(2):585-586. Girgis GF, Prabhu PA, Saez SI, Scangos SK, Gurkoff GG, O'Connor OK, Ditterich DJ, Carter CC, Smucny SJ, Shahlaie SK. .
      View in: Publisher Site   Mentions:
    26. What We've Got Here Is Failure to Communicate: Improving Interventional Psychiatry With Closed-Loop Stimulation. Biol Psychiatry. 2018 10 15; 84(8):e55-e57. Scangos KW, Ross DA. PMID: 30261977; PMCID: PMC6698893.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    27. F85. An Electrophysiological Biomarker That Predicts Treatment Response to ECT. Biological Psychiatry. 2018 May 1; 83(9):s270-s271. Scangos SK, Weiner WR, Coffey CE, Krystal KA. .
      View in: Publisher Site   Mentions:
    28. Effect of Short-Term Theta Frequency Stimulation of the Vagus Nerve on Cognition among Patients with Refractory Epilepsy: A Pilot Study. The FASEB Journal. 2018 Apr 1; 32:lb448-lb448. Strong SE, Scangos SK, Mefford MA, Lee LD, Shahlaie SK. .
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    29. A pilot study of subthalamic theta frequency deep brain stimulation for cognitive dysfunction in Parkinson's disease. Brain Stimul. 2018 Mar - Apr; 11(2):456-458. Scangos KW, Carter CS, Gurkoff G, Zhang L, Shahlaie K. PMID: 29203130.
      View in: PubMed   Mentions: 11     Fields:    
    30. 545 Effects of tDCS on Cognitive Control and Cortical Network Oscillations in Schizophrenia. Biological Psychiatry. 2017 May 1; 81(10):s221. Scangos SK, Roberts RB, Ragland RJ, Ranganath RC, Carter CC. .
      View in: Publisher Site   Mentions:
    31. Acute Frequency-Dependent Hypomania Induced by Ventral Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease: A Case Report. Biol Psychiatry. 2017 09 01; 82(5):e39-e41. Scangos KW, Shahlaie K. PMID: 28017300.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    32. Multiple Long-Acting Injectable Antipsychotics for Treatment-Resistant Schizophrenia: Case Report. J Clin Psychopharmacol. 2016 Jun; 36(3):283-5. Scangos KW, Caton M, Newman WJ. PMID: 27035492.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    33. Performance monitoring by presupplementary and supplementary motor area during an arm movement countermanding task. J Neurophysiol. 2013 Apr; 109(7):1928-39. Scangos KW, Aronberg R, Stuphorn V. PMID: 23324325; PMCID: PMC3628008.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    34. Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans. Genetics. 2012 Mar; 190(3):1043-57. Hale VA, Guiney EL, Goldberg LY, Haduong JH, Kwartler CS, Scangos KW, Goutte C. PMID: 22209900; PMCID: PMC3296241.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. Supplementary motor area exerts proactive and reactive control of arm movements. J Neurosci. 2010 Nov 03; 30(44):14657-75. Chen X, Scangos KW, Stuphorn V. PMID: 21048123; PMCID: PMC2990193.
      View in: PubMed   Mentions: 89     Fields:    Translation:Animals
    36. Medial frontal cortex motivates but does not control movement initiation in the countermanding task. J Neurosci. 2010 Feb 03; 30(5):1968-82. Scangos KW, Stuphorn V. PMID: 20130204; PMCID: PMC4041090.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    37. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005 Apr 07; 46(1):13-21. Chen X, Ye H, Kuruvilla R, Ramanan N, Scangos KW, Zhang C, Johnson NM, England PM, Shokat KM, Ginty DD. PMID: 15820690.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
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