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Kazuki Tajima, MD, PhD

Title(s)Postdoctoral Scholar, Diabetes Center
SchoolSchool of Medicine
Phone415-476-9644
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shimoda H, Yagi H, Higashi H, Tajima K, Kuroda K, Abe Y, Kitago M, Shinoda M, Kitagawa Y. Decellularized liver scaffolds promote liver regeneration after partial hepatectomy. Sci Rep. 2019 Aug 29; 9(1):12543. PMID: 31467359.
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    2. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019 Aug; 572(7771):614-619. PMID: 31435015.
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    3. Narimatsu A, Hattori T, Koike N, Tajima K, Nakagawa H, Yamakawa N, Usui Y, Kumakura S, Matsumoto T, Goto H. Corneal lymphangiogenesis ameliorates corneal inflammation and edema in late stage of bacterial keratitis. Sci Rep. 2019 Feb 27; 9(1):2984. PMID: 30814667.
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    4. Chen Y, Ikeda K, Yoneshiro T, Scaramozza A, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature. 2019 01; 565(7738):180-185. PMID: 30568302.
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    5. Inomata K, Tajima K, Yagi H, Higashi H, Shimoda H, Matsubara K, Hibi T, Abe Y, Tsujikawa H, Kitago M, Shinoda M, Obara H, Itano O, Soto-Gutierrez A, Kitagawa Y. A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus. Sci Rep. 2018 10 09; 8(1):14987. PMID: 30301901.
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    6. Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y. Signaling between pancreatic ß cells and macrophages via S100 calcium-binding protein A8 exacerbates ß-cell apoptosis and islet inflammation. J Biol Chem. 2018 04 20; 293(16):5934-5946. PMID: 29496993.
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    7. Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y. Serum Quantitative Proteomic Analysis Reveals Soluble EGFR To Be a Marker of Insulin Resistance in Male Mice and Humans. Endocrinology. 2017 12 01; 158(12):4152-4164. PMID: 29028997.
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    8. Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P, Tajima K, Ajuwon KM, Soga T, Kajimura S. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med. 2017 Dec; 23(12):1454-1465. PMID: 29131158.
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    9. Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y. Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic ß cell proliferation after the withdrawal of OSI-906. Sci Rep. 2017 06 23; 7(1):4119. PMID: 28646158.
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    10. Takahashi K, Ohba K, Tajima K, Nishijima T, Sakurai S. Soluble (Pro)renin Receptor and Obstructive Sleep Apnea Syndrome: Oxidative Stress in Brain? Int J Mol Sci. 2017 Jun 20; 18(6). PMID: 28632190.
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    11. Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamazaki S, Tajima K, Togashi Y, Terauchi Y. Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets. Sci Rep. 2017 05 24; 7(1):2364. PMID: 28539593.
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    12. Tajima K, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Togashi Y, Terauchi Y. Effects of metformin on compensatory pancreatic ß-cell hyperplasia in mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 2017 09 01; 313(3):E367-E380. PMID: 28512156.
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    13. Katsuki Y, Yagi H, Okitsu T, Kitago M, Tajima K, Kadota Y, Hibi T, Abe Y, Shinoda M, Itano O, Takeuchi S, Kitagawa Y. Endocrine pancreas engineered using porcine islets and partial pancreatic scaffolds. Pancreatology. 2016 Sep-Oct; 16(5):922-30. PMID: 27350058.
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    14. Shibata E, Aoki K, Tajima K, Taguri M, Terauchi Y. Comparison of efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal in patients with type 2 diabetes. Expert Opin Pharmacother. 2016; 17(7):889-94. PMID: 26918556.
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    15. Aoki K, Tajima K, Taguri M, Terauchi Y. Effect of dehydroepiandrosterone (DHEA) on Akt and protein kinase C zeta (PKC?) phosphorylation in different tissues of C57BL6, insulin receptor substrate (IRS)1(-/-), and IRS2(-/-) male mice fed a high-fat diet. J Steroid Biochem Mol Biol. 2016 May; 159:110-20. PMID: 26976654.
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    16. Shirakawa J, Okuyama T, Kyohara M, Yoshida E, Togashi Y, Tajima K, Yamazaki S, Kaji M, Koganei M, Sasaki H, Terauchi Y. DPP-4 inhibition improves early mortality, ß cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid. Diabetol Metab Syndr. 2016; 8:16. PMID: 26937254.
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    17. Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Nagashima Y, Terauchi Y. Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model. Eur J Pharmacol. 2016 Feb 05; 772:22-32. PMID: 26724391.
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    18. Komatsu Y, Nakamura A, Takihata M, Inoue Y, Yahagi S, Tajima K, Tsuchiya H, Takano T, Yamakawa T, Yoshida M, Miyoshi H, Terauchi Y. Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia. Endocr J. 2016; 63(3):311-4. PMID: 26598136.
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    19. Tajima K, Miyake T, Koike N, Hattori T, Takahashi H, Matsumoto T, Fujita K, Kuroda M, Ito N, Goto H. Two Different Concentrations of Topical Levofloxacin for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Keratitis. J Ocul Pharmacol Ther. 2015 Dec; 31(10):636-41. PMID: 26348840.
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    20. Shibata-Seki T, Tajima K, Takahashi H, Seki H, Masai J, Goto H, Kobatake E, Akaike T, Itoh N. AFM characterization of chemically treated corneal cells. Anal Bioanal Chem. 2015 Mar; 407(9):2631-5. PMID: 25633218.
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    21. Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y. ß-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice. Endocrinology. 2014 May; 155(5):1643-52. PMID: 24517226.
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    22. Aoki K, Kamiyama H, Masuda K, Kamiko K, Noguchi Y, Tajima K, Terauchi Y. Effects of miglitol, vildagliptin, or their combination on serum insulin and peptide YY levels and plasma glucose, cholecystokinin, ghrelin, and obestatin levels. Endocr J. 2014; 61(3):249-56. PMID: 24389993.
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    23. Tajima K, Miyake T, Koike N, Hattori T, Kumakura S, Yamaguchi T, Matsumoto T, Fujita K, Kuroda M, Ito N, Goto H. In vivo challenging of polymyxins and levofloxacin eye drop against multidrug-resistant Pseudomonas aeruginosa keratitis. J Infect Chemother. 2014 Jun; 20(6):343-9. PMID: 24726376.
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    24. Okunuki Y, Usui Y, Nakagawa H, Tajima K, Matsuda R, Ueda S, Hattori T, Kezuka T, Goto H. Peroxisome proliferator-activated receptor-? agonist pioglitazone suppresses experimental autoimmune uveitis. Exp Eye Res. 2013 Nov; 116:291-7. PMID: 24107513.
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    25. Zolzaya K, Nakamura A, Tajima K, Terauchi Y. Role of insulin receptor substrate-1 for diethylnitrosamine plus high-fat diet-induced hepatic tumorigenesis in mice. J Diabetes Investig. 2014 Feb 12; 5(1):27-30. PMID: 24843733.
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    26. Tajima K, Nakamura A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y. Metformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice. Am J Physiol Endocrinol Metab. 2013 Oct 15; 305(8):E987-98. PMID: 23964070.
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    27. Shirakawa J, Togashi Y, Sakamoto E, Kaji M, Tajima K, Orime K, Inoue H, Kubota N, Kadowaki T, Terauchi Y. Glucokinase activation ameliorates ER stress-induced apoptosis in pancreatic ß-cells. Diabetes. 2013 Oct; 62(10):3448-58. PMID: 23801577.
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    28. Tajima K, Shirakawa J, Togashi Y, Inoue H, Sato K, Orime K, Ito Y, Kaji M, Sakamoto E, Nakamura A, Aoki K, Goshima Y, Atsumi T, Terauchi Y. AMPK is involved in the regulation of incretin receptors expression in pancreatic islets under a low glucose concentration. PLoS One. 2013; 8(5):e64633. PMID: 23717642.
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    29. Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Ito Y, Sato K, Nakamura A, Aoki K, Goshima Y, Terauchi Y. Trefoil factor 2 promotes cell proliferation in pancreatic ß-cells through CXCR-4-mediated ERK1/2 phosphorylation. Endocrinology. 2013 Jan; 154(1):54-64. PMID: 23183167.
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    30. Nakamura A, Tajima K, Zolzaya K, Sato K, Inoue R, Yoneda M, Fujita K, Nozaki Y, Kubota KC, Haga H, Kubota N, Nagashima Y, Nakajima A, Maeda S, Kadowaki T, Terauchi Y. Protection from non-alcoholic steatohepatitis and liver tumourigenesis in high fat-fed insulin receptor substrate-1-knockout mice despite insulin resistance. Diabetologia. 2012 Dec; 55(12):3382-91. PMID: 22955994.
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    31. Shirakawa J, Tanami R, Togashi Y, Tajima K, Orime K, Kubota N, Kadowaki T, Goshima Y, Terauchi Y. Effects of liraglutide on ß-cell-specific glucokinase-deficient neonatal mice. Endocrinology. 2012 Jul; 153(7):3066-75. PMID: 22569791.
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    32. Shirakawa J, Togashi Y, Tajima K, Orime K, Kikuchi K, Miyazaki T, Sato K, Kimura M, Goshima Y, Terauchi Y. Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes. Diabetes Res Clin Pract. 2012 Jul; 97(1):e9-12. PMID: 22497969.
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    33. Nakamura A, Yoneda M, Fujita K, Tajima K, Kikuchi K, Nakajima A, Maeda S, Terauchi Y. Impact of glucose tolerance on the severity of non-alcoholic steatohepatitis. J Diabetes Investig. 2011 Nov 30; 2(6):483-9. PMID: 24843533.
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    34. Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased ß cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem. 2011 Jul 22; 286(29):25467-76. PMID: 21613229.
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