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Kean Hooi Ang, PhD

Title(s)Specialist, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address1700 4th St
San Francisco CA 94158
Phone415-514-1367
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesPharmaceutical Chemistry
    National University of SingaporePhDBiological Sciences
    Australian National UniversityBSc(Hons) 1st.Molecular Biology & Biochemistry

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan. G3 (Bethesda). 2020 02 06; 10(2):849-862. Zhang P, Zhai Y, Cregg J, Ang KK, Arkin M, Kenyon C. PMID: 31879284.
      View in: PubMed   Mentions:    Fields:    
    3. Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. PLoS One. 2019; 14(12):e0226270. Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. PMID: 31851699.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection. SLAS Discov. 2020 01; 25(1):79-86. Walhart T, Isaacson-Wechsler E, Ang KH, Arkin M, Tugizov S, Palefsky JM. PMID: 31361520.
      View in: PubMed   Mentions:    Fields:    
    5. Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. Microb Cell. 2019 Jan 07; 6(1):65-101. Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, Chi P, Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E. PMID: 30652106.
      View in: PubMed   Mentions:
    6. Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris. mBio. 2018 10 30; 9(5). Laurie MT, White CV, Retallack H, Wu W, Moser MS, Sakanari JA, Ang K, Wilson C, Arkin MR, DeRisi JL. PMID: 30377287.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    7. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    8. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 09 01; 159(9):3321-3330. Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. PMID: 30059978.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Small-Molecule Screening for Genetic Diseases. Annu Rev Genomics Hum Genet. 2018 08 31; 19:263-288. Markossian S, Ang KK, Wilson CG, Arkin MR. PMID: 29799800.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. 2017 06; 66(6):1703-1712. Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. PMID: 28246293.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016 07 20; 5. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. PMID: 27435960.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    12. A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver. Elife. 2015 Dec 11; 4. Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. PMID: 26653140.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    14. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Comb Chem High Throughput Screen. 2014 May; 17(4):333-42. Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. PMID: 24661212.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2013 Sep 10; 2:e00508. Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. PMID: 24040509.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. PMID: 23738709.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    17. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. PMID: 23741617.
      View in: PubMed   Mentions: 144     Fields:    Translation:HumansAnimalsCells
    18. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. PMID: 23400640.
      View in: PubMed   Mentions:
    19. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. PLoS Negl Trop Dis. 2012; 6(7):e1736. Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. PMID: 22860142.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    20. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. J Nat Prod. 2011 Dec 27; 74(12):2545-55. Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, Boundy-Mills K, Nukanto A, Kanti A, Julistiono H, Kardono LB, Bjeldanes LF, Crews P. PMID: 22129061.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis. 2011 Jul; 5(7):e1253. De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. PMID: 21811648.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    22. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    23. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. J Biomol Screen. 2011 Jun; 16(5):545-51. Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. PMID: 21441416.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405. Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. PMID: 21262276.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    25. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother. 2010 Aug; 54(8):3326-34. Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. PMID: 20547819.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    26. Discovery of novel benzoxaborole-based potent antitrypanosomal agents. ACS Med Chem Lett. 2010 Jul 08; 1(4):165-9. Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ. PMID: 24900190.
      View in: PubMed   Mentions:
    27. ACS Med. Chem. Lett. Discovery of novel benzoxaborole-based potent antitrypanosomal agents. 2010; 1(4):165-169. Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, McKerrow JH, Jacobs RT, Zhou H, Plattner JJ.
    28. Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi. Bioorg Med Chem. 2010 Apr 01; 18(7):2566-74. Watts KR, Ratnam J, Ang KH, Tenney K, Compton JE, McKerrow J, Crews P. PMID: 20303767.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    29. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. J Med Chem. 2010 Feb 25; 53(4):1763-73. Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. PMID: 20088534.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    30. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. J Med Chem. 2010 Jan 14; 53(1):52-60. Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. PMID: 19908842.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    31. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. PMID: 19773167.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    32. Divergent modes of enzyme inhibition in a homologous structure-activity series. J Med Chem. 2009 Aug 27; 52(16):5005-8. Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. PMID: 19637873.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    33. The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. Org Lett. 2009 May 07; 11(9):1975-8. Johnson TA, Amagata T, Sashidhara KV, Oliver AG, Tenney K, Matainaho T, Ang KK, McKerrow JH, Crews P. PMID: 19385671.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    34. Phytochemistry Letters. A benzopyrroloisoquinoline alkaloid from Ficus fistulosa. 2009; 2(2):88-90. Subramaniam G., Ang KKH, Ng S, Buss AD, Butler MS.
    35. The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness. J Nat Prod. 2009 Feb 27; 72(2):218-22. Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P. PMID: 19159277.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. PLoS Negl Trop Dis. 2009; 3(2):e372. Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. PMID: 19190730.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    37. New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea. J Nat Prod. 2002 Apr; 65(4):476-80. Hu JF, Schetz JA, Kelly M, Peng JN, Ang KK, Flotow H, Leong CY, Ng SB, Buss AD, Wilkins SP, Hamann MT. PMID: 11975483.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    38. Immune-mediated parasite clearance in mice infected with Plasmodium berghei following treatment with manzamine A. Parasitol Res. 2001 Sep; 87(9):715-21. Ang KK, Holmes MJ, Kara UA. PMID: 11570556.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    39. New manzamine alkaloids with potent activity against infectious diseases. J Am Chem Soc. 2001 Mar 07; 123(9):1804-8. El Sayed KA, Kelly M, Kara UA, Ang KK, Katsuyama I, Dunbar DC, Khan AA, Hamann MT. PMID: 11456797.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    40. In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrob Agents Chemother. 2000 Jun; 44(6):1645-9. Ang KK, Holmes MJ, Higa T, Hamann MT, Kara UA. PMID: 10817722.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    41. Appl. Spectrosc. Resonance raman microspectroscopy of normal erythrocytes and Plasmodium berghei-Infected erythrocytes. 1999; 53(9):1097-1101. Ong CW, Shen ZX, Ang KKH, Kara UAK, Tang SH.
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