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Keelan Guiley, PhD

Title(s)Postdoctoral Research Fellow, Howard Hughes Medical Instit
SchoolSchool of Medicine
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    Collapse Research 
    Collapse Research Activities and Funding
    Cell cycle control through DREAM and MMB complexes
    NIH/NCI F31CA206244Apr 1, 2016 - Mar 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vorster PJ, Goetsch P, Wijeratne TU, Guiley KZ, Andrejka L, Tripathi S, Larson BJ, Rubin SM, Strome S, Lipsick JS. A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes. Biol Open. 2020 Apr 15. PMID: 32295830.
      View in: PubMed
    2. Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 12 13; 366(6471). PMID: 31831640.
      View in: PubMed
    3. Guiley KZ, Iness AN, Saini S, Tripathi S, Lipsick JS, Litovchick L, Rubin SM. Structural mechanism of Myb-MuvB assembly. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):10016-10021. PMID: 30224471.
      View in: PubMed
    4. Iness AN, Felthousen J, Ananthapadmanabhan V, Sesay F, Saini S, Guiley KZ, Rubin SM, Dozmorov M, Litovchick L. The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. Oncogene. 2019 02; 38(7):1080-1092. PMID: 30206359.
      View in: PubMed
    5. Guiley KZ, Liban TJ, Felthousen JG, Ramanan P, Litovchick L, Rubin SM. Structural mechanisms of DREAM complex assembly and regulation. Genes Dev. 2015 May 01; 29(9):961-74. PMID: 25917549.
      View in: PubMed
    6. Lau PW, Guiley KZ, De N, Potter CS, Carragher B, MacRae IJ. The molecular architecture of human Dicer. Nat Struct Mol Biol. 2012 Mar 18; 19(4):436-40. PMID: 22426548.
      View in: PubMed
    7. Guiley KZ, Pratt AJ, MacRae IJ. Single-pot enzymatic synthesis of Dicer-substrate siRNAs. Nucleic Acids Res. 2012 Mar; 40(5):e40. PMID: 22189103.
      View in: PubMed