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Keith Mostov, MD, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentAnatomy
Address600 16th St
San Francisco CA 94158
Phone415-476-6048
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    Collapse Biography 
    Collapse Education and Training
    Oxford Rhodes Scholar, Oxford, EnglandNeurobiology
    Rockefeller (Guenter Blobel), New YorkPhDCell Biology
    Cornell Medical, New YorkMDMedicine
    Whitehead - PI , Cambridge MACell Bio
    Collapse Awards and Honors
    American Society for Cell Biology2017Inaugural Fellow Lifetime Achievement
    NIH NIAID2002  - 2012MERIT Award
    American Association Anatomists1998Bensley Award
    American Heart Associatio1992  - 1995Established Investigator Award
    Mallinckrodt Foundation1991  - 1994Scholar
    Searle Foundation1989  - 1992Scholar
    Cancer Research Institute (New York)1990  - 1992Investigator Award
    Hood Foundation1985  - 1988Scholar
    Rhodes Trust1976  - 1977Rhodes Scholar
    National Merit Foundation1972  - 1976National Merit Scholar

    Collapse Overview 
    Collapse Overview
    Formation and regeneration of epithelial tubes.

    Epithelia are the most common type of tissue in animals. Epithelial cells form sheets of cells that line surfaces and internal cavities. Most internal organs, such as the respiratory, digestive, genito-urinary and vascular systems, consist of a network of tubes that are lined by a single layer of epithelial cells, surrounded by other tissue types, such as muscle, neurons and connective tissue. We are studying how these epithelial tubes form and how they regenerate. We are using as models the tubes in several mammalian organ systems, such as the kidney and digestive system.

    We are particularly interested in how the size of tubes is regulated and how this impacts regeneration. For instance, the mammalian small intestine consists of villi that project into the lumen of the intestine to increase the surface area available to absorb nutrients from the intestinal lumen. In between the villi are crypts, outpouchings of the wall of the small intestine. Epithelial stem cells are located at the base of the crypts. Some daughters of the stem cells differentiate and move up the crypts into the villi and are eventually shed from the tips of the villi. A single crypt stem cell can regenerate an entire crypt-villus structure.

    The small intestine grows enormously in length both in the embryo and after birth, reaching a length of about 6 meters in the adult human. However, the small intestine never regenerates in length, either in the embryo or after birth. If the small intestine is abnormally short for any reason, such as mutation, injury or surgery, it can never recover in length. This is in stark contrast to the ability of a single stem cell in the base of the crypt to regenerate the entire crypt-villus structure. Almost nothing is known about the mechanisms that control the length of the small intestine. We have found multiple genes that control the length of the small intestine and have used them to uncover several signaling pathways that regulate the length of the small intestine. These genes and pathways open the door to therapies to promote regeneration of the length of the small intestine.


    Collapse Research 
    Collapse Research Activities and Funding
    A novel approach to acute kidney injury
    NIH/NIDDK P30 DK079307Aug 1, 2017 - Jul 31, 2019
    Role: Project Leader
    Exploring Design Principles of Cellular Control Circuits
    NIH/NIGMS P50 GM081879Jul 1, 2016 - Jun 30, 2018
    Role: Project Leader
    Control of Epithelial Polarity
    NIH/NIDDK R01DK091530Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Formation of bile ducts in three dimensional culture
    NIH/NIDDK R01DK083330Jun 1, 2010 - Apr 30, 2013
    Role: Principal Investigator
    Recovery from acute kidney injury
    NIH/NIDDK R01DK074398Apr 1, 2006 - May 31, 2016
    Role: Principal Investigator
    Control of Orientation of Epithelial Polarity
    NIH/NIDDK R01DK067153Apr 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    Multiphoton Microscope Facility for UCSF Mission Bay
    NIH/NCRR S10RR017973Apr 1, 2003 - Mar 31, 2004
    Role: Principal Investigator
    Mucosal Immune Barrier in Infection and Immunity
    NIH/NIAID P01AI053194Sep 30, 2002 - Aug 31, 2014
    Role: Principal Investigator
    Novel Method for Mucosal Delivery of Protein Drugs
    NIH/NIDDK R01DK058061Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    NOVEL METHOD FOR MUCOSAL GENE DELIVERY
    NIH/NIDDK R21DK055772Apr 15, 1999 - Sep 30, 2001
    Role: Principal Investigator
    Regulation of Transcytosis of Polymeric Immunoglobulins
    NIH/NIAID R01AI036953Sep 30, 1995 - May 31, 2011
    Role: Principal Investigator
    HOST CELL DETERMINANTS IN PSEUDOMONAS PNEUMONIA
    NIH/NHLBI R01HL055980Sep 30, 1995 - Nov 30, 2005
    Role: Principal Investigator
    NOVEL METHOD FOR INTESTINAL ABSORPTION OF ANTIBODIES
    NIH/NIAID R01AI039161Sep 30, 1995 - Aug 31, 2000
    Role: Principal Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH/NIDDK P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Co-Investigator
    Transport of Immunoglobulins Across Epithelial Cells
    NIH/NIAID R37AI025144Aug 1, 1987 - Jul 31, 2013
    Role: Principal Investigator
    TRANSPORT OF IMMUNOGLOBULINS ACROSS EPITHELIAL CELLS
    NIH/NIAID R01AI025144Aug 1, 1987 - Jul 31, 2002
    Role: Principal Investigator
    RECEPTOR-MEDIATED TRANSPORT OF IGA AND IGM ACROSS CELLS
    NIH/NIAID R23AI021752Jan 1, 1985 - Dec 31, 1987
    Role: Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kwon SH, Oh S, Nacke M, Mostov K, Lipschutz JH. Adaptor protein CD2AP and L-type lectin LMAN2 regulate exosome cargo protein trafficking through the Golgi complex. J Biol Chem. 2017 10 06; 292(40):16523. PMID: 28986432.
      View in: PubMed
    2. Datta A, Sandilands E, Mostov K, Bryant DM. Fibroblast-derived HGF drives acinar lung cancer cell polarization through integrin-dependent RhoA-ROCK1 inhibition. Cell Signal. 2017 Dec; 40:91-98. PMID: 28888686.
      View in: PubMed
    3. Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov K, Bryant DM, Luby-Phelps K, Marciano DK. Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017 10 01; 144(19):3511-3520. PMID: 28860115.
      View in: PubMed
    4. Ruch TR, Bryant DM, Mostov K, Engel JN. Par3 integrates Tiam1 and phosphatidylinositol 3-kinase signaling to change apical membrane identity. Mol Biol Cell. 2017 Jan 15; 28(2):252-260. PMID: 27881661.
      View in: PubMed
    5. Kwon SH, Oh S, Nacke M, Mostov K, Lipschutz JH. Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex. J Biol Chem. 2016 Dec 02; 291(49):25462-25475. PMID: 27765817.
      View in: PubMed
    6. Nedvetsky PI, Zhao X, Mathivet T, Aspalter IM, Stanchi F, Metzger RJ, Mostov K, Gerhardt H. cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner. Development. 2016 10 01; 143(19):3582-3590. PMID: 27702786.
      View in: PubMed
    7. Kim M, M Shewan A, Ewald AJ, Werb Z, Mostov K. p114RhoGEF governs cell motility and lumen formation during tubulogenesis through a ROCK-myosin-II pathway. J Cell Sci. 2015 Dec 01; 128(23):4317-27. PMID: 26483385; PMCID: PMC4712812 [Available on 12/01/16].
    8. Peng J, Awad A, Sar S, Komaiha OH, Moyano R, Rayal A, Samuel D, Shewan A, Vanhaesebroeck B, Mostov K, Gassama-Diagne A. Phosphoinositide 3-kinase p110d promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization. Nat Commun. 2015 Jan 13; 6:5937. PMID: 25583025.
      View in: PubMed
    9. Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov K. A molecular switch for the orientation of epithelial cell polarization. Dev Cell. 2014 Oct 27; 31(2):171-87. PMID: 25307480; PMCID: PMC4248238.
    10. Nedvetsky PI, Emmerson E, Finley JK, Ettinger A, Cruz-Pacheco N, Prochazka J, Haddox CL, Northrup E, Hodges C, Mostov K, Hoffman MP, Knox SM. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014 Aug 25; 30(4):449-62. PMID: 25158854; PMCID: PMC4155578.
    11. Tran CS, Eran Y, Ruch TR, Bryant DM, Datta A, Brakeman P, Kierbel A, Wittmann T, Metzger RJ, Mostov K, Engel JN. Host cell polarity proteins participate in innate immunity to Pseudomonas aeruginosa infection. Cell Host Microbe. 2014 May 14; 15(5):636-43. PMID: 24832456; PMCID: PMC4062193.
    12. Kwon SH, Liu KD, Mostov K. Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth. Curr Biol. 2014 Jan 20; 24(2):199-204. PMID: 24412205; PMCID: PMC3938203.
    13. Cerruti B, Puliafito A, Shewan AM, Yu W, Combes AN, Little MH, Chianale F, Primo L, Serini G, Mostov K, Celani A, Gamba A. Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures. J Cell Biol. 2013 Oct 28; 203(2):359-72. PMID: 24145168; PMCID: PMC3812962.
    14. Rousso T, Shewan AM, Mostov K, Schejter ED, Shilo BZ. Apical targeting of the formin Diaphanous in Drosophila tubular epithelia. Elife. 2013 Jul 09; 2:e00666. PMID: 23853710; PMCID: PMC3707080.
    15. Roignot J, Peng X, Mostov K. Polarity in mammalian epithelial morphogenesis. Cold Spring Harb Perspect Biol. 2013 Feb 01; 5(2). PMID: 23378592; PMCID: PMC3552506.
    16. Cai L, Mostov K. Cell height: Tao rising. J Cell Biol. 2012 Dec 24; 199(7):1023-4. PMID: 23266952; PMCID: PMC3529524.
    17. Gálvez-Santisteban M, Rodriguez-Fraticelli AE, Bryant DM, Vergarajauregui S, Yasuda T, Bañón-Rodríguez I, Bernascone I, Datta A, Spivak N, Young K, Slim CL, Brakeman PR, Fukuda M, Mostov K, Martín-Belmonte F. Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells. Nat Cell Biol. 2012 Aug; 14(8):838-49. PMID: 22820376; PMCID: PMC3433678.
    18. Senga K, Mostov K, Mitaka T, Miyajima A, Tanimizu N. Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25. Mol Biol Cell. 2012 Aug; 23(15):2845-55. PMID: 22696678; PMCID: PMC3408412.
    19. Nedvetsky PI, Kwon SH, Debnath J, Mostov K. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81. PMID: 22675028; PMCID: PMC3408423.
    20. Eastburn DJ, Zegers MM, Mostov K. Scrib regulates HGF-mediated epithelial morphogenesis and is stabilized by Sgt1-HSP90. J Cell Sci. 2012 Sep 01; 125(Pt 17):4147-57. PMID: 22623728; PMCID: PMC3482320.
    21. Su T, Chapin SJ, Bryant DM, Shewan AM, Young K, Mostov K. Reduced immunoglobulin A transcytosis associated with immunoglobulin A nephropathy and nasopharyngeal carcinoma. J Biol Chem. 2011 Dec 30; 286(52):44921-5. PMID: 22086919; PMCID: PMC3247984.
    22. Cheung ID, Bagnat M, Ma TP, Datta A, Evason K, Moore JC, Lawson ND, Mostov K, Moens CB, Stainier DY. Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. Dev Biol. 2012 Jan 01; 361(1):68-78. PMID: 22020048; PMCID: PMC3235368.
    23. Shewan A, Eastburn DJ, Mostov K. Phosphoinositides in cell architecture. Cold Spring Harb Perspect Biol. 2011 Aug 01; 3(8):a004796. PMID: 21576256; PMCID: PMC3140688.
    24. Lepanto P, Bryant DM, Rossello J, Datta A, Mostov K, Kierbel A. Pseudomonas aeruginosa interacts with epithelial cells rapidly forming aggregates that are internalized by a Lyn-dependent mechanism. Cell Microbiol. 2011 Aug; 13(8):1212-22. PMID: 21615664; PMCID: PMC3813436.
    25. Marciano DK, Brakeman PR, Lee CZ, Spivak N, Eastburn DJ, Bryant DM, Beaudoin GM, Hofmann I, Mostov K, Reichardt LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011 May; 138(10):2099-109. PMID: 21521738; PMCID: PMC3082309.
    26. Engelberg JA, Datta A, Mostov K, Hunt CA. MDCK cystogenesis driven by cell stabilization within computational analogues. PLoS Comput Biol. 2011 Apr; 7(4):e1002030. PMID: 21490722; PMCID: PMC3072361.
    27. Datta A, Bryant DM, Mostov K. Molecular regulation of lumen morphogenesis. Curr Biol. 2011 Feb 08; 21(3):R126-36. PMID: 21300279; PMCID: PMC3771703.
    28. Roland JT, Bryant DM, Datta A, Itzen A, Mostov K, Goldenring JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2789-94. PMID: 21282656; PMCID: PMC3041130.
    29. Kwon SH, Nedvetsky PI, Mostov K. Transcriptional profiling identifies TNS4 function in epithelial tubulogenesis. Curr Biol. 2011 Jan 25; 21(2):161-6. PMID: 21236678; PMCID: PMC3031161.
    30. Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov K. A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2010 Dec; 12(12):1143-53. PMID: 21037565; PMCID: PMC3072784.
    31. Bagnat M, Navis A, Herbstreith S, Brand-Arzamendi K, Curado S, Gabriel S, Mostov K, Huisken J, Stainier DY. Cse1l is a negative regulator of CFTR-dependent fluid secretion. Curr Biol. 2010 Oct 26; 20(20):1840-5. PMID: 20933420; PMCID: PMC2963654.
    32. Bryant DM, Datta A, Rodríguez-Fraticelli AE, Peränen J, Martín-Belmonte F, Mostov K. A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol. 2010 Nov; 12(11):1035-45. PMID: 20890297; PMCID: PMC2975675.
    33. Kim M, O'Brien LE, Kwon SH, Mostov K. STAT1 is required for redifferentiation during Madin-Darby canine kidney tubulogenesis. Mol Biol Cell. 2010 Nov 15; 21(22):3926-33. PMID: 20861313; PMCID: PMC2982126.
    34. Rodriguez-Fraticelli AE, Vergarajauregui S, Eastburn DJ, Datta A, Alonso MA, Mostov K, Martín-Belmonte F. The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol. 2010 May 17; 189(4):725-38. PMID: 20479469; PMCID: PMC2872911.
    35. Eastburn DJ, Mostov K. Laying the foundation for epithelia: insights into polarized basement membrane deposition. EMBO Rep. 2010 May; 11(5):329-30. PMID: 20379219; PMCID: PMC2868545.
    36. Kim SH, Matthay MA, Mostov K, Hunt CA. Simulation of lung alveolar epithelial wound healing in vitro. J R Soc Interface. 2010 Aug 06; 7(49):1157-70. PMID: 20236957; PMCID: PMC2894878.
    37. Kim SH, Debnath J, Mostov K, Park S, Hunt CA. A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst Biol. 2009 Dec 31; 3:122. PMID: 20043854; PMCID: PMC2814811.
    38. Bucior I, Mostov K, Engel JN. Pseudomonas aeruginosa-mediated damage requires distinct receptors at the apical and basolateral surfaces of the polarized epithelium. Infect Immun. 2010 Mar; 78(3):939-53. PMID: 20008530; PMCID: PMC2825949.
    39. Cai L, Mostov K. Polarity is destiny. Cell. 2009 Nov 13; 139(4):660-2. PMID: 19914162; PMCID: PMC2900917.
    40. Kim SH, Park S, Mostov K, Debnath J, Hunt CA. Computational investigation of epithelial cell dynamic phenotype in vitro. Theor Biol Med Model. 2009 May 28; 6:8. PMID: 19476639; PMCID: PMC2696420.
    41. Luton F, Hexham MJ, Zhang M, Mostov K. Identification of a cytoplasmic signal for apical transcytosis. Traffic. 2009 Aug; 10(8):1128-42. PMID: 19522755; PMCID: PMC2920487.
    42. Tanimizu N, Miyajima A, Mostov K. Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol Biol Cell. 2009 May; 20(9):2486-94. PMID: 19297530; PMCID: PMC2675627.
    43. Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA. A computational approach to understand in vitro alveolar morphogenesis. PLoS One. 2009; 4(3):e4819. PMID: 19283073; PMCID: PMC2653231.
    44. Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov K. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F564-74. PMID: 19116242; PMCID: PMC2660185.
    45. Bryant DM, Mostov K. From cells to organs: building polarized tissue. Nat Rev Mol Cell Biol. 2008 Nov; 9(11):887-901. PMID: 18946477; PMCID: PMC2921794.
    46. Shafikhani SH, Mostov K, Engel J. Focal adhesion components are essential for mammalian cell cytokinesis. Cell Cycle. 2008 Sep 15; 7(18):2868-76. PMID: 18787414; PMCID: PMC2745397.
    47. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov K. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 2008 Sep; 9(9):923-9. PMID: 18660750; PMCID: PMC2529350.
    48. Martín-Belmonte F, Yu W, Rodríguez-Fraticelli AE, Ewald AJ, Ewald A, Werb Z, Alonso MA, Mostov K. Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol. 2008 Apr 08; 18(7):507-13. PMID: 18394894; PMCID: PMC2405957.
    49. Martin-Belmonte F, Mostov K. Regulation of cell polarity during epithelial morphogenesis. Curr Opin Cell Biol. 2008 Apr; 20(2):227-34. PMID: 18282696.
      View in: PubMed
    50. Engelberg JA, Kim M, Mostov K, Hunt CA. In silico simulation of epithelial cell tubulogenesis. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1036-9. PMID: 19162839.
      View in: PubMed
    51. Bryant D, Mostov K. Development: inflationary pressures. Nature. 2007 Oct 04; 449(7162):549-50. PMID: 17914384.
      View in: PubMed
    52. Jacobson C, Mostov K. Catch the KIF5B train to the apical surface. Dev Cell. 2007 Oct; 13(4):457-8. PMID: 17925219.
      View in: PubMed
    53. Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov K. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1633-40. PMID: 17804488.
      View in: PubMed
    54. Kim M, Datta A, Brakeman P, Yu W, Mostov K. Polarity proteins PAR6 and aPKC regulate cell death through GSK-3beta in 3D epithelial morphogenesis. J Cell Sci. 2007 Jul 15; 120(Pt 14):2309-17. PMID: 17606986.
      View in: PubMed
    55. Bagnat M, Cheung ID, Mostov K, Stainier DY. Genetic control of single lumen formation in the zebrafish gut. Nat Cell Biol. 2007 Aug; 9(8):954-60. PMID: 17632505.
      View in: PubMed
    56. Krtolica A, Genbacev O, Escobedo C, Zdravkovic T, Nordstrom A, Vabuena D, Nath A, Simon C, Mostov K, Fisher SJ. Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation. Stem Cells. 2007 Sep; 25(9):2215-23. PMID: 17569786.
      View in: PubMed
    57. Martin-Belmonte F, Mostov K. Phosphoinositides control epithelial development. Cell Cycle. 2007 Aug 15; 6(16):1957-61. PMID: 17712229.
      View in: PubMed
    58. Bryant DM, Kerr MC, Hammond LA, Joseph SR, Mostov K, Teasdale RD, Stow JL. EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin. J Cell Sci. 2007 May 15; 120(Pt 10):1818-28. PMID: 17502486.
      View in: PubMed
    59. Kierbel A, Gassama-Diagne A, Rocha C, Radoshevich L, Olson J, Mostov K, Engel J. Pseudomonas aeruginosa exploits a PIP3-dependent pathway to transform apical into basolateral membrane. J Cell Biol. 2007 Apr 09; 177(1):21-7. PMID: 17403925; PMCID: PMC2064102.
    60. Leroy P, Mostov K. Slug is required for cell survival during partial epithelial-mesenchymal transition of HGF-induced tubulogenesis. Mol Biol Cell. 2007 May; 18(5):1943-52. PMID: 17344479; PMCID: PMC1855025.
    61. Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis. Mol Biol Cell. 2007 May; 18(5):1693-700. PMID: 17332496; PMCID: PMC1855040.
    62. Tanimizu N, Miyajima A, Mostov K. Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. Mol Biol Cell. 2007 Apr; 18(4):1472-9. PMID: 17314404; PMCID: PMC1838984.
    63. Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K. PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell. 2007 Jan 26; 128(2):383-97. PMID: 17254974; PMCID: PMC1865103.
    64. Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K. A model of intussusceptive angiogenesis. Novartis Found Symp. 2007; 283:37-42; discussion 42-5, 238-41. PMID: 18300412.
      View in: PubMed
    65. Reiter JF, Mostov K. Vesicle transport, cilium formation, and membrane specialization: the origins of a sensory organelle. Proc Natl Acad Sci U S A. 2006 Dec 05; 103(49):18383-4. PMID: 17132734; PMCID: PMC1693671.
    66. Vergés M, Sebastián I, Mostov K. Phosphoinositide 3-kinase regulates the role of retromer in transcytosis of the polymeric immunoglobulin receptor. Exp Cell Res. 2007 Feb 15; 313(4):707-18. PMID: 17184770; PMCID: PMC1810347.
    67. Gassama-Diagne A, Yu W, ter Beest M, Martin-Belmonte F, Kierbel A, Engel J, Mostov K. Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat Cell Biol. 2006 Sep; 8(9):963-70. PMID: 16921364.
      View in: PubMed
    68. Grant MR, Mostov K, Tlsty TD, Hunt CA. Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol. 2006 Oct 06; 2(10):e129. PMID: 17029556; PMCID: PMC1592363.
    69. Mostov K, Martin-Belmonte F. Developmental biology: the hole picture. Nature. 2006 Jul 27; 442(7101):363-4. PMID: 16871199.
      View in: PubMed
    70. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov K, Stokoe D, Shokat KM, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. PMID: 16697955; PMCID: PMC2925230.
    71. Mostov K. mTOR is out of control in polycystic kidney disease. Proc Natl Acad Sci U S A. 2006 Apr 04; 103(14):5247-8. PMID: 16567652; PMCID: PMC1459339.
    72. O'Brien LE, Yu W, Tang K, Jou TS, Zegers MM, Mostov K. Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods Enzymol. 2006; 406:676-91. PMID: 16472697.
      View in: PubMed
    73. ter Beest MB, Chapin SJ, Avrahami D, Mostov K. The role of syntaxins in the specificity of vesicle targeting in polarized epithelial cells. Mol Biol Cell. 2005 Dec; 16(12):5784-92. PMID: 16207812; PMCID: PMC1289421.
    74. Kierbel A, Gassama-Diagne A, Mostov K, Engel JN. The phosphoinositol-3-kinase-protein kinase B/Akt pathway is critical for Pseudomonas aeruginosa strain PAK internalization. Mol Biol Cell. 2005 May; 16(5):2577-85. PMID: 15772151; PMCID: PMC1087259.
    75. Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. Formation of multicellular epithelial structures. Novartis Found Symp. 2005; 269:193-200; discussion 200-5, 223-30. PMID: 16355541.
      View in: PubMed
    76. Yu W, Datta A, Leroy P, O'Brien LE, Mak G, Jou TS, Matlin KS, Mostov K, Zegers MM. Beta1-integrin orients epithelial polarity via Rac1 and laminin. Mol Biol Cell. 2005 Feb; 16(2):433-45. PMID: 15574881; PMCID: PMC545874.
    77. Tanimizu N, Saito H, Mostov K, Miyajima A. Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci. 2004 Dec 15; 117(Pt 26):6425-34. PMID: 15572411.
      View in: PubMed
    78. Vergés M, Luton F, Gruber C, Tiemann F, Reinders LG, Huang L, Burlingame AL, Haft CR, Mostov K. The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol. 2004 Aug; 6(8):763-9. PMID: 15247922.
      View in: PubMed
    79. O'Brien LE, Tang K, Kats ES, Schutz-Geschwender A, Lipschutz JH, Mostov K. ERK and MMPs sequentially regulate distinct stages of epithelial tubule development. Dev Cell. 2004 Jul; 7(1):21-32. PMID: 15239951.
      View in: PubMed
    80. Matsumura S, Van De Water J, Leung P, Odin JA, Yamamoto K, Gores GJ, Mostov K, Ansari AA, Coppel RL, Shiratori Y, Gershwin ME. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis. Hepatology. 2004 May; 39(5):1415-22. PMID: 15122771.
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    81. Kazmierczak BI, Mostov K, Engel JN. Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa. Mol Biol Cell. 2004 Feb; 15(2):411-9. PMID: 14595106; PMCID: PMC329196.
    82. Pollack AL, Apodaca G, Mostov K. Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity. Am J Physiol Cell Physiol. 2004 Mar; 286(3):C482-94. PMID: 14592813.
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    83. Zegers MM, Forget MA, Chernoff J, Mostov K, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. EMBO J. 2003 Aug 15; 22(16):4155-65. PMID: 12912914; PMCID: PMC175788.
    84. Mostov K. Epithelial polarity and morphogenesis. Methods. 2003 Jul; 30(3):189-90. PMID: 12798132.
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    85. Lai JF, Juang SH, Hung YM, Cheng HY, Cheng TL, Mostov K, Jou TS. An ecdysone and tetracycline dual regulatory expression system for studies on Rac1 small GTPase-mediated signaling. Am J Physiol Cell Physiol. 2003 Sep; 285(3):C711-9. PMID: 12736135.
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    86. Mostov K, Su T, ter Beest M. Polarized epithelial membrane traffic: conservation and plasticity. Nat Cell Biol. 2003 Apr; 5(4):287-93. PMID: 12669082.
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    87. Zegers MM, O'Brien LE, Yu W, Datta A, Mostov K. Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol. 2003 Apr; 13(4):169-76. PMID: 12667754.
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    88. Lipschutz JH, Lingappa VR, Mostov K. The exocyst affects protein synthesis by acting on the translocation machinery of the endoplasmic reticulum. J Biol Chem. 2003 Jun 06; 278(23):20954-60. PMID: 12665531.
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    89. Mostov K, Zegers M. Cell biology: Just mix and patch. Nature. 2003 Mar 20; 422(6929):267-8. PMID: 12646903.
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    90. Yu W, O'Brien LE, Wang F, Bourne H, Mostov K, Zegers MM. Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures. Mol Biol Cell. 2003 Feb; 14(2):748-63. PMID: 12589067; PMCID: PMC150005.
    91. van Ijzendoorn SC, Mostov K, Hoekstra D. Role of rab proteins in epithelial membrane traffic. Int Rev Cytol. 2003; 232:59-88. PMID: 14711116.
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    92. O'Brien LE, Zegers MM, Mostov K. Opinion: Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol. 2002 Jul; 3(7):531-7. PMID: 12094219.
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    93. Lipschutz JH, Mostov K. Exocytosis: the many masters of the exocyst. Curr Biol. 2002 Mar 19; 12(6):R212-4. PMID: 11909549.
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    94. van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov K. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Dev Cell. 2002 Feb; 2(2):219-28. PMID: 11832247.
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    95. von Zastrow M, Mostov K. Signal transduction. A new thread in an intricate web. Science. 2001 Nov 30; 294(5548):1845-7. PMID: 11729293.
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    96. Kazmierczak BI, Jou TS, Mostov K, Engel JN. Rho GTPase activity modulates Pseudomonas aeruginosa internalization by epithelial cells. Cell Microbiol. 2001 Feb; 3(2):85-98. PMID: 11207623.
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    97. Kazmierczak BI, Mostov K, Engel JN. Interaction of bacterial pathogens with polarized epithelium. Annu Rev Microbiol. 2001; 55:407-35. PMID: 11544362.
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    98. van Ooij C, Kalman L. Host cell-derived sphingolipids are required for the intracellular growth of Chlamydia trachomatis. Cell Microbiol. 2000 Dec; 2(6):627-37. PMID: 11207614.
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    99. Mostov K, ter Beest MB, Chapin SJ. Catch the mu1B train to the basolateral surface. Cell. 1999 Oct 15; 99(2):121-2. PMID: 10535730.
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    100. Altschuler Y, Liu S, Katz L, Tang K, Hardy S, Brodsky F, Apodaca G, Mostov K. ADP-ribosylation factor 6 and endocytosis at the apical surface of Madin-Darby canine kidney cells. J Cell Biol. 1999 Oct 04; 147(1):7-12. PMID: 10508850; PMCID: PMC2164974.
    101. Weimbs T, Mostov K, Low SH, Hofmann K. A model for structural similarity between different SNARE complexes based on sequence relationships. Trends Cell Biol. 1998 Jul; 8(7):260-2. PMID: 9714596.
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    102. Hauser AR, Fleiszig S, Kang PJ, Mostov K, Engel JN. Defects in type III secretion correlate with internalization of Pseudomonas aeruginosa by epithelial cells. Infect Immun. 1998 Apr; 66(4):1413-20. PMID: 9529061; PMCID: PMC108068.
    103. Kang PJ, Hauser AR, Apodaca G, Fleiszig SM, Wiener-Kronish J, Mostov K, Engel JN. Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol. 1997 Jun; 24(6):1249-62. PMID: 9218773.
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    104. Mostov K, Werb Z. Journey across the osteoclast. Science. 1997 Apr 11; 276(5310):219-20. PMID: 9132944.
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    105. Reich V, Mostov K, Aroeti B. The basolateral sorting signal of the polymeric immunoglobulin receptor contains two functional domains. J Cell Sci. 1996 Aug; 109 ( Pt 8):2133-9. PMID: 8856509.
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    106. Cardone M, Mostov K. Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulin receptor. FEBS Lett. 1995 Nov 27; 376(1-2):74-6. PMID: 8521971.
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    107. Song W, Apodaca G, Mostov K. Transcytosis of the polymeric immunoglobulin receptor is regulated in multiple intracellular compartments. J Biol Chem. 1994 Nov 25; 269(47):29474-80. PMID: 7961930.
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    108. Crepaldi T, Pollack AL, Prat M, Zborek A, Mostov K, Comoglio PM. Targeting of the SF/HGF receptor to the basolateral domain of polarized epithelial cells. J Cell Biol. 1994 Apr; 125(2):313-20. PMID: 8163548; PMCID: PMC2120024.
    109. Song W, Bomsel M, Casanova J, Vaerman JP, Mostov K. Stimulation of transcytosis of the polymeric immunoglobulin receptor by dimeric IgA. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):163-6. PMID: 8278358; PMCID: PMC42906.
    110. Mostov K. Protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor as a model system. J Cell Sci Suppl. 1993; 17:21-6. PMID: 8144699.
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    111. Bomsel M, Mostov K. Role of heterotrimeric G proteins in membrane traffic. Mol Biol Cell. 1992 Dec; 3(12):1317-28. PMID: 1493332; PMCID: PMC275702.
    112. Mostov K, Apodaca G, Aroeti B, Okamoto C. Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol. 1992 Feb; 116(3):577-83. PMID: 1730769; PMCID: PMC2289323.
    113. Aroeti B, Casanova J, Okamoto C, Cardone M, Pollack A, Tang K, Mostov K. Polymeric immunoglobulin receptor. Int Rev Cytol. 1992; 137B:157-68. PMID: 1478818.
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    114. Mostov K. The polymeric immunoglobulin receptor. Semin Cell Biol. 1991 Dec; 2(6):411-8. PMID: 1813030.
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    115. Bomsel M, Mostov K. Sorting of plasma membrane proteins in epithelial cells. Curr Opin Cell Biol. 1991 Aug; 3(4):647-53. PMID: 1772657.
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    116. Le Bivic A, Sambuy Y, Mostov K, Rodriguez-Boulan E. Vectorial targeting of an endogenous apical membrane sialoglycoprotein and uvomorulin in MDCK cells. J Cell Biol. 1990 May; 110(5):1533-9. PMID: 2335561; PMCID: PMC2200188.
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