Kevin Lou, PhD

Title(s)Assistant Researcher, Bioengineering
SchoolSchool of Pharmacy
Address600 16th Street, #N514
San Francisco CA 94158
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    Investigating functional interactions with KRAS G12C inhibition
    NIH F30CA239476Mar 1, 2019 - Feb 28, 2022
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A design approach for bitopic kinase inhibitors. Nature. 2026 Sep 23. Stevenson JW, Lou K, Reynolds JA, Outhwaite IR, Huang K, Sokirniy I, Peterson SYJ, Munir AZ, Wang CD, Inam H, Gebauer EL, Leyte-Vidal A, Grynyova A, Figueroa SM, Rees MG, Ronan MM, Salangsang F, Zeng Y, Steri V, Roth JA, Shah NP, Echeverria I, Šali A, Zhang Z, Moslehi JJ, Seeliger MA, Pritchard JR, Shokat KM. PMID: 42778601.
      View in: PubMed   Mentions:
    2. Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response. Nat Chem Biol. 2026 Sep 08. O'Loughlin TA, Arab A, Misiukiewicz S, Montesano E, Yogodzinski C, Borah AA, Quarantotti V, Lou K, Rosen BS, Corn JE, Gianni D, Kabir S, Forment JV, Gilbert LA. PMID: 42711491.
      View in: PubMed   Mentions:
    3. A Dimeric Protein-RNA Glue Promotes Multivalent eIF4A-RNA Assembly. ACS Cent Sci. 2026 Aug 26; 12(8):1195-1206. Liu J, Moore MK, Lou K, Wassarman DR, Arab A, Ojeda S, Karakyriakou B, Koglin AS, Ott CJ, Gilbert LA, Shokat KM. PMID: 42666664; PMCID: PMC13523671.
      View in: PubMed   Mentions:
    4. Single-cell transcriptomic unveils tumor-mediated reprogramming of neutrophils and their unique vulnerability that inhibits metastasis. Sci Adv. 2026 Jul 17; 12(29):eaee9308. Putzbach W, Zappia MP, Magdy A, Li J, Nogueira V, Lou K, Shokat KM, Islam ABMMK, Frolov M, Hay N. PMID: 42455928; PMCID: PMC13371899.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. A deep learning algorithm for fully automated volumetric measurement of meningioma burden. Neurooncol Adv. 2026 Jan-Dec; 8(1):vdag137. Cleveland MC, Kim AE, McNeal TN, Viera M, McCall OC, Lou KW, Patel JB, Pulido-Arias D, Plotkin S, Kalpathy-Cramer J, Brastianos PK, Bridge CP, Gerstner ER. PMID: 42487903; PMCID: PMC13391153.
      View in: PubMed   Mentions:
    6. A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly. bioRxiv. 2026 Mar 10. Liu J, Moore MK, Lou K, Wassarman DR, Arab A, Ojeda S, Karakyriakou B, Koglin AS, Ott CJ, Gilbert LA, Shokat KM. PMID: 41958995; PMCID: PMC13060801.
      View in: PubMed   Mentions:
    7. The GENEVA platform models tumor mosaicism to reveal variations of responses to KRAS inhibitors and identify improved drug combinations. Nat Cancer. 2026 Mar; 7(3):522-537. Yu JX, Suh JM, Popova KD, Garcia K, Joshi T, Culbertson B, Spinelli JB, Subramanyam V, Lou K, Charbonneau T, Shokat KM, Weissman J, Goodarzi H. PMID: 41735640; PMCID: PMC13035475.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Programmable translational inhibition by a molecular glue-oligonucleotide conjugate. bioRxiv. 2025 Jul 16. Wang S, Kovalski JR, Zapatero-Belinchón FJ, Bennett M, Kuzuoglu-Öztürk D, Li Q, Stevenson E, Liu J, Krogan NJ, Ott M, Swaney DL, Ruggero D, Lou K, Shokat KM. PMID: 40791481; PMCID: PMC12338673.
      View in: PubMed   Mentions:
    9. Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations. bioRxiv. 2024 Dec 16. Yu JX, Suh JM, Popova KD, Garcia K, Joshi T, Culbertson B, Spinelli JB, Subramanyam V, Lou K, Shokat KM, Weissman J, Goodarzi H. PMID: 39763922; PMCID: PMC11702557.
      View in: PubMed   Mentions:
    10. Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib. Leukemia. 2024 09; 38(9):2046-2050. Leyte-Vidal A, DeFilippis R, Outhwaite IR, Kwan I, Lee JY, Leavitt C, Miller KB, Rea D, Rangwala AM, Lou K, Patel S, Alvarez A, Shokat KM, Bahar I, Seeliger MA, Shah NP. PMID: 39085402; PMCID: PMC11347358.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    11. Abnormal vascular structure and function within brain metastases is linked to pembrolizumab resistance. Neuro Oncol. 2024 05 03; 26(5):965-974. Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist R, Krop I, Lawrence D, Ligibel J, Tolaney S, Mayer E, Winer E, Perrino CM, Summers EJ, Mahar M, Oh K, Shih HA, Cahill DP, Rosen BR, Yen YF, Kalpathy-Cramer J, Martinez-Lage M, Sullivan RJ, Brastianos PK, Emblem KE, Gerstner ER. PMID: 38070147; PMCID: PMC11066943.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCTClinical Trials
    12. Correction: Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report. Cardiooncology. 2023 Nov 29; 9(1):43. Patel K, Hsu KY, Lou K, Soni K, Lee YJ, Mulvey CK, Baik AH. PMID: 38031204; PMCID: PMC10685548.
      View in: PubMed   Mentions:
    13. Osimertinib-induced biventricular cardiomyopathy with abnormal cardiac MRI findings: a case report. Cardiooncology. 2023 Oct 31; 9(1):38. Patel K, Hsu KY, Lou K, Soni K, Lee YJ, Mulvey CK, Baik AH. PMID: 37908018; PMCID: PMC10617075.
      View in: PubMed   Mentions: 8  
    14. Structural and functional vascular dysfunction within brain metastases is linked to pembrolizumab inefficacy. bioRxiv. 2023 Aug 28. Kim AE, Lou KW, Giobbie-Hurder A, Chang K, Gidwani M, Hoebel K, Patel JB, Cleveland MC, Singh P, Bridge CP, Ahmed SR, Bearce BA, Liu W, Fuster-Garcia E, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist R, Krop I, Lawrence D, Ligibel J, Tolaney S, Mayer E, Winer E, Perrino CM, Summers EJ, Mahar M, Oh K, Shih HA, Cahill DP, Rosen BR, Yen YF, Kalpathy-Cramer J, Martinez-Lage M, Sullivan RJ, Brastianos PK, Emblem KE, Gerstner ER. PMID: 37693537; PMCID: PMC10491098.
      View in: PubMed   Mentions:
    15. IFITM proteins assist cellular uptake of diverse linked chemotypes. Science. 2022 12 09; 378(6624):1097-1104. Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. PMID: 36480603; PMCID: PMC9924227.
      View in: PubMed   Mentions: 14     Fields:    
    16. Brain-restricted mTOR inhibition with binary pharmacology. Nature. 2022 09; 609(7928):822-828. Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM. PMID: 36104566; PMCID: PMC9492542.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    17. Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas. Nat Commun. 2022 03 14; 13(1):1325. Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, Chukwueke U, Forst DA, Arrillaga-Romany IC, Dietrich J, Corbin Z, Moliterno J, Baehring J, White M, Lou KW, Larson J, de Sauvage MA, Evancic K, Mora J, Nayyar N, Loeffler J, Oh K, Shih HA, Curry WT, Cahill DP, Barker FG, Gerstner ER, Santagata S. PMID: 35289329; PMCID: PMC8921328.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCTClinical Trials
    18. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859; PMCID: PMC7431030.
      View in: PubMed   Mentions: 2749     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    19. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing. bioRxiv. 2020 Mar 27. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Naing ZZC, Zhou Y, Peng S, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Shen W, Shi Y, Zhang Z, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Ramachandran R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Wankowicz SA, Bohn M, Sharp PP, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Roesch F, Vallet T, Meyer B, White KM, Miorin L, Rosenberg OS, Verba KA, Agard D, Ott M, Emerman M, Ruggero D, García-Sastre A, Jura N, von Zastrow M, Taunton J, Ashworth A, Schwartz O, Vignuzzi M, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor S, Fraser JS, Gross J, Sali A, Kortemme T, Beltrao P, Shokat K, Shoichet BK, Krogan NJ. PMID: 32511329; PMCID: PMC7239059.
      View in: PubMed   Mentions: 7  
    20. p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition. Science. 2019 12 13; 366(6471). Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM. PMID: 31831640; PMCID: PMC7592119.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    21. A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry. 2019 08 06; 58(31):3328-3330. Lou K, Gilbert LA, Shokat KM. PMID: 31343870.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 05 28; 12(583). Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. PMID: 31138768; PMCID: PMC6871662.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    23. Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biol Open. 2018 Jul 23; 7(7). Mavor D, Barlow KA, Asarnow D, Birman Y, Britain D, Chen W, Green EM, Kenner LR, Mensa B, Morinishi LS, Nelson CA, Poss EM, Suresh P, Tian R, Arhar T, Ary BE, Bauer DP, Bergman ID, Brunetti RM, Chio CM, Dai SA, Dickinson MS, Elledge SK, Helsell CVM, Hendel NL, Kang E, Kern N, Khoroshkin MS, Kirkemo LL, Lewis GR, Lou K, Marin WM, Maxwell AM, McTigue PF, Myers-Turnbull D, Nagy TL, Natale AM, Oltion K, Pourmal S, Reder GK, Rettko NJ, Rohweder PJ, Schwarz DMC, Tan SK, Thomas PV, Tibble RW, Town JP, Tsai MK, Ugur FS, Wassarman DR, Wolff AM, Wu TS, Bogdanoff D, Li J, Thorn KS, O'Conchúir S, Swaney DL, Chow ED, Madhani HD, Redding S, Bolon DN, Kortemme T, DeRisi JL, Kampmann M, Fraser JS. PMID: 30037883; PMCID: PMC6078352.
      View in: PubMed   Mentions: 15     Fields:    
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