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Leveraging microenvironmental synthetic lethalities to treat cancer. J Clin Invest. 2021 Mar 15; 131(6).
Metcalf KJ, Alazzeh A, Werb Z, Weaver VM. PMID: 33720045.
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2 Fields:
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Synthetic Tuning of Domain Stoichiometry in Nanobody-Enzyme Megamolecules. Bioconjug Chem. 2021 01 20; 32(1):143-152.
Metcalf KJ, Kimmel BR, Sykora DJ, Modica JA, Parker KA, Berens E, Dai R, Dravid VP, Werb Z, Mrksich M. PMID: 33301672.
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Concepts of extracellular matrix remodelling in tumour progression and metastasis. Nat Commun. 2020 10 09; 11(1):5120.
Winkler J, Abisoye-Ogunniyan A, Metcalf KJ, Werb Z. PMID: 33037194.
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PubMed Mentions:
44 Fields:
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HumansAnimalsCells
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Role of Lipopolysaccharide in Protecting OmpT from Autoproteolysis during In Vitro Refolding. Biomolecules. 2020 06 18; 10(6).
Sinsinbar G, Gudlur S, Metcalf KJ, Mrksich M, Nallani M, Liedberg B. PMID: 32570704.
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PubMed Mentions: Fields:
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Cells
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Photoactivatable Reaction for Covalent Nanoscale Patterning of Multiple Proteins. ACS Appl Mater Interfaces. 2018 Nov 28; 10(47):40452-40459.
Zhou S, Metcalf KJ, Bugga P, Grant J, Mrksich M. PMID: 30379516.
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HumansAnimalsCells
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Long-Range Energy Transfer in Protein Megamolecules. J Am Chem Soc. 2018 11 21; 140(46):15731-15743.
Taylor EL, Metcalf KJ, Carlotti B, Lai CT, Modica JA, Schatz GC, Mrksich M, Goodson T. PMID: 30375862.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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An estimate is worth about a thousand experiments: using order-of-magnitude estimates to identify cellular engineering targets. Microb Cell Fact. 2018 Aug 30; 17(1):135.
Metcalf KJ, Slininger Lee MF, Jakobson CM, Tullman-Ercek D. PMID: 30165868.
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Use of Transcriptional Control to Increase Secretion of Heterologous Proteins in T3S Systems. Methods Mol Biol. 2017; 1531:71-79.
Metcalf KJ, Tullman-Ercek D. PMID: 27837482.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Proteins adopt functionally active conformations after type III secretion. Microb Cell Fact. 2016 Dec 23; 15(1):213.
Metcalf KJ, Bevington JL, Rosales SL, Burdette LA, Valdivia E, Tullman-Ercek D. PMID: 28010734.
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PubMed Mentions:
4 Fields:
Translation:
Cells
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Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor. Biotechnol J. 2016 Mar; 11(3):425-36.
Burns ML, Malott TM, Metcalf KJ, Puguh A, Chan JR, Shusta EV. PMID: 26580314.
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AnimalsCells
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Type III secretion as a generalizable strategy for the production of full-length biopolymer-forming proteins. Biotechnol Bioeng. 2016 11; 113(11):2313-20.
Azam A, Li C, Metcalf KJ, Tullman-Ercek D. PMID: 25993982.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Using transcriptional control to increase titers of secreted heterologous proteins by the type III secretion system. Appl Environ Microbiol. 2014 Oct; 80(19):5927-34.
Metcalf KJ, Finnerty C, Azam A, Valdivia E, Tullman-Ercek D. PMID: 25038096.
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PubMed Mentions:
6 Fields:
Translation:
Cells
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Directed evolution of brain-derived neurotrophic factor for improved folding and expression in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Sep; 80(18):5732-42.
Burns ML, Malott TM, Metcalf KJ, Hackel BJ, Chan JR, Shusta EV. PMID: 25015885.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells