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Krystof Bankiewicz, MD, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Address1855 Folsom Street
San Francisco CA 94103
Phone415-502-3132
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Dr. Krystof Bankiewicz holds an M.D. from Jagiellonian University in Crakow and a Ph.D., D.Sc. from the Institute of Neurology and Psychiatry in Warsaw, Poland and Professor title by the President of Republic of Poland. Dr. Bankiewicz was a recipient of Fogarty Fellowship and trained at the National Institutes of Neurological Disorders and Stroke at NIH, Bethesda, MD.
    Dr. Krystof Bankiewicz is an expert in local delivery of therapeutics to the brain as well as gene therapy and has brought multiple drug and gene therapies to the clinic. He is the Kinetics Foundation Chair in Translational Research and Professor in Residence of Neurological Surgery and Neurology at the University of California at San Francisco. Dr. Bankiewicz is also Vice Chair for Research in the Department of Neurosurgery and Director of Interventional Neurology Center at UCSF. Dr. Bankiewicz has both industry and academic experience, is an inventor on numerous patents and has published more than 180 peer-reviewed research articles. He has considerable experience in supervising multi-investigator translational programs and is a principal investigator on several multi-center, multi-investigator grants and clinical trials. He has supervised a total of 35 postdoctoral fellows and manages a core research group of 20 people, including technicians, postdoctoral fellows and senior scientists. Throughout his career, Dr. Bankiewicz has maintained a strong focus on the development of translational approaches to drug, gene and cell replacement therapies, and he has displayed the ability to synthesize distinct technologies into powerful new approaches to the treatment of serious diseases, including brain cancer, Parkinson's disease, Huntington’s disease, Alzheimer’s diseases, pediatric neurotransmitter deficiency and lysosomal storage disorders.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of a nanoparticle-based gene editing technology for neurological applications
    NIH/NINDS UG3NS115599Sep 15, 2019 - Jul 31, 2022
    Role: Principal Investigator
    A Safety and Efficacy study of AAV2-hAADC for AADC deficiency
    NIH/NINDS R01NS094292Apr 17, 2018 - Jun 30, 2020
    Role: Principal Investigator
    Translational AAV Delivery Platform to the Brain
    NIH/NINDS R01NS073940Aug 1, 2011 - Jul 31, 2016
    Role: Principal Investigator
    Preclinical development of a gene therapy for Niemann-Pick disease, type A
    NIH/NINDS R01NS056107Aug 1, 2007 - Jul 31, 2012
    Role: Principal Investigator
    Focal Dopamine Indicated in Dyskinesias in MPTP Monkeys
    NIH/NINDS R01NS050156Aug 2, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Parkinson's Disease Gene Therapy Study Group
    NIH/NINDS U54NS045309Sep 30, 2002 - Aug 31, 2009
    Role: Co-Investigator
    Enzymatic Replacement in PD Monkeys by Gene Transfer
    NIH/NINDS R21NS043707Mar 15, 2002 - Feb 29, 2004
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gene therapy for Parkinson's disease: contemporary practice and emerging concepts. Expert Rev Neurother. 2020 May 19; 1-14. Merola A, Van Laar A, Lonser R, Bankiewicz K. PMID: 32425079.
      View in: PubMed   Mentions:    Fields:    
    2. AAV viral vector delivery to the brain by shape-conforming MR-guided infusions. J Control Release. 2016 10 28; 240:434-442. Bankiewicz KS, Sudhakar V, Samaranch L, San Sebastian W, Bringas J, Forsayeth J. PMID: 26924352.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Translational fidelity of intrathecal delivery of self-complementary AAV9-survival motor neuron 1 for spinal muscular atrophy. Hum Gene Ther. 2014 Jul; 25(7):619-30. Passini MA, Bu J, Richards AM, Treleaven CM, Sullivan JA, O'Riordan CR, Scaria A, Kells AP, Samaranch L, San Sebastian W, Federici T, Fiandaca MS, Boulis NM, Bankiewicz KS, Shihabuddin LS, Cheng SH. PMID: 24617515.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    4. Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors. Nanomedicine (Lond). 2014 Jul; 9(14):2099-108. Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW. PMID: 24494810.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    5. Chronic cortical and electromyographic recordings from a fully implantable device: preclinical experience in a nonhuman primate. J Neural Eng. 2014 Feb; 11(1):016009. Ryapolova-Webb E, Afshar P, Stanslaski S, Denison T, de Hemptinne C, Bankiewicz K, Starr PA. PMID: 24445430.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    6. AAV9-mediated expression of a non-self protein in nonhuman primate central nervous system triggers widespread neuroinflammation driven by antigen-presenting cell transduction. Mol Ther. 2014 Feb; 22(2):329-337. Samaranch L, Sebastian WS, Kells AP, Salegio EA, Heller G, Bringas JR, Pivirotto P, DeArmond S, Forsayeth J, Bankiewicz KS. PMID: 24419081.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    7. Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med. 2014 Jan; 71(1):19-25. Park I, Larson PE, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. PMID: 24346964.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    8. Evaluation of doxorubicin-loaded 3-helix micelles as nanocarriers. Biomacromolecules. 2013 Oct 14; 14(10):3697-705. Dube N, Shu JY, Dong H, Seo JW, Ingham E, Kheirolomoom A, Chen PY, Forsayeth J, Bankiewicz K, Ferrara KW, Xu T. PMID: 24050265.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Adeno-associated virus type 6 is retrogradely transported in the non-human primate brain. Gene Ther. 2013 Dec; 20(12):1178-83. San Sebastian W, Samaranch L, Heller G, Kells AP, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. PMID: 24067867.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    10. Gene therapy for misfolding protein diseases of the central nervous system. Neurotherapeutics. 2013 Jul; 10(3):498-510. San Sebastian W, Samaranch L, Kells AP, Forsayeth J, Bankiewicz KS. PMID: 23700209.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    11. Automated segmentation tool for brain infusions. PLoS One. 2013; 8(6):e64452. Rosenbluth KH, Gimenez F, Kells AP, Salegio EA, Mittermeyer GM, Modera K, Kohal A, Bankiewicz KS. PMID: 23755125.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model. Cancer Gene Ther. 2013 Jun; 20(6):336-41. Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS. PMID: 23703472.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. Strong cortical and spinal cord transduction after AAV7 and AAV9 delivery into the cerebrospinal fluid of nonhuman primates. Hum Gene Ther. 2013 May; 24(5):526-32. Samaranch L, Salegio EA, San Sebastian W, Kells AP, Bringas JR, Forsayeth J, Bankiewicz KS. PMID: 23517473.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    14. Rapid inverse planning for pressure-driven drug infusions in the brain. PLoS One. 2013; 8(2):e56397. Rosenbluth KH, Martin AJ, Mittermeyer S, Eschermann J, Dickinson PJ, Bankiewicz KS. PMID: 23457563.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Advances in thin tissue Golgi-Cox impregnation: fast, reliable methods for multi-assay analyses in rodent and non-human primate brain. J Neurosci Methods. 2013 Mar 15; 213(2):214-27. Levine ND, Rademacher DJ, Collier TJ, O'Malley JA, Kells AP, San Sebastian W, Bankiewicz KS, Steece-Collier K. PMID: 23313849.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease. Pharmacol Rep. 2013; 65(1):44-9. Schwenkgrub J, Joniec-Maciejak I, Sznejder-Pacholek A, Wawer A, Ciesielska A, Bankiewicz K, Czlonkowska A, Czlonkowski A. PMID: 23563022.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Comparing routes of delivery for nanoliposomal irinotecan shows superior anti-tumor activity of local administration in treating intracranial glioblastoma xenografts. Neuro Oncol. 2013 Feb; 15(2):189-97. Chen PY, Ozawa T, Drummond DC, Kalra A, Fitzgerald JB, Kirpotin DB, Wei KC, Butowski N, Prados MD, Berger MS, Forsayeth JR, Bankiewicz K, James CD. PMID: 23262509.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    18. Cerebral infusion of AAV9 vector-encoding non-self proteins can elicit cell-mediated immune responses. Mol Ther. 2013 Jan; 21(1):158-66. Ciesielska A, Hadaczek P, Mittermeyer G, Zhou S, Wright JF, Bankiewicz KS, Forsayeth J. PMID: 22929660.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    19. Evaluation of pressure-driven brain infusions in nonhuman primates by intra-operative 7 Tesla MRI. J Magn Reson Imaging. 2012 Dec; 36(6):1339-46. Rosenbluth KH, Martin AJ, Bringas J, Bankiewicz KS. PMID: 22887937.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    20. Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Hum Gene Ther. 2012 Aug; 23(8):891-902. Salegio EA, Samaranch L, Jenkins RW, Clarke CJ, Lamarre C, Beyer J, Kells AP, Bringas J, Sebastian WS, Richardson RM, Rosenbluth KH, Hannun YA, Bankiewicz KS, Forsayeth J. PMID: 22574943.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Merits of combination cortical, subcortical, and cerebellar injections for the treatment of Niemann-Pick disease type A. Mol Ther. 2012 Oct; 20(10):1893-901. Bu J, Ashe KM, Bringas J, Marshall J, Dodge JC, Cabrera-Salazar MA, Forsayeth J, Schuchman EH, Bankiewicz KS, Cheng SH, Shihabuddin LS, Passini MA. PMID: 22828503.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    22. Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel). 2012 Jun 04; 5(6):553-90. Fiandaca MS, Bankiewicz KS, Federoff HJ. PMID: 24281662.
      View in: PubMed   Mentions:
    23. Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease. Hum Gene Ther. 2012 Apr; 23(4):377-81. Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS. PMID: 22424171.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCellsCTClinical Trials
    24. Adeno-associated virus serotype 9 transduction in the central nervous system of nonhuman primates. Hum Gene Ther. 2012 Apr; 23(4):382-9. Samaranch L, Salegio EA, San Sebastian W, Kells AP, Foust KD, Bringas JR, Lamarre C, Forsayeth J, Kaspar BK, Bankiewicz KS. PMID: 22201473.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    25. Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther. 2013 Mar; 20(3):348-52. Salegio EA, Samaranch L, Kells AP, Mittermeyer G, San Sebastian W, Zhou S, Beyer J, Forsayeth J, Bankiewicz KS. PMID: 22418061.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    26. Systemic rapamycin alone may not be a treatment option for malignant glioma: evidence from an in vivo study. J Neurooncol. 2012 May; 108(1):53-8. Mendiburu-Eliçabe M, Yin D, Hadaczek P, Zhai Y, Forsayeth J, Bankiewicz KS. PMID: 22350373.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    27. Safety and tolerability of magnetic resonance imaging-guided convection-enhanced delivery of AAV2-hAADC with a novel delivery platform in nonhuman primate striatum. Hum Gene Ther. 2012 Feb; 23(2):210-7. San Sebastian W, Richardson RM, Kells AP, Lamarre C, Bringas J, Pivirotto P, Salegio EA, Dearmond SJ, Forsayeth J, Bankiewicz KS. PMID: 22017504.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    28. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. PLoS One. 2011; 6(11):e27728. Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 22132130.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Guided delivery of adeno-associated viral vectors into the primate brain. Adv Drug Deliv Rev. 2012 May 15; 64(7):598-604. Salegio EA, Samaranch L, Kells AP, Forsayeth J, Bankiewicz K. PMID: 22036906.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Glial-derived neurotrophic factor gene transfer for Parkinson's disease: anterograde distribution of AAV2 vectors in the primate brain. Neurobiol Dis. 2012 Nov; 48(2):228-35. Kells AP, Forsayeth J, Bankiewicz KS. PMID: 22019719.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. Analysis of a simulation algorithm for direct brain drug delivery. Neuroimage. 2012 Feb 01; 59(3):2423-9. Rosenbluth KH, Eschermann JF, Mittermeyer G, Thomson R, Mittermeyer S, Bankiewicz KS. PMID: 21945468.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    32. Distribution of acid sphingomyelinase in rodent and non-human primate brain after intracerebroventricular infusion. Exp Neurol. 2011 Oct; 231(2):261-71. Ziegler RJ, Salegio EA, Dodge JC, Bringas J, Treleaven CM, Bercury SD, Tamsett TJ, Shihabuddin L, Hadaczek P, Fiandaca M, Bankiewicz K, Scheule RK. PMID: 21777586.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    33. T2 imaging in monitoring of intraparenchymal real-time convection-enhanced delivery. Neurosurgery. 2011 Jul; 69(1):154-63; discussion 163. Richardson RM, Gimenez F, Salegio EA, Su X, Bringas J, Berger MS, Bankiewicz KS. PMID: 21430597.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    34. AAV9: over the fence and into the woods . . . Mol Ther. 2011 Jun; 19(6):1006-7. Forsayeth JR, Bankiewicz KS. PMID: 21629257.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    35. An a-synuclein AAV gene silencing vector ameliorates a behavioral deficit in a rat model of Parkinson's disease, but displays toxicity in dopamine neurons. Brain Res. 2011 Jun 13; 1395:94-107. Khodr CE, Sapru MK, Pedapati J, Han Y, West NC, Kells AP, Bankiewicz KS, Bohn MC. PMID: 21565333.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    36. Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain. Stereotact Funct Neurosurg. 2011; 89(3):141-51. Richardson RM, Kells AP, Martin AJ, Larson PS, Starr PA, Piferi PG, Bates G, Tansey L, Rosenbluth KH, Bringas JR, Berger MS, Bankiewicz KS. PMID: 21494065.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    37. The use of convection-enhanced delivery with liposomal toxins in neurooncology. Toxins (Basel). 2011 04; 3(4):369-97. Fiandaca MS, Berger MS, Bankiewicz KS. PMID: 22069714.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease. Mol Ther. 2011 Jun; 19(6):1048-57. Richardson RM, Kells AP, Rosenbluth KH, Salegio EA, Fiandaca MS, Larson PS, Starr PA, Martin AJ, Lonser RR, Federoff HJ, Forsayeth JR, Bankiewicz KS. PMID: 21343917.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    39. Design of an in-dwelling cannula for convection-enhanced delivery. J Neurosci Methods. 2011 Mar 15; 196(1):118-23. Rosenbluth KH, Luz M, Mohr E, Mittermeyer S, Bringas J, Bankiewicz KS. PMID: 21187114.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    40. Human/nonhuman primate AC-PC ratio--considerations for translational brain measurements. J Neurosci Methods. 2011 Mar 15; 196(1):124-30. Fiandaca MS, Salegio EA, Yin D, Richardson RM, Valles FE, Larson PS, Starr PA, Lonser RR, Bankiewicz KS. PMID: 21185868.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    41. An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease. J Neurosci. 2010 Dec 08; 30(49):16469-74. Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X, Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz KS, Forsayeth J, Zhang HS. PMID: 21147986.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    42. Gene therapy for Parkinson's disease: where are we now and where are we going? Expert Rev Neurother. 2010 Dec; 10(12):1839-45. Forsayeth J, Bankiewicz KS, Aminoff MJ. PMID: 21091315.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Anterograde axonal transport of AAV2-GDNF in rat basal ganglia. Mol Ther. 2011 May; 19(5):922-7. Ciesielska A, Mittermeyer G, Hadaczek P, Kells AP, Forsayeth J, Bankiewicz KS. PMID: 21102559.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    44. Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease. Neurosurgery. 2010 Nov; 67(5):1377-85. Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS. PMID: 20871425.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    45. Gene therapy for Parkinson's disease: from non-human primates to humans. Curr Opin Mol Ther. 2010 Oct; 12(5):519-29. Fiandaca MS, Bankiewicz KS. PMID: 20886383.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    46. Magnetic resonance imaging-guided delivery of adeno-associated virus type 2 to the primate brain for the treatment of lysosomal storage disorders. Hum Gene Ther. 2010 Sep; 21(9):1093-103. Salegio EA, Kells AP, Richardson RM, Hadaczek P, Forsayeth J, Bringas J, Sardi SP, Passini MA, Shihabuddin LS, Cheng SH, Fiandaca MS, Bankiewicz KS. PMID: 20408734.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. Cannula placement for effective convection-enhanced delivery in the nonhuman primate thalamus and brainstem: implications for clinical delivery of therapeutics. J Neurosurg. 2010 Aug; 113(2):240-8. Yin D, Richardson RM, Fiandaca MS, Bringas J, Forsayeth J, Berger MS, Bankiewicz KS. PMID: 20367078.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    48. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. J Neurosci. 2010 Jul 14; 30(28):9567-77. Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 20631185.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    49. Real-time MR imaging with Gadoteridol predicts distribution of transgenes after convection-enhanced delivery of AAV2 vectors. Mol Ther. 2010 08; 18(8):1490-5. Su X, Kells AP, Salegio EA, Salegio EA, Richardson RM, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Forsayeth J, Bankiewicz KS. PMID: 20551915.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    50. Ultrasound-enhanced drug transport and distribution in the brain. AAPS PharmSciTech. 2010 Sep; 11(3):1005-17. Liu Y, Paliwal S, Bankiewicz KS, Bringas JR, Heart G, Mitragotri S, Prausnitz MR. PMID: 20532711.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    51. Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. Mol Ther. 2010 Aug; 18(8):1458-61. Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS. PMID: 20531394.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    52. Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells. Gene Ther. 2010 Nov; 17(11):1363-71. Kato T, Natsume A, Toda H, Iwamizu H, Sugita T, Hachisu R, Watanabe R, Yuki K, Motomura K, Bankiewicz K, Wakabayashi T. PMID: 20520650.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    53. Canine spontaneous glioma: a translational model system for convection-enhanced delivery. Neuro Oncol. 2010 Sep; 12(9):928-40. Dickinson PJ, LeCouteur RA, Higgins RJ, Bringas JR, Larson RF, Yamashita Y, Krauze MT, Forsayeth J, Noble CO, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS. PMID: 20488958.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    54. Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats. Cell Stem Cell. 2010 Mar 05; 6(3):238-50. Martínez-Cerdeño V, Noctor SC, Espinosa A, Ariza J, Parker P, Orasji S, Daadi MM, Bankiewicz K, Alvarez-Buylla A, Kriegstein AR. PMID: 20207227.
      View in: PubMed   Mentions: 46     Fields:    Translation:Animals
    55. Pharmacokinetics and bioactivity of glial cell line-derived factor (GDNF) and neurturin (NTN) infused into the rat brain. Neuropharmacology. 2010 Jun; 58(7):1114-21. Hadaczek P, Johnston L, Forsayeth J, Bankiewicz KS. PMID: 20153340.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    56. Image-guided convection-enhanced delivery of GDNF protein into monkey putamen. Neuroimage. 2011 Jan; 54 Suppl 1:S189-95. Gimenez F, Krauze MT, Valles F, Hadaczek P, Bringas J, Sharma N, Forsayeth J, Bankiewicz KS. PMID: 20080195.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    57. Optimized cannula design and placement for convection-enhanced delivery in rat striatum. J Neurosci Methods. 2010 Mar 15; 187(1):46-51. Yin D, Forsayeth J, Bankiewicz KS. PMID: 20026357.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    58. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Hum Gene Ther. 2009 Dec; 20(12):1627-40. Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19671001.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    59. Notch-induced rat and human bone marrow stromal cell grafts reduce ischemic cell loss and ameliorate behavioral deficits in chronic stroke animals. Stem Cells Dev. 2009 Dec; 18(10):1501-14. Yasuhara T, Matsukawa N, Hara K, Maki M, Ali MM, Yu SJ, Bae E, Yu G, Xu L, McGrogan M, Bankiewicz K, Case C, Borlongan CV. PMID: 19301956.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    60. Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology. 2009 Nov 17; 73(20):1662-9. Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ. PMID: 19828868.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCTClinical Trials
    61. Optimal region of the putamen for image-guided convection-enhanced delivery of therapeutics in human and non-human primates. Neuroimage. 2011 Jan; 54 Suppl 1:S196-203. Yin D, Valles FE, Fiandaca MS, Bringas J, Gimenez F, Berger MS, Forsayeth J, Bankiewicz KS. PMID: 19761848.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    62. Anatomic compression caused by high-volume convection-enhanced delivery to the brain. Neurosurgery. 2009 Sep; 65(3):579-85; discussion 585-6. Valles F, Fiandaca MS, Bringas J, Dickinson P, LeCouteur R, Higgins R, Berger M, Forsayeth J, Bankiewicz KS. PMID: 19687704.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    63. Non-PEGylated liposomes for convection-enhanced delivery of topotecan and gadodiamide in malignant glioma: initial experience. J Neurooncol. 2009 Nov; 95(2):185-197. Grahn AY, Bankiewicz KS, Dugich-Djordjevic M, Bringas JR, Hadaczek P, Johnson GA, Eastman S, Luz M. PMID: 19466380.
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    64. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):497-510. Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19203243.
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    65. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Hum Gene Ther. 2009 May; 20(5):511-8. Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. PMID: 19254173.
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    66. Future applications: gene therapy. Neurosurg Clin N Am. 2009 Apr; 20(2):205-10. Richardson RM, Varenika V, Forsayeth JR, Bankiewicz KS. PMID: 19555883.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    67. Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. Hum Gene Ther. 2009 Mar; 20(3):225-37. Hadaczek P, Forsayeth J, Mirek H, Munson K, Bringas J, Pivirotto P, McBride JL, Davidson BL, Bankiewicz KS. PMID: 19292604.
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    68. Efficient gene therapy-based method for the delivery of therapeutics to primate cortex. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2407-11. Kells AP, Hadaczek P, Yin D, Bringas J, Varenika V, Forsayeth J, Bankiewicz KS. PMID: 19193857.
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    69. Controlled dissemination of AAV vectors in the primate brain. Prog Brain Res. 2009; 175:163-72. Varenika V, Kells AP, Valles F, Hadaczek P, Forsayeth J, Bankiewicz KS. PMID: 19660655.
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    70. Convection-enhanced delivery of liposomes to primate brain. Methods Enzymol. 2009; 465:349-62. Krauze MT, Forsayeth J, Yin D, Bankiewicz KS. PMID: 19913176.
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    71. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. PMID: 19095069.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    72. Convection-enhanced delivery of polyethylene glycol-coated liposomal doxorubicin: characterization and efficacy in rat intracranial glioma models. J Neurosurg. 2008 Nov; 109(5):867-73. Kikuchi T, Saito R, Sugiyama S, Yamashita Y, Kumabe T, Krauze M, Bankiewicz K, Tominaga T. PMID: 18976076.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    73. Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. J Neurosurg. 2008 Nov; 109(5):874-80. Varenika V, Dickinson P, Bringas J, LeCouteur R, Higgins R, Park J, Fiandaca M, Berger M, Sampson J, Bankiewicz K. PMID: 18976077.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    74. Gene and cell delivery to the degenerated striatum: status of preclinical efforts in primate models. Neurosurgery. 2008 Oct; 63(4):629-442; dicussion 642-4. Richardson RM, Larson PS, Bankiewicz KS. PMID: 18981876.
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    75. Striatal volume differences between non-human and human primates. J Neurosci Methods. 2009 Jan 30; 176(2):200-5. Yin D, Valles FE, Fiandaca MS, Forsayeth J, Larson P, Starr P, Bankiewicz KS. PMID: 18809434.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    76. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Mol Ther. 2008 Oct; 16(10):1737-44. Herzog CD, Dass B, Gasmi M, Bakay R, Stansell JE, Tuszynski M, Bankiewicz K, Chen EY, Chu Y, Bishop K, Kordower JH, Bartus RT. PMID: 18728639.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    77. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Mol Ther. 2008 Aug; 16(8):1392-9. Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. PMID: 18545225.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    78. Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain. Mol Ther. 2008 Jul; 16(7):1267-75. Cunningham J, Pivirotto P, Bringas J, Suzuki B, Vijay S, Sanftner L, Kitamura M, Chan C, Bankiewicz KS. PMID: 18523450.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    79. Canine model of convection-enhanced delivery of liposomes containing CPT-11 monitored with real-time magnetic resonance imaging: laboratory investigation. J Neurosurg. 2008 May; 108(5):989-98. Dickinson PJ, LeCouteur RA, Higgins RJ, Bringas JR, Roberts B, Larson RF, Yamashita Y, Krauze M, Noble CO, Drummond D, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS. PMID: 18447717.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsPHPublic Health
    80. Results from a phase I safety trial of hAADC gene therapy for Parkinson disease. Neurology. 2008 May 20; 70(21):1980-3. Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ. PMID: 18401019.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCTClinical Trials
    81. PET 6-[F]fluoro-L-m-tyrosine Studies of Dopaminergic Function in Human and Nonhuman Primates. Front Hum Neurosci. 2007; 1:9. Eberling JL, Bankiewicz KS, O'Neil JP, Jagust WJ. PMID: 18958223.
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    82. Image-guided convection-enhanced delivery platform in the treatment of neurological diseases. Neurotherapeutics. 2008 Jan; 5(1):123-7. Fiandaca MS, Forsayeth JR, Dickinson PJ, Bankiewicz KS. PMID: 18164491.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    83. Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective. Exp Neurol. 2008 Apr; 210(2):638-44. Krauze MT, Vandenberg SR, Yamashita Y, Saito R, Forsayeth J, Noble C, Park J, Bankiewicz KS. PMID: 18295759.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    84. The immunophilin ligand GPI-1046 does not have neuroregenerative effects in MPTP-treated monkeys. Exp Neurol. 2002 Dec; 178(2):236-42. Eberling JL, Pivirotto P, Bringas J, Steiner JP, Kordower JH, Chu Y, Emborg ME, Bankiewicz KS. PMID: 12504882.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    85. Preclinical models of Parkinson's disease. Curr Protoc Neurosci. 2001 May; Chapter 9:Unit9.4. Bankiewicz KS, Sanchez-Pernaute R, Oiwa Y, Kohutnicka M, Cummins A, Eberling J. PMID: 18428552.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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