Laura Hertel, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address5700 Martin Luther King Jr Way
Oakland CA 94609
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    Collapse Biography 
    Collapse Education and Training
    University of Torino, Torino, ItalyB.Sc.07/1995Biological Sciences
    University of Torino, Torino, ItalyPh.D10/2000Immunology
    Stanford University, CaliforniaPostdoctoral Fellow9/2004Molecular Virology
    Stanford University, CaliforniaResearch Associate2/2005Molecular Virology
    Collapse Awards and Honors
    The University of Western Ontario2006  - 2007Students’ Council Award of Excellence in teaching in Microbiology and Immunology
    The University of Western Ontario2007  - 2008Students’ Council Award of Excellence in teaching in Microbiology and Immunology
    The University of Western Ontario2008  - 2009Students’ Council Award of Excellence in teaching in Microbiology and Immunology
    Stanford University2000  - 2001Stanford School of Medicine Dean’s Fellowship

    Collapse Overview 
    Collapse Overview
    My current research focuses on the interactions between human Cytomegalovirus (CMV) and specific hematopoietic and oral mucosal cell types. CMV is the source of serious disease in immunocompromised individuals including newborns, transplant recipients and AIDS patients. Our ultimate goal is to understand virus transmission, develop effective anti-CMV vaccines, and design new therapies to target CMV lytic and latent infections.

    Collapse Research 
    Collapse Research Activities and Funding
    Cytomegalovirus Tropisms for Oral Cells: Key to a Vaccine to Prevent Maternal Infection
    NIH R01AI128912Aug 17, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Mechanisms mediating HCMV genome maintenance during latency
    NIH R01AI099372Apr 15, 2013 - Nov 30, 2019
    Role: Principal Investigator
    Mechanisms mediating HCMV genome maintenance during latency
    NIH R56AI099372Sep 20, 2012 - Apr 14, 2013
    Role: Principal Investigator
    RASCAL: a new tropism determinant encoded by human cytomegalovirus?
    NIH R21AI088481Dec 3, 2010 - Nov 30, 2013
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genome sequences of human cytomegalovirus strain TB40/E variants propagated in fibroblasts and epithelial cells. Virol J. 2021 Jun 03; 18(1):112. Al Qaffas A, Camiolo S, Vo M, Aguiar A, Ourahmane A, Sorono M, Davison AJ, McVoy MA, Hertel L. PMID: 34082757.
      View in: PubMed   Mentions:    Fields:    
    2. LoReTTA, a user-friendly tool for assembling viral genomes from PacBio sequence data. Virus Evol. 2021 Jan; 7(1):veab042. Al Qaffas A, Nichols J, Davison AJ, Ourahmane A, Hertel L, McVoy MA, Camiolo S. PMID: 33996146.
      View in: PubMed   Mentions:
    3. Cytomegalovirus Strain TB40/E Restrictions and Adaptations to Growth in ARPE-19 Epithelial Cells. Microorganisms. 2020 Apr 24; 8(4). Vo M, Aguiar A, McVoy MA, Hertel L. PMID: 32344555.
      View in: PubMed   Mentions:
    4. Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies. Microbiol Resour Announc. 2020 Apr 23; 9(17). Al Qaffas A, Camiolo S, Nichols J, Davison AJ, Ourahmane A, Cui X, Schleiss MR, Hertel L, Dittmer DP, McVoy MA. PMID: 32327516.
      View in: PubMed   Mentions:
    5. Comparative neutralizing potencies of antibodies suggest conservation as well as mechanistic differences in human cytomegalovirus entry into epithelial and endothelial cells. Virol J. 2020 04 08; 17(1):50. Qi Y, He L, Cui X, Hertel L, Freed DC, Fu TM, Kauvar LM, McVoy MA, Ruan Q. PMID: 32268919.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Single-Cell Transcriptome Analysis of CD34+ Stem Cell-Derived Myeloid Cells Infected With Human Cytomegalovirus. Front Microbiol. 2019; 10:577. Galinato M, Shimoda K, Aguiar A, Hennig F, Boffelli D, McVoy MA, Hertel L. PMID: 30949159.
      View in: PubMed   Mentions:
    7. Inclusion of Antibodies to Cell Culture Media Preserves the Integrity of Genes Encoding RL13 and the Pentameric Complex Components During Fibroblast Passage of Human Cytomegalovirus. Viruses. 2019 03 05; 11(3). Ourahmane A, Cui X, He L, Catron M, Dittmer DP, Al Qaffasaa A, Schleiss MR, Hertel L, McVoy MA. PMID: 30841507.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    8. Activation of Langerhans-Type Dendritic Cells Alters Human Cytomegalovirus Infection and Reactivation in a Stimulus-Dependent Manner. Front Microbiol. 2016; 7:1445. Coronel R, Jesus DM, Dalle Ore L, Mymryk JS, Hertel L. PMID: 27683575.
      View in: PubMed   Mentions:
    9. Dynamics of Human Cytomegalovirus Infection in CD34+ Hematopoietic Cells and Derived Langerhans-Type Dendritic Cells. J Virol. 2015 May; 89(10):5615-32. Coronel R, Takayama S, Juwono T, Hertel L. PMID: 25762731.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. Human cytomegalovirus tropism for mucosal myeloid dendritic cells. Rev Med Virol. 2014 Nov; 24(6):379-95. Hertel L. PMID: 24888709.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Human cytomegalovirus infection of langerhans-type dendritic cells does not require the presence of the gH/gL/UL128-131A complex and is blocked after nuclear deposition of viral genomes in immature cells. J Virol. 2014 Jan; 88(1):403-16. Lauron EJ, Yu D, Fehr AR, Hertel L. PMID: 24155395.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    12. Herpesviruses and intermediate filaments: close encounters with the third type. Viruses. 2011 07; 3(7):1015-40. Hertel L. PMID: 21994768.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels. Mol Immunol. 2011 May; 48(9-10):1160-7. Lee AW, Wang N, Hornell TM, Harding JJ, Deshpande C, Hertel L, Lacaille V, Pashine A, Macaubas C, Mocarski ES, Mellins ED. PMID: 21458073.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    14. RASCAL is a new human cytomegalovirus-encoded protein that localizes to the nuclear lamina and in cytoplasmic vesicles at late times postinfection. J Virol. 2010 Jul; 84(13):6483-96. Miller MS, Furlong WE, Pennell L, Geadah M, Hertel L. PMID: 20392852.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton. J Virol. 2009 Jul; 83(14):7015-28. Miller MS, Hertel L. PMID: 19403668.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis. J Gen Virol. 2009 May; 90(Pt 5):1172-1182. Mandic L, Miller MS, Coulter C, Munshaw B, Hertel L. PMID: 19264602.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness. J Virol. 2009 Mar; 83(6):2728-42. Jagannathan P, Osborne CM, Royce C, Manion MM, Tilton JC, Li L, Fischer S, Hallahan CW, Metcalf JA, McLaughlin M, Pipeling M, McDyer JF, Manley TJ, Meier JL, Altman JD, Hertel L, Davey RT, Connors M, Migueles SA. PMID: 19129459.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    18. Viral and cell cycle-regulated kinases in cytomegalovirus-induced pseudomitosis and replication. PLoS Pathog. 2007 Jan; 3(1):e6. Hertel L, Chou S, Mocarski ES. PMID: 17206862.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    19. Human cytomegalovirus alters localization of MHC class II and dendrite morphology in mature Langerhans cells. J Immunol. 2006 Sep 15; 177(6):3960-71. Lee AW, Hertel L, Louie RK, Burster T, Lacaille V, Pashine A, Abate DA, Mocarski ES, Mellins ED. PMID: 16951359.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    20. Dynamics of recurrent viral infection. Proc Biol Sci. 2006 Sep 07; 273(1598):2193-9. Yao W, Hertel L, Wahl LM. PMID: 16901839.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    21. Global analysis of host cell gene expression late during cytomegalovirus infection reveals extensive dysregulation of cell cycle gene expression and induction of Pseudomitosis independent of US28 function. J Virol. 2004 Nov; 78(21):11988-2011. Hertel L, Mocarski ES. PMID: 15479839.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    22. Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus. J Virol. 2003 Jul; 77(13):7563-74. Hertel L, Lacaille VG, Strobl H, Mellins ED, Mocarski ES. PMID: 12805456.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    23. The interferon-inducible 204 gene is transcriptionally activated by mouse cytomegalovirus and is required for its replication. Virology. 2001 Aug 01; 286(2):249-55. Rolle S, De Andrea M, Gioia D, Lembo D, Hertel L, Landolfo S, Gariglio M. PMID: 11485393.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    24. The retinoblastoma protein is an essential mediator that links the interferon-inducible 204 gene to cell-cycle regulation. Oncogene. 2000 Jul 27; 19(32):3598-608. Hertel L, Rolle S, De Andrea M, Azzimonti B, Osello R, Gribaudo G, Gariglio M, Landolfo S. PMID: 10951565.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. The interferon-inducible 204 gene, a member of the Ifi 200 family, is not involved in the antiviral state induction by IFN-alpha, but is required by the mouse cytomegalovirus for its replication. Virology. 1999 Sep 15; 262(1):1-8. Hertel L, De Andrea M, Azzimonti B, Rolle A, Gariglio M, Landolfo S. PMID: 10489335.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry. J Med Virol. 1999 Sep; 59(1):110-6. Azzimonti B, Hertel L, Aluffi P, Pia F, Monga G, Zocchi M, Landolfo S, Gariglio M. PMID: 10440817.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. The HMG protein T160 colocalizes with DNA replication foci and is down-regulated during cell differentiation. Exp Cell Res. 1999 Aug 01; 250(2):313-28. Hertel L, De Andrea M, Bellomo G, Santoro P, Landolfo S, Gariglio M. PMID: 10413586.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. In vitro and in vivo expression analysis of the interferon-inducible 203 gene. J Interferon Cytokine Res. 1999 Feb; 19(2):129-36. Gribaudo G, Riera L, Hertel L, Landolfo S. PMID: 10090398.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    29. Human cytomegalovirus stimulates cellular dihydrofolate reductase activity in quiescent cells. Intervirology. 1999; 42(1):30-6. Lembo D, Gribaudo G, Cavallo R, Riera L, Angeretti A, Hertel L, Landolfo S. PMID: 10393501.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    30. Overexpression of cellular dihydrofolate reductase abolishes the anticytomegaloviral activity of methotrexate. Arch Virol. 1999; 144(7):1397-403. Lembo D, Cavallo R, Cornaglia M, Mondo A, Hertel L, Angeretti A, Landolfo S. PMID: 10481745.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    31. Decreased expression of the high-mobility group protein T160 by antisense RNA impairs the growth of mouse fibroblasts. Biochimie. 1997 Dec; 79(12):717-23. Hertel L, Foresta P, Barbiero G, Ying GG, Bonelli G, Baccino FM, Landolfo S, Gariglio M. PMID: 9523013.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    32. The high-mobility group protein T160 binds to both linear and cruciform DNA and mediates DNA bending as determined by ring closure. Exp Cell Res. 1997 Nov 01; 236(2):472-81. Gariglio M, Ying GG, Hertel L, Gaboli M, Clerc RG, Landolfo S. PMID: 9367632.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. Suppression of high mobility group protein T160 expression impairs mouse cytomegalovirus replication. J Gen Virol. 1997 Mar; 78 ( Pt 3):665-70. Gariglio M, Foresta P, Sacchi C, Lembo M, Hertel L, Landolfo S. PMID: 9049420.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    34. Constitutive expression of the interferon-inducible protein p202 in NIH 3T3 cells affects cell cycle progression. J Biol Regul Homeost Agents. 1995 Apr-Jun; 9(2):42-6. Lembo D, Angeretti A, Benefazio S, Hertel L, Gariglio M, Novelli F, Landolfo S. PMID: 9127631.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
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