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Laura Koth

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-514-4369
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityM.D.1994School of Medicine

    Collapse Overview 
    Collapse Overview
    Laura Koth received a B.S. degree from the University of California, Los Angeles in Biochemistry and an M.D. degree from Harvard Medical School in 1994. She completed her Internal Residency training at Massachusetts General Hospital in Boston, Massachusetts and her Pulmonary/Critical Care fellowship at the University of California, San Francisco. She joined the UCSF Pulmonary faculty in 2003.

    Her research activities focus on the immunologic mechanisms of lung inflammation and macrophage activation. Her clinical interest is Granulomatous Interstitial Lung Diseases and she is the Director of the Granulomatous Interstitial Lung Disease Research Program at UCSF. Dr. Koth started the Sarcoidosis Research Program in 2010, and oversees a longitudinal cohort of patients with sarcoidosis and unaffected volunteers.

    Dr. Koth is the Principal Investigator of the West Coast site of the NIH-funded GRADS (GENOMIC RESEARCH IN ALPHA 1 ANTITRYPSIN DEFICIENCY AND SARCOIDOSIS) study which should begin enrollment in 2013 and its goal is to study the role of infection in sarcoidosis and A1AT. If you wish to learn more or participate, please contact us at 415-476-5896. You can also visit our web site at http://sarcoidosis.ucsf.edu.


    Collapse Research 
    Collapse Research Activities and Funding
    Interferon gamma-Producing Th17 Subsets: Major Contributors to Th1 Diseases
    NIH/NIAID R03AI122131Jun 13, 2016 - May 31, 2018
    Role: Principal Investigator
    GLILD in CVID
    NIH/NIAID R34AI106570Jul 10, 2014 - Jun 30, 2015
    Role: Co-Principal Investigator
    Genomic Phenotyping and Mechanisms in sarcoidosis and AAT
    NIH/NHLBI U01HL112696May 1, 2012 - Apr 30, 2015
    Role: Principal Investigator
    Immunophenotyping and Lymphocyte Effector Functions in Sarcoidosis
    NIH/NIAID R56AI087652Aug 27, 2010 - Jul 31, 2012
    Role: Principal Investigator
    Effector function of natural killer T (NKT) cells in sarcoidosis
    NIH/NIAID R03AI079340Apr 15, 2009 - Mar 31, 2011
    Role: Principal Investigator
    MCP-1 and TGFb in Macrophage Activation and Emphysema
    NIH/NHLBI K08HL072915May 5, 2003 - Apr 30, 2009
    Role: Principal Investigator

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    Collapse Clinical Trials
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Benn BS, Lehman Z, Kidd SA, Ho M, Sun S, Ramstein J, Arger NK, Nguyen CP, Su R, Gomez A, Gelfand JM, Koth L. Clinical and Biological Insights from the University of California San Francisco Prospective and Longitudinal Cohort. Lung. 2017 Jul 13. PMID: 28707108.
      View in: PubMed
    2. Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth L. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 Jun 1; 193(11):1281-91. PMID: 26649486.
      View in: PubMed
    3. Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth L, Lee JS, Ley B, Wolters PJ, Collard HR, et al. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax. 2016 May 31. PMID: 27245779.
      View in: PubMed
    4. Moller DR, Koth L, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 2015 Oct; 12(10):1561-71. PMID: 26193069; PMCID: PMC4627423 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    5. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth L, Shum AK, Wolters PJ, Collard HR, Lee JS. Survival in interstitial pneumonia with features of autoimmune disease: A comparison of proposed criteria. Respir Med. 2015 Oct; 109(10):1326-31. PMID: 26303338.
      View in: PubMed
    6. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth L, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug; 109(8):1058-62. PMID: 26140806; PMCID: PMC4522344 [Available on 08/01/16].
      View in: PubMed, PubMed Central
    7. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015 Jun; 147(6):1558-65. PMID: 25412059; PMCID: PMC4451710 [Available on 06/01/16].
      View in: PubMed, PubMed Central
    8. Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth L. Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Eur Respir J. 2014 Oct; 44(4):985-93. PMID: 25142485.
      View in: PubMed
    9. Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW. The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014; 31(1):19-27. PMID: 24751450.
      View in: PubMed
    10. Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth L, King TE, Collard HR. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014 Apr; 145(4):723-8. PMID: 24114524.
      View in: PubMed
    11. Mooney JJ, Koth L. Surgical lung biopsy over bronchoalveolar lavage in chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2014 Feb 1; 189(3):371-2. PMID: 24484347.
      View in: PubMed
    12. Su R, Nguyen ML, Agarwal MR, Kirby C, Nguyen CP, Ramstein J, Darnell EP, Gomez AD, Ho M, Woodruff PG, Koth L. Interferon-inducible chemokines reflect severity and progression in sarcoidosis. Respir Res. 2013; 14:121. PMID: 24199653; PMCID: PMC4176097.
      View in: PubMed, PubMed Central
    13. Snyder-Cappione JE, Nixon DF, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth L. Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis. Eur J Immunol. 2013 Aug; 43(8):2194-205. PMID: 23661497; PMCID: PMC3869389.
      View in: PubMed, PubMed Central
    14. Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth L, King TE, Wolters PJ, Collard HR. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J. 2013 Sep; 42(3):750-7. PMID: 23222877.
      View in: PubMed
    15. Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth L, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR. Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis. Thorax. 2012 May; 67(5):407-11. PMID: 22426899.
      View in: PubMed
    16. Koth L, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63. PMID: 21852540; PMCID: PMC3262024.
      View in: PubMed, PubMed Central
    17. Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth L, Nixon DF. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-a and MIP1-ß, a lack of IL-17, and a Th1-bias in males. PLoS One. 2010; 5(11):e15412. PMID: 21082024; PMCID: PMC2972714.
      View in: PubMed, PubMed Central
    18. Koth L, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol. 2010 Jun 1; 184(11):6522-8. PMID: 20421649; PMCID: PMC4091814.
      View in: PubMed, PubMed Central
    19. Kinder BW, Shariat C, Collard HR, Koth L, Wolters PJ, Golden JA, Panos RJ, King TE. Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. Lung. 2010 Apr; 188(2):143-9. PMID: 20069430; PMCID: PMC2837880.
      View in: PubMed, PubMed Central
    20. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth L, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):388-95. PMID: 19483109; PMCID: PMC2742757.
      View in: PubMed, PubMed Central
    21. Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth L. Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice. COPD. 2009 Apr; 6(2):86-94. PMID: 19378221; PMCID: PMC2873864.
      View in: PubMed, PubMed Central
    22. Koth L, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. PMID: 17641300; PMCID: PMC2219547.
      View in: PubMed, PubMed Central
    23. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Am J Respir Crit Care Med. 2007 Oct 1; 176(7):691-7. PMID: 17556720; PMCID: PMC1994238.
      View in: PubMed, PubMed Central
    24. Woodruff PG, Koth L, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec 1; 172(11):1383-92. PMID: 16166618; PMCID: PMC2718436.
      View in: PubMed, PubMed Central
    25. Marras TK, Wallace RJ, Koth L, Stulbarg MS, Cowl CT, Daley CL. Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water. Chest. 2005 Feb; 127(2):664-71. PMID: 15706013.
      View in: PubMed
    26. Koth L, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ. Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respir Res. 2004; 5:12. PMID: 15377395; PMCID: PMC520828.
      View in: PubMed, PubMed Central
    27. Barczak A, Rodriguez MW, Hanspers K, Koth L, Tai YC, Bolstad BM, Speed TP, Erle DJ. Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res. 2003 Jul; 13(7):1775-85. PMID: 12805270; PMCID: PMC403751.
      View in: PubMed, PubMed Central
    28. Gotway MB, Golden JA, Warnock M, Koth L, Webb R, Reddy GP, Balmes JR. Hard metal interstitial lung disease: high-resolution computed tomography appearance. J Thorac Imaging. 2002 Oct; 17(4):314-8. PMID: 12362071.
      View in: PubMed
    29. Kuperman DA, Huang X, Koth L, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9. PMID: 12091879.
      View in: PubMed
    30. Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A. Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression. Chest. 2002 Mar; 121(3 Suppl):80S. PMID: 11893700.
      View in: PubMed
    31. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85. PMID: 11694453.
      View in: PubMed
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