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Laura Koth

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-514-4369
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityM.D.1994School of Medicine

    Collapse Overview 
    Collapse Overview
    Laura Koth received a B.S. degree from the University of California, Los Angeles in Biochemistry and an M.D. degree from Harvard Medical School in 1994. She completed her Internal Residency training at Massachusetts General Hospital in Boston, Massachusetts and her Pulmonary/Critical Care fellowship at the University of California, San Francisco. She joined the UCSF Pulmonary faculty in 2003.

    Her research activities focus on the immunologic mechanisms of lung inflammation and macrophage activation. Her clinical interest is Granulomatous Interstitial Lung Diseases and she is the Director of the Granulomatous Interstitial Lung Disease Research Program at UCSF. Dr. Koth started the Sarcoidosis Research Program in 2010, and oversees a longitudinal cohort of patients with sarcoidosis and unaffected volunteers.

    Dr. Koth is the Principal Investigator of the West Coast site of the NIH-funded GRADS (GENOMIC RESEARCH IN ALPHA 1 ANTITRYPSIN DEFICIENCY AND SARCOIDOSIS) study which should begin enrollment in 2013 and its goal is to study the role of infection in sarcoidosis and A1AT. If you wish to learn more or participate, please contact us at 415-476-5896. You can also visit our web site at http://sarcoidosis.ucsf.edu.

    Collapse Research 
    Collapse Research Activities and Funding
    A Prospective Study of T cell Immune-phenotype and Disease Outcome in Pulmonary Sarcoidosis
    NIH/NHLBI R01HL136681Apr 15, 2018 - Feb 28, 2022
    Role: Co-Principal Investigator
    Interferon gamma-Producing Th17 Subsets: Major Contributors to Th1 Diseases
    NIH/NIAID R03AI122131Jun 13, 2016 - May 31, 2018
    Role: Principal Investigator
    GLILD in CVID
    NIH/NIAID R34AI106570Jul 10, 2014 - Jun 30, 2015
    Role: Co-Principal Investigator
    Genomic Phenotyping and Mechanisms in sarcoidosis and AAT
    NIH/NHLBI U01HL112696May 1, 2012 - Apr 30, 2015
    Role: Principal Investigator
    Immunophenotyping and Lymphocyte Effector Functions in Sarcoidosis
    NIH/NIAID R56AI087652Aug 27, 2010 - Jul 31, 2012
    Role: Principal Investigator
    Effector function of natural killer T (NKT) cells in sarcoidosis
    NIH/NIAID R03AI079340Apr 15, 2009 - Mar 31, 2011
    Role: Principal Investigator
    MCP-1 and TGFb in Macrophage Activation and Emphysema
    NIH/NHLBI K08HL072915May 5, 2003 - Apr 30, 2009
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Arger NK, Ho ME, Allen IE, Benn BS, Woodruff PG, Koth LL. CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis. Respir Med. 2019 Nov 20; 161:105822. PMID: 31783271.
      View in: PubMed
    2. Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V. Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis. J Am Heart Assoc. 2019 Sep 17; 8(18):e010952. PMID: 31538835.
      View in: PubMed
    3. Arger NK, Ho M, Woodruff PG, Koth LL. Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis. Respir Med. 2019 Jun; 152:89-96. PMID: 31128616.
      View in: PubMed
    4. Gu BH, Choi JC, Shen YH, Song LZ, Scheurer ME, Luong A, Rodriguez A, Woodruff P, Koth L, Corry DB, Kheradmand F, LeMaire SA. Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2019 Apr 16; 8(8):e011671. PMID: 30957625.
      View in: PubMed
    5. Santhosh L, Koth L, Baudendistel TE, Sharpe B, Monash B. Tissue Isn't the Issue. J Hosp Med. 2018 07 01; 13(7):500-504. PMID: 29694457.
      View in: PubMed
    6. Gelfand JM, Gelfand AA, Goadsby PJ, Benn BS, Koth LL. Migraine is common in patients with sarcoidosis. Cephalalgia. 2018 12; 38(14):2079-2082. PMID: 29580067.
      View in: PubMed
    7. Benn BS, Lehman Z, Kidd SA, Miaskowski C, Sunwoo BY, Ho M, Sun S, Ramstein J, Gelfand JM, Koth LL. Sleep disturbance and symptom burden in sarcoidosis. Respir Med. 2018 11; 144S:S35-S40. PMID: 29628134.
      View in: PubMed
    8. Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M. Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes. Eur Respir J. 2018 03; 51(3). PMID: 29449421.
      View in: PubMed
    9. Gerke AK, Judson MA, Cozier YC, Culver DA, Koth LL. Disease Burden and Variability in Sarcoidosis. Ann Am Thorac Soc. 2017 Dec; 14(Supplement_6):S421-S428. PMID: 29087725.
      View in: PubMed
    10. Gelfand JM, Bradshaw MJ, Stern BJ, Clifford DB, Wang Y, Cho TA, Koth LL, Hauser SL, Dierkhising J, Vu N, Sriram S, Moses H, Bagnato F, Kaufmann JA, Ammah DJ, Yohannes TH, Hamblin MJ, Venna N, Green AJ, Pawate S. Infliximab for the treatment of CNS sarcoidosis: A multi-institutional series. Neurology. 2017 Nov 14; 89(20):2092-2100. PMID: 29030454.
      View in: PubMed
    11. Benn BS, Lehman Z, Kidd SA, Ho M, Sun S, Ramstein J, Arger NK, Nguyen CP, Su R, Gomez A, Gelfand JM, Koth LL. Clinical and Biological Insights from the University of California San Francisco Prospective and Longitudinal Cohort. Lung. 2017 Oct; 195(5):553-561. PMID: 28707108.
      View in: PubMed
    12. Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL. Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis. Chest. 2017 09; 152(3):502-509. PMID: 28223152.
      View in: PubMed
    13. Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 06 01; 193(11):1281-91. PMID: 26649486.
      View in: PubMed
    14. Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Wolters PJ, Collard HR. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax. 2016 10; 71(10):951-4. PMID: 27245779.
      View in: PubMed
    15. Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 2015 Oct; 12(10):1561-71. PMID: 26193069.
      View in: PubMed
    16. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS. Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria. Respir Med. 2015 Oct; 109(10):1326-31. PMID: 26303338.
      View in: PubMed
    17. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug; 109(8):1058-62. PMID: 26140806.
      View in: PubMed
    18. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015 Jun; 147(6):1558-1565. PMID: 25412059.
      View in: PubMed
    19. Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL. Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Eur Respir J. 2014 Oct; 44(4):985-93. PMID: 25142485.
      View in: PubMed
    20. Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW. The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014 Apr 18; 31(1):19-27. PMID: 24751450.
      View in: PubMed
    21. Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE, Collard HR. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014 Apr; 145(4):723-728. PMID: 24114524.
      View in: PubMed
    22. Mooney JJ, Koth LL. Surgical lung biopsy over bronchoalveolar lavage in chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):371-2. PMID: 24484347.
      View in: PubMed
    23. Su R, Nguyen ML, Agarwal MR, Kirby C, Nguyen CP, Ramstein J, Darnell EP, Gomez AD, Ho M, Woodruff PG, Koth LL. Interferon-inducible chemokines reflect severity and progression in sarcoidosis. Respir Res. 2013 Nov 07; 14:121. PMID: 24199653.
      View in: PubMed
    24. Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen MLT, Woodruff PG, Jones KD, Collard HR, King TE, Koth LL. Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis. Chest. 2013 Aug; 144(2):586-592. PMID: 23392130.
      View in: PubMed
    25. Snyder-Cappione JE, Nixon DF, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth LL. Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis. Eur J Immunol. 2013 Aug; 43(8):2194-205. PMID: 23661497.
      View in: PubMed
    26. Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE, Wolters PJ, Collard HR. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J. 2013 Sep; 42(3):750-7. PMID: 23222877.
      View in: PubMed
    27. Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR. Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis. Thorax. 2012 May; 67(5):407-11. PMID: 22426899.
      View in: PubMed
    28. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63. PMID: 21852540.
      View in: PubMed
    29. Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-a and MIP1-ß, a lack of IL-17, and a Th1-bias in males. PLoS One. 2010 Nov 03; 5(11):e15412. PMID: 21082024.
      View in: PubMed
    30. Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol. 2010 Jun 01; 184(11):6522-8. PMID: 20421649.
      View in: PubMed
    31. Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE. Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. Lung. 2010 Apr; 188(2):143-9. PMID: 20069430.
      View in: PubMed
    32. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009 Sep 01; 180(5):388-95. PMID: 19483109.
      View in: PubMed
    33. Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL. Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice. COPD. 2009 Apr; 6(2):86-94. PMID: 19378221.
      View in: PubMed
    34. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. PMID: 17641300.
      View in: PubMed
    35. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Am J Respir Crit Care Med. 2007 Oct 01; 176(7):691-7. PMID: 17556720.
      View in: PubMed
    36. Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec 01; 172(11):1383-92. PMID: 16166618.
      View in: PubMed
    37. Marras TK, Wallace RJ, Koth LL, Stulbarg MS, Cowl CT, Daley CL. Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water. Chest. 2005 Feb; 127(2):664-71. PMID: 15706013.
      View in: PubMed
    38. Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ. Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respir Res. 2004 Sep 15; 5:12. PMID: 15377395.
      View in: PubMed
    39. Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ. Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res. 2003 Jul; 13(7):1775-85. PMID: 12805270.
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    40. Gotway MB, Golden JA, Warnock M, Koth LL, Webb R, Reddy GP, Balmes JR. Hard metal interstitial lung disease: high-resolution computed tomography appearance. J Thorac Imaging. 2002 Oct; 17(4):314-8. PMID: 12362071.
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    41. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9. PMID: 12091879.
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    42. Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A. Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression. Chest. 2002 Mar; 121(3 Suppl):80S. PMID: 11893700.
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    43. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85. PMID: 11694453.
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