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Laura Koth

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address505 Parnassus Avenue
San Francisco CA 94117
Phone415-514-4369
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    Collapse Biography 
    Collapse Education and Training
    Harvard University, Boston, MAM.D.06/1994Medicine
    UCLA, Los Angeles, CAB.S.06/1990Biochemistry
    UCSF, San Francisco, CAM.A.06/2021Data Science
    UCSF, San Francisco10/2020Diversity, Equity, and Inclusion Champion Training
    Collapse Awards and Honors
    UCSF2015  - 2021Robert L. Kroc Chair in Rheumatic and Connective Tissue Diseases IV

    Collapse Overview 
    Collapse Overview
    Laura Koth received a B.S. degree from the University of California, Los Angeles in Biochemistry and an M.D. degree from Harvard Medical School in 1994. She completed her Internal Residency training at Massachusetts General Hospital in Boston, Massachusetts and her Pulmonary/Critical Care fellowship at the University of California, San Francisco. She joined the UCSF Pulmonary faculty in 2003. She is completing a Master's Degree in Data Science in 2021.

    Her research activities focus on the immunologic mechanisms of lung inflammation and macrophage activation. Her clinical interest is Granulomatous Interstitial Lung Diseases and she launched the first research program focused on sarcoidosis in 2010.

    She currently serves as Principle Investigator for a number of studies and research cohorts.

    Collapse Research 
    Collapse Research Activities and Funding
    A Prospective Study of T cell Immune-phenotype and Disease Outcome in Pulmonary Sarcoidosis
    NIH R01HL136681Apr 15, 2018 - Feb 28, 2022
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
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    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Molecular profiling in sarcoidosis. Curr Opin Pulm Med. 2020 09; 26(5):562-567. Arger NK, O'Connor B, Koth LL. PMID: 32701678.
      View in: PubMed   Mentions:    Fields:    
    2. T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis. Front Immunol. 2020; 11:1129. Arger NK, Machiraju S, Allen IE, Woodruff PG, Koth LL. PMID: 32774332.
      View in: PubMed   Mentions:    Fields:    
    3. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 04 15; 201(8):e26-e51. Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau AS, Patterson KC, Abston E, Bernstein RC, Blankstein R, Chen ES, Culver DA, Drake W, Drent M, Gerke AK, Ghobrial M, Govender P, Hamzeh N, James WE, Judson MA, Kellermeyer L, Knight S, Koth LL, Poletti V, Raman SV, Tukey MH, Westney GE, Baughman RP. PMID: 32293205.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    4. CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis. Respir Med. 2020 01; 161:105822. Arger NK, Ho ME, Allen IE, Benn BS, Woodruff PG, Koth LL. PMID: 31783271.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis. J Am Heart Assoc. 2019 09 17; 8(18):e010952. Rosenthal DG, Parwani P, Murray TO, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth LL, Pampaloni MH, Zikherman J, Vedantham V. PMID: 31538835.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis. Respir Med. 2019 06; 152:89-96. Arger NK, Ho M, Woodruff PG, Koth LL. PMID: 31128616.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. Elastin-Specific Autoimmunity in Smokers With Thoracic Aortic Aneurysm and Dissection is Independent of Chronic Obstructive Pulmonary Disease. J Am Heart Assoc. 2019 04 16; 8(8):e011671. Gu BH, Choi JC, Shen YH, Song LZ, Scheurer ME, Luong A, Rodriguez A, Woodruff P, Koth L, Corry DB, Kheradmand F, LeMaire SA. PMID: 30957625.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. Tissue Isn't the Issue. J Hosp Med. 2018 07 01; 13(7):500-504. Santhosh L, Koth L, Baudendistel TE, Sharpe B, Monash B. PMID: 29694457.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Migraine is common in patients with sarcoidosis. Cephalalgia. 2018 12; 38(14):2079-2082. Gelfand JM, Gelfand AA, Goadsby PJ, Benn BS, Koth LL. PMID: 29580067.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Sleep disturbance and symptom burden in sarcoidosis. Respir Med. 2018 11; 144S:S35-S40. Benn BS, Lehman Z, Kidd SA, Miaskowski C, Sunwoo BY, Ho M, Sun S, Ramstein J, Gelfand JM, Koth LL. PMID: 29628134.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Increased T-helper 17.1 cells in sarcoidosis mediastinal lymph nodes. Eur Respir J. 2018 03; 51(3). Broos CE, Koth LL, van Nimwegen M, In 't Veen JCCM, Paulissen SMJ, van Hamburg JP, Annema JT, Heller-Baan R, Kleinjan A, Hoogsteden HC, Wijsenbeek MS, Hendriks RW, van den Blink B, Kool M. PMID: 29449421.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    12. Disease Burden and Variability in Sarcoidosis. Ann Am Thorac Soc. 2017 Dec; 14(Supplement_6):S421-S428. Gerke AK, Judson MA, Cozier YC, Culver DA, Koth LL. PMID: 29087725.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    13. Infliximab for the treatment of CNS sarcoidosis: A multi-institutional series. Neurology. 2017 Nov 14; 89(20):2092-2100. Gelfand JM, Bradshaw MJ, Stern BJ, Clifford DB, Wang Y, Cho TA, Koth LL, Hauser SL, Dierkhising J, Vu N, Sriram S, Moses H, Bagnato F, Kaufmann JA, Ammah DJ, Yohannes TH, Hamblin MJ, Venna N, Green AJ, Pawate S. PMID: 29030454.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    14. Clinical and Biological Insights from the University of California San Francisco Prospective and Longitudinal Cohort. Lung. 2017 Oct; 195(5):553-561. Benn BS, Lehman Z, Kidd SA, Ho M, Sun S, Ramstein J, Arger NK, Nguyen CP, Su R, Gomez A, Gelfand JM, Koth LL. PMID: 28707108.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis. Chest. 2017 09; 152(3):502-509. Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL. PMID: 28223152.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    16. IFN-?-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells. Am J Respir Crit Care Med. 2016 06 01; 193(11):1281-91. Ramstein J, Broos CE, Simpson LJ, Ansel KM, Sun SA, Ho ME, Woodruff PG, Bhakta NR, Christian L, Nguyen CP, Antalek BJ, Benn BS, Hendriks RW, van den Blink B, Kool M, Koth LL. PMID: 26649486.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    17. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax. 2016 10; 71(10):951-4. Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Wolters PJ, Collard HR. PMID: 27245779.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc. 2015 Oct; 12(10):1561-71. Moller DR, Koth LL, Maier LA, Morris A, Drake W, Rossman M, Leader JK, Collman RG, Hamzeh N, Sweiss NJ, Zhang Y, O'Neal S, Senior RM, Becich M, Hochheiser HS, Kaminski N, Wisniewski SR, Gibson KF, . PMID: 26193069.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    19. Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria. Respir Med. 2015 Oct; 109(10):1326-31. Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS. PMID: 26303338.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug; 109(8):1058-62. Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR. PMID: 26140806.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Lung transplantation for hypersensitivity pneumonitis. Chest. 2015 Jun; 147(6):1558-1565. Kern RM, Singer JP, Koth L, Mooney J, Golden J, Hays S, Greenland J, Wolters P, Ghio E, Jones KD, Leard L, Kukreja J, Blanc PD. PMID: 25412059.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes. Eur Respir J. 2014 Oct; 44(4):985-93. Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL. PMID: 25142485.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    23. The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014 Apr 18; 31(1):19-27. Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shijubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW. PMID: 24751450.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    24. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014 Apr; 145(4):723-728. Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, Elicker BM, Wolters PJ, Koth LL, King TE, Collard HR. PMID: 24114524.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    25. Surgical lung biopsy over bronchoalveolar lavage in chronic hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):371-2. Mooney JJ, Koth LL. PMID: 24484347.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Interferon-inducible chemokines reflect severity and progression in sarcoidosis. Respir Res. 2013 Nov 07; 14:121. Su R, Nguyen ML, Agarwal MR, Kirby C, Nguyen CP, Ramstein J, Darnell EP, Gomez AD, Ho M, Woodruff PG, Koth LL. PMID: 24199653.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    27. Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis. Chest. 2013 Aug; 144(2):586-592. Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen MLT, Woodruff PG, Jones KD, Collard HR, King TE, Koth LL. PMID: 23392130.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    28. Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis. Eur J Immunol. 2013 Aug; 43(8):2194-205. Snyder-Cappione JE, Nixon DF, Chi JC, Nguyen ML, Kirby CK, Milush JM, Koth LL. PMID: 23661497.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Prevalence and prognosis of unclassifiable interstitial lung disease. Eur Respir J. 2013 Sep; 42(3):750-7. Ryerson CJ, Urbania TH, Richeldi L, Mooney JJ, Lee JS, Jones KD, Elicker BM, Koth LL, King TE, Wolters PJ, Collard HR. PMID: 23222877.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    30. Relative versus absolute change in forced vital capacity in idiopathic pulmonary fibrosis. Thorax. 2012 May; 67(5):407-11. Richeldi L, Ryerson CJ, Lee JS, Wolters PJ, Koth LL, Ley B, Elicker BM, Jones KD, King TE, Ryu JH, Collard HR. PMID: 22426899.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    31. Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1153-63. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, Woodruff PG. PMID: 21852540.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    32. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-a and MIP1-ß, a lack of IL-17, and a Th1-bias in males. PLoS One. 2010 Nov 03; 5(11):e15412. Snyder-Cappione JE, Tincati C, Eccles-James IG, Cappione AJ, Ndhlovu LC, Koth LL, Nixon DF. PMID: 21082024.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    33. DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2. J Immunol. 2010 Jun 01; 184(11):6522-8. Koth LL, Cambier CJ, Ellwanger A, Solon M, Hou L, Lanier LL, Abram CL, Hamerman JA, Woodruff PG. PMID: 20421649.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    34. Undifferentiated connective tissue disease-associated interstitial lung disease: changes in lung function. Lung. 2010 Apr; 188(2):143-9. Kinder BW, Shariat C, Collard HR, Koth LL, Wolters PJ, Golden JA, Panos RJ, King TE. PMID: 20069430.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009 Sep 01; 180(5):388-95. Woodruff PG, Modrek B, Choy DF, Jia G, Abbas AR, Ellwanger A, Koth LL, Arron JR, Fahy JV. PMID: 19483109.
      View in: PubMed   Mentions: 455     Fields:    Translation:HumansCells
    36. Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice. COPD. 2009 Apr; 6(2):86-94. Woodruff PG, Ellwanger A, Solon M, Cambier CJ, Pinkerton KE, Koth LL. PMID: 19378221.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    37. Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):651-9. Koth LL, Alex B, Hawgood S, Nead MA, Sheppard D, Erle DJ, Morris DG. PMID: 17641300.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease? Am J Respir Crit Care Med. 2007 Oct 01; 176(7):691-7. Kinder BW, Collard HR, Koth L, Daikh DI, Wolters PJ, Elicker B, Jones KD, King TE. PMID: 17556720.
      View in: PubMed   Mentions: 67     Fields:    Translation:Humans
    39. A distinctive alveolar macrophage activation state induced by cigarette smoking. Am J Respir Crit Care Med. 2005 Dec 01; 172(11):1383-92. Woodruff PG, Koth LL, Yang YH, Rodriguez MW, Favoreto S, Dolganov GM, Paquet AC, Erle DJ. PMID: 16166618.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    40. Hypersensitivity pneumonitis reaction to Mycobacterium avium in household water. Chest. 2005 Feb; 127(2):664-71. Marras TK, Wallace RJ, Koth LL, Stulbarg MS, Cowl CT, Daley CL. PMID: 15706013.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCellsPHPublic Health
    41. Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2. Respir Res. 2004 Sep 15; 5:12. Koth LL, Rodriguez MW, Bernstein XL, Chan S, Huang X, Charo IF, Rollins BJ, Erle DJ. PMID: 15377395.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    42. Spotted long oligonucleotide arrays for human gene expression analysis. Genome Res. 2003 Jul; 13(7):1775-85. Barczak A, Rodriguez MW, Hanspers K, Koth LL, Tai YC, Bolstad BM, Speed TP, Erle DJ. PMID: 12805270.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    43. Hard metal interstitial lung disease: high-resolution computed tomography appearance. J Thorac Imaging. 2002 Oct; 17(4):314-8. Gotway MB, Golden JA, Warnock M, Koth LL, Webb R, Reddy GP, Balmes JR. PMID: 12362071.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    44. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002 Aug; 8(8):885-9. Kuperman DA, Huang X, Koth LL, Chang GH, Dolganov GM, Zhu Z, Elias JA, Sheppard D, Erle DJ. PMID: 12091879.
      View in: PubMed   Mentions: 273     Fields:    Translation:HumansAnimalsCells
    45. Use of spotted oligonucleotide arrays for large-scale analysis of mammalian gene expression. Chest. 2002 Mar; 121(3 Suppl):80S. Erle DJ, Koth L, Abramson O, Rodriguez MW, Barczak A. PMID: 11893700.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Interleukin-13 induces dramatically different transcriptional programs in three human airway cell types. Am J Respir Cell Mol Biol. 2001 Oct; 25(4):474-85. Lee JH, Kaminski N, Dolganov G, Grunig G, Koth L, Solomon C, Erle DJ, Sheppard D. PMID: 11694453.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
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