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Laurence Cheng, MD, PhD

TitleAssistant Clinical Professor
SchoolUCSF School of Medicine
DepartmentPediatrics
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-2654
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency School of Medicine
    University of WashingtonM.D.2004School of Medicine

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    NIH/NIAID K08AI095319Sep 9, 2011 - Aug 31, 2016
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ahmed A, Reith W, Puck JM, Cheng L. Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol. 2015 Aug; 35(6):521-2. PMID: 26271388.
      View in: PubMed
    2. Bose O, Baluk P, Looney MR, Cheng L, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
    3. Cheng L, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 6; 212(4):513-24. PMID: 25779634; PMCID: PMC4387286.
    4. Cheng L, Cabana MD. Dishing it out to allergies. Pediatrics. 2015 Mar; 135(3):e707-8. PMID: 25713279; PMCID: PMC4338328 [Available on 03/01/16].
    5. Cheng L, Locksley RM. Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2015 Mar; 7(3):a016352. PMID: 25414367.
      View in: PubMed
    6. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng L, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376; PMCID: PMC3795960.
    7. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng L, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. PMID: 23420878; PMCID: PMC3600903.
    8. Cheng L, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. PMID: 23290520; PMCID: PMC3576928.
    9. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng L, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. PMID: 21552267; PMCID: PMC3271435.
    10. Cheng L, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 1; 185(9):5040-7. PMID: 20870945; PMCID: PMC3085987.
    11. Cheng L, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31. PMID: 19375390; PMCID: PMC2800791.
    12. Cheng L, Greenberg PD. Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol. 2002 Nov 1; 169(9):4990-7. PMID: 12391213.
      View in: PubMed
    13. Blattman JN, Cheng L, Greenberg PD. CD8(+) T cell responses: it's all downhill after their prime. Nat Immunol. 2002 Jul; 3(7):601-2. PMID: 12087413.
      View in: PubMed
    14. Ohlén C, Kalos M, Cheng L, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. 2002 Jun 3; 195(11):1407-18. PMID: 12045239; PMCID: PMC2193546.
    15. Cheng L, Ohlén C, Nelson BH, Greenberg PD. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):3001-6. PMID: 11867736; PMCID: PMC122462.
    16. Cheng L, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75. PMID: 9155013; PMCID: PMC1169790.
    17. Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol. 1995 Nov; 15(11):6364-76. PMID: 7565789; PMCID: PMC230888.
    18. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8. PMID: 7739548; PMCID: PMC230498.
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