Laurence Cheng, MD, PhD

Title(s)Volunteer Associate Clinical Professor, Pediatrics
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE, #205A
San Francisco CA 94143
Phone415-476-2491
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    Collapse Biography 
    Collapse education and training
    University of California, San Francisco and Stanford UniversityClinical Fellowship2009Allergy and Immunology
    University of California, San FranciscoResidency 2006Pediatrics
    University of WashingtonM.D.2004School of Medicine
    University of WashingtonPh.D.2002Immunology

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    Collapse Research 
    Collapse research activities and funding
    Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    NIH K08AI095319Sep 9, 2011 - Aug 31, 2016
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study. Allergy. 2024 04; 79(4):924-936. Bissonnette R, DuBois J, Facheris P, Del Duca E, Kim M, Correa Da Rosa J, Trujillo DL, Bose S, Pagan AD, Wustrow D, Brockstedt DG, Wong B, Kassner PD, Jankicevic J, Ho W, Cheng LE, Guttman-Yassky E. PMID: 37984453.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
    2. Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study. ACR Open Rheumatol. 2022 Oct; 4(10):903-911. Abuqayyas L, Cheng LE, Teixeira Dos Santos M, Sullivan BA, Ruiz-Santiago N, Wang H, Zhou Y, Chindalore V, Cohen S, Kivitz AJ, Posch MG, Parnes JR. PMID: 35899378; PMCID: PMC9555197.
      View in: PubMed   Mentions: 5  
    3. Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target. Front Immunol. 2021; 12:782788. Kroenke MA, Barger TE, Hu J, Miller MJ, Kalenian K, He L, Hsu H, Bartley Y, Chow VF, Teixeira Dos Santos MC, Sullivan BA, Cheng LE, Parnes JR, Padaki R, Kuhns S, Mytych DT. PMID: 34970265; PMCID: PMC8712722.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. FRI0084 SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, IMMUNOGENICITY, AND PRELIMINARY EFFICACY OF ROZIBAFUSP ALFA IN SUBJECTS WITH RHEUMATOID ARTHRITIS: INTERIM ANALYSIS OF A PHASE 1B RANDOMIZED, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE CLINICAL TRIAL. Annals of the Rheumatic Diseases. 2020 Jun 2; 79(Suppl 1):619-620. Abuqayyas AL, Cheng CL, Mitragotri MD, Smith SS, Teixeira Dos Santos TM, Zhou ZY, Chindalore CV, Cohen CS, Kivitz KA, Posch PM, Sullivan SB, Parnes PJ. .
      View in: Publisher Site   Mentions:
    5. AB0521 Safety, pharmacokinetics, and pharmacodynamics of single doses of a bispecific icosl and baff inhibitor, amg 570, in healthy subjects. Annals of the Rheumatic Diseases. 2018 Jun 1; 77:1418. Cheng CL, Kankam KM, Siebers SN, Stoltz SR, Abuqayyas AL, Ertik EB, Sullivan SB, Zhou ZL, Mitragotri MD, Parnes PJ. .
      View in: Publisher Site   Mentions:
    6. AB0521 Safety, pharmacokinetics, and pharmacodynamics of single doses of a bispecific icosl and baff inhibitor, amg 570, in healthy subjects. Annals of the Rheumatic Diseases. 2018 Jun 1; 77:1418. Cheng CL, Kankam KM, Siebers SN, Stoltz SR, Abuqayyas AL, Ertik EB, Sullivan SB, Zhou ZL, Mitragotri MD, Parnes PJ. .
      View in: Publisher Site   Mentions:
    7. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 07; 70(7):1071-1076. Cheng LE, Amoura Z, Cheah B, Hiepe F, Sullivan BA, Zhou L, Arnold GE, Tsuji WH, Merrill JT, Chung JB. PMID: 29513931; PMCID: PMC6032945.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    8. OP0234 Clinical and biologic effects of icosl blockade by amg 557 in subjects with lupus arthritis. Annals of the Rheumatic Diseases. 2017 Jun 1; 76:151-152. Cheng CL, Amoura AZ, Cheah CB, Hiepe HF, Sullivan SB, Zhou ZL, Arnold AG, Tsuji TW, Merrill MJ, Chung CJ. .
      View in: Publisher Site   Mentions:
    9. OP0234 Clinical and biologic effects of icosl blockade by amg 557 in subjects with lupus arthritis. Annals of the Rheumatic Diseases. 2017 Jun 1; 76:151-152. Cheng CL, Amoura AZ, Cheah CB, Hiepe HF, Sullivan SB, Zhou ZL, Arnold AG, Tsuji TW, Merrill MJ, Chung CJ. .
      View in: Publisher Site   Mentions:
    10. Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol. 2015 Aug; 35(6):521-2. Ahmed A, Reith W, Puck JM, Cheng LE. PMID: 26271388; PMCID: PMC5512707.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of Cell Biology. 2015 Mar 30; 208(7):2087oia41. Cheng CL, Sullivan SB, Retana RL, Allen AC, Liang LH, Locksley LR. .
      View in: Publisher Site   Mentions:
    12. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. PMID: 25789765; PMCID: PMC4366375.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. PMID: 25779634; PMCID: PMC4387286.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    14. Dishing it out to allergies. Pediatrics. 2015 Mar; 135(3):e707-8. Cheng LE, Cabana MD. PMID: 25713279; PMCID: PMC4338328.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    15. Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(3):a016352. Cheng LE, Locksley RM. PMID: 25414367; PMCID: PMC4355269.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    16. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. PMID: 24037376; PMCID: PMC3795960.
      View in: PubMed   Mentions: 499     Fields:    Translation:AnimalsCells
    17. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. PMID: 23420878; PMCID: PMC3600903.
      View in: PubMed   Mentions: 428     Fields:    
    18. TREC Newborn Screening Can Identify Patients with Leaky SCID and May Improve Outcome. Journal of Allergy and Clinical Immunology. 2013 Feb 1; 131(2):ab231. Chan CA, Cowan CM, Puck PJ, Cheng CL. .
      View in: Publisher Site   Mentions:
    19. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. PMID: 23290520; PMCID: PMC3576928.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    20. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. PMID: 21552267; PMCID: PMC3271435.
      View in: PubMed   Mentions: 119     Fields:    
    21. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 01; 185(9):5040-7. Cheng LE, Wang ZE, Locksley RM. PMID: 20870945; PMCID: PMC3085987.
      View in: PubMed   Mentions: 24     Fields:    
    22. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. PMID: 19375390; PMCID: PMC2800791.
      View in: PubMed   Mentions: 22     Fields:    
    23. Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol. 2002 Nov 01; 169(9):4990-7. Cheng LE, Greenberg PD. PMID: 12391213.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    24. CD8(+) T cell responses: it's all downhill after their prime. Nat Immunol. 2002 Jul; 3(7):601-2. Blattman JN, Cheng LE, Greenberg PD. PMID: 12087413.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. 2002 Jun 03; 195(11):1407-18. Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. PMID: 12045239; PMCID: PMC2193546.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    26. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3001-6. Cheng LE, Ohlén C, Nelson BH, Greenberg PD. PMID: 11867736; PMCID: PMC122462.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    27. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75. Cheng LE, Chan FK, Cado D, Winoto A. PMID: 9155013; PMCID: PMC1169790.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    28. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol. 1995 Nov; 15(11):6364-76. Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. PMID: 7565789; PMCID: PMC230888.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    29. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. PMID: 7739548; PMCID: PMC230498.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
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