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Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 07; 70(7):1071-1076.
Cheng LE, Amoura Z, Cheah B, Hiepe F, Sullivan BA, Zhou L, Arnold GE, Tsuji WH, Merrill JT, Chung JB. PMID: 29513931.
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8 Fields:
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HumansCTClinical Trials
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Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol. 2015 Aug; 35(6):521-2.
Ahmed A, Reith W, Puck JM, Cheng LE. PMID: 26271388.
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1 Fields:
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HumansAnimalsCells
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of Cell Biology. 2015 Mar 30; 208(7):2087oia41.
Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, Richard M. Locksley. .
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Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513.
Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. PMID: 25789765.
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PubMed Mentions:
4 Fields:
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AnimalsCells
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24.
Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. PMID: 25779634.
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PubMed Mentions:
19 Fields:
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AnimalsCells
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Dishing it out to allergies. Pediatrics. 2015 Mar; 135(3):e707-8.
Cheng LE, Cabana MD. PMID: 25713279.
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HumansPHPublic Health
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Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(3):a016352.
Cheng LE, Locksley RM. PMID: 25414367.
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11 Fields:
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Humans
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Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. PMID: 24037376.
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PubMed Mentions:
331 Fields:
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AnimalsCells
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Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49.
Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. PMID: 23420878.
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PubMed Mentions:
322 Fields:
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AnimalsCells
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TREC Newborn Screening Can Identify Patients with Leaky SCID and May Improve Outcome. Journal of Allergy and Clinical Immunology. 2013 Feb 1; 131(2):ab231.
Alice Chan, Morton Cowan, Jennifer M. Puck, Laurence E. Cheng. .
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Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75.
Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. PMID: 23290520.
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PubMed Mentions:
38 Fields:
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AnimalsCells
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Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35.
Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. PMID: 21552267.
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PubMed Mentions:
107 Fields:
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HumansAnimalsCells
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Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 01; 185(9):5040-7.
Cheng LE, Wang ZE, Locksley RM. PMID: 20870945.
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PubMed Mentions:
19 Fields:
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AnimalsCells
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Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31.
Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. PMID: 19375390.
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22 Fields:
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Humans
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Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol. 2002 Nov 01; 169(9):4990-7.
Cheng LE, Greenberg PD. PMID: 12391213.
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PubMed Mentions:
9 Fields:
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AnimalsCells
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CD8(+) T cell responses: it's all downhill after their prime. Nat Immunol. 2002 Jul; 3(7):601-2.
Blattman JN, Cheng LE, Greenberg PD. PMID: 12087413.
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4 Fields:
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HumansAnimalsCells
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CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. 2002 Jun 03; 195(11):1407-18.
Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. PMID: 12045239.
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52 Fields:
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AnimalsCells
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Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3001-6.
Cheng LE, Ohlén C, Nelson BH, Greenberg PD. PMID: 11867736.
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PubMed Mentions:
19 Fields:
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AnimalsCells
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Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75.
Cheng LE, Chan FK, Cado D, Winoto A. PMID: 9155013.
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87 Fields:
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AnimalsCells
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Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol. 1995 Nov; 15(11):6364-76.
Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. PMID: 7565789.
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55 Fields:
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AnimalsCells
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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8.
Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. PMID: 7739548.
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59 Fields:
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HumansAnimalsCells