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Laurence Cheng, MD, PhD

Title(s)Assistant Clinical Professor, Pediatrics
SchoolSchool of Medicine
Phone415-476-2654
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco and Stanford UniversityClinical Fellowship2009Allergy and Immunology
    University of California, San FranciscoResidency 2006Pediatrics
    University of WashingtonM.D.2004School of Medicine
    University of WashingtonPh.D.2002Immunology

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Surveillance of Serum Contents by Mast Cells and Regulation of Allergic Immunity
    NIH/NIAID K08AI095319Sep 9, 2011 - Aug 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Cheng LE, Amoura Z, Cheah B, Hiepe F, Sullivan BA, Zhou L, Arnold GE, Tsuji WH, Merrill JT, Chung JB. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 07; 70(7):1071-1076. PMID: 29513931.
      View in: PubMed
    2. Ahmed A, Reith W, Puck JM, Cheng LE. Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol. 2015 Aug; 35(6):521-2. PMID: 26271388.
      View in: PubMed
    3. Laurence E. Cheng, Brandon M. Sullivan, Lizett E. Retana, Christopher D.C. Allen, Hong-Erh Liang, Richard M. Locksley. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of Cell Biology. 2015 Mar 30; 208(7):2087oia41.
      View in: Publisher Site
    4. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765.
      View in: PubMed
    5. Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24. PMID: 25779634.
      View in: PubMed
    6. Cheng LE, Cabana MD. Dishing it out to allergies. Pediatrics. 2015 Mar; 135(3):e707-8. PMID: 25713279.
      View in: PubMed
    7. Cheng LE, Locksley RM. Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(3):a016352. PMID: 25414367.
      View in: PubMed
    8. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376.
      View in: PubMed
    9. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. PMID: 23420878.
      View in: PubMed
    10. Alice Chan, Morton Cowan, Jennifer M. Puck, Laurence E. Cheng. TREC Newborn Screening Can Identify Patients with Leaky SCID and May Improve Outcome. Journal of Allergy and Clinical Immunology. 2013 Feb 1; 131(2):ab231.
      View in: Publisher Site
    11. Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75. PMID: 23290520.
      View in: PubMed
    12. Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35. PMID: 21552267.
      View in: PubMed
    13. Cheng LE, Wang ZE, Locksley RM. Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 01; 185(9):5040-7. PMID: 20870945.
      View in: PubMed
    14. Cheng LE, Kanwar B, Tcheurekdjian H, Grenert JP, Muskat M, Heyman MB, McCune JM, Wara DW. Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome. Clin Immunol. 2009 Jul; 132(1):124-31. PMID: 19375390.
      View in: PubMed
    15. Cheng LE, Greenberg PD. Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol. 2002 Nov 01; 169(9):4990-7. PMID: 12391213.
      View in: PubMed
    16. Blattman JN, Cheng LE, Greenberg PD. CD8(+) T cell responses: it's all downhill after their prime. Nat Immunol. 2002 Jul; 3(7):601-2. PMID: 12087413.
      View in: PubMed
    17. Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. 2002 Jun 03; 195(11):1407-18. PMID: 12045239.
      View in: PubMed
    18. Cheng LE, Ohlén C, Nelson BH, Greenberg PD. Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3001-6. PMID: 11867736.
      View in: PubMed
    19. Cheng LE, Chan FK, Cado D, Winoto A. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75. PMID: 9155013.
      View in: PubMed
    20. Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol. 1995 Nov; 15(11):6364-76. PMID: 7565789.
      View in: PubMed
    21. Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8. PMID: 7739548.
      View in: PubMed