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Clinical and molecular effects of oral CCR4 antagonist RPT193 in atopic dermatitis: A Phase 1 study. Allergy. 2024 04; 79(4):924-936.
Bissonnette R, DuBois J, Facheris P, Del Duca E, Kim M, Correa Da Rosa J, Trujillo DL, Bose S, Pagan AD, Wustrow D, Brockstedt DG, Wong B, Kassner PD, Jankicevic J, Ho W, Cheng LE, Guttman-Yassky E. PMID: 37984453.
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7 Fields:
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HumansCellsCTClinical Trials
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Safety and Biological Activity of Rozibafusp alfa, a Bispecific Inhibitor of Inducible Costimulator Ligand and B Cell Activating Factor, in Patients With Rheumatoid Arthritis: Results of a Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study. ACR Open Rheumatol. 2022 Oct; 4(10):903-911.
Abuqayyas L, Cheng LE, Teixeira Dos Santos M, Sullivan BA, Ruiz-Santiago N, Wang H, Zhou Y, Chindalore V, Cohen S, Kivitz AJ, Posch MG, Parnes JR. PMID: 35899378; PMCID: PMC9555197.
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Immune Complex Formation Is Associated With Loss of Tolerance and an Antibody Response to Both Drug and Target. Front Immunol. 2021; 12:782788.
Kroenke MA, Barger TE, Hu J, Miller MJ, Kalenian K, He L, Hsu H, Bartley Y, Chow VF, Teixeira Dos Santos MC, Sullivan BA, Cheng LE, Parnes JR, Padaki R, Kuhns S, Mytych DT. PMID: 34970265; PMCID: PMC8712722.
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5 Fields:
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HumansCells
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FRI0084 SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, IMMUNOGENICITY, AND PRELIMINARY EFFICACY OF ROZIBAFUSP ALFA IN SUBJECTS WITH RHEUMATOID ARTHRITIS: INTERIM ANALYSIS OF A PHASE 1B RANDOMIZED, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE CLINICAL TRIAL. Annals of the Rheumatic Diseases. 2020 Jun 2; 79(Suppl 1):619-620.
Abuqayyas AL, Cheng CL, Mitragotri MD, Smith SS, Teixeira Dos Santos TM, Zhou ZY, Chindalore CV, Cohen CS, Kivitz KA, Posch PM, Sullivan SB, Parnes PJ. .
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AB0521 Safety, pharmacokinetics, and pharmacodynamics of single doses of a bispecific icosl and baff inhibitor, amg 570, in healthy subjects. Annals of the Rheumatic Diseases. 2018 Jun 1; 77:1418.
Cheng CL, Kankam KM, Siebers SN, Stoltz SR, Abuqayyas AL, Ertik EB, Sullivan SB, Zhou ZL, Mitragotri MD, Parnes PJ. .
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AB0521 Safety, pharmacokinetics, and pharmacodynamics of single doses of a bispecific icosl and baff inhibitor, amg 570, in healthy subjects. Annals of the Rheumatic Diseases. 2018 Jun 1; 77:1418.
Cheng CL, Kankam KM, Siebers SN, Stoltz SR, Abuqayyas AL, Ertik EB, Sullivan SB, Zhou ZL, Mitragotri MD, Parnes PJ. .
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Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 07; 70(7):1071-1076.
Cheng LE, Amoura Z, Cheah B, Hiepe F, Sullivan BA, Zhou L, Arnold GE, Tsuji WH, Merrill JT, Chung JB. PMID: 29513931; PMCID: PMC6032945.
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26 Fields:
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HumansCTClinical Trials
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OP0234 Clinical and biologic effects of icosl blockade by amg 557 in subjects with lupus arthritis. Annals of the Rheumatic Diseases. 2017 Jun 1; 76:151-152.
Cheng CL, Amoura AZ, Cheah CB, Hiepe HF, Sullivan SB, Zhou ZL, Arnold AG, Tsuji TW, Merrill MJ, Chung CJ. .
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OP0234 Clinical and biologic effects of icosl blockade by amg 557 in subjects with lupus arthritis. Annals of the Rheumatic Diseases. 2017 Jun 1; 76:151-152.
Cheng CL, Amoura AZ, Cheah CB, Hiepe HF, Sullivan SB, Zhou ZL, Arnold AG, Tsuji TW, Merrill MJ, Chung CJ. .
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Novel Mutation in the Class II Transactivator Associated with Immunodeficiency and Autoimmunity. J Clin Immunol. 2015 Aug; 35(6):521-2.
Ahmed A, Reith W, Puck JM, Cheng LE. PMID: 26271388; PMCID: PMC5512707.
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2 Fields:
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HumansAnimalsCells
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. The Journal of Cell Biology. 2015 Mar 30; 208(7):2087oia41.
Cheng CL, Sullivan SB, Retana RL, Allen AC, Liang LH, Locksley LR. .
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Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513.
Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. PMID: 25789765; PMCID: PMC4366375.
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6 Fields:
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AnimalsCells
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IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015 Apr 06; 212(4):513-24.
Cheng LE, Sullivan BM, Retana LE, Allen CD, Liang HE, Locksley RM. PMID: 25779634; PMCID: PMC4387286.
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35 Fields:
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AnimalsCells
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Dishing it out to allergies. Pediatrics. 2015 Mar; 135(3):e707-8.
Cheng LE, Cabana MD. PMID: 25713279; PMCID: PMC4338328.
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HumansPHPublic Health
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Allergic inflammation--innately homeostatic. Cold Spring Harb Perspect Biol. 2014 Nov 20; 7(3):a016352.
Cheng LE, Locksley RM. PMID: 25414367; PMCID: PMC4355269.
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16 Fields:
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Humans
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Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. PMID: 24037376; PMCID: PMC3795960.
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548 Fields:
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458 Fields:
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AnimalsCells
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TREC Newborn Screening Can Identify Patients with Leaky SCID and May Improve Outcome. Journal of Allergy and Clinical Immunology. 2013 Feb 1; 131(2):ab231.
Chan CA, Cowan CM, Puck PJ, Cheng CL. .
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Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity. 2013 Jan 24; 38(1):166-75.
Cheng LE, Hartmann K, Roers A, Krummel MF, Locksley RM. PMID: 23290520; PMCID: PMC3576928.
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53 Fields:
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AnimalsCells
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Genetic analysis of basophil function in vivo. Nat Immunol. 2011 Jun; 12(6):527-35.
Sullivan BM, Liang HE, Bando JK, Wu D, Cheng LE, McKerrow JK, Allen CD, Locksley RM. PMID: 21552267; PMCID: PMC3271435.
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140 Fields:
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HumansAnimalsCells
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Murine B cells regulate serum IgE levels in a CD23-dependent manner. J Immunol. 2010 Nov 01; 185(9):5040-7.
Cheng LE, Wang ZE, Locksley RM. PMID: 20870945; PMCID: PMC3085987.
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28 Fields:
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AnimalsCells
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27 Fields:
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Humans
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Selective delivery of augmented IL-2 receptor signals to responding CD8+ T cells increases the size of the acute antiviral response and of the resulting memory T cell pool. J Immunol. 2002 Nov 01; 169(9):4990-7.
Cheng LE, Greenberg PD. PMID: 12391213.
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12 Fields:
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AnimalsCells
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CD8(+) T cell responses: it's all downhill after their prime. Nat Immunol. 2002 Jul; 3(7):601-2.
Blattman JN, Cheng LE, Greenberg PD. PMID: 12087413.
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5 Fields:
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HumansAnimalsCells
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CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function. J Exp Med. 2002 Jun 03; 195(11):1407-18.
Ohlén C, Kalos M, Cheng LE, Shur AC, Hong DJ, Carson BD, Kokot NC, Lerner CG, Sather BD, Huseby ES, Greenberg PD. PMID: 12045239; PMCID: PMC2193546.
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57 Fields:
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AnimalsCells
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Enhanced signaling through the IL-2 receptor in CD8+ T cells regulated by antigen recognition results in preferential proliferation and expansion of responding CD8+ T cells rather than promotion of cell death. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3001-6.
Cheng LE, Ohlén C, Nelson BH, Greenberg PD. PMID: 11867736; PMCID: PMC122462.
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37 Fields:
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AnimalsCells
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Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997 Apr 15; 16(8):1865-75.
Cheng LE, Chan FK, Cado D, Winoto A. PMID: 9155013; PMCID: PMC1169790.
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102 Fields:
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AnimalsCells
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Regulation of the Nur77 orphan steroid receptor in activation-induced apoptosis. Mol Cell Biol. 1995 Nov; 15(11):6364-76.
Woronicz JD, Lina A, Calnan BJ, Szychowski S, Cheng L, Winoto A. PMID: 7565789; PMCID: PMC230888.
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57 Fields:
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AnimalsCells
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Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. Mol Cell Biol. 1995 May; 15(5):2682-8.
Chan FK, Zhang J, Cheng L, Shapiro DN, Winoto A. PMID: 7739548; PMCID: PMC230498.
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67 Fields:
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HumansAnimalsCells