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Lawrence Chan, MD

Title(s)RESIDENT PHYSICIAN, Ophthalmology
SchoolSchool of Medicine
Address513 PARNASSUS AVE
SAN FRANCISCO CA 94143
Phone415-476-1239
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MABA05/2013Chemistry and Physics
    Yale School of Medicine, New Haven, CTMD05/2019Medicine
    University of California, San Francisco06/2020Surgery Internship

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Disease asymmetry and hyperautofluorescent ring shape in retinitis pigmentosa patients. Sci Rep. 2020 02 25; 10(1):3364. Jauregui R, Chan L, Oh JK, Cho A, Sparrow JR, Tsang SH. PMID: 32098976.
      View in: PubMed   Mentions:    Fields:    
    2. Spinal Ewing Sarcoma Metastatic to Bilateral Orbits. Ophthalmic Plast Reconstr Surg. 2018 Nov/Dec; 34(6):e206-e208. Chan L, Megalla M, Kim JM, Pointdujour-Lim R. PMID: 30365478.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Genome Surgery and Gene Therapy in Retinal Disorders. Yale J Biol Med. 2017 12; 90(4):523-532. Chan L, Mahajan VB, Tsang SH. PMID: 29259518.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic ß Cells. Sci Rep. 2017 01 19; 7:40855. Chen E, Tsai TH, Li L, Saha P, Chan L, Chang BH. PMID: 28102311.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    5. MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. Hum Mol Genet. 2016 07 15; 25(14):3029-3041. Kyle SM, Saha PK, Brown HM, Chan LC, Justice MJ. PMID: 27288453.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    6. Personalized Medicine: Cell and Gene Therapy Based on Patient-Specific iPSC-Derived Retinal Pigment Epithelium Cells. Adv Exp Med Biol. 2016; 854:549-55. Li Y, Chan L, Nguyen HV, Tsang SH. PMID: 26427458.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    7. Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina. J Biol Chem. 2016 Feb 26; 291(9):4698-710. Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrústegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB. PMID: 26677218.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    8. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. PMID: 26375425.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    9. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. PMID: 26192107.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. PMID: 26081744.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice. PLoS One. 2015; 10(6):e0128996. Willecke F, Yuan C, Oka K, Chan L, Hu Y, Barnhart S, Bornfeldt KE, Goldberg IJ, Fisher EA. PMID: 26046657.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    12. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-48. Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. PMID: 25953849.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. Rapid resolution of retinoschisis with acetazolamide. Doc Ophthalmol. 2015 Aug; 131(1):63-70. Zhang L, Reyes R, Lee W, Chen CL, Chan L, Sujirakul T, Chang S, Tsang SH. PMID: 25796216.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis). Trans Am Ophthalmol Soc. 2014 Jul; 112:103-15. Tsang SH, Chan L, Tsai YT, Wu WH, Hsu CW, Yang J, Tosi J, Wert KJ, Davis RJ, Mahajan VB. PMID: 25646031.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    15. Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Mol Ther. 2014 Sep; 22(9):1688-97. Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH. PMID: 24895994.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    16. Gene therapy for neuropathic pain by silencing of TNF-a expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One. 2014; 9(3):e92073. Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. PMID: 24642694.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    17. Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS Lett. 2014 Mar 18; 588(6):1080-6. Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H. PMID: 24583009.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    18. Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Trends Endocrinol Metab. 2014 Apr; 25(4):178-87. Kojima H, Kim J, Chan L. PMID: 24507996.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    19. Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines. Hum Mol Genet. 2014 Jul 01; 23(13):3445-55. Yang J, Li Y, Chan L, Tsai YT, Wu WH, Nguyen HV, Hsu CW, Li X, Brown LM, Egli D, Sparrow JR, Tsang SH. PMID: 24497574.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    20. Paper-based, capacitive touch pads. Adv Mater. 2012 Jun 05; 24(21):2850-6. Mazzeo AD, Kalb WB, Chan L, Killian MG, Bloch JF, Mazzeo BA, Whitesides GM. PMID: 22539155.
      View in: PubMed   Mentions: 10     Fields:    
    21. An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption. J Lipid Res. 2010 Jul; 51(7):1929-42. Iqbal J, Li X, Chang BH, Chan L, Schwartz GJ, Chua SC, Hussain MM. PMID: 20164094.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    22. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 Nov; 16(11):1805-12. Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. PMID: 18781141.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    23. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L. PMID: 14578284.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
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