Lawrence Litt, MD, PhD

Title(s)Professor Emeritus, Anesthesia
SchoolSchool of Medicine
AddressLocation Required, #001
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    Columbia College, New York, NYA.B.06/1963physics
    Harvard Graduate School of Arts and Sciences, Cambridge, MAPhD06/1971physics
    Univ of Miami School of Medicine, Miami, FLM.D.06/1979medicine
    UCSF, San Francisco, CA06/1982Anesthesia Residency

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    Now an emeritus professor, I am retired from all research, teaching, and clinical activities. Laboratory research was supported by 28 years of NIH funding via R01 GM034767, during which time I was a member of NIH's Neurology A Study Section for 7 years, and then a member of the Surgery, Anesthesiology and Trauma Study Section for 5 years. Publications listed below are from a list of 88 peer-reviewed publications in professional journals, with 21 being as an experimental elementary particle physicist with post-doc and junior faculty appointments at Harvard, Rockefeller University, and Michigan State University, and visiting scientist appointments at the Centre Européenne pour la Recherche Nucléaire (CERN), Brookhaven, and Fermilab. Approximately 40% of my time during my 33 years at the Parnassus Campus was in clinical anesthesia teaching and care in the Moffitt-Long Hospital Operating rooms, with an emphasis on anesthesia for neurological surgery.

    Collapse Research 
    Collapse Research Activities and Funding
    Comprehensive Anesthesia Research Training
    NIH T32GM008440Jul 1, 1995 - Jun 30, 2022
    Role: Co-Principal Investigator
    Hypothermia, anesthesia and NMR metabolomics in ischemic neonatal brain slices
    NIH R01GM034767Jul 1, 1985 - Jul 31, 2013
    Role: Principal Investigator
    ANESTHETIC PROTECTION IN BRAIN HYPOXIA: A P31 NMR STUDY
    NIH R23GM034767Jul 1, 1985 - Jun 30, 1988
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. 13C NMR metabolomic evaluation of immediate and delayed mild hypothermia in cerebrocortical slices after oxygen-glucose deprivation. Anesthesiology. 2013 Nov; 119(5):1120-36. Liu J, Segal MR, Kelly MJ, Pelton JG, Kim M, James TL, Litt L. PMID: 23748856; PMCID: PMC3890426.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    2. 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries. Pediatr Res. 2013 Aug; 74(2):170-9. Liu J, Sheldon RA, Segal MR, Kelly MJ, Pelton JG, Ferriero DM, James TL, Litt L. PMID: 23708689; PMCID: PMC3734529.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    3. Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites. Int J Mol Sci. 2011; 12(10):6469-501. Liu J, Litt L, Segal MR, Kelly MJ, Pelton JG, Kim M. PMID: 22072900; PMCID: PMC3210991.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    4. Cholecystectomy in the presence of a large patent foramen ovale: laparoscopic or open? J Clin Anesth. 2010 Nov; 22(7):553-6. Thoma MS, Maa J, Schiller NB, Litt L. PMID: 21056814.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia. J Cereb Blood Flow Metab. 2011 Feb; 31(2):547-59. Liu J, Litt L, Segal MR, Kelly MJ, Yoshihara HA, James TL. PMID: 20717124; PMCID: PMC3010526.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    6. Anesthetic concerns in patients with known cerebrovascular insufficiency. Anesthesiol Clin. 2010 Mar; 28(1):1-12. Logvinova AV, Litt L, Young WL, Lee CZ. PMID: 20400036.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices. Brain Res. 2008 Oct 31; 1238:230-8. Liu J, Hirai K, Litt L. PMID: 18725216; PMCID: PMC2584668.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices. Anesthesiology. 2007 Oct; 107(4):630-40. Zeng J, Liu J, Yang GY, Kelly MJ, James TL, Litt L. PMID: 17893460.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    9. Awareness without recall during anesthesia for electroconvulsive therapy. Anesthesiology. 2007 Apr; 106(4):871-2. Litt L, Li D. PMID: 17413926.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices. J Cereb Blood Flow Metab. 2007 Feb; 27(2):304-15. Zeng J, Yang GY, Ying W, Kelly M, Hirai K, James TL, Swanson RA, Litt L. PMID: 16736046.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    11. Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices. J Bioenerg Biomembr. 2004 Aug; 36(4):415-9. Zeng J, Hirai K, Yang GY, Ying W, Swanson RA, Kelly M, Mayer M, James TL, Litt L. PMID: 15377881.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. Anesth Analg. 2004 Aug; 99(2):393-8, table of contents. Fourcade O, Simon MF, Litt L, Samii K, Chap H. PMID: 15271713.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. Brain Res Mol Brain Res. 2004 Apr 29; 124(1):51-61. Hirai K, Hayashi T, Chan PH, Zeng J, Yang GY, Basus VJ, James TL, Litt L. PMID: 15093685.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    14. Physiologic monitoring and anesthesia considerations in acute ischemic stroke. J Vasc Interv Radiol. 2004 Jan; 15(1 Pt 2):S13-9. Lee CZ, Litt L, Hashimoto T, Young WL. PMID: 15101512.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Temperature control of respiring rat brain slices during high field NMR spectroscopy. Brain Res Brain Res Protoc. 2003 Feb; 10(3):191-8. Litt L, Hirai K, Basus VJ, James TL. PMID: 12565690.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. J Cereb Blood Flow Metab. 2002 Mar; 22(3):342-52. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. PMID: 11891440.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
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