Lei Wang, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South, #452X
San Francisco CA 94158
ORCID ORCID Icon0000-0002-5859-2526 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California at BerkeleyPh.D.2002Department of Chemistry
    Peking UniversityM.S.1997Department of Chemistry
    Peking UniversityB.S.1994Department of Chemistry
    Collapse Awards and Honors
    The Protein Society2021Emil Thomas Kaiser Award
    National Institutes of Health2008NIH Director’s New Innovator Award
    March of Dimes2008Basil O’Connor Starter Scholar
    California Institute for Regenerative Medicine2008New Faculty Award
    Ray Thomas Edwards Foundation2007Career Development Award
    Searle Scholars Program2006Searle Scholar
    Arnold and Mabel Beckman Foundation2006Beckman Young Investigator
    MIT Technology Review 2004Top Young Innovator
    Sino-American Biotechnology & Pharmaceutical Professional Association and American Chemical Society2004San Diego BioPharma Award
    Science (American Association for the Advancement of Science)2003Young Scientist Award
    Damon Runyon Cancer Research Foundation2003  - 2005Merck Fellow
    US National Inventors Hall of Fame2002Collegiate Inventor

    Collapse Overview 
    Collapse Overview
    Lei Wang received BS and MS from Peking University mentored by Zhongfan Liu, and PhD from UC Berkeley mentored by Peter G. Schultz. His graduate research resulted in the first expansion of the genetic code to include unnatural amino acids (Uaas) in 2001, for which he was awarded the Young Scientist Award by the journal Science. After postdoctoral training with Roger Y. Tsien, Wang started his group at the Salk Institute in 2005, and moved to UCSF in 2014. Wang’s group has developed new methods for the expansion of the genetic code in a variety of cells and model organisms, including mammalian cells, stem cells, C. elegans, and recently embryonic mouse. His group discovered that release factor one (RF1) is nonessential in E. coli, and engineered autonomous bacteria capable of incorporating Uaas at multiple sites with high efficiency. By developing the concept of proximity-enabled bioreactivity, Wang’s group designed and demonstrated that a new class of Uaas, the bioreactive Uaas, can be genetically encoded in live systems. These bioreactive Uaas enable novel covalent bonding abilities to be specifically introduced into proteins and biosystems, opening the door for new protein engineering and biological research in vivo. Wang is a 2006 Beckman Young Investigator, a 2006 Searle Scholar, a 2008 National Institutes of Health Director’s New Innovator Award recipient, and the 2021 Emil Thomas Kaiser Award recipient of the Protein Society.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biospecific Chemistry for Covalent Linking of Biomacromolecules. Chem Rev. 2024 Jun 24. Cao L, Wang L. PMID: 38913432.
      View in: PubMed   Mentions:    Fields:    
    2. The proximity-enabled sulfur fluoride exchange reaction in the protein context. Chem Sci. 2023 Jul 26; 14(29):7913-7921. Yu B, Cao L, Li S, Klauser PC, Wang L. PMID: 37502323; PMCID: PMC10370592.
      View in: PubMed   Mentions: 3  
    3. Covalent Proteins as Targeted Radionuclide Therapies Enhance Antitumor Effects. ACS Cent Sci. 2023 Jun 28; 9(6):1241-1251. Klauser PC, Chopra S, Cao L, Bobba KN, Yu B, Seo Y, Chan E, Flavell RR, Evans MJ, Wang L. PMID: 37396859; PMCID: PMC10311652.
      View in: PubMed   Mentions: 6  
    4. Residue selective crosslinking of proteins through photoactivatable or proximity-enabled reactivity. Curr Opin Chem Biol. 2023 06; 74:102285. Liu J, Yang B, Wang L. PMID: 36913752; PMCID: PMC10225350.
      View in: PubMed   Mentions: 3     Fields:    
    5. Genetically encoded chemical crosslinking of carbohydrate. Nat Chem. 2023 01; 15(1):33-42. Li S, Wang N, Yu B, Sun W, Wang L. PMID: 36216893; PMCID: PMC9840686.
      View in: PubMed   Mentions: 10     Fields:    
    6. Genetically encoded chemical crosslinking of RNA in vivo. Nat Chem. 2023 01; 15(1):21-32. Sun W, Wang N, Liu H, Yu B, Jin L, Ren X, Shen Y, Wang L. PMID: 36202986; PMCID: PMC9840682.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    7. Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants. Chem. 2022 Oct 13; 8(10):2766-2783. Yu B, Li S, Tabata T, Wang N, Cao L, Kumar GR, Sun W, Liu J, Ott M, Wang L. PMID: 35874165; PMCID: PMC9288967.
      View in: PubMed   Mentions: 14  
    8. Encoding latent SuFEx reactive meta-fluorosulfate tyrosine to expand covalent bonding of proteins. Chem Commun (Camb). 2022 Jun 14; 58(48):6861-6864. Klauser PC, Berdan VY, Cao L, Wang L. PMID: 35621237; PMCID: PMC9816398.
      View in: PubMed   Mentions: 5     Fields:    
    9. Accelerating PERx Reaction Enables Covalent Nanobodies for Potent Neutralization of SARS-Cov-2 and Variants. bioRxiv. 2022 Mar 14. Yu B, Li S, Tabata T, Wang N, Kumar GR, Liu J, Ott MM, Wang L. PMID: 35313590; PMCID: PMC8936105.
      View in: PubMed   Mentions:
    10. Genetically encoding latent bioreactive amino acids and the development of covalent protein drugs. Curr Opin Chem Biol. 2022 02; 66:102106. Wang N, Wang L. PMID: 34968810.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    11. New covalent bonding ability for proteins. Protein Sci. 2022 02; 31(2):312-322. Cao L, Wang L. PMID: 34761448; PMCID: PMC8819847.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    12. A Genetically Encoded Fluorosulfonyloxybenzoyl-l-lysine for Expansive Covalent Bonding of Proteins via SuFEx Chemistry. J Am Chem Soc. 2021 07 14; 143(27):10341-10351. Liu J, Cao L, Klauser PC, Cheng R, Berdan VY, Sun W, Wang N, Ghelichkhani F, Yu B, Rozovsky S, Wang L. PMID: 34213894; PMCID: PMC8310613.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    13. Genetic Incorporation of ϵ-N-Benzoyllysine by Engineering Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase. Chembiochem. 2021 08 03; 22(15):2530-2534. Cao L, Liu J, Ghelichkhani F, Rozovsky S, Wang L. PMID: 34118176; PMCID: PMC8406699.
      View in: PubMed   Mentions: 3     Fields:    
    14. Covalent peptides and proteins for therapeutics. Bioorg Med Chem. 2021 01 01; 29:115896. Berdan VY, Klauser PC, Wang L. PMID: 33285408.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    15. Targeting Phosphotyrosine in Native Proteins with Conditional, Bispecific Antibody Traps. J Am Chem Soc. 2020 10 14; 142(41):17703-17713. Zhou XX, Bracken CJ, Zhang K, Zhou J, Mou Y, Wang L, Cheng Y, Leung KK, Wells JA. PMID: 32924468; PMCID: PMC8168474.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    16. Genetically Encoded Quinone Methides Enabling Rapid, Site-Specific, and Photocontrolled Protein Modification with Amine Reagents. J Am Chem Soc. 2020 10 07; 142(40):17057-17068. Liu J, Cheng R, Van Eps N, Wang N, Morizumi T, Ou WL, Klauser PC, Rozovsky S, Ernst OP, Wang L. PMID: 32915556; PMCID: PMC7581489.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    17. Genetically encoding thyronine for fluorescent detection of peroxynitrite. Bioorg Med Chem. 2020 09 15; 28(18):115665. Li S, Yang B, Kobayashi T, Yu B, Liu J, Wang L. PMID: 32828428; PMCID: PMC7461609.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics. Cell. 2020 07 09; 182(1):85-97.e16. Li Q, Chen Q, Klauser PC, Li M, Zheng F, Wang N, Li X, Zhang Q, Fu X, Wang Q, Xu Y, Wang L. PMID: 32579975.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    19. Acid-brightening fluorescent protein (abFP) for imaging acidic vesicles and organelles. Methods Enzymol. 2020; 639:167-189. Wang N, Wang L. PMID: 32475400; PMCID: PMC7318887.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    20. Synthesis of Chiral Spin-Labeled Amino Acids. Org Lett. 2019 12 20; 21(24):10149-10153. Vuong W, Mosquera-Guagua F, Sanichar R, McDonald TR, Ernst OP, Wang L, Vederas JC. PMID: 31820646.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    21. Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes. Angew Chem Int Ed Engl. 2019 12 19; 58(52):18839-18843. Liu J, Cai L, Sun W, Cheng R, Wang N, Jin L, Rozovsky S, Seiple IB, Wang L. PMID: 31644827; PMCID: PMC6917869.
      View in: PubMed   Mentions: 14     Fields:    
    22. Genetically Encoding Photocaged Quinone Methide to Multitarget Protein Residues Covalently in Vivo. J Am Chem Soc. 2019 06 19; 141(24):9458-9462. Liu J, Li S, Aslam NA, Zheng F, Yang B, Cheng R, Wang N, Rozovsky S, Wang PG, Wang Q, Wang L. PMID: 31184146; PMCID: PMC7050464.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    23. Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins. J Am Chem Soc. 2019 05 15; 141(19):7698-7703. Yang B, Wang N, Schnier PD, Zheng F, Zhu H, Polizzi NF, Ittuveetil A, Saikam V, DeGrado WF, Wang Q, Wang PG, Wang L. PMID: 31038942; PMCID: PMC6556376.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    24. Genetically encoding photoswitchable click amino acids for general optical control of conformation and function of proteins. Methods Enzymol. 2019; 624:249-264. Hoppmann C, Wang L. PMID: 31370932; PMCID: PMC6684330.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    25. Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry. Proc Natl Acad Sci U S A. 2018 10 30; 115(44):11162-11167. Yang B, Wu H, Schnier PD, Liu Y, Liu J, Wang N, DeGrado WF, Wang L. PMID: 30322930; PMCID: PMC6217395.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    26. Building and Breaking Bonds via a Compact S-Propargyl-Cysteine to Chemically Control Enzymes and Modify Proteins. Angew Chem Int Ed Engl. 2018 09 24; 57(39):12702-12706. Liu J, Cheng R, Wu H, Li S, Wang PG, DeGrado WF, Rozovsky S, Wang L. PMID: 30118570; PMCID: PMC6169525.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    27. Genetically Encoding Quinoline Reverses Chromophore Charge and Enables Fluorescent Protein Brightening in Acidic Vesicles. J Am Chem Soc. 2018 09 05; 140(35):11058-11066. Fu C, Kobayashi T, Wang N, Hoppmann C, Yang B, Irannejad R, Wang L. PMID: 30132658; PMCID: PMC6145950.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    28. Site-Specific Incorporation of Selenocysteine Using an Expanded Genetic Code and Palladium-Mediated Chemical Deprotection. J Am Chem Soc. 2018 07 18; 140(28):8807-8816. Liu J, Zheng F, Cheng R, Li S, Rozovsky S, Wang Q, Wang L. PMID: 29984990; PMCID: PMC6082430.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    29. Genetically Encoding Fluorosulfate-l-tyrosine To React with Lysine, Histidine, and Tyrosine via SuFEx in Proteins in Vivo. J Am Chem Soc. 2018 04 18; 140(15):4995-4999. Wang N, Yang B, Fu C, Zhu H, Zheng F, Kobayashi T, Liu J, Li S, Ma C, Wang PG, Wang Q, Wang L. PMID: 29601199; PMCID: PMC6031228.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    30. Genetically Encoding Unnatural Amino Acids in Neurons In Vitro and in the Embryonic Mouse Brain for Optical Control of Neuronal Proteins. Methods Mol Biol. 2018; 1728:263-277. Kang JY, Kawaguchi D, Wang L. PMID: 29405004; PMCID: PMC6031227.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    31. Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions. Nat Commun. 2017 12 21; 8(1):2240. Yang B, Tang S, Ma C, Li ST, Shao GC, Dang B, DeGrado WF, Dong MQ, Wang PG, Ding S, Wang L. PMID: 29269770; PMCID: PMC5740110.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    32. Engineering the Genetic Code in Cells and Animals: Biological Considerations and Impacts. Acc Chem Res. 2017 11 21; 50(11):2767-2775. Wang L. PMID: 28984438; PMCID: PMC5698093.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    33. Site-specific incorporation of phosphotyrosine using an expanded genetic code. Nat Chem Biol. 2017 Aug; 13(8):842-844. Hoppmann C, Wong A, Yang B, Li S, Hunter T, Shokat KM, Wang L. PMID: 28604697; PMCID: PMC5577362.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    34. Optocontrol of glutamate receptor activity by single side-chain photoisomerization. Elife. 2017 05 23; 6. Klippenstein V, Hoppmann C, Ye S, Wang L, Paoletti P. PMID: 28534738; PMCID: PMC5441875.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    35. Heritable expansion of the genetic code in mouse and zebrafish. Cell Res. 2017 02; 27(2):294-297. Chen Y, Ma J, Lu W, Tian M, Thauvin M, Yuan C, Volovitch M, Wang Q, Holst J, Liu M, Vriz S, Ye S, Wang L, Li D. PMID: 27934867; PMCID: PMC5339847.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    36. Using Protein-Confined Proximity To Determine Chemical Reactivity. J Am Chem Soc. 2016 11 16; 138(45):14832-14835. Kobayashi T, Hoppmann C, Yang B, Wang L. PMID: 27797495; PMCID: PMC5310709.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    37. Editorial overview: Chemistry for biopolymers to investigate and even move beyond nature. Curr Opin Chem Biol. 2016 10; 34:v-vi. Pentelute BL, Wang L. PMID: 27751659.
      View in: PubMed   Mentions:    Fields:    
    38. Genetically encoding new bioreactivity. N Biotechnol. 2017 Sep 25; 38(Pt A):16-25. Wang L. PMID: 27721014; PMCID: PMC5382139.
      View in: PubMed   Mentions: 39     Fields:    
    39. Cysteine Sulfoxidation Increases the Photostability of Red Fluorescent Proteins. ACS Chem Biol. 2016 10 21; 11(10):2679-2684. Ren H, Yang B, Ma C, Hu YS, Wang PG, Wang L. PMID: 27603966; PMCID: PMC5310686.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    40. Development of background-free tame fluorescent probes for intracellular live cell imaging. Nat Commun. 2016 06 20; 7:11964. Alamudi SH, Satapathy R, Kim J, Su D, Ren H, Das R, Hu L, Alvarado-Martínez E, Lee JY, Hoppmann C, Peña-Cabrera E, Ha HH, Park HS, Wang L, Chang YT. PMID: 27321135; PMCID: PMC4915154.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    41. Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons. J Vis Exp. 2016 Mar 28; (109):e53818. Kang JY, Kawaguchi D, Wang L. PMID: 27078635; PMCID: PMC4841325.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    42. Proximity-enabled bioreactivity to generate covalent peptide inhibitors of p53-Mdm4. Chem Commun (Camb). 2016 Apr 14; 52(29):5140-3. Hoppmann C, Wang L. PMID: 26996321.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    43. In Situ Formation of an Azo Bridge on Proteins Controllable by Visible Light. J Am Chem Soc. 2015 Sep 09; 137(35):11218-21. Hoppmann C, Maslennikov I, Choe S, Wang L. PMID: 26301538; PMCID: PMC5356928.
      View in: PubMed   Mentions: 45     Fields:    Translation:Cells
    44. A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time. Cell Rep. 2014 Dec 11; 9(5):1946-1958. Li YC, Rodewald LW, Hoppmann C, Wong ET, Lebreton S, Safar P, Patek M, Wang L, Wertman KF, Wahl GM. PMID: 25464845; PMCID: PMC4269221.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    45. Genetically encoding an electrophilic amino acid for protein stapling and covalent binding to native receptors. ACS Chem Biol. 2014 Sep 19; 9(9):1956-61. Chen XH, Xiang Z, Hu YS, Lacey VK, Cang H, Wang L. PMID: 25010185; PMCID: PMC4168779.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    46. Response and adaptation of Escherichia coli to suppression of the amber stop codon. Chembiochem. 2014 Aug 18; 15(12):1744-9. Wang Q, Sun T, Xu J, Shen Z, Briggs SP, Zhou D, Wang L. PMID: 25044429; PMCID: PMC4156322.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    47. Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells. Angew Chem Int Ed Engl. 2014 Apr 07; 53(15):3932-6. Hoppmann C, Lacey VK, Louie GV, Wei J, Noel JP, Wang L. PMID: 24615769; PMCID: PMC4051619.
      View in: PubMed   Mentions: 47     Fields:    Translation:Cells
    48. Proximity-enabled protein crosslinking through genetically encoding haloalkane unnatural amino acids. Angew Chem Int Ed Engl. 2014 Feb 17; 53(8):2190-3. Xiang Z, Lacey VK, Ren H, Xu J, Burban DJ, Jennings PA, Wang L. PMID: 24449339; PMCID: PMC5356931.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    49. Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR. Cell. 2013 Dec 05; 155(6):1258-69. Coin I, Katritch V, Sun T, Xiang Z, Siu FY, Beyermann M, Stevens RC, Wang L. PMID: 24290358; PMCID: PMC3916339.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    50. In vivo expression of a light-activatable potassium channel using unnatural amino acids. Neuron. 2013 Oct 16; 80(2):358-70. Kang JY, Kawaguchi D, Coin I, Xiang Z, O'Leary DD, Slesinger PA, Wang L. PMID: 24139041; PMCID: PMC3815458.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    51. Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings. Chembiochem. 2013 Nov 04; 14(16):2100-5. Lacey VK, Louie GV, Noel JP, Wang L. PMID: 24019075; PMCID: PMC3947478.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    52. Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity. Nat Methods. 2013 Sep; 10(9):885-8. Xiang Z, Ren H, Hu YS, Coin I, Wei J, Cang H, Wang L. PMID: 23913257; PMCID: PMC3882359.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    53. Expression of fluorescent cyclotides using protein trans-splicing for easy monitoring of cyclotide-protein interactions. Angew Chem Int Ed Engl. 2013 Mar 11; 52(11):3126-31. Jagadish K, Borra R, Lacey V, Majumder S, Shekhtman A, Wang L, Camarero JA. PMID: 23322720; PMCID: PMC3767473.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    54. Release factor one is nonessential in Escherichia coli. ACS Chem Biol. 2012 Aug 17; 7(8):1337-44. Johnson DB, Wang C, Xu J, Schultz MD, Schmitz RJ, Ecker JR, Wang L. PMID: 22662873; PMCID: PMC3423824.
      View in: PubMed   Mentions: 49     Fields:    Translation:Cells
    55. Expanding the genetic code of Caenorhabditis elegans using bacterial aminoacyl-tRNA synthetase/tRNA pairs. ACS Chem Biol. 2012 Jul 20; 7(7):1292-302. Parrish AR, She X, Xiang Z, Coin I, Shen Z, Briggs SP, Dillin A, Wang L. PMID: 22554080; PMCID: PMC3401359.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    56. Genetic incorporation of unnatural amino acids into proteins in yeast. Methods Mol Biol. 2012; 794:199-213. Wang Q, Wang L. PMID: 21956564; PMCID: PMC3965369.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    57. RF1 knockout allows ribosomal incorporation of unnatural amino acids at multiple sites. Nat Chem Biol. 2011 Sep 18; 7(11):779-86. Johnson DB, Xu J, Shen Z, Takimoto JK, Schultz MD, Schmitz RJ, Xiang Z, Ecker JR, Briggs SP, Wang L. PMID: 21926996; PMCID: PMC3201715.
      View in: PubMed   Mentions: 134     Fields:    Translation:Cells
    58. Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40. Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel JP, Gage FH, Wang L. PMID: 21681861; PMCID: PMC3209808.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    59. A fluorescent reporter of the phosphorylation status of the substrate protein STAT3. Angew Chem Int Ed Engl. 2011 Sep 05; 50(37):8692-6. Lacey VK, Parrish AR, Han S, Shen Z, Briggs SP, Ma Y, Wang L. PMID: 21805546; PMCID: PMC3197789.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    60. Photo-cross-linkers incorporated into G-protein-coupled receptors in mammalian cells: a ligand comparison. Angew Chem Int Ed Engl. 2011 Aug 22; 50(35):8077-81. Coin I, Perrin MH, Vale WW, Wang L. PMID: 21751313; PMCID: PMC3262126.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    61. Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid L-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid. J Org Chem. 2011 Aug 05; 76(15):6367-71. Xiang Z, Wang L. PMID: 21732687; PMCID: PMC3155268.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    62. Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. ACS Chem Biol. 2011 Jul 15; 6(7):733-43. Takimoto JK, Dellas N, Noel JP, Wang L. PMID: 21545173; PMCID: PMC3137230.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    63. Genetic Incorporation of Unnatural Amino Acids into Proteins. Comprehensive Natural Products Chemistry II Chemistry and Biology. 2010; 5:587-617. Parrish AR, Wang L. View Publication.
    64. Esterification of an unnatural amino acid structurally deviating from canonical amino acids promotes its uptake and incorporation into proteins in mammalian cells. Chembiochem. 2010 Nov 02; 11(16):2268-72. Takimoto JK, Xiang Z, Kang JY, Wang L. PMID: 20872394; PMCID: PMC3029096.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    65. Imprints of the genetic code in the ribosome. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8298-303. Johnson DB, Wang L. PMID: 20385807; PMCID: PMC2889578.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    66. Impact of nonnatural amino acid mutagenesis on the in vivo function and binding modes of a transcriptional activator. J Am Chem Soc. 2009 Oct 14; 131(40):14240-2. Majmudar CY, Lee LW, Lancia JK, Nwokoye A, Wang Q, Wands AM, Wang L, Mapp AK. PMID: 19764747; PMCID: PMC4182099.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    67. Improving orthogonal tRNA-synthetase recognition for efficient unnatural amino acid incorporation and application in mammalian cells. Mol Biosyst. 2009 Sep; 5(9):931-4. Takimoto JK, Adams KL, Xiang Z, Wang L. PMID: 19668857.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    68. Expanding the genetic code for biological studies. Chem Biol. 2009 Mar 27; 16(3):323-36. Wang Q, Parrish AR, Wang L. PMID: 19318213; PMCID: PMC2696486.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    69. Unique interactions between the chromophore and glutamate 16 lead to far-red emission in a red fluorescent protein. Protein Sci. 2009 Feb; 18(2):460-6. Shu X, Wang L, Colip L, Kallio K, Remington SJ. PMID: 19165727; PMCID: PMC2708057.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    70. Selective labeling of proteins with chemical probes in living cells. Physiology (Bethesda). 2008 Jun; 23:131-41. Lin MZ, Wang L. PMID: 18556466.
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    71. Unnatural Amino Acids to Investigate Biological Processes. Wiley Encyclopedia of Chemical Biology. 2008; 10.1002/9780470048672.wecb585. Johnson DBF, Takimoto JK, Xu J, Wang L. View Publication.
    72. New methods enabling efficient incorporation of unnatural amino acids in yeast. J Am Chem Soc. 2008 May 14; 130(19):6066-7. Wang Q, Wang L. PMID: 18426210.
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    73. Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci. 2007 Aug; 10(8):1063-72. Wang W, Takimoto JK, Louie GV, Baiga TJ, Noel JP, Lee KF, Slesinger PA, Wang L. PMID: 17603477; PMCID: PMC2692200.
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    74. Manipulating proteins for neuroscience. Curr Opin Neurobiol. 2006 Oct; 16(5):585-92. Parrish AR, Wang W, Wang L. PMID: 16956756.
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    75. Evolving proteins in mammalian cells using somatic hypermutation. Nat Protoc. 2006; 1(3):1346-50. Wang L, Tsien RY. PMID: 17406421.
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    76. Expanding the genetic code. Annu Rev Biophys Biomol Struct. 2006; 35:225-49. Wang L, Xie J, Schultz PG. PMID: 16689635.
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    77. Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Protein Sci. 2005 May; 14(5):1340-9. Zhang Y, Wang L, Schultz PG, Wilson IA. PMID: 15840835; PMCID: PMC2253270.
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    78. Expanding the genetic code. Angew Chem Int Ed Engl. 2004 Dec 17; 44(1):34-66. Wang L, Schultz PG. PMID: 15599909.
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    79. Evolution of new nonantibody proteins via iterative somatic hypermutation. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16745-9. Wang L, Jackson WC, Steinbach PA, Tsien RY. PMID: 15556995; PMCID: PMC529417.
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    80. The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination. Nat Biotechnol. 2004 Oct; 22(10):1297-301. Xie J, Wang L, Wu N, Brock A, Spraggon G, Schultz PG. PMID: 15378068.
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    81. Amersham Prize winner. Expanding the genetic code. Science. 2003 Oct 24; 302(5645):584-5. Wang L. PMID: 14576413.
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    82. A new strategy for the site-specific modification of proteins in vivo. Biochemistry. 2003 Jun 10; 42(22):6735-46. Zhang Z, Smith BA, Wang L, Brock A, Cho C, Schultz PG. PMID: 12779328.
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    83. A method for the generation of glycoprotein mimetics. J Am Chem Soc. 2003 Feb 19; 125(7):1702-3. Liu H, Wang L, Brock A, Wong CH, Schultz PG. PMID: 12580587.
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    84. Generation of a bacterium with a 21 amino acid genetic code. J Am Chem Soc. 2003 Jan 29; 125(4):935-9. Mehl RA, Anderson JC, Santoro SW, Wang L, Martin AB, King DS, Horn DM, Schultz PG. PMID: 12537491.
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    85. Unnatural amino acid mutagenesis of green fluorescent protein. J Org Chem. 2003 Jan 10; 68(1):174-6. Wang L, Xie J, Deniz AA, Schultz PG. PMID: 12515477.
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    86. Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A. 2003 Jan 07; 100(1):56-61. Wang L, Zhang Z, Brock A, Schultz PG. PMID: 12518054; PMCID: PMC140882.
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    87. An efficient system for the evolution of aminoacyl-tRNA synthetase specificity. Nat Biotechnol. 2002 Oct; 20(10):1044-8. Santoro SW, Wang L, Herberich B, King DS, Schultz PG. PMID: 12244330.
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    88. Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc. 2002 Aug 07; 124(31):9026-7. Chin JW, Santoro SW, Martin AB, King DS, Wang L, Schultz PG. PMID: 12148987.
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    89. The selective incorporation of alkenes into proteins in Escherichia coli. Angew Chem Int Ed Engl. 2002 Aug 02; 41(15):2840-2. Zhang Z, Wang L, Brock A, Schultz PG. PMID: 12203503.
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    90. Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11020-4. Chin JW, Martin AB, King DS, Wang L, Schultz PG. PMID: 12154230; PMCID: PMC123203.
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    91. Adding L-3-(2-Naphthyl)alanine to the genetic code of E. coli. J Am Chem Soc. 2002 Mar 06; 124(9):1836-7. Wang L, Brock A, Schultz PG. PMID: 11866580.
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    92. Expanding the genetic code. Chem Commun (Camb). 2002 Jan 07; (1):1-11. Wang L, Schultz PG. PMID: 12120285.
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    93. A general approach for the generation of orthogonal tRNAs. Chem Biol. 2001 Sep; 8(9):883-90. Wang L, Schultz PG. PMID: 11564556.
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    94. Expanding the genetic code of Escherichia coli. Science. 2001 Apr 20; 292(5516):498-500. Wang L, Brock A, Herberich B, Schultz PG. PMID: 11313494.
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    95. A New Functional Suppressor tRNA/Aminoacyl-tRNA Synthetase Pair for the in vivo Incorporation of Unnatural Amino Acids into Proteins. J Am Chem Soc. 2000; 122(20):5010-5011. Wang L, Magliery TJ, Liu DR, Schultz PG.
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    97. Developing High Resolution Electrical Probing System Based on Atomic Force Microscopy. Molecular Crystals and Liquid Crystals. 1997; 294(1):91-94. Chen Y, Wang L, He HX, Liu ZF. View Publication.
    98. Fabrication of Gold Nanostructures on Graphite Using Atomic Force Microscope. Molecular Crystals and Liquid Crystals. 1997; 294(1):51-54. Song JQ, Li CZ, He HX, Chen Y, Wang L, Liu ZF. View Publication.
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