Lennart Mucke, MD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-734-2504
ORCID ORCID Icon0000-0001-6256-9559 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Overview 
    Collapse Overview
    Areas of investigation
    We study processes that result in memory loss and other major neurological deficits, with an emphasis on Alzheimerís disease (AD) and related neurodegenerative disorders. Our long-term goal is to advance the understanding of the healthy and the diseased central nervous system to a point where rational strategies can be developed for the prevention and cure of these conditions.

    Significance
    Molecules similar to those involved in neurodegenerative diseases are highly expressed in the nervous system of diverse species and appear to function in learning, synaptic plasticity, and regeneration. We are particularly curious about the roles of amyloid precursor proteins and apolipoprotein E in AD, and a-synuclein in Parkinsonís disease (PD). AD and PD are the most frequent neurodegenerative disorders. They erode peopleís ability to think and control their movements, two of the most critical and intriguing functions of the central nervous system. Both conditions are on the rise and neither can be prevented or cured. These facts underline the significance and urgency of our research efforts.

    Approaches
    We use transgenic mouse models and neural cultures to study potential pathogenic factors and pathways at the molecular, cellular, network, and behavioral level. Mouse models are also used to develop and evaluate novel treatment strategies. Their relevance is assessed through comparative studies of humans and postmortem tissues in collaboration with clinical programs.


    Contributions
    In AD-related transgenic models, we discovered that amyloid-ß peptides (Aß) can damage synapses and disrupt neural memory circuits independent of their deposition into the visible amyloid plaques that form in AD brains. The plaque-independent toxicity of Aß was inhibited by apolipoprotein E3, but not E4, which may relate to the differential effects of these molecules on AD risk and age of onset. Pathogenic interactions between Aß and a-synuclein worsened cognitive and motor deficits in doubly transgenic mice, a finding of potential relevance to the frequent overlap between AD and PD. Most recently, we discovered that neural network activity in AD-related mouse models fluctuates between abnormal excitation (epilepsy-like) and abnormal inhibition. Remarkably, reducing the protein tau effectively prevented these alterations as well as Aß-induced cognitive deficits. Ongoing studies aim to determine whether such network dysfunction also contributes to cognitive deficits in AD.

    Some questions addressed in ongoing studies

    How does Aß affect synaptic function and neuronal survival?
    How does tau reduction make the brain resistant against Aß-induced deficits?
    Can the beneficial effect of tau reduction be exploited therapeutically?
    Which drugs can block the aberrant network activity that Aß triggers?
    Will these drugs also normalize cognitive functions and prevent neurological decline in AD?
    What can the selective vulnerability of specific neuronal populations to different neurodegenerative disorders teach us about the uniqueness of the affected cells and the pathogenic cascades involved?
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease
    NIH P01AG073082Aug 15, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Evolving CRISPR-based platforms for the discovery of Alzheimer relevant neurodegenerative pathways
    NIH R21AG069183Sep 1, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis
    NIH RF1AG063519May 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis
    NIH/NIA R01AG063519May 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Identification and Development of Tau-Lowering Small-Molecule Drugs
    NIH R56AG060631Apr 15, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Therapeutic Potential and Mechanisms of Tau Reduction in Autism Models
    NIH R01MH115679Jul 3, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Effect of Aging on Efficacy of Alzheimer-focused Therapeutic Strategies
    NIH UH2NS100128Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Effect of Aging on Efficacy of Alzheimer-focused Therapeutic Strategies
    NIH UH3NS100128Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Contribution of DNA Repair Deficits to Alzheimer Pathogenesis
    NIH RF1AG053981Aug 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Neurobiology and Therapeutic Potential of Klotho
    NIH R01NS088532Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Mouse Models with Regulatable Cell Type-specific Expression of Anti-Tau shRNAs
    NIH R21AG039259Mar 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Behavioral Core
    NIH P30NS065780Feb 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Novel Therapeutic Approaches to Alzheimer's Disease
    NIH P30NS069496Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Proteinopathies of the Aging Central Nervous System
    NIH P01AG022074Jun 15, 2003 - Nov 30, 2013
    Role: Principal Investigator
    A Beta Vaccination: Mechanisms and Therapautic Impact
    NIH R01NS043945Sep 30, 2001 - Aug 31, 2007
    Role: Principal Investigator
    Kinases Linking Abeta and Tau to Synaptic Dysfunction
    NIH R01NS041787May 1, 2001 - Feb 29, 2016
    Role: Principal Investigator
    THERAPEUTIC TARGETS IN TRANSGENIC MICE
    NIH R01MH058164Aug 1, 1997 - Jul 31, 2001
    Role: Principal Investigator
    TRANSGENIC MODELS TO STUDY AIDS DEMENTIA COMPLEX
    NIH R01NS034602Jul 18, 1995 - May 31, 2000
    Role: Principal Investigator
    IN VIVO CNS EFFECTS OF HIV1 COAT PROTEINS AND NEF
    NIH R01NS033056Apr 1, 1994 - Mar 31, 1998
    Role: Principal Investigator
    Synaptic Dysfunction Affecting DNA Integrity in Alzheimer's Disease
    NIH R01AG011385Sep 1, 1992 - May 31, 2019
    Role: Principal Investigator
    Transgenic Models to Study Alzheimer's Disease
    NIH R37AG011385Sep 1, 1992 - Mar 31, 2013
    Role: Principal Investigator
    AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    NIH P50MH047680Sep 30, 1990 - Aug 31, 2001
    Role: Co-Investigator
    Aging Disease--Prion/Transgenic/Immunologic Studies
    NIH P01AG004342Aug 1, 1983 - Nov 30, 2009
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model. Sci Transl Med. 2022 04 27; 14(642):eabm5527. Shao E, Chang CW, Li Z, Yu X, Ho K, Zhang M, Wang X, Simms J, Lo I, Speckart J, Holtzman J, Yu GQ, Roberson ED, Mucke L. PMID: 35476595; PMCID: PMC9102397.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial. JAMA Neurol. 2021 11 01; 78(11):1345-1354. Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE. PMID: 34570177; PMCID: PMC8477304.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    3. Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony. Cell Rep. 2021 10 19; 37(3):109855. Chang CW, Evans MD, Yu X, Yu GQ, Mucke L. PMID: 34686344; PMCID: PMC8648275.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models. iScience. 2021 Nov 19; 24(11):103245. Das M, Mao W, Shao E, Tamhankar S, Yu GQ, Yu X, Ho K, Wang X, Wang J, Mucke L. PMID: 34755090; PMCID: PMC8561005.
      View in: PubMed   Mentions:
    5. Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice. eNeuro. 2021 May-Jun; 8(3). Gulbranson DR, Ho K, Yu GQ, Yu X, Das M, Shao E, Kim D, Zhang WJ, Choudhary K, Thomas R, Mucke L. PMID: 33833046; PMCID: PMC8121260.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science. 2021 02 26; 371(6532). Chang CW, Shao E, Mucke L. PMID: 33632820; PMCID: PMC8118650.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    7. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science. 2021; 371(6532):eabb8255. Che-Wei Chang, Eric Shao, Lennart Mucke. . View Publication.
    8. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1. Mol Neurodegener. 2020 09 14; 15(1):53. Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L. PMID: 32921309; PMCID: PMC7489007.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    9. A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Sci Transl Med. 2020 08 26; 12(558). Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB. PMID: 32848093; PMCID: PMC8409261.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    10. Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit. Elife. 2020 08 24; 9. Díaz-Alonso J, Morishita W, Incontro S, Simms J, Holtzman J, Gill M, Mucke L, Malenka RC, Nicoll RA. PMID: 32831170; PMCID: PMC7500950.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. Tau Reduction Prevents Key Features of Autism in Mouse Models. Neuron. 2020 05 06; 106(3):421-437.e11. Tai C, Chang CW, Yu GQ, Lopez I, Yu X, Wang X, Guo W, Mucke L. PMID: 32126198; PMCID: PMC7210056.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    12. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathol Commun. 2019 05 17; 7(1):77. Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. PMID: 31101070; PMCID: PMC6524256.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    13. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019 03 20; 101(6):1099-1108.e6. Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K. PMID: 30737131; PMCID: PMC6602536.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    14. Klotho controls the brain-immune system interface in the choroid plexus. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11388-E11396. Zhu L, Stein LR, Kim D, Ho K, Yu GQ, Zhan L, Larsson TE, Mucke L. PMID: 30413620; PMCID: PMC6275534.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    15. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    16. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 09 10; 28(17):R909-R914. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. PMID: 30205056; PMCID: PMC8163022.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    17. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    18. Neuronal levels and sequence of tau modulate the power of brain rhythms. Neurobiol Dis. 2018 09; 117:181-188. Das M, Maeda S, Hu B, Yu GQ, Guo W, Lopez I, Yu X, Tai C, Wang X, Mucke L. PMID: 29859869.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    19. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 04 04; 98(1):75-89.e5. Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. PMID: 29551491; PMCID: PMC5886814.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    20. Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiol Dis. 2018 02; 110:29-36. Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L. PMID: 29100987; PMCID: PMC5747997.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    21. The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease. Wellcome Open Res. 2017; 2:84. Tosh JL, Rickman M, Rhymes E, Norona FE, Clayton E, Mucke L, Isaacs AM, Fisher EMC, Wiseman FK. PMID: 29062914; PMCID: PMC5645710.
      View in: PubMed   Mentions: 10  
    22. Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture. Mol Neurodegener. 2017 05 19; 12(1):41. Miyamoto T, Stein L, Thomas R, Djukic B, Taneja P, Knox J, Vossel K, Mucke L. PMID: 28526038; PMCID: PMC5438564.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    23. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016 12; 17(12):777-792. Palop JJ, Mucke L. PMID: 27829687; PMCID: PMC8162106.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansAnimalsCells
    24. Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Ann Neurol. 2016 12; 80(6):858-870. Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. PMID: 27696483; PMCID: PMC5177487.
      View in: PubMed   Mentions: 125     Fields:    Translation:Humans
    25. Tau Phosphorylation-Much More than a Biomarker. Neuron. 2016 Oct 19; 92(2):265-267. Maeda S, Mucke L. PMID: 27764656.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    26. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016 04; 17(4):530-51. Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L. PMID: 26931567; PMCID: PMC4818780.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    27. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun. 2015 Nov 30; 6:8897. Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L. PMID: 26615780; PMCID: PMC4674776.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    28. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016 Jan 22; 291(4):1719-1734. Miyamoto T, Kim D, Knox JA, Johnson E, Mucke L. PMID: 26589795; PMCID: PMC4722453.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    29. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol. 2015 11; 2(11):1012-28. Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L. PMID: 26732627; PMCID: PMC4693622.
      View in: PubMed   Mentions: 19     Fields:    
    30. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice. Nat Neurosci. 2015 Aug; 18(8):1183-9. Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L. PMID: 26192747; PMCID: PMC8049446.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    31. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. J Cell Biol. 2015 May 11; 209(3):419-33. Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L. PMID: 25963821; PMCID: PMC4427789.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    32. Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death Dis. 2015 Apr 16; 6:e1725. Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K. PMID: 25880092; PMCID: PMC4650558.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    33. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci. 2015 Feb 11; 35(6):2358-71. Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. PMID: 25673831; PMCID: PMC4323521.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    34. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. PMID: 25622143; PMCID: PMC4340760.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    35. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PLoS One. 2014; 9(12):e115765. Cheng JS, Craft R, Yu GQ, Ho K, Wang X, Mohan G, Mangnitsky S, Ponnusamy R, Mucke L. PMID: 25551452; PMCID: PMC4281043.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    36. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. PMID: 25261995; PMCID: PMC4196723.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    37. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014 Sep; 76(3):443-56. Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L. PMID: 25042160; PMCID: PMC4338764.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    38. Life extension factor klotho enhances cognition. Cell Rep. 2014 May 22; 7(4):1065-76. Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L. PMID: 24813892; PMCID: PMC4176932.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    39. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 01; 70(9):1158-66. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. PMID: 23835471; PMCID: PMC4013391.
      View in: PubMed   Mentions: 230     Fields:    Translation:Humans
    40. Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β. Nat Neurosci. 2013 May; 16(5):613-21. Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L. PMID: 23525040; PMCID: PMC3637871.
      View in: PubMed   Mentions: 207     Fields:    Translation:HumansAnimalsCells
    41. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiol Aging. 2013 Jun; 34(6):1523-9. Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. PMID: 23332171; PMCID: PMC3596503.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    42. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS One. 2012; 7(9):e45881. Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L. PMID: 23029293; PMCID: PMC3454317.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    43. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):E2895-903. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L. PMID: 22869752; PMCID: PMC3479491.
      View in: PubMed   Mentions: 248     Fields:    Translation:HumansAnimalsCells
    44. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a006338. Mucke L, Selkoe DJ. PMID: 22762015; PMCID: PMC3385944.
      View in: PubMed   Mentions: 416     Fields:    Translation:HumansAnimalsCells
    45. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012 Apr 27; 149(3):708-21. Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. PMID: 22541439; PMCID: PMC3375906.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansAnimalsCells
    46. Alzheimer mechanisms and therapeutic strategies. Cell. 2012 Mar 16; 148(6):1204-22. Huang Y, Mucke L. PMID: 22424230; PMCID: PMC3319071.
      View in: PubMed   Mentions: 655     Fields:    Translation:HumansAnimals
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    116. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci. 1999 Jun 15; 19(12):4867-80. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW. PMID: 10366621; PMCID: PMC6782676.
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    117. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 1999 Jun; 23(2):297-308. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. PMID: 10399936.
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    118. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3228-33. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L. PMID: 10077666; PMCID: PMC15924.
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    119. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10914-9. Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L. PMID: 9724804; PMCID: PMC27995.
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    120. Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis. J Biol Chem. 1998 May 15; 273(20):12548-54. Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, Mucke L. PMID: 9575214.
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    121. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998 Apr 17; 93(2):189-201. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. PMID: 9568712.
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    122. Novel role of human CD4 molecule identified in neurodegeneration. Nat Med. 1998 Apr; 4(4):441-6. Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L. PMID: 9546790.
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    123. Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience. 1998 Apr; 83(3):691-700. Krucker T, Toggas SM, Mucke L, Siggins GR. PMID: 9483553.
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    124. Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12655-60. Xu X, Raber J, Yang D, Su B, Mucke L. PMID: 9356505; PMCID: PMC25073.
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    125. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J. 1997 Oct 15; 16(20):6057-65. Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B. PMID: 9321385; PMCID: PMC1326289.
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    126. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature. 1997 Oct 09; 389(6651):603-6. Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L. PMID: 9335500.
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    127. Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice . J Neuroimmunol. 1997 Jul; 77(1):45-50. Wyss-Coray T, Borrow P, Brooker MJ, Mucke L. PMID: 9209267.
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    128. Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects. J Biol Chem. 1997 Jun 13; 272(24):15057-60. Raber J, Chen S, Mucke L, Feng L. PMID: 9182522.
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    129. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 1997 May; 78(1):135-46. Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L. PMID: 9135095.
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    130. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Res Brain Res Rev. 1997 Feb; 23(1-2):47-61. Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L. PMID: 9063586.
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    131. Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. Virology. 1996 Dec 15; 226(2):362-73. Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L. PMID: 8955056.
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    132. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J Biol Chem. 1996 Dec 06; 271(49):31407-11. Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. PMID: 8940150.
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    133. Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein. Neuroreport. 1996 Nov 04; 7(15-17):2807-11. D'Hooge R, Nagels G, Westland CE, Mucke L, De Deyn PP. PMID: 8981472.
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    134. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci. 1996 Sep 15; 16(18):5795-811. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D. PMID: 8795633; PMCID: PMC6578961.
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    135. Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule L1 by mouse astrocytes. Eur J Neurosci. 1996 Jun; 8(6):1085-97. Mohajeri MH, Bartsch U, van der Putten H, Sansig G, Mucke L, Schachner M. PMID: 8752578.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    136. Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. J Clin Invest. 1996 Feb 01; 97(3):789-98. Wyss-Coray T, Masliah E, Toggas SM, Rockenstein EM, Brooker MJ, Lee HS, Mucke L. PMID: 8609236; PMCID: PMC507117.
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    137. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Ann N Y Acad Sci. 1996 Jan 17; 777:82-8. Mucke L, Abraham CR, Masliah E. PMID: 8624131.
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    138. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res. 1996 Jan 15; 706(2):303-7. Toggas SM, Masliah E, Mucke L. PMID: 8822372.
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    139. Transgenic models in the study of AIDS dementia complex. Curr Top Microbiol Immunol. 1996; 206:223-41. Toggas SM, Mucke L. PMID: 8608719.
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    140. Pathogenesis of HIV-1 associated neurodegeneration. Crit Rev Neurobiol. 1996; 10(1):57-67. Masliah E, Ge N, Mucke L. PMID: 8853954.
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    141. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem. 1995 Nov 24; 270(47):28257-67. Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. PMID: 7499323.
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    142. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron. 1995 Nov; 15(5):1183-91. Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, Oldstone MB. PMID: 7576660; PMCID: PMC7135899.
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    143. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. J Exp Med. 1995 Nov 01; 182(5):1201-12. Rall GF, Mucke L, Oldstone MB. PMID: 7595191; PMCID: PMC2192211.
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    144. Immunization-induced inflammatory infiltration of the central nervous system in transgenic mice expressing a microbial antigen in astrocytes. J Neuroimmunol. 1995 Sep; 61(2):133-49. Borrow P, Cornell JL, Ruppe MD, Mucke L. PMID: 7593549.
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    145. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am J Pathol. 1995 Jul; 147(1):53-67. Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L. PMID: 7604885; PMCID: PMC1869892.
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    146. Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and Müller cells. Invest Ophthalmol Vis Sci. 1995 May; 36(6):1137-43. Verderber L, Johnson W, Mucke L, Sarthy V. PMID: 7730023.
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    147. gp120 and neurotoxicity in vivo. Trends Pharmacol Sci. 1995 Apr; 16(4):122. Lipton SA, Brenneman DE, Silverstein FS, Masliah E, Mucke L. PMID: 7610496.
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    148. Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. J Exp Med. 1995 Apr 01; 181(4):1551-6. Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E. PMID: 7699335; PMCID: PMC2191956.
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    149. Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes. Glia. 1995 Mar; 13(3):174-84. Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, Mucke L. PMID: 7782103.
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    150. Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines. Curr Top Microbiol Immunol. 1995; 202:187-205. Mucke L, Masliah E, Campbell IL. PMID: 7587363.
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    151. Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res. 1994 Dec 15; 666(2):151-67. Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR. PMID: 7882025.
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    152. A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes. J Neuroimmunol. 1994 Jun; 52(1):61-8. Rall GF, Mucke L, Nerenberg M, Oldstone MB. PMID: 8207120; PMCID: PMC7119529.
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    153. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 1994 Jan 13; 367(6459):188-93. Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L. PMID: 8114918.
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    154. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):10061-5. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L. PMID: 7694279; PMCID: PMC47713.
      View in: PubMed   Mentions: 275     Fields:    Translation:AnimalsCells
    155. Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB J. 1993 Oct; 7(13):1226-32. Mucke L, Eddleston M. PMID: 8405808.
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    156. Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes. Brain Res. 1993 Sep 10; 621(2):222-32. Abraham CR, Kanemaru K, Mucke L. PMID: 8242336.
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    157. Molecular profile of reactive astrocytes--implications for their role in neurologic disease. Neuroscience. 1993 May; 54(1):15-36. Eddleston M, Mucke L. PMID: 8515840; PMCID: PMC7130906.
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    158. Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein. Ann N Y Acad Sci. 1992 Dec 31; 674:174-9. Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L. PMID: 1288362.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    159. The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). J Neuroimmunol. 1992 Feb; 36(2-3):193-8. Mucke L, Oldstone MB. PMID: 1732281; PMCID: PMC7119833.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    160. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science. 1991 Sep 13; 253(5025):1283-5. Joly E, Mucke L, Oldstone MB. PMID: 1891717.
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    161. Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury. New Biol. 1991 May; 3(5):465-74. Mucke L, Oldstone MB, Morris JC, Nerenberg MI. PMID: 1883812.
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    162. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J Neurosci. 1990 Feb; 10(2):520-30. Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM. PMID: 2303857; PMCID: PMC6570158.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    163. Prolonged survival and partial recovery in AIDS-associated progressive multifocal leukoencephalopathy. Neurology. 1988 Jul; 38(7):1060-5. Berger JR, Mucke L. PMID: 3386823.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    164. Anterior ectosylvian visual area (AEV) of the cat: physiological properties. Prog Brain Res. 1988; 75:245-55. Benedek G, Mucke L, Norita M, Albowitz B, Creutzfeldt OD. PMID: 3187054.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    165. Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization. Acta Physiol Scand. 1987 Dec; 131(4):631-2. Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH, et al. PMID: 3442246.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    166. Clinical management of neuropathic pain. Neurol Clin. 1987 Nov; 5(4):649-63. Mucke L, Maciewicz R. PMID: 2828905.
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    167. Connections of the anterior ectosylvian visual area (AEV). Exp Brain Res. 1986; 62(2):225-40. Norita M, Mucke L, Benedek G, Albowitz B, Katoh Y, Creutzfeldt OD. PMID: 3709710.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    168. Physiologic and anatomic investigation of a visual cortical area situated in the ventral bank of the anterior ectosylvian sulcus of the cat. Exp Brain Res. 1982; 46(1):1-11. Mucke L, Norita M, Benedek G, Creutzfeldt O. PMID: 7067781.
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