Lennart Mucke, MD

Title(s)Professor, Neurology
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-6256-9559 Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


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    Collapse Overview
    Overview
    Lennart Mucke’s laboratory aims to unravel how major neurologic and psychiatric conditions cause cognitive deficits, behavioral abnormalities, and other disabling symptoms, with an emphasis on dementias, epilepsy, and autism.

    Our group uses mouse models and brain cell cultures to study disease-causing factors and pathways at molecular, cellular, network, and behavioral levels. Such models are also used to identify and validate novel entry points for therapeutic interventions.

    The clinical relevance of discoveries is assessed through collaborative studies of human patients and brain tissues. Several findings we originally made in mouse models were subsequently identified for the first time in the human condition, highlighting the validity and power of experimental models. The most informative models have been used to identify novel strategies to counteract the development of brain dysfunctions and decline.


    Major Contributions
    • Instigated paradigm shifts in understanding and preventing the pathogenesis of Alzheimer’s disease

    • Advanced the field from its traditional focus on morphological changes toward an understanding of Alzheimer’s disease at the synaptic and neural network level

    • Defined molecular and cellular mechanisms underlying cognitive decline in Alzheimer’s disease

    • Discovered unexpected links among Alzheimer’s disease, epilepsy and autism

    • Identified novel therapeutic strategies and paved the path toward the development of tau-lowering therapeutics

    • Provided critical guidance for the design of clinical trials aimed at reversing network hyperexcitability in Alzheimer’s disease

    • Encouraged and enabled the translation of scientific discoveries into better treatments for brain diseases that are frequent, devastating, and costly to populations around the world


    Interests and Ongoing Studies
    • Mechanisms and treatment of dementia, epilepsy, and autism spectrum disorders

    • Pathobiology of amyloid proteins, tau, apolipoprotein E, α-synuclein, TREM2, PTEN, and related signaling pathways

    • Neural processes underlying important brain functions

    • Role of glia in health and disease

    • Dissection of complex neuropathogenic pathways in experimental models

    • Development and (pre)clinical assessment of novel therapeutic strategies

    • Establishment and guidance of interdisciplinary research programs
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    Collapse Research 
    Collapse Research Activities and Funding
    Decoding the Multifactorial Etiology of Neural Network Dysfunction in Alzheimer's Disease
    NIH P01AG073082Aug 15, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Evolving CRISPR-based platforms for the discovery of Alzheimer relevant neurodegenerative pathways
    NIH R21AG069183Sep 1, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis
    NIH RF1AG063519May 1, 2019 - Mar 31, 2024
    Role: Principal Investigator
    Neural network and immune cell dysfunctions in Alzheimer's disease pathogenesis
    NIH/NIA R01AG063519May 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Identification and Development of Tau-Lowering Small-Molecule Drugs
    NIH R56AG060631Apr 15, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Therapeutic Potential and Mechanisms of Tau Reduction in Autism Models
    NIH R01MH115679Jul 3, 2018 - Apr 30, 2023
    Role: Principal Investigator
    Effect of Aging on Efficacy of Alzheimer-focused Therapeutic Strategies
    NIH UH2NS100128Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Effect of Aging on Efficacy of Alzheimer-focused Therapeutic Strategies
    NIH UH3NS100128Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Contribution of DNA Repair Deficits to Alzheimer Pathogenesis
    NIH RF1AG053981Aug 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Neurobiology and Therapeutic Potential of Klotho
    NIH R01NS088532Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Mouse Models with Regulatable Cell Type-specific Expression of Anti-Tau shRNAs
    NIH R21AG039259Mar 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Behavioral Core
    NIH P30NS065780Feb 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Novel Therapeutic Approaches to Alzheimer's Disease
    NIH P30NS069496Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    New Approaches to Dementia Heterogeneity
    NIH P50AG023501Apr 1, 2004 - Mar 31, 2019
    Role: Co-Investigator
    Proteinopathies of the Aging Central Nervous System
    NIH P01AG022074Jun 15, 2003 - Nov 30, 2013
    Role: Principal Investigator
    A Beta Vaccination: Mechanisms and Therapautic Impact
    NIH R01NS043945Sep 30, 2001 - Aug 31, 2007
    Role: Principal Investigator
    Kinases Linking Abeta and Tau to Synaptic Dysfunction
    NIH R01NS041787May 1, 2001 - Feb 29, 2016
    Role: Principal Investigator
    THERAPEUTIC TARGETS IN TRANSGENIC MICE
    NIH R01MH058164Aug 1, 1997 - Jul 31, 2001
    Role: Principal Investigator
    TRANSGENIC MODELS TO STUDY AIDS DEMENTIA COMPLEX
    NIH R01NS034602Jul 18, 1995 - May 31, 2000
    Role: Principal Investigator
    IN VIVO CNS EFFECTS OF HIV1 COAT PROTEINS AND NEF
    NIH R01NS033056Apr 1, 1994 - Mar 31, 1998
    Role: Principal Investigator
    Synaptic Dysfunction Affecting DNA Integrity in Alzheimer's Disease
    NIH R01AG011385Sep 1, 1992 - May 31, 2019
    Role: Principal Investigator
    Transgenic Models to Study Alzheimer's Disease
    NIH R37AG011385Sep 1, 1992 - Mar 31, 2013
    Role: Principal Investigator
    AIDS DEMENTIA--MOLECULAR AND CELLULAR MECHANISMS
    NIH P50MH047680Sep 30, 1990 - Aug 31, 2001
    Role: Co-Investigator
    Aging Disease--Prion/Transgenic/Immunologic Studies
    NIH P01AG004342Aug 1, 1983 - Nov 30, 2009
    Role: Co-Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2024 Oct 03. Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L. PMID: 39363060.
      View in: PubMed   Mentions:    Fields:    
    2. CHOIR improves significance-based detection of cell types and states from single-cell data. bioRxiv. 2024 Jan 23. Petersen C, Mucke L, Corces MR. PMID: 38328105; PMCID: PMC10849522.
      View in: PubMed   Mentions:
    3. Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models. Neurobiol Dis. 2023 10 01; 186:106263. Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT, Mucke L. PMID: 37591465; PMCID: PMC10681293.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    4. TAU ablation in excitatory neurons and postnatal TAU knockdown reduce epilepsy, SUDEP, and autism behaviors in a Dravet syndrome model. Sci Transl Med. 2022 04 27; 14(642):eabm5527. Shao E, Chang CW, Li Z, Yu X, Ho K, Zhang M, Wang X, Simms J, Lo I, Speckart J, Holtzman J, Yu GQ, Roberson ED, Mucke L. PMID: 35476595; PMCID: PMC9102397.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    5. Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial. JAMA Neurol. 2021 11 01; 78(11):1345-1354. Vossel K, Ranasinghe KG, Beagle AJ, La A, Ah Pook K, Castro M, Mizuiri D, Honma SM, Venkateswaran N, Koestler M, Zhang W, Mucke L, Howell MJ, Possin KL, Kramer JH, Boxer AL, Miller BL, Nagarajan SS, Kirsch HE. PMID: 34570177; PMCID: PMC8477304.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCTClinical Trials
    6. Tau reduction affects excitatory and inhibitory neurons differently, reduces excitation/inhibition ratios, and counteracts network hypersynchrony. Cell Rep. 2021 10 19; 37(3):109855. Chang CW, Evans MD, Yu X, Yu GQ, Mucke L. PMID: 34686344; PMCID: PMC8648275.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    7. Interdependence of neural network dysfunction and microglial alterations in Alzheimer's disease-related models. iScience. 2021 Nov 19; 24(11):103245. Das M, Mao W, Shao E, Tamhankar S, Yu GQ, Yu X, Ho K, Wang X, Wang J, Mucke L. PMID: 34755090; PMCID: PMC8561005.
      View in: PubMed   Mentions: 11  
    8. Phenotypic Differences between the Alzheimer's Disease-Related hAPP-J20 Model and Heterozygous Zbtb20 Knock-Out Mice. eNeuro. 2021 May-Jun; 8(3). Gulbranson DR, Ho K, Yu GQ, Yu X, Das M, Shao E, Kim D, Zhang WJ, Choudhary K, Thomas R, Mucke L. PMID: 33833046; PMCID: PMC8121260.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    9. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science. 2021 02 26; 371(6532). Chang CW, Shao E, Mucke L. PMID: 33632820; PMCID: PMC8118650.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimalsCells
    10. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science. 2021; 371(6532):eabb8255. Che-Wei Chang, Eric Shao, Lennart Mucke. . View Publication.
    11. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1. Mol Neurodegener. 2020 09 14; 15(1):53. Johnson ECB, Ho K, Yu GQ, Das M, Sanchez PE, Djukic B, Lopez I, Yu X, Gill M, Zhang W, Paz JT, Palop JJ, Mucke L. PMID: 32921309; PMCID: PMC7489007.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    12. A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Sci Transl Med. 2020 08 26; 12(558). Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris JA, Miller BL, Bennett DA, Arnold AP, De Jager PL, Palop JJ, Panning B, Yokoyama JS, Mucke L, Dubal DB. PMID: 32848093; PMCID: PMC8409261.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    13. Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit. Elife. 2020 08 24; 9. Díaz-Alonso J, Morishita W, Incontro S, Simms J, Holtzman J, Gill M, Mucke L, Malenka RC, Nicoll RA. PMID: 32831170; PMCID: PMC7500950.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    14. Tau Reduction Prevents Key Features of Autism in Mouse Models. Neuron. 2020 05 06; 106(3):421-437.e11. Tai C, Chang CW, Yu GQ, Lopez I, Yu X, Wang X, Guo W, Mucke L. PMID: 32126198; PMCID: PMC7210056.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    15. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathol Commun. 2019 05 17; 7(1):77. Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. PMID: 31101070; PMCID: PMC6524256.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    16. Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. Neuron. 2019 03 20; 101(6):1099-1108.e6. Merlini M, Rafalski VA, Rios Coronado PE, Gill TM, Ellisman M, Muthukumar G, Subramanian KS, Ryu JK, Syme CA, Davalos D, Seeley WW, Mucke L, Nelson RB, Akassoglou K. PMID: 30737131; PMCID: PMC6602536.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    17. Klotho controls the brain-immune system interface in the choroid plexus. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11388-E11396. Zhu L, Stein LR, Kim D, Ho K, Yu GQ, Zhan L, Larsson TE, Mucke L. PMID: 30413620; PMCID: PMC6275534.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    18. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimals
    19. The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease. Wellcome Open Res. 2017; 2:84. Tosh JL, Rickman M, Rhymes E, Norona FE, Clayton E, Mucke L, Isaacs AM, Fisher EMC, Wiseman FK. PMID: 29062914; PMCID: PMC5645710.
      View in: PubMed   Mentions: 12  
    20. The mouse as a model for neuropsychiatric drug development. Curr Biol. 2018 09 10; 28(17):R909-R914. Howe JR, Bear MF, Golshani P, Klann E, Lipton SA, Mucke L, Sahin M, Silva AJ. PMID: 30205056; PMCID: PMC8163022.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    21. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 2018 07 26; 174(3):505-520. Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ. PMID: 30053424; PMCID: PMC6247911.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    22. Neuronal levels and sequence of tau modulate the power of brain rhythms. Neurobiol Dis. 2018 09; 117:181-188. Das M, Maeda S, Hu B, Yu GQ, Guo W, Lopez I, Yu X, Tai C, Wang X, Mucke L. PMID: 29859869.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    23. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 2018 04 04; 98(1):75-89.e5. Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ. PMID: 29551491; PMCID: PMC5886814.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    24. Istradefylline reduces memory deficits in aging mice with amyloid pathology. Neurobiol Dis. 2018 02; 110:29-36. Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L. PMID: 29100987; PMCID: PMC5747997.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    25. Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture. Mol Neurodegener. 2017 05 19; 12(1):41. Miyamoto T, Stein L, Thomas R, Djukic B, Taneja P, Knox J, Vossel K, Mucke L. PMID: 28526038; PMCID: PMC5438564.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    26. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016 12; 17(12):777-792. Palop JJ, Mucke L. PMID: 27829687; PMCID: PMC8162106.
      View in: PubMed   Mentions: 423     Fields:    Translation:HumansAnimalsCells
    27. Incidence and impact of subclinical epileptiform activity in Alzheimer's disease. Ann Neurol. 2016 12; 80(6):858-870. Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, Darwish SM, Van Berlo V, Barnes DE, Mantle M, Karydas AM, Coppola G, Roberson ED, Miller BL, Garcia PA, Kirsch HE, Mucke L, Nagarajan SS. PMID: 27696483; PMCID: PMC5177487.
      View in: PubMed   Mentions: 212     Fields:    Translation:Humans
    28. Tau Phosphorylation-Much More than a Biomarker. Neuron. 2016 Oct 19; 92(2):265-267. Maeda S, Mucke L. PMID: 27764656.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    29. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. EMBO Rep. 2016 04; 17(4):530-51. Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L. PMID: 26931567; PMCID: PMC4818780.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    30. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nat Commun. 2015 Nov 30; 6:8897. Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L. PMID: 26615780; PMCID: PMC4674776.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    31. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016 Jan 22; 291(4):1719-1734. Miyamoto T, Kim D, Knox JA, Johnson E, Mucke L. PMID: 26589795; PMCID: PMC4722453.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    32. Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia. Ann Clin Transl Neurol. 2015 11; 2(11):1012-28. Morris M, Sanchez PE, Verret L, Beagle AJ, Guo W, Dubal D, Ranasinghe KG, Koyama A, Ho K, Yu GQ, Vossel KA, Mucke L. PMID: 26732627; PMCID: PMC4693622.
      View in: PubMed   Mentions: 30     Fields:    
    33. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice. Nat Neurosci. 2015 Aug; 18(8):1183-9. Morris M, Knudsen GM, Maeda S, Trinidad JC, Ioanoviciu A, Burlingame AL, Mucke L. PMID: 26192747; PMCID: PMC8049446.
      View in: PubMed   Mentions: 224     Fields:    Translation:AnimalsCells
    34. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β. J Cell Biol. 2015 May 11; 209(3):419-33. Vossel KA, Xu JC, Fomenko V, Miyamoto T, Suberbielle E, Knox JA, Ho K, Kim DH, Yu GQ, Mucke L. PMID: 25963821; PMCID: PMC4427789.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    35. Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell Death Dis. 2015 Apr 16; 6:e1725. Shields LY, Kim H, Zhu L, Haddad D, Berthet A, Pathak D, Lam M, Ponnusamy R, Diaz-Ramirez LG, Gill TM, Sesaki H, Mucke L, Nakamura K. PMID: 25880092; PMCID: PMC4650558.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    36. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci. 2015 Feb 11; 35(6):2358-71. Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. PMID: 25673831; PMCID: PMC4323521.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    37. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci. 2015 Mar; 18(3):423-34. Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. PMID: 25622143; PMCID: PMC4340760.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    38. Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice. PLoS One. 2014; 9(12):e115765. Cheng JS, Craft R, Yu GQ, Ho K, Wang X, Mohan G, Mangnitsky S, Ponnusamy R, Mucke L. PMID: 25551452; PMCID: PMC4281043.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    39. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. PMID: 25261995; PMCID: PMC4196723.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    40. Tau reduction prevents disease in a mouse model of Dravet syndrome. Ann Neurol. 2014 Sep; 76(3):443-56. Gheyara AL, Ponnusamy R, Djukic B, Craft RJ, Ho K, Guo W, Finucane MM, Sanchez PE, Mucke L. PMID: 25042160; PMCID: PMC4338764.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    41. Life extension factor klotho enhances cognition. Cell Rep. 2014 May 22; 7(4):1065-76. Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L. PMID: 24813892; PMCID: PMC4176932.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    42. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013 Sep 01; 70(9):1158-66. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA, Miller BL, Mucke L. PMID: 23835471; PMCID: PMC4013391.
      View in: PubMed   Mentions: 319     Fields:    Translation:Humans
    43. Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β. Nat Neurosci. 2013 May; 16(5):613-21. Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, Mucke L. PMID: 23525040; PMCID: PMC3637871.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansAnimalsCells
    44. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiol Aging. 2013 Jun; 34(6):1523-9. Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. PMID: 23332171; PMCID: PMC3596503.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    45. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS One. 2012; 7(9):e45881. Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L. PMID: 23029293; PMCID: PMC3454317.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    46. Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):E2895-903. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L. PMID: 22869752; PMCID: PMC3479491.
      View in: PubMed   Mentions: 305     Fields:    Translation:HumansAnimalsCells
    47. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med. 2012 Jul; 2(7):a006338. Mucke L, Selkoe DJ. PMID: 22762015; PMCID: PMC3385944.
      View in: PubMed   Mentions: 513     Fields:    Translation:HumansAnimalsCells
    48. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012 Apr 27; 149(3):708-21. Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. PMID: 22541439; PMCID: PMC3375906.
      View in: PubMed   Mentions: 582     Fields:    Translation:HumansAnimalsCells
    49. Alzheimer mechanisms and therapeutic strategies. Cell. 2012 Mar 16; 148(6):1204-22. Huang Y, Mucke L. PMID: 22424230; PMCID: PMC3319071.
      View in: PubMed   Mentions: 733     Fields:    Translation:HumansAnimals
    50. Selective targeting of microglia by quantum dots. J Neuroinflammation. 2012 Jan 24; 9:22. Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. PMID: 22272874; PMCID: PMC3292839.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    51. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PLoS One. 2011; 6(12):e29257. Morris M, Koyama A, Masliah E, Mucke L. PMID: 22206005; PMCID: PMC3242771.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    52. Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice. J Neurosci. 2011 Jul 20; 31(29):10427-31. Cissé M, Sanchez PE, Kim DH, Ho K, Yu GQ, Mucke L. PMID: 21775587; PMCID: PMC3314063.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    53. The many faces of tau. Neuron. 2011 May 12; 70(3):410-26. Morris M, Maeda S, Vossel K, Mucke L. PMID: 21555069; PMCID: PMC3319390.
      View in: PubMed   Mentions: 422     Fields:    Translation:HumansAnimalsCells
    54. Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):700-11. Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L. PMID: 21228179; PMCID: PMC3325794.
      View in: PubMed   Mentions: 368     Fields:    Translation:AnimalsCells
    55. Quantifying biomarkers of cognitive dysfunction and neuronal network hyperexcitability in mouse models of Alzheimer's disease: depletion of calcium-dependent proteins and inhibitory hippocampal remodeling. Methods Mol Biol. 2011; 670:245-62. Palop JJ, Mucke L, Roberson ED. PMID: 20967595; PMCID: PMC8153735.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    56. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature. 2011 Jan 06; 469(7328):47-52. Cissé M, Halabisky B, Harris J, Devidze N, Dubal DB, Sun B, Orr A, Lotz G, Kim DH, Hamto P, Ho K, Yu GQ, Mucke L. PMID: 21113149; PMCID: PMC3030448.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansAnimalsCells
    57. Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron. 2010 Nov 04; 68(3):428-41. Harris JA, Devidze N, Verret L, Ho K, Halabisky B, Thwin MT, Kim D, Hamto P, Lo I, Yu GQ, Palop JJ, Masliah E, Mucke L. PMID: 21040845; PMCID: PMC3050043.
      View in: PubMed   Mentions: 172     Fields:    Translation:HumansAnimalsCells
    58. Tau reduction prevents Abeta-induced defects in axonal transport. Science. 2010 Oct 08; 330(6001):198. Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L. PMID: 20829454; PMCID: PMC3024010.
      View in: PubMed   Mentions: 263     Fields:    Translation:AnimalsCells
    59. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol. 2010 Aug; 177(2):563-9. Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. PMID: 20595630; PMCID: PMC2913361.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    60. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci. 2010 Jul; 13(7):812-8. Palop JJ, Mucke L. PMID: 20581818; PMCID: PMC3072750.
      View in: PubMed   Mentions: 761     Fields:    Translation:HumansCells
    61. Phospholipase A2 and arachidonic acid in Alzheimer's disease. Biochim Biophys Acta. 2010 Aug; 1801(8):784-90. Sanchez-Mejia RO, Mucke L. PMID: 20553961; PMCID: PMC3024142.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    62. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. J Neurosci. 2010 Jan 06; 30(1):372-81. Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. PMID: 20053918; PMCID: PMC3064502.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    63. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 2009 Dec 04; 5(6):624-33. Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. PMID: 19951690; PMCID: PMC2823799.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    64. Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin? Neuromolecular Med. 2010 Mar; 12(1):48-55. Palop JJ, Mucke L. PMID: 19838821; PMCID: PMC3319077.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    65. Neuroscience: Alzheimer's disease. Nature. 2009 Oct 15; 461(7266):895-7. Mucke L. PMID: 19829367.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimals
    66. A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimers Dement. 2009 Mar; 5(2):85-92. Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirier J, Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H, Grundman M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs RC, Carrillo M, Corey-Bloom JP, Foster NL, Jacobsen S, Lee V, Potter WZ, Sabbagh MN, Salmon D, Trojanowski JQ, Wexler N, Bain LJ. PMID: 19328434; PMCID: PMC3959165.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    67. Alzheimer's disease: A prion protein connection. Nature. 2009 Feb 26; 457(7233):1090-1. Cisse M, Mucke L. PMID: 19242462.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    68. Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci. 2009 Feb 18; 29(7):1977-86. Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L. PMID: 19228952; PMCID: PMC2768427.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    69. Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol. 2009 Apr; 66(4):435-40. Palop JJ, Mucke L. PMID: 19204149; PMCID: PMC2812914.
      View in: PubMed   Mentions: 312     Fields:    Translation:HumansAnimalsCells
    70. Collagen VI protects neurons against Abeta toxicity. Nat Neurosci. 2009 Feb; 12(2):119-21. Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L. PMID: 19122666; PMCID: PMC2812922.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    71. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci. 2008 Nov; 11(11):1311-8. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. PMID: 18931664; PMCID: PMC2597064.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    72. Genes contributing to prion pathogenesis. J Gen Virol. 2008 Jul; 89(Pt 7):1777-1788. Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB. PMID: 18559949; PMCID: PMC2828448.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    73. Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2008 May 07; 28(19):5007-17. Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L. PMID: 18463254; PMCID: PMC3315282.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    74. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 2008 Apr 10; 58(1):10-4. Gan L, Mucke L. PMID: 18400158; PMCID: PMC8245119.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimals
    75. Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 2008 Apr; 7(3):344-54. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L. PMID: 17908176.
      View in: PubMed   Mentions: 71     Fields:    Translation:Animals
    76. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007 Sep 06; 55(5):697-711. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. PMID: 17785178; PMCID: PMC8055171.
      View in: PubMed   Mentions: 819     Fields:    Translation:HumansAnimalsCells
    77. Spatial cognition and the human navigation network in AD and MCI. Neurology. 2007 Sep 04; 69(10):986-97. deIpolyi AR, Rankin KP, Mucke L, Miller BL, Gorno-Tempini ML. PMID: 17785667.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    78. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem. 2007 Aug 17; 282(33):23818-28. Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. PMID: 17548355.
      View in: PubMed   Mentions: 224     Fields:    Translation:HumansAnimals
    79. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science. 2007 May 04; 316(5825):750-4. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L. PMID: 17478722.
      View in: PubMed   Mentions: 950     Fields:    Translation:HumansAnimalsCells
    80. Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease. J Neurosci. 2007 Mar 14; 27(11):2727-33. Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L. PMID: 17360894; PMCID: PMC6672562.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    81. Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiol Aging. 2008 Feb; 29(2):253-66. Deipolyi AR, Fang S, Palop JJ, Yu GQ, Wang X, Mucke L. PMID: 17126954.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    82. 100 years and counting: prospects for defeating Alzheimer's disease. Science. 2006 Nov 03; 314(5800):781-4. Roberson ED, Mucke L. PMID: 17082448; PMCID: PMC3544944.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsPHPublic Health
    83. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest. 2006 Nov; 116(11):3060-9. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. PMID: 17080199; PMCID: PMC1626127.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansAnimalsCells
    84. A network dysfunction perspective on neurodegenerative diseases. Nature. 2006 Oct 19; 443(7113):768-73. Palop JJ, Chin J, Mucke L. PMID: 17051202.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansAnimalsCells
    85. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 2006 Sep 21; 51(6):703-14. Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. PMID: 16982417.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansAnimalsCells
    86. PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8215-20. Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO. PMID: 16698938; PMCID: PMC1472455.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    87. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J Neurosci. 2006 May 10; 26(19):5167-79. Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L. PMID: 16687508; PMCID: PMC6674260.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    88. RETRACTED ARTICLE: A needle from the haystack Nature. 2006 03 16; 440(7082):284-5. Morris R, Mucke L. PMID: 16541054.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    89. Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice. J Neurosci. 2005 Oct 19; 25(42):9686-93. Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L. PMID: 16237173; PMCID: PMC6725729.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimals
    90. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2005 Oct 19; 25(42):9694-703. Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. PMID: 16237174; PMCID: PMC6725734.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    91. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem. 2005 Dec 02; 280(48):40364-74. Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. PMID: 16183991.
      View in: PubMed   Mentions: 319     Fields:    Translation:HumansAnimalsCells
    92. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. J Biol Chem. 2005 Sep 23; 280(38):32957-67. Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. PMID: 16027115.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    93. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J Neurochem. 2004 Dec; 91(6):1260-74. Esposito L, Gan L, Yu GQ, Essrich C, Mucke L. PMID: 15584903.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    94. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med. 2004 Nov; 10(11):1190-2. Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L. PMID: 15502844.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    95. RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice. EMBO J. 2004 Oct 13; 23(20):4096-105. Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS. PMID: 15457210; PMCID: PMC524347.
      View in: PubMed   Mentions: 151     Fields:    Translation:AnimalsCells
    96. Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD. Neuron. 2004 Sep 02; 43(5):596-9. Mucke L, Pitas RE. PMID: 15339638.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    97. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Neurosci. 2004 May 12; 24(19):4692-7. Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. PMID: 15140940; PMCID: PMC6729387.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    98. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci. 2004 Mar 10; 24(10):2527-34. Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y. PMID: 15014128; PMCID: PMC6729489.
      View in: PubMed   Mentions: 206     Fields:    Translation:HumansAnimalsCells
    99. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. J Mol Neurosci. 2004; 23(3):189-204. Huang Y, Weisgraber KH, Mucke L, Mahley RW. PMID: 15181247.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    100. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10966-71. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. PMID: 12939405; PMCID: PMC196910.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimalsCells
    101. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9572-7. Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. PMID: 12881482; PMCID: PMC170959.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    102. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci. 2002 Dec 15; 22(24):10539-48. Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L. PMID: 12486146; PMCID: PMC6758409.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    103. Inflammation in neurodegenerative disease--a double-edged sword. Neuron. 2002 Aug 01; 35(3):419-32. Wyss-Coray T, Mucke L. PMID: 12165466.
      View in: PubMed   Mentions: 529     Fields:    Translation:HumansAnimalsCells
    104. Androgens protect against apolipoprotein E4-induced cognitive deficits. J Neurosci. 2002 Jun 15; 22(12):5204-9. Raber J, Bongers G, LeFevour A, Buttini M, Mucke L. PMID: 12077215; PMCID: PMC6757715.
      View in: PubMed   Mentions: 78     Fields:    Translation:Animals
    105. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12245-50. Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L. PMID: 11572944; PMCID: PMC59799.
      View in: PubMed   Mentions: 258     Fields:    Translation:HumansAnimalsCells
    106. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nat Med. 2001 May; 7(5):612-8. Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. PMID: 11329064.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansAnimalsCells
    107. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. Am J Pathol. 2000 Dec; 157(6):2003-10. Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. PMID: 11106573; PMCID: PMC1885780.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    108. Ibuprofen, inflammation and Alzheimer disease. Nat Med. 2000 Sep; 6(9):973-4. Wyss-Coray T, Mucke L. PMID: 10973311.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    109. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci. 2000 Jun 01; 20(11):4050-8. Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L. PMID: 10818140; PMCID: PMC6772621.
      View in: PubMed   Mentions: 888     Fields:    Translation:HumansAnimalsCells
    110. Alzheimer's disease-like cerebrovascular pathology in transforming growth factor-beta 1 transgenic mice and functional metabolic correlates. Ann N Y Acad Sci. 2000 Apr; 903:317-23. Wyss-Coray T, Lin C, von Euw D, Masliah E, Mucke L, Lacombe P. PMID: 10818521.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    111. Apolipoprotein E and cognitive performance. Nature. 2000 Mar 23; 404(6776):352-4. Raber J, Wong D, Yu GQ, Buttini M, Mahley RW, Pitas RE, Mucke L. PMID: 10746713.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimals
    112. Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations. J Neurosci. 2000 Mar 01; 20(5):2064-71. Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, Mucke L. PMID: 10684907; PMCID: PMC6772921.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    113. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science. 2000 Feb 18; 287(5456):1265-9. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L. PMID: 10678833.
      View in: PubMed   Mentions: 592     Fields:    Translation:HumansAnimalsCells
    114. Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience. 2000; 97(2):207-10. Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L. PMID: 10799751.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    115. Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice. Am J Pathol. 2000 Jan; 156(1):139-50. Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E. PMID: 10623661; PMCID: PMC1868631.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    116. Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120. Eur J Neurosci. 1999 Dec; 11(12):4398-402. D'hooge R, Franck F, Mucke L, De Deyn PP. PMID: 10594667.
      View in: PubMed   Mentions: 53  Translation:AnimalsCells
    117. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am J Pathol. 1999 Nov; 155(5):1741-7. Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L. PMID: 10550330; PMCID: PMC1866996.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    118. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7547-52. Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L. PMID: 10377452; PMCID: PMC22123.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    119. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci. 1999 Jun 15; 19(12):4867-80. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW. PMID: 10366621; PMCID: PMC6782676.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    120. Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron. 1999 Jun; 23(2):297-308. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV. PMID: 10399936.
      View in: PubMed   Mentions: 469     Fields:    Translation:AnimalsCells
    121. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3228-33. Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L. PMID: 10077666; PMCID: PMC15924.
      View in: PubMed   Mentions: 472     Fields:    Translation:HumansAnimals
    122. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10914-9. Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L. PMID: 9724804; PMCID: PMC27995.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    123. Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis. J Biol Chem. 1998 May 15; 273(20):12548-54. Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, Mucke L. PMID: 9575214.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    124. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998 Apr 17; 93(2):189-201. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV. PMID: 9568712.
      View in: PubMed   Mentions: 239     Fields:    Translation:AnimalsCells
    125. Novel role of human CD4 molecule identified in neurodegeneration. Nat Med. 1998 Apr; 4(4):441-6. Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L. PMID: 9546790.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    126. Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience. 1998 Apr; 83(3):691-700. Krucker T, Toggas SM, Mucke L, Siggins GR. PMID: 9483553.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    127. Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12655-60. Xu X, Raber J, Yang D, Su B, Mucke L. PMID: 9356505; PMCID: PMC25073.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    128. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J. 1997 Oct 15; 16(20):6057-65. Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MB, Weissmann C, Chesebro B. PMID: 9321385; PMCID: PMC1326289.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    129. Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease. Nature. 1997 Oct 09; 389(6651):603-6. Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L. PMID: 9335500.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    130. Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice . J Neuroimmunol. 1997 Jul; 77(1):45-50. Wyss-Coray T, Borrow P, Brooker MJ, Mucke L. PMID: 9209267.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    131. Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects. J Biol Chem. 1997 Jun 13; 272(24):15057-60. Raber J, Chen S, Mucke L, Feng L. PMID: 9182522.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    132. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 1997 May; 78(1):135-46. Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L. PMID: 9135095.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    133. Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Res Brain Res Rev. 1997 Feb; 23(1-2):47-61. Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L. PMID: 9063586.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    134. Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase. Virology. 1996 Dec 15; 226(2):362-73. Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L. PMID: 8955056.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    135. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J Biol Chem. 1996 Dec 06; 271(49):31407-11. Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. PMID: 8940150.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    136. Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein. Neuroreport. 1996 Nov 04; 7(15-17):2807-11. D'Hooge R, Nagels G, Westland CE, Mucke L, De Deyn PP. PMID: 8981472.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    137. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci. 1996 Sep 15; 16(18):5795-811. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D. PMID: 8795633; PMCID: PMC6578961.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    138. Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule L1 by mouse astrocytes. Eur J Neurosci. 1996 Jun; 8(6):1085-97. Mohajeri MH, Bartsch U, van der Putten H, Sansig G, Mucke L, Schachner M. PMID: 8752578.
      View in: PubMed   Mentions: 7  Translation:AnimalsCells
    139. Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. J Clin Invest. 1996 Feb 01; 97(3):789-98. Wyss-Coray T, Masliah E, Toggas SM, Rockenstein EM, Brooker MJ, Lee HS, Mucke L. PMID: 8609236; PMCID: PMC507117.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    140. Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Ann N Y Acad Sci. 1996 Jan 17; 777:82-8. Mucke L, Abraham CR, Masliah E. PMID: 8624131.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    141. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res. 1996 Jan 15; 706(2):303-7. Toggas SM, Masliah E, Mucke L. PMID: 8822372.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    142. Transgenic models in the study of AIDS dementia complex. Curr Top Microbiol Immunol. 1996; 206:223-41. Toggas SM, Mucke L. PMID: 8608719.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    143. Pathogenesis of HIV-1 associated neurodegeneration. Crit Rev Neurobiol. 1996; 10(1):57-67. Masliah E, Ge N, Mucke L. PMID: 8853954.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    144. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem. 1995 Nov 24; 270(47):28257-67. Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. PMID: 7499323.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    145. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron. 1995 Nov; 15(5):1183-91. Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, Oldstone MB. PMID: 7576660; PMCID: PMC7135899.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    146. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo. J Exp Med. 1995 Nov 01; 182(5):1201-12. Rall GF, Mucke L, Oldstone MB. PMID: 7595191; PMCID: PMC2192211.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    147. Immunization-induced inflammatory infiltration of the central nervous system in transgenic mice expressing a microbial antigen in astrocytes. J Neuroimmunol. 1995 Sep; 61(2):133-49. Borrow P, Cornell JL, Ruppe MD, Mucke L. PMID: 7593549.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    148. Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1. Am J Pathol. 1995 Jul; 147(1):53-67. Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, Mucke L. PMID: 7604885; PMCID: PMC1869892.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    149. Differential regulation of a glial fibrillary acidic protein-LacZ transgene in retinal astrocytes and Müller cells. Invest Ophthalmol Vis Sci. 1995 May; 36(6):1137-43. Verderber L, Johnson W, Mucke L, Sarthy V. PMID: 7730023.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    150. gp120 and neurotoxicity in vivo. Trends Pharmacol Sci. 1995 Apr; 16(4):122. Lipton SA, Brenneman DE, Silverstein FS, Masliah E, Mucke L. PMID: 7610496.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    151. Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein. J Exp Med. 1995 Apr 01; 181(4):1551-6. Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E. PMID: 7699335; PMCID: PMC2191956.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    152. Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: in vivo comparison of distinct GFAP-lacZ transgenes. Glia. 1995 Mar; 13(3):174-84. Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, Mucke L. PMID: 7782103.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    153. Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines. Curr Top Microbiol Immunol. 1995; 202:187-205. Mucke L, Masliah E, Campbell IL. PMID: 7587363.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    154. Synaptotrophic effects of human amyloid beta protein precursors in the cortex of transgenic mice. Brain Res. 1994 Dec 15; 666(2):151-67. Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, Abraham CR. PMID: 7882025.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    155. A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes. J Neuroimmunol. 1994 Jun; 52(1):61-8. Rall GF, Mucke L, Nerenberg M, Oldstone MB. PMID: 8207120; PMCID: PMC7119529.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    156. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 1994 Jan 13; 367(6459):188-93. Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, Mucke L. PMID: 8114918.
      View in: PubMed   Mentions: 267     Fields:    Translation:HumansAnimalsCells
    157. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):10061-5. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MB, Mucke L. PMID: 7694279; PMCID: PMC47713.
      View in: PubMed   Mentions: 305     Fields:    Translation:AnimalsCells
    158. Astrocytes in infectious and immune-mediated diseases of the central nervous system. FASEB J. 1993 Oct; 7(13):1226-32. Mucke L, Eddleston M. PMID: 8405808.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    159. Expression of cathepsin G-like and alpha 1-antichymotrypsin-like proteins in reactive astrocytes. Brain Res. 1993 Sep 10; 621(2):222-32. Abraham CR, Kanemaru K, Mucke L. PMID: 8242336.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    160. Molecular profile of reactive astrocytes--implications for their role in neurologic disease. Neuroscience. 1993 May; 54(1):15-36. Eddleston M, Mucke L. PMID: 8515840; PMCID: PMC7130906.
      View in: PubMed   Mentions: 309     Fields:    Translation:HumansCells
    161. Purification and cloning of brain proteases capable of degrading the beta-amyloid precursor protein. Ann N Y Acad Sci. 1992 Dec 31; 674:174-9. Abraham CR, Razzaboni BL, Papastoitsis G, Picard E, Kanemaru K, Meckelein B, Mucke L. PMID: 1288362.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    162. The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). J Neuroimmunol. 1992 Feb; 36(2-3):193-8. Mucke L, Oldstone MB. PMID: 1732281; PMCID: PMC7119833.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    163. Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science. 1991 Sep 13; 253(5025):1283-5. Joly E, Mucke L, Oldstone MB. PMID: 1891717.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    164. Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury. New Biol. 1991 May; 3(5):465-74. Mucke L, Oldstone MB, Morris JC, Nerenberg MI. PMID: 1883812.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    165. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J Neurosci. 1990 Feb; 10(2):520-30. Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM. PMID: 2303857; PMCID: PMC6570158.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    166. Prolonged survival and partial recovery in AIDS-associated progressive multifocal leukoencephalopathy. Neurology. 1988 Jul; 38(7):1060-5. Berger JR, Mucke L. PMID: 3386823.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    167. Anterior ectosylvian visual area (AEV) of the cat: physiological properties. Prog Brain Res. 1988; 75:245-55. Benedek G, Mucke L, Norita M, Albowitz B, Creutzfeldt OD. PMID: 3187054.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    168. Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization. Acta Physiol Scand. 1987 Dec; 131(4):631-2. Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH, et al. PMID: 3442246.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    169. Clinical management of neuropathic pain. Neurol Clin. 1987 Nov; 5(4):649-63. Mucke L, Maciewicz R. PMID: 2828905.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    170. Connections of the anterior ectosylvian visual area (AEV). Exp Brain Res. 1986; 62(2):225-40. Norita M, Mucke L, Benedek G, Albowitz B, Katoh Y, Creutzfeldt OD. PMID: 3709710.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    171. Physiologic and anatomic investigation of a visual cortical area situated in the ventral bank of the anterior ectosylvian sulcus of the cat. Exp Brain Res. 1982; 46(1):1-11. Mucke L, Norita M, Benedek G, Creutzfeldt O. PMID: 7067781.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
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