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Lewis Lanier, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMicrobiology and Immunology
AddressCore Campus, HSE
San Francisco CA 94143
Phone415-514-0829
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    Other Positions
    TitleChair, Microbiology and Immunology


    Collapse Biography 
    Collapse Education and Training
    Virginia TechB.S.1975Biology
    University of North Carolina Chapel HillPh.D.1978Microbiology and Immunology
    Collapse Awards and Honors
    University of California San Francisco2013J. Michael Bishop MD Distinguished Professor
    University of North Carolina - Chapel Hill2013Distinguished UNC Alumnus Award
    American Academy of Arts and Sciences2011Member
    University of California San Francisco2011Faculty Research Lecture - Basic Science
    American Academy of Microbiology2011Fellow
    National Academy of Sciences2010Member
    American Association of Immunologists2006  - 2007President
    American Society for Histocompatibility & Immunogenetics2005Rose Payne Award
    American Cancer Society2003Research Professor
    Cancer Research Institute2002William B Coley Award for Distinguished Research in Basic and Tumor
    American Association of Immunologists 2001Distinguished Service Award
    Becton Dickinson1990Research Fellow
    Damon Runyon - Walter Winchell Cancer Fund1979  - 1981Postdoctoral Fellow

    Collapse Overview 
    Collapse Overview
    Natural killer (NK) cells are a type of white blood cell that provides protection against microbial pathogens and tumors. Since the early 1980’s, our lab has investigated how NK cells distinguish between normal healthy cells and cells that are transformed or infected with viruses. NK cells express a diverse array of inhibitory and activating receptors on their cells surface that bind to ligands expressed on the cell surface of potential target cells. When encountering healthy cells, signals transmitted by inhibitory NK receptors dominate and prevent autoimmunity, whereas the loss of ligands for the inhibitory receptors or the upregulation of ligands for the activating NK receptors on infected or transformed cells allows NK cells to kill these abnormal cells and secrete cytokine that influence the subsequent response by T cells and B cells. We have developed mouse models systems in which key signaling molecules such as DAP10 and DAP12 have been ablated to explore the physiological role of these NK receptors in resistance to viral infections (cytomegalovirus, poxviruses, and influenza) and primary tumorigenesis.


    Collapse Research 
    Collapse Research Activities and Funding
    Human natural killer cell recognition of cytomegalovirus
    NIH/NIAID R21AI108860Jun 16, 2014 - May 31, 2016
    Role: Principal Investigator
    UCSF DVS CyTOF Mass Cytometer
    NIH S10OD018040May 1, 2014 - Apr 30, 2015
    Role: Principal Investigator
    13th International Meeting of the Society for Natural Immunity April 20-24, 2012
    NIH/NIAID R13AI098278Mar 1, 2012 - Feb 28, 2013
    Role: Principal Investigator
    Bay Area Hepatitis C Cooperative Research Center
    NIH U19AI088790Jun 15, 2010 - May 31, 2015
    Role: Co-Investigator
    Human Natural Killer Cell Biology
    NIH/NIAID P01AI064520Sep 16, 2005 - Feb 28, 2011
    Role: Co-Investigator
    Systems Approach to Innate Immunity-Inflammation-Sepsis
    NIH U54AI054523Sep 30, 2002 - Jul 31, 2008
    Role: Co-Investigator
    NK Cell Biology
    NIH/NCI R01CA095137Apr 1, 2002 - Jan 31, 2015
    Role: Principal Investigator
    Biology of Leukocyte Regulatory Receptor
    NIH/NIAID R13AI051933Apr 1, 2002 - Mar 31, 2003
    Role: Principal Investigator
    NK and T Cell Costimulation by NKG2D/DAP10
    NIH/NIAID R37AI066897Mar 1, 2001 - Feb 29, 2016
    Role: Principal Investigator
    NK AND T CELL COSTIMULATION BY NKG2D/DAP10
    NIH/NCI R01CA089189Feb 1, 2001 - Jan 31, 2006
    Role: Principal Investigator
    NK Memory
    NIH/NIAID R01AI068129Jan 9, 2001 - Mar 31, 2021
    Role: Principal Investigator
    NK CELL RECEPTORS AND THEIR LIGANDS
    NIH/NCI R01CA089294Jan 9, 2001 - Dec 31, 2005
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA082103Aug 5, 1999 - May 31, 2018
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Nabekura T, Chen Z, Schroeder C, Park T, Vivier E, Lanier L, Liu D. Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection. J Immunol. 2018 Apr 04. PMID: 29618525.
      View in: PubMed
    2. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier L, Spies T. Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729. J Immunol. 2018 Apr 01; 200(7):2231-2233. PMID: 29555676.
      View in: PubMed
    3. Cerwenka A, Lanier L. Natural killers join the fight against cancer. Science. 2018 03 30; 359(6383):1460-1461. PMID: 29599226.
      View in: PubMed
    4. Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier L, Ryan JC, McCune JM, Hartigan-O'Connor DJ. Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. J Immunol. 2018 Feb 01; 200(3):1124-1132. PMID: 29263212.
      View in: PubMed
    5. Sun JC, Lanier L. Is There Natural Killer Cell Memory and Can It Be Harnessed by Vaccination? NK Cell Memory and Immunization Strategies against Infectious Diseases and Cancer. Cold Spring Harb Perspect Biol. 2017 Dec 18. PMID: 29254979.
      View in: PubMed
    6. Pan YG, Yu YL, Lin CC, Lanier L, Chu CL. FceRI ?-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells. Front Immunol. 2017; 8:1424. PMID: 29163499.
      View in: PubMed
    7. Mukherjee S, Stewart D, Stewart W, Lanier L, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4(8):170811. PMID: 28879015.
      View in: PubMed
    8. Jensen H, Potempa M, Gotthardt D, Lanier L. Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells. J Immunol. 2017 09 15; 199(6):1967-1972. PMID: 28784848.
      View in: PubMed
    9. Nabekura T, Gotthardt D, Niizuma K, Trsan T, Jenus T, Jonjic S, Lanier L. Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. J Immunol. 2017 09 01; 199(5):1567-1571. PMID: 28760883.
      View in: PubMed
    10. Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier L, Kaser A, Blumberg R. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017 Oct 02; 214(10):2985-2997. PMID: 28747426.
      View in: PubMed
    11. Vadstrup K, Galsgaard ED, Jensen H, Lanier L, Ryan JC, Chen SY, Nolan GP, Vester-Andersen MK, Pedersen JS, Gerwien J, Jensen T, Bendtsen F. NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration. Exp Mol Pathol. 2017 08; 103(1):56-70. PMID: 28684217.
      View in: PubMed
    12. Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier L, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10(485). PMID: 28655861.
      View in: PubMed
    13. Morvan MG, Champsaur M, Reizis B, Lanier L. Chronic In Vivo Interaction of Dendritic Cells Expressing the Ligand Rae-1e with NK Cells Impacts NKG2D Expression and Function. Immunohorizons. 2017 May 01; 1(3):10-19. PMID: 28815225.
      View in: PubMed
    14. Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier L, Ohashi PS. A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat Med. 2017 Mar; 23(3):368-375. PMID: 28165478.
      View in: PubMed
    15. Jensen H, Chen SY, Folkersen L, Nolan GP, Lanier L. EBI3 regulates the NK cell response to mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):1625-1630. PMID: 28143936.
      View in: PubMed
    16. Lam VC, Lanier L. NK cells in host responses to viral infections. Curr Opin Immunol. 2017 Feb; 44:43-51. PMID: 27984782.
      View in: PubMed
    17. Nabekura T, Lanier L. Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection. J Exp Med. 2016 Nov 14; 213(12):2745-2758. PMID: 27810928.
      View in: PubMed
    18. Nabekura T, Lanier L. Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection. Immunity. 2016 07 19; 45(1):74-82. PMID: 27438766.
      View in: PubMed
    19. Spits H, Bernink JH, Lanier L. NK cells and type 1 innate lymphoid cells: partners in host defense. Nat Immunol. 2016 06 21; 17(7):758-64. PMID: 27328005.
      View in: PubMed
    20. Kohrt HE, Tumeh PC, Benson D, Bhardwaj N, Brody J, Formenti S, Fox BA, Galon J, June CH, Kalos M, Kirsch I, Kleen T, Kroemer G, Lanier L, Levy R, Lyerly HK, Maecker H, Marabelle A, Melenhorst J, Miller J, Melero I, Odunsi K, Palucka K, Peoples G, Ribas A, Robins H, Robinson W, Serafini T, Sondel P, Vivier E, Weber J, Wolchok J, Zitvogel L, Disis ML, Cheever MA. Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials. J Immunother Cancer. 2016; 4:15. PMID: 26981245; PMCID: PMC4791805.
    21. Cerwenka A, Lanier L. Natural killer cell memory in infection, inflammation and cancer. Nat Rev Immunol. 2016 Feb; 16(2):112-23. PMID: 26806484.
      View in: PubMed
    22. Madera S, Rapp M, Firth MA, Beilke JN, Lanier L, Sun JC. Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med. 2016 Feb 08; 213(2):225-33. PMID: 26755706; PMCID: PMC4749923.
    23. Hendricks DW, Min-Oo G, Lanier L. Sweet Is the Memory of Past Troubles: NK Cells Remember. Curr Top Microbiol Immunol. 2016; 395:147-71. PMID: 26099194.
      View in: PubMed
    24. Morvan MG, Lanier L. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer. 2016 Jan; 16(1):7-19. PMID: 26694935.
      View in: PubMed
    25. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier L, Lomvardas S, Basbaum AI. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101. PMID: 26642091; PMCID: PMC4703328.
    26. O'Sullivan TE, Sun JC, Lanier L. Natural Killer Cell Memory. Immunity. 2015 Oct 20; 43(4):634-45. PMID: 26488815; PMCID: PMC4621966 [Available on 10/20/16].
    27. Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier L, Cao W. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-? Production via the Generation of Reactive Oxygen Species. Cell Rep. 2015 Aug 18; 12(7):1120-32. PMID: 26257170; PMCID: PMC4545388.
    28. Lanier L. NKG2D Receptor and Its Ligands in Host Defense. Cancer Immunol Res. 2015 Jun; 3(6):575-82. PMID: 26041808; PMCID: PMC4457299.
    29. Nabekura T, Girard JP, Lanier L. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. J Immunol. 2015 Jun 15; 194(12):5948-52. PMID: 25926677; PMCID: PMC4458425.
    30. Lee J, Zhang T, Hwang I, Kim A, Nitschke L, Kim M, Scott JM, Kamimura Y, Lanier L, Kim S. Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals. Immunity. 2015 Mar 17; 42(3):431-42. PMID: 25786175; PMCID: PMC4537797.
    31. Tanimura K, Jin H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama M, Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier L, Atsumi T, Yamada H, Arase H. ß2-Glycoprotein I/HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Blood. 2015 Apr 30; 125(18):2835-44. PMID: 25733579; PMCID: PMC4424631.
    32. Kamimura Y, Lanier L. Homeostatic control of memory cell progenitors in the natural killer cell lineage. Cell Rep. 2015 Jan 13; 10(2):280-91. PMID: 25578733; PMCID: PMC4359047.
    33. Min-Oo G, Lanier L. Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection. J Exp Med. 2014 Dec 15; 211(13):2669-80. PMID: 25422494; PMCID: PMC4267234.
    34. Nabekura T, Lanier L. Antigen-specific expansion and differentiation of natural killer cells by alloantigen stimulation. J Exp Med. 2014 Nov 17; 211(12):2455-65. PMID: 25366966; PMCID: PMC4235640.
    35. Weinger JG, Plaisted WC, Maciejewski SM, Lanier L, Walsh CM, Lane TE. Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis. Stem Cells. 2014 Oct; 32(10):2690-701. PMID: 24898518; PMCID: PMC4165828.
    36. Lanier L. Just the FACS. J Immunol. 2014 Sep 01; 193(5):2043-4. PMID: 25128548.
      View in: PubMed
    37. Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier L. Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12823-8. PMID: 25136121; PMCID: PMC4156766.
    38. Du J, Lopez-Verges S, Pitcher BN, Johnson J, Jung SH, Zhou L, Hsu K, Czuczman MS, Cheson B, Kaplan L, Lanier L, Venstrom JM. CALGB 150905 (Alliance): rituximab broadens the antilymphoma response by activating unlicensed NK cells. Cancer Immunol Res. 2014 Sep; 2(9):878-89. PMID: 24958280; PMCID: PMC4264658.
    39. Min-Oo G, Bezman NA, Madera S, Sun JC, Lanier L. Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection. J Exp Med. 2014 Jun 30; 211(7):1289-96. PMID: 24958849; PMCID: PMC4076589.
    40. Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier L, Jabri B. Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12. J Immunol. 2014 Jul 15; 193(2):610-6. PMID: 24935923; PMCID: PMC4091631.
    41. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier L, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96. PMID: 24838750; PMCID: PMC4101792.
    42. Kamimura Y, Lanier L. Rapid and sequential quantitation of salivary gland-associated mouse cytomegalovirus in oral lavage. J Virol Methods. 2014 Sep 01; 205:53-6. PMID: 24747009.
      View in: PubMed
    43. Hendricks DW, Balfour HH, Dunmire SK, Schmeling DO, Hogquist KA, Lanier L. Cutting edge: NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. J Immunol. 2014 May 15; 192(10):4492-6. PMID: 24740502; PMCID: PMC4013527.
    44. Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier L, Arase H. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3787-92. PMID: 24567378; PMCID: PMC3956152.
    45. Lanier L. Of snowflakes and natural killer cell subsets. Nat Biotechnol. 2014 Feb; 32(2):140-2. PMID: 24509762.
      View in: PubMed
    46. Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier L. Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection. Immunity. 2014 Feb 20; 40(2):225-34. PMID: 24440149; PMCID: PMC3943894.
    47. Dangl JL, Lanier L. Founding father of FACS: Professor Leonard A. Herzenberg (1931–2013). Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20848-9. PMID: 24344298; PMCID: PMC3876245.
    48. Milush JM, López-Vergès S, York VA, Deeks SG, Martin JN, Hecht FM, Lanier L, Nixon DF. CD56negCD16? NK cells are activated mature NK cells with impaired effector function during HIV-1 infection. Retrovirology. 2013 Dec 18; 10:158. PMID: 24351015; PMCID: PMC3892122.
    49. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier L, Manos MM, McCune JM. Monocyte activation by interferon a is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection. J Infect Dis. 2014 May 15; 209(10):1602-12. PMID: 24325966; PMCID: PMC3997582.
    50. Kim CC, Lanier L. Beyond the transcriptome: completion of act one of the Immunological Genome Project. Curr Opin Immunol. 2013 Oct; 25(5):593-7. PMID: 24168965; PMCID: PMC3855358.
    51. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier L, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36. PMID: 23999497; PMCID: PMC3782052.
    52. Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier L, Bárcena A, Fisher SJ. Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy. Biol Reprod. 2013 Jun; 88(6):155. PMID: 23553431; PMCID: PMC4070869.
    53. Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier L, Blumberg RS. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep; 43(9):2473-83. PMID: 23696226; PMCID: PMC3775953.
    54. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. PMID: 23644507; PMCID: PMC3660436.
    55. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier L. MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52. PMID: 23550637; PMCID: PMC3621029.
    56. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun; 14(6):633-43. PMID: 23624555; PMCID: PMC3690947.
    57. Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier L, Rudensky AY, Sun JC. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6967-72. PMID: 23572582; PMCID: PMC3637707.
    58. Min-Oo G, Kamimura Y, Hendricks DW, Nabekura T, Lanier L. Natural killer cells: walking three paths down memory lane. Trends Immunol. 2013 Jun; 34(6):251-8. PMID: 23499559; PMCID: PMC3674190.
    59. Lanier L. Shades of grey--the blurring view of innate and adaptive immunity. Nat Rev Immunol. 2013 02; 13(2):73-4. PMID: 23469373.
      View in: PubMed
    60. Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, Lanier L, Saito T, Arase H. Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. Int Immunol. 2013 Apr; 25(4):235-46. PMID: 23334921; PMCID: PMC3597850.
    61. Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier L, Kallas EG, York VA, Chang D, Liao W, Unemori P, Leslie KS, Maurer T, Nixon DF. Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol. 2013 Jan; 22(1):64-6. PMID: 23278897; PMCID: PMC3777400.
    62. Benoist C, Lanier L, Merad M, Mathis D. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol. 2012 10; 12(10):734-40. PMID: 22955842.
      View in: PubMed
    63. Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier L. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012 Oct; 13(10):1000-9. PMID: 22902830; PMCID: PMC3572860.
    64. Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier L, Heissmeyer V, Ansel KM. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 05; 120(1):130-42. PMID: 22613798; PMCID: PMC3390952.
    65. Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier L. NK cells are not required for spontaneous autoimmune diabetes in NOD mice. PLoS One. 2012; 7(4):e36011. PMID: 22558306; PMCID: PMC3338490.
    66. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier L, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91. PMID: 22570807.
      View in: PubMed
    67. Sun JC, Madera S, Bezman NA, Beilke JN, Kaplan MH, Lanier L. Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med. 2012 May 07; 209(5):947-54. PMID: 22493516; PMCID: PMC3348098.
    68. Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier L. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43. PMID: 22383801; PMCID: PMC3335380.
    69. Nielsen N, Ødum N, Ursø B, Lanier L, Spee P. Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS One. 2012; 7(2):e31959. PMID: 22384114; PMCID: PMC3284517.
    70. Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, Ames E, Bruhn KW, Craft N, Wiltrout RH, Longo DL, Lanier L, Blazar BR, Redelman D, Murphy WJ. Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy. Blood. 2012 Mar 29; 119(13):3073-83. PMID: 22251483; PMCID: PMC3321869.
    71. Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, Lopez-Vergès S, Lanier L, Weisdorf D, Miller JS. Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood. 2012 Mar 15; 119(11):2665-74. PMID: 22180440; PMCID: PMC3311280.
    72. Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier L, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med. 2011 Dec 19; 208(13):2633-40. PMID: 22143889; PMCID: PMC3244030.
    73. Bezman NA, Chakraborty T, Bender T, Lanier L. miR-150 regulates the development of NK and iNKT cells. J Exp Med. 2011 Dec 19; 208(13):2717-31. PMID: 22124110; PMCID: PMC3244033.
    74. Sun JC, Lanier L. NK cell development, homeostasis and function: parallels with CD8? T cells. Nat Rev Immunol. 2011 Aug 26; 11(10):645-57. PMID: 21869816; PMCID: PMC4408539.
    75. Lopez-Vergès S, Milush JM, Schwartz BS, Pando MJ, Jarjoura J, York VA, Houchins JP, Miller S, Kang SM, Norris PJ, Nixon DF, Lanier L. Expansion of a unique CD57?NKG2Chi natural killer cell subset during acute human cytomegalovirus infection. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14725-32. PMID: 21825173; PMCID: PMC3169160.
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    178. Zingoni A, Sornasse T, Cocks BG, Tanaka Y, Santoni A, Lanier L. Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions. J Immunol. 2004 Sep 15; 173(6):3716-24. PMID: 15356117.
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    179. Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier L, Groh V, Spies T, Ebert EC, Green PH, Jabri B. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity. 2004 Sep; 21(3):357-66. PMID: 15357947.
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    181. Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier L. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity. 2004 Jun; 20(6):757-67. PMID: 15189740.
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    182. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier L, Lowell CA, Nakamura MC. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63. PMID: 15073337; PMCID: PMC395939.
    183. Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier L, Shibuya A. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol. 2004 Apr; 16(4):533-8. PMID: 15039383.
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    184. Arase H, Lanier L. Specific recognition of virus-infected cells by paired NK receptors. Rev Med Virol. 2004 Mar-Apr; 14(2):83-93. PMID: 15027001.
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    185. Shiratori I, Ogasawara K, Saito T, Lanier L, Arase H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 2004 Feb 16; 199(4):525-33. PMID: 14970179; PMCID: PMC2211832.
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    187. Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier L, Nakamura MC. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res. 2004 Feb; 19(2):224-34. PMID: 14969392.
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    188. Westgaard IH, Dissen E, Torgersen KM, Lazetic S, Lanier L, Phillips JH, Fossum S. The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. J Exp Med. 2003 Jun 02; 197(11):1551-61. PMID: 12782717; PMCID: PMC2193914.
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    190. Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier L. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J Exp Med. 2003 May 19; 197(10):1245-53. PMID: 12756263; PMCID: PMC2193789.
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    192. Wu J, Lanier L. Natural killer cells and cancer. Adv Cancer Res. 2003; 90:127-56. PMID: 14710949.
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    193. Cooper MD, Lanier L, Conley ME, Puck JM. Immunodeficiency disorders. Hematology Am Soc Hematol Educ Program. 2003; 314-30. PMID: 14633788.
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    194. Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier L. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity. 2003 Jan; 18(1):41-51. PMID: 12530974.
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    195. Michaëlsson J, Teixeira de Matos C, Achour A, Lanier L, Kärre K, Söderström K. A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med. 2002 Dec 02; 196(11):1403-14. PMID: 12461076; PMCID: PMC2194258.
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    197. Ogasawara K, Yoshinaga SK, Lanier L. Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells. J Immunol. 2002 Oct 01; 169(7):3676-85. PMID: 12244160.
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    198. Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier L, Vaage JT, Ryan JC. Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands. J Immunol. 2002 Jul 01; 169(1):22-30. PMID: 12077224.
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    199. Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 2002 May 17; 296(5571):1323-6. PMID: 11950999.
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    200. Cerwenka A, O'Callaghan CA, Hamerman JA, Yadav R, Ajayi W, Roopenian DC, Joyce S, Lanier L. Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D. J Immunol. 2002 Apr 01; 168(7):3131-4. PMID: 11907062.
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    201. Masuda H, Saeki Y, Nomura M, Shida K, Matsumoto M, Ui M, Lanier L, Seya T. High levels of RAE-1 isoforms on mouse tumor cell lines assessed by anti-"pan" RAE-1 antibody confer tumor susceptibility to NK cells. Biochem Biophys Res Commun. 2002 Jan 11; 290(1):140-5. PMID: 11779145.
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