Li Che, MD

TitleAssociate Specialist
InstitutionUniversity of California San Francisco
Address513 Parnassus Avenue
San Francisco CA 94117
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    Collapse Biography 
    Collapse Education and Training
    Xi’an Jiaotong University(Xi’an Medical University), ChinaM.D.1993Clinical Medicine
    Peking University, Beijing,ChinaM.Sc2007Medical Science
    University of California, San Francisco , CA,USAPostdoctoral Scholar2017Cancer Research
    University of California, San Francisco, CA,USAAssociate SpecialistLiver Cancer

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang J, Dong M, Xu Z, Song X, Zhang S, Qiao Y, Che L, Gordan J, Hu K, Liu Y, Calvisi DF, Chen X. Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice. Oncogene. 2018 Mar 16. PMID: 29545603.
      View in: PubMed
    2. Zhang S, Wang J, Wang H, Fan L, Fan B, Zeng B, Tao J, Li X, Che L, Cigliano A, Ribback S, Dombrowski F, Chen B, Cong W, Wei L, Calvisi DF, Chen X. Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans. Am J Pathol. 2018 Apr; 188(4):995-1006. PMID: 29378174.
      View in: PubMed
    3. Wu H, Tao J, Li X, Zhang T, Zhao L, Wang Y, Zhang L, Xiong J, Zeng Z, Zhan N, Steer CJ, Che L, Dong M, Wang X, Niu J, Li Z, Yan G, Chen X, Song G. MicroRNA-206 prevents the pathogenesis of hepatocellular carcinoma by modulating expression of met proto-oncogene and cyclin-dependent kinase 6 in mice. Hepatology. 2017 12; 66(6):1952-1967. PMID: 28714063.
      View in: PubMed
    4. Huang X, Jiang D, Zhu Y, Fang Z, Che L, Lin Y, Xu S, Li J, Huang C, Zou Y, Li L, Feng B. Chronic High Dose Zinc Supplementation Induces Visceral Adipose Tissue Hypertrophy without Altering Body Weight in Mice. Nutrients. 2017 Oct 18; 9(10). PMID: 29057818.
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    5. Antonio Cigliano, Maria G Pilo, Lei Li, Gavinella Latte, Marta Szydlowska, Maria M Simile, Panagiotis Paliogiannis, Li Che, Giovanni M Pes, Giuseppe Palmieri, Maria C Sini, Antonio Cossu, Alberto Porcu, Gianpaolo Vidili, Maria A Seddaiu, Rosa M Pascale, Silvia Ribback, Frank Dombrowski, Xin Chen, Diego F Calvisi.Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis. Oncotarget. 2017; 8:90638-90650.
    6. Pin Liu, Diego F. Calvisi, Andras Kiss, Antonio Cigliano, Zsuzsa Schaff, Li Che, Silvia Ribback, Frank Dombrowski, Dongchi Zhao, Xin Chen.Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development. Oncotarget. 2017; 8:73433-73447.
    7. Zhang S, Song X, Cao D, Xu Z, Fan B, Che L, Hu J, Chen B, Dong M, Pilo MG, Cigliano A, Evert K, Ribback S, Dombrowski F, Pascale RM, Cossu A, Vidili G, Porcu A, Simile MM, Pes GM, Giannelli G, Gordan J, Wei L, Evert M, Cong W, Calvisi DF, Chen X. Pan-mTOR inhibitor MLN0128 is effective against intrahepatic cholangiocarcinoma in mice. J Hepatol. 2017 Dec; 67(6):1194-1203. PMID: 28733220.
      View in: PubMed
    8. Méndez-Lucas A, Li X, Hu J, Che L, Song X, Jia J, Wang J, Xie C, Driscoll PC, Tschaharganeh DF, Calvisi DF, Yuneva M, Chen X. Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities. Cancer Res. 2017 08 15; 77(16):4355-4364. PMID: 28630053.
      View in: PubMed
    9. Liu P, Ge M, Hu J, Li X, Che L, Sun K, Cheng L, Huang Y, Pilo MG, Cigliano A, Pes GM, Pascale RM, Brozzetti S, Vidili G, Porcu A, Cossu A, Palmieri G, Sini MC, Ribback S, Dombrowski F, Tao J, Calvisi DF, Chen L, Chen X. A functional mammalian target of rapamycin complex 1 signaling is indispensable for c-Myc-driven hepatocarcinogenesis. Hepatology. 2017 07; 66(1):167-181. PMID: 28370287.
      View in: PubMed
    10. Lin Y, Cheng X, Sutovsky P. Effect of intra-uterine growth restriction on long-term fertility in boars. Reprod Fertil Dev. 2017 Feb; 29(2):374-382. PMID: 26293651.
      View in: PubMed
    11. Che L, Pilo MG, Cigliano A, Latte G, Simile MM, Ribback S, Dombrowski F, Evert M, Chen X, Calvisi DF. Oncogene dependent requirement of fatty acid synthase in hepatocellular carcinoma. Cell Cycle. 2017 Mar 19; 16(6):499-507. PMID: 28118080.
      View in: PubMed
    12. Che L, Fan B, Pilo MG, Xu Z, Liu Y, Cigliano A, Cossu A, Palmieri G, Pascale RM, Porcu A, Vidili G, Serra M, Dombrowski F, Ribback S, Calvisi DF, Chen X. Jagged 1 is a major Notch ligand along cholangiocarcinoma development in mice and humans. Oncogenesis. 2016 Dec 05; 5(12):e274. PMID: 27918553.
      View in: PubMed
    13. Hale G, Liu X, Hu J, Xu Z, Che L, Solomon D, Tsokos C, Shafizadeh N, Chen X, Gill R, Kakar S. Correlation of exon 3 ß-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. Mod Pathol. 2016 Nov; 29(11):1370-1380. PMID: 27469330.
      View in: PubMed
    14. Cao D, Song X, Che L, Li X, Pilo MG, Vidili G, Porcu A, Solinas A, Cigliano A, Pes GM, Ribback S, Dombrowski F, Chen X, Li L, Calvisi DF. Both de novo synthetized and exogenous fatty acids support the growth of hepatocellular carcinoma cells. Liver Int. 2017 01; 37(1):80-89. PMID: 27264722.
      View in: PubMed
    15. Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y. [(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice. Mol Imaging Biol. 2016 06; 18(3):360-7. PMID: 26567114; PMCID: PMC4866912.
    16. Li L, Che L, Tharp KM, Park HM, Pilo MG, Cao D, Cigliano A, Latte G, Xu Z, Ribback S, Dombrowski F, Evert M, Gores GJ, Stahl A, Calvisi DF, Chen X. Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. Hepatology. 2016 06; 63(6):1900-13. PMID: 26910791; PMCID: PMC4874885 [Available on 06/01/17].
    17. Ding N, Che L, Li XL, Liu Y, Jiang LJ, Fan B, Tao JY, Chen X, Ji JF. Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice. World J Gastroenterol. 2016 Feb 14; 22(6):2071-80. PMID: 26877611; PMCID: PMC4726679.
    18. Hu J, Che L, Li L, Pilo MG, Cigliano A, Ribback S, Li X, Latte G, Mela M, Evert M, Dombrowski F, Zheng G, Chen X, Calvisi DF. Co-activation of AKT and c-Met triggers rapid hepatocellular carcinoma development via the mTORC1/FASN pathway in mice. Sci Rep. 2016 Feb 09; 6:20484. PMID: 26857837; PMCID: PMC4746674.
    19. Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, Demartis MI, Tao J, Gui B, Pilo MG, Ribback S, Dombrowski F, Evert M, Calvisi DF, Chen X. Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade. Liver Int. 2016 08; 36(8):1176-86. PMID: 26716908; PMCID: PMC4929046 [Available on 08/01/17].
    20. Juric V, Ruffell B, Evason KJ, Hu J, Che L, Wang L, Chen X, Bishop JM. Monocytes promote liver carcinogenesis in an oncogene-specific manner. J Hepatol. 2016 Apr; 64(4):881-90. PMID: 26639397; PMCID: PMC4799762 [Available on 04/01/17].
    21. Li L, Pilo GM, Li X, Cigliano A, Latte G, Che L, Joseph C, Mela M, Wang C, Jiang L, Ribback S, Simile MM, Pascale RM, Dombrowski F, Evert M, Semenkovich CF, Chen X, Calvisi DF. Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans. J Hepatol. 2016 Feb; 64(2):333-341. PMID: 26476289.
      View in: PubMed
    22. Huntzicker EG, Hötzel K, Choy L, Che L, Ross J, Pau G, Sharma N, Siebel CW, Chen X, French DM. Differential effects of targeting Notch receptors in a mouse model of liver cancer. Hepatology. 2015 Mar; 61(3):942-52. PMID: 25311838; PMCID: PMC4447303.
    23. Ren J, Di L, Song G, Yu J, Jia J, Zhu Y, Yan Y, Jiang H, Liang X, Che L, Zhang J, Wan F, Wang X, Zhou X, Lyerly HK. Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences. Clin Transl Oncol. 2013 Oct; 15(10):780-8. PMID: 23359185.
      View in: PubMed
    24. Che L, Yuan YH, Jia J, Ren J. Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients. Chin J Cancer Res. 2012 Dec; 24(4):323-31. PMID: 23359030; PMCID: PMC3551326.
    25. Liang X, Zhang J, Zhu Y, Lu Y, Zhou X, Wang Z, Yu J, Yan Y, Di L, Che L, Jiang H, Shao B, Wang X, Yang H, Lyerly HK, Ren J. Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients. Clin Transl Oncol. 2013 Apr; 15(4):331-4. PMID: 23143946.
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    26. Di L, Zhu Y, Jia J, Yu J, Song G, Zhang J, Che L, Yang H, Han Y, Ma B, Zhang C, Yuan Y, You M, Wan F, Wang X, Zhou X, Ren J. Clinical safety of induced CTL infusion through recombinant adeno-associated virus-transfected dendritic cell vaccination in Chinese cancer patients. Clin Transl Oncol. 2012 Sep; 14(9):675-81. PMID: 22855148.
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    27. Dong N, Yu J, Wang C, Zheng X, Wang Z, Di L, Song G, Zhu B, Che L, Jia J, Jiang H, Zhou X, Wang X, Ren J. Pharmacogenetic assessment of clinical outcome in patients with metastatic breast cancer treated with docetaxel plus capecitabine. J Cancer Res Clin Oncol. 2012 Jul; 138(7):1197-203. PMID: 22426923.
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    28. Yu J, Ren J, Di LJ, Song GH, Zhu YL, Zhang J, Liang X, Che L, Jiang HF, Jia J, Zhang CR. Mobilization of Peripheral Blood Stem Cells Using Regimen Combining Docetaxel with Granulocyte Colony-stimulating Factor in Breast Cancer Patients. Chin J Cancer Res. 2011 Mar; 23(1):49-53. PMID: 23467566; PMCID: PMC3587530.
    29. Yu J, DI Lj, Song Gh, Che L, Jiang Hf, Zhu Yl, Liang X, Jia J, Zhang J, Yang Hb, Wang Xl, Zhou Xn, Ren J. [Randomized clinical case-control trial for the comparison of docetaxel plus thiotepa versus docetaxel plus capecitabine in patients with metastatic breast cancer]. Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Feb 18; 43(1):151-6. PMID: 21321641.
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    30. Jiang HF, Fang J, Ren J, DI LJ, Song GH, Che L, Yu J, Zhu YL. [Concurrent versus sequential systemic chemotherapy and whole brain radiation therapy for brain matastases in non-small-cell lung cancer patients]. Zhonghua Zhong Liu Za Zhi. 2011 Jan; 33(1):58-62. PMID: 21575467.
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    31. Che L, Ren J, Yuan YH, Jia J, Di LJ, Song GH, Yu J, Wang XL. [Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas]. Beijing Da Xue Xue Bao Yi Xue Ban. 2008 Dec 18; 40(6):616-23. PMID: 19088834.
      View in: PubMed
    32. Di LJ, Ren J, Song GH, Yu J, Fang J, Che L, Zhu YL. [Treatment of malignant effusions with the injection of dendritic cells derived from autologous peripheral CD34+ stem cells]. Beijing Da Xue Xue Bao Yi Xue Ban. 2008 Oct 18; 40(5):486-8. PMID: 18931710.
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