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Li Gan, PhD

Title(s)Affiliate, Neurology
SchoolSchool of Medicine
Address1650 Owens St
San Francisco CA 94107
Phone415-734-2524
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Yale University School of MedicinePh.D1996Department of Cellular and Molecular Physiology

    Collapse Overview 
    Collapse Overview
    Dr. Gan studies the molecular mechanisms behind the loss of functional neurons in neurodegenerative diseases, including Alzheimer’s disease and Frontotemporal Dementia. Her lab explores the relationship between the aging of neural circuits, the accumulation of toxic proteins and the subsequent activation of a chronic inflammatory response. Understanding how these processes become dysfunctional in neurodegeneration could lead to new therapeutic strategies to tackle Alzheimer’s disease and Frontotemporal dementia.

    One aspect of Dr. Gan’s research focuses on why toxic proteins accumulate in the brains of Alzheimer patients. Dr. Gan and her team discovered new cellular mechanisms that could lead to novel approaches to get rid of the toxic proteins from aging neurons. Dr. Gan’s research also explores stem cell-based regenerative approaches 
in Alzheimer’s disease—a promising yet highly challenging therapeutic direction. Her study showed that neural stem cells in the hippocampus of mice genetically modified to mimic Alzheimer’s symptoms develop abnormally and integrate poorly into the network of neural circuits. More importantly, Dr. Gan and her colleagues find that they can offset these deficits by manipulating electrical signals via pharmacological approaches. Their research provides important clues to encourage the development of new brain cells in those with Alzheimer’s disease.

    At UCSF, Dr. Gan is active in graduate training and has joint appointments in the Neuroscience Graduate Program and the Biomedical Sciences Graduate Program. She is also a member of several scientific and professional societies, including the Society for Neuroscience. Dr. Gan has served as a referee
 for several government and private grant agencies, including the National Institutes of Health, the Alzheimer’s Association and the California Department of Health Services. She is also an ad hoc reviewer for numerous professional journals including Neuron, Nature Medicine, Journal of Neuroscience, and Journal of Cell Biology.

    Dr. Gan received a bachelor’s degree in physiology from China’s Peking University and a PhD in cellular and molecular physiology from Yale University School of Medicine. Later, she did postdoctoral training at Yale University School of Medicine, Harvard Medical School and the Gladstone Institutes.

    Collapse Research 
    Collapse Research Activities and Funding
    Tau acetylation in Alzheimer's disease
    NIH/NIA R01AG054214Sep 13, 2018 - Apr 30, 2022
    Role: Principal Investigator
    Functional characterization of Alzheimer's disease associated genetic variants
    NIH/NIA R01AG057497Sep 30, 2017 - May 31, 2022
    Role: Co-Principal Investigator
    Linking tau proteostasis with neuronal activity in FTD
    NIH/NINDS U54NS100717Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Molecular mechanisms in progranulin deficient frontotemporal dementia
    NIH/NIA R01AG051390Sep 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Screening for inhibitors of p300-mediated tau acetylation for Alzheimer's Disease
    NIH/NIA R21AG046526Jul 1, 2014 - Apr 30, 2016
    Role: Co-Principal Investigator
    SIRT1 Limits Microglial Toxicity in Alzheimer's Disease
    NIH/NIA R01AG036884Aug 1, 2012 - Apr 30, 2017
    Role: Principal Investigator
    The Role of Cathepsin B and Cystatin C in Alzheimer's Disease
    NIH/NIA R01AG030207Mar 15, 2010 - Feb 28, 2015
    Role: Principal Investigator
    Cathepsin B and cystatin C in AD-related neuronal damage
    NIH/NIA R21AG024447Aug 15, 2004 - Jun 30, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TAU-MEDIATED CELL DEATH MECHANISMS IN MAPT V337M IPSC-DERIVED HUMAN NEURONS. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p1006. Panos Theofilas, Mifrah Hayath, Chao Wang, David Butler, Salome McAllen, Michelle Arkin, Jason Gestwicki, Ana Maria Cuervo, Rakez Kayed, Celeste M. Karch, Sally Temple, Li Gan, Lea T. Grinberg. .
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    2. ASTROGLIAL AND MICROGLIAL MODULATION OF NEURAL FUNCTIONS IN MODELS OF ALZHEIMER’S DISEASE. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p188. Lennart Mucke, Katerina Akassoglou, Melanie Das, Li Gan, Kaitlyn Ho, Mario Merlini, Anna Orr, Victoria A. Rafalski, Jae Kyu Ryu, Faten Sayed, William W. Seeley, Gui-Qiu Yu. .
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    3. A NOVEL ROLE FOR THE FTD-CAUSING PROTEIN PROGRANULIN IN APOPTOSIS SIGNALING. Alzheimer's & Dementia. 2019 Jul 1; 15(7):p1509. Claire Clelland, J. Iker Etchegaray, Lay Kodama, Faten Sayed, Aradhana Sachdev, Yaqiao Li, David Le, Lihong Zhan, Yungui Zhou, Duc Duong, Nicholas T. Seyfried, Thomas G. Kukar, Li Xuan Tan, Aparna Lakkaraju, Bruce Conklin, Li Gan. .
      View in: Publisher Site   Mentions:
    4. ACETYLATED TAU DISTRIBUTION IN THE HUMAN HIPPOCAMPUS. Alzheimer's & Dementia. 2018 Jul 1; 14(7):p751. Alexander J. Ehrenberg, Dulce Ovando Morales, Cathrine Petersen, Mackenzie Hepker, Alissa Nana Li, Celica Glenn Cosme, Bruce L. Miller, Li Gan, William W. Seeley, Lea Tenenholz Grinberg. .
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    5. POST-TRANSLATIONAL MODIFICATIONS OF TAU IN ALZHEIMER'S DISEASE: A POSTMORTEM STUDY IN HUMANS. Alzheimer's & Dementia. 2018 Jul 1; 14(7):p368-p370. Alexander J. Ehrenberg, Cathrine Petersen, Dulce Ovando Morales, Panagiotis Theofilas, Mackenzie Hepker, Alissa Nana Li, Celica Glenn Cosme, Claudia K. Suemoto, Ana T. Alho, Renata Elaine Paraizo Leite, Roberta Diehl Rodriguez, José Marcelo Farfel, Renata Eloah de Lucena Ferretti-Rebustini, Camila F. Nascimento, Ricardo Nitrini, Carlos Augusto Pasquallucci, Wilson Jacob-Filho, Bruce L. Miller, William W. Seeley, Li Gan, Lea Tenenholz Grinberg. .
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    6. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. Bioessays. 2017 04; 39(4). Tracy TE, Gan L. PMID: 28083916.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    7. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016 06 29; 11(1):47. Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L. PMID: 27356871.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    8. Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor. Glia. 2016 10; 64(10):1788-94. Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW. PMID: 27246804.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    9. Targeting microglia for the treatment of Alzheimer's Disease. Glia. 2016 10; 64(10):1710-32. Wes PD, Sayed FA, Bard F, Gan L. PMID: 27100611.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    10. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 04 20; 90(2):245-60. Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L. PMID: 27041503.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    11. Chapter 5 Molecular Pathways in Alzheimer’s Disease and Cognitive Function New Insights into Pathobiology of Tau. Genes, Environment and Alzheimer\u0027s Disease. 2016 Jan 1; 135-167. Xu Chen, Meredith C. Reichert, Li Gan. .
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    12. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med. 2015 Oct; 21(10):1154-62. Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L. PMID: 26390242.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    13. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with a7 nicotinic acetylcholine receptor agonists. Biochem Pharmacol. 2015 Oct 15; 97(4):454-462. Minami SS, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee CH, Li J, Donnelly-Roberts D, Gan L. PMID: 26206194.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    14. PL-03-02: Inge grundke-iqbal award for Alzheimer's research: Progranulin protects against amyloid b deposition and toxicity in Alzheimer's disease mouse models. Alzheimer's & Dementia. 2015 Jul 1; 11(7S_Part_5):p216-p216. Li Gan. .
      View in: Publisher Site   Mentions:
    15. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1ß. J Neurosci. 2015 Jan 14; 35(2):807-18. Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L. PMID: 25589773.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    16. Progranulin protects against amyloid ß deposition and toxicity in Alzheimer's disease mouse models. Nat Med. 2014 Oct; 20(10):1157-64. Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L. PMID: 25261995.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    17. Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. J Exp Med. 2014 Sep 22; 211(10):1937-45. Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L. PMID: 25155018.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    18. CRITICAL ROLE OF ACETYLATION IN TAU-MEDIATED NEURODEGENERATION AND COGNITIVE DEFICITS. Alzheimer's & Dementia. 2014 Jul 1; 10(4):p146. Li Gan, Sang-Won Min, Tara Tracy, Xu Chen, Peter Sohn, Chao Wang, Sakura Minami, Yungui Zhou, Li Yaqiao. .
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    19. Evaluation of a prototype ration aimed at increasing caloric intake in a field environment. Mil Med. 2014 Feb; 179(2):190-6. Huang L, Gan LS, Law LY. PMID: 24491616.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci. 2013 Sep 25; 5:53. Min SW, Sohn PD, Cho SH, Swanson RA, Gan L. PMID: 24093018.
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    21. Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation. Biochim Biophys Acta. 2013 Aug; 1833(8):1985-91. Kauppinen TM, Gan L, Swanson RA. PMID: 23597856.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    22. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathol. 2013 Apr; 125(4):581-93. Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. PMID: 23371364.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    23. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov; 122(11):3955-9. Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. PMID: 23041626.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    24. Cathepsin B degrades amyloid-ß in mice expressing wild-type human amyloid precursor protein. J Biol Chem. 2012 Nov 16; 287(47):39834-41. Wang C, Sun B, Zhou Y, Grubb A, Gan L. PMID: 23024364.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    25. Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience. 2012 Dec 13; 226:10-20. Pappas DJ, Gabatto PA, Oksenberg D, Khankhanian P, Baranzini SE, Gan L, Oksenberg JR. PMID: 22986168.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Selective targeting of microglia by quantum dots. J Neuroinflammation. 2012 Jan 24; 9:22. Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. PMID: 22272874.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    27. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid ß. J Neuroinflammation. 2011 Nov 03; 8:152. Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA. PMID: 22051244.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    28. Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol. 2011 Nov; 95(3):373-95. Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J. PMID: 21930182.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    29. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem. 2011 Sep 16; 286(37):32713-22. Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. PMID: 21771791.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    30. Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy. Neuron. 2010 Nov 1; 68(4):801. Sang-Won Min, Seo-Hyun Cho, Yungui Zhou, Sebastian Schroeder, Vahram Haroutunian, William W. Seeley, Eric J. Huang, Yong Shen, Eliezer Masliah, Chandrani Mukherjee, David Meyers, Philip A. Cole, Melanie Ott, Li Gan. .
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    31. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66. Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. PMID: 20869593.
      View in: PubMed   Mentions: 259     Fields:    Translation:HumansAnimalsCells
    32. Therapeutic potential and challenges of targeting sirtuins in neurodegenerative diseases. Frontiers in Biology. 2010 Aug 1; 5(4):324-330. Li Gan. .
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    33. Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction. Malar J. 2010 May 21; 9:134. Gan LS, Loh JP. PMID: 20487570.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    34. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 2009 Dec 04; 5(6):624-33. Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. PMID: 19951690.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    35. Sirtuin signaling in Alzheimer's disease. Alzheimer's & Dementia. 2009 Jul 1; 5(4):p120. Li Gan. .
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    36. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron. 2008 Oct 23; 60(2):247-57. Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. PMID: 18957217.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    37. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci. 2008 Nov; 11(11):1311-8. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. PMID: 18931664.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    38. P3-384: Impaired hippocampal adult neurogenesis in an animal model of Alzheimer's disease. Alzheimer's & Dementia. 2008 Jul 1; 4(4):t634. Brian E. Halabisky, Binggui Sun, Yungui Zhou, Sarah Mueller-Steiner, Xin Wang, Giuqiu Yu, Lennart Mucke, Li Gan. .
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    39. O4-02-03: Phospholipase A2 reduction ameliorates cognitive deficits in mouse model of Alzheimer's disease. Alzheimer's & Dementia. 2008 Jul 1; 4(4):t186-t187. Rene O. Sanchez-Mejia, John W. Newman, Sandy Toh, Gui-Qiu Yu, Yungui Zhou, Kimberly Scearce-Levie, Irene H. Cheng, Li Gan, Jorge J. Palop, Joseph V. Bonventre, Lennart Mucke. .
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    40. P1-414: Regulation of amyloid-beta by cathepsin B and cystatin C. Alzheimer's & Dementia. 2008 Jul 1; 4(4):t341. Li Gan, Binggui Sun, Yungui Zhou, Xin Wang, Seo-hyun Cho. .
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    41. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 2008 Apr 10; 58(1):10-4. Gan L, Mucke L. PMID: 18400158.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimals
    42. Therapeutic potential of sirtuin-activating compounds in Alzheimer's disease. Drug News Perspect. 2007 May; 20(4):233-9. Gan L. PMID: 17637936.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    43. Therapeutic potential of amyloid -degrading enzymes in Alzheimers disease. Future Neurology. 2007 Mar 1; 2(2):133-137. Li Gan. .
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    44. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 2006 Sep 21; 51(6):703-14. Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. PMID: 16982417.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    45. O4-06-05 Anti-amyloidogenic and neuroprotective functions of cathepsin B: Implications for Alzheimer’s disease. Alzheimer's & Dementia. 2006 Jul 1; 2(3):s88. Li Gan, Sarah Mueller-Steiner, Yungui Zhou, Hideaki Arai, Erik D. Roberson, Xin Wang, Jennifer Chen, Guiqiu Yu, Luke Esposito, Lennart Mucke. .
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    46. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem. 2005 Dec 02; 280(48):40364-74. Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. PMID: 16183991.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimalsCells
    47. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hear Res. 2005 Aug; 206(1-2):133-45. Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. PMID: 16081004.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    48. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J Neurochem. 2004 Dec; 91(6):1260-74. Esposito L, Gan L, Yu GQ, Essrich C, Mucke L. PMID: 15584903.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    49. New non-viral method for gene transfer into primary cells. Methods. 2004 Jun; 33(2):151-63. Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S, Hammermann R, Wolf J, Müller-Hartmann H, Nix M, Siebenkotten G, Kraus G, Lun K. PMID: 15121170.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    50. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. J Biol Chem. 2004 Feb 13; 279(7):5565-72. Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S, Patthy L, Gonzalez-Zulueta M, Nikolich K, Urfer R. PMID: 14612454.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    51. Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes. Biochem Biophys Res Commun. 2003 Aug 15; 308(1):23-8. Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD. PMID: 12890474.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    52. Localization of the Slack potassium channel in the rat central nervous system. J Comp Neurol. 2002 Dec 16; 454(3):241-54. Bhattacharjee A, Gan L, Kaczmarek LK. PMID: 12442315.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    53. Specific interference with gene expression and gene function mediated by long dsRNA in neural cells. J Neurosci Methods. 2002 Dec 15; 121(2):151-7. Gan L, Anton KE, Masterson BA, Vincent VA, Ye S, Gonzalez-Zulueta M. PMID: 12468005.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    54. Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter. J Neurochem. 1999 Oct; 73(4):1350-62. Gan L, Hahn SJ, Kaczmarek LK. PMID: 10501178.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    55. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7547-52. Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L. PMID: 10377452.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    56. When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons. J Neurobiol. 1998 Oct; 37(1):69-79. Gan L, Kaczmarek LK. PMID: 9777733.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    57. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nat Neurosci. 1998 Oct; 1(6):462-9. Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. PMID: 10196543.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    58. Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. J Physiol. 1998 May 15; 509 ( Pt 1):183-94. Wang LY, Gan L, Forsythe ID, Kaczmarek LK. PMID: 9547392.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    59. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1882-7. Wang LY, Gan L, Perney TM, Schwartz I, Kaczmarek LK. PMID: 9465111.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    60. Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons. J Biol Chem. 1996 Mar 08; 271(10):5859-65. Gan L, Perney TM, Kaczmarek LK. PMID: 8621457.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    61. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. J Neurophysiol. 1995 Jul; 74(1):207-17. Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. PMID: 7472324.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    62. [Current aspects of drug therapy of cancer]. Rev Clin Esp. 1970 Dec 31; 119(6):501-16. Vicente J. PMID: 4928318.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
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