Liang You, MD, PhD

Title(s)Professor, Surgery
SchoolSchool of Medicine
Address2340 Sutter Street, #N221
San Francisco CA 94115
Phone415-476-6906
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of Cul4A in Genome Stability and Cancer Development
    NIH R01CA140654Jul 9, 2010 - May 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. A novel isoform of Homeodomain-interacting protein kinase-2 promotes YAP/TEAD transcriptional activity in NSCLC cells. Oncotarget. 2021 Feb 02; 12(3):173-184. Dai Y, Kyoyama H, Yang YL, Wang Y, Liu S, Wang Y, Mao JH, Xu Z, Uematsu K, Jablons DM, You L. PMID: 33613845; PMCID: PMC7869571.
      View in: PubMed   Mentions: 2     Fields:    
    2. The Crosstalk between Src and Hippo/YAP Signaling Pathways in Non-Small Cell Lung Cancer (NSCLC). Cancers (Basel). 2020 May 26; 12(6). Hsu PC, Yang CT, Jablons DM, You L. PMID: 32466572; PMCID: PMC7352956.
      View in: PubMed   Mentions: 23  
    3. Inhibition of cyclin-dependent kinase 7 down-regulates yes-associated protein expression in mesothelioma cells. J Cell Mol Med. 2020 01; 24(1):1087-1098. Miao J, Kyoyama H, Liu L, Chan G, Wang Y, Urisman A, Yang YL, Liu S, Xu Z, Bin H, Li H, Jablons DM, You L. PMID: 31755214; PMCID: PMC6933402.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC). Int J Mol Sci. 2019 Aug 05; 20(15). Hsu PC, Jablons DM, Yang CT, You L. PMID: 31387256; PMCID: PMC6695603.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    5. The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region. J Biol Chem. 2019 09 13; 294(37):13545-13559. Agnew C, Liu L, Liu S, Xu W, You L, Yeung W, Kannan N, Jablons D, Jura N. PMID: 31341017; PMCID: PMC6746438.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    6. Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. Oncol Rep. 2019 Aug; 42(2):697-707. Hsu PC, Tian B, Yang YL, Wang YC, Liu S, Urisman A, Yang CT, Xu Z, Jablons DM, You L. PMID: 31233205; PMCID: PMC6610039.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    7. Cul4A Modulates Invasion and Metastasis of Lung Cancer Through Regulation of ANXA10. Cancers (Basel). 2019 May 02; 11(5). Hung MS, Chen YC, Lin P, Li YC, Hsu CC, Lung JH, You L, Xu Z, Mao JH, Jablons DM, Yang CT. PMID: 31052599; PMCID: PMC6562482.
      View in: PubMed   Mentions: 13  
    8. The Role of Yes-Associated Protein (YAP) in Regulating Programmed Death-Ligand 1 (PD-L1) in Thoracic Cancer. Biomedicines. 2018 Dec 07; 6(4). Hsu PC, Yang CT, Jablons DM, You L. PMID: 30544524; PMCID: PMC6315659.
      View in: PubMed   Mentions: 17  
    9. Inhibition of yes-associated protein down-regulates PD-L1 (CD274) expression in human malignant pleural mesothelioma. J Cell Mol Med. 2018 06; 22(6):3139-3148. Hsu PC, Miao J, Wang YC, Zhang WQ, Yang YL, Wang CW, Yang CT, Huang Z, You J, Xu Z, Jablons DM, You L. PMID: 29575535; PMCID: PMC5980156.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    10. Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model. J Cell Mol Med. 2018 06; 22(6):3073-3085. Hsu PC, Miao J, Huang Z, Yang YL, Xu Z, You J, Dai Y, Yeh CC, Chan G, Liu S, Urisman A, Yang CT, Jablons DM, You L. PMID: 29575527; PMCID: PMC5980132.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. YAP regulates PD-L1 expression in human NSCLC cells. Oncotarget. 2017 Dec 29; 8(70):114576-114587. Miao J, Hsu PC, Yang YL, Xu Z, Dai Y, Wang Y, Chan G, Huang Z, Hu B, Li H, Jablons DM, You L. PMID: 29383103; PMCID: PMC5777715.
      View in: PubMed   Mentions: 67     Fields:    
    12. Hippo pathway in lung development. J Thorac Dis. 2017 Aug; 9(8):2246-2250. Dai Y, Jablons D, You L. PMID: 28932516; PMCID: PMC5594189.
      View in: PubMed   Mentions: 11  
    13. Drug development against the hippo pathway in mesothelioma. Transl Lung Cancer Res. 2017 Jun; 6(3):335-342. Woodard GA, Yang YL, You L, Jablons DM. PMID: 28713678; PMCID: PMC5504108.
      View in: PubMed   Mentions: 17  
    14. DCLK1 is correlated with MET and ERK5 expression, and associated with prognosis in malignant pleural mesothelioma. Int J Oncol. 2017 Jul; 51(1):91-103. Wang H, Dai YY, Zhang WQ, Hsu PC, Yang YL, Wang YC, Chan G, Au A, Xu ZD, Jiang SJ, Wang W, Jablons DM, You L. PMID: 28560410; PMCID: PMC5467791.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Targeting YAP in malignant pleural mesothelioma. J Cell Mol Med. 2017 Nov; 21(11):2663-2676. Zhang WQ, Dai YY, Hsu PC, Wang H, Cheng L, Yang YL, Wang YC, Xu ZD, Liu S, Chan G, Hu B, Li H, Jablons DM, You L. PMID: 28470935; PMCID: PMC5661117.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    16. YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells. Oncotarget. 2017 Jan 17; 8(3):4096-4109. Dai Y, Liu S, Zhang WQ, Yang YL, Hang P, Wang H, Cheng L, Hsu PC, Wang YC, Xu Z, Jablons DM, You L. PMID: 27911857; PMCID: PMC5354815.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    17. YAP promotes erlotinib resistance in human non-small cell lung cancer cells. Oncotarget. 2016 Aug 09; 7(32):51922-51933. Hsu PC, You B, Yang YL, Zhang WQ, Wang YC, Xu Z, Dai Y, Liu S, Yang CT, Li H, Hu B, Jablons DM, You L. PMID: 27409162; PMCID: PMC5239524.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    18. Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells. J Cell Mol Med. 2016 07; 20(7):1295-306. Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Lung JH, Yang CT, Liu ST. PMID: 26969027; PMCID: PMC4929302.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    19. Knockdown of Cul4A increases chemosensitivity to gemcitabine through upregulation of TGFBI in lung cancer cells. Oncol Rep. 2015 Dec; 34(6):3187-95. Hung MS, Chen IC, You L, Jablons DM, Li YC, Mao JH, Xu Z, Hsieh MJ, Lin YC, Yang CT, Liu ST, Tsai YH. PMID: 26503734.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    20. Cul4A overexpression associated with Gli1 expression in malignant pleural mesothelioma. J Cell Mol Med. 2015 Oct; 19(10):2385-96. Yang YL, Ni J, Hsu PC, Mao JH, Hsieh D, Xu A, Chan G, Au A, Xu Z, Jablons DM, You L. PMID: 26218750; PMCID: PMC4594680.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    21. Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene. Thorac Cancer. 2015 Jul; 6(4):480-7. Wang Y, Xu Z, Mao JH, Hung MS, Hsieh D, Au A, Jablons DM, You L. PMID: 26273405; PMCID: PMC4511328.
      View in: PubMed   Mentions: 3     Fields:    
    22. PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer. Zhongguo Fei Ai Za Zhi. 2015 Jun; 18(6):345-50. Wang Y, Xu Z, Mao JH, Hsieh D, Au A, Jablons DM, Li H, You L. PMID: 26104890; PMCID: PMC5999902.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    23. Genistein Suppresses Growth of Human Uterine Sarcoma Cell Lines via Multiple Mechanisms. Anticancer Res. 2015 Jun; 35(6):3167-73. Yeh CC, Fan Y, Jiang L, Yang YL, He B, You L, Mann M. PMID: 26026076.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    24. Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells. Oncotarget. 2015 Feb 28; 6(6):4357-68. You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM, You L. PMID: 25738359; PMCID: PMC4414195.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    25. CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells. J Exp Clin Cancer Res. 2014 Nov 25; 33:93. Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons DM, You L. PMID: 25422081; PMCID: PMC4254219.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    26. An alternative way to initiate Notch1 signaling in non-small cell lung cancer. Transl Lung Cancer Res. 2014 Aug; 3(4):238-41. Yang YL, Jablons D, You L. PMID: 25806306; PMCID: PMC4367706.
      View in: PubMed   Mentions: 4  
    27. Lung tumourigenesis in a conditional Cul4A transgenic mouse model. J Pathol. 2014 Jun; 233(2):113-23. Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L. PMID: 24648314; PMCID: PMC4084828.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res. 2014 Jan 15; 74(2):520-31. Wang Y, Wen M, Kwon Y, Xu Y, Liu Y, Zhang P, He X, Wang Q, Huang Y, Jen KY, LaBarge MA, You L, Kogan SC, Gray JW, Mao JH, Wei G. PMID: 24305877; PMCID: PMC3934357.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    29. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol. 2013 Nov; 43(5):1517-22. Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L. PMID: 24008396; PMCID: PMC3823374.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    30. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. BMC Pharmacol Toxicol. 2013 Jul 11; 14:36. Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons DM, You L. PMID: 23845105; PMCID: PMC3726451.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer. 2013 Jul 01; 13:316. Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons DM, You L. PMID: 23815780; PMCID: PMC3707790.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    32. Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med. 2013 Jul; 17(7):854-62. Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons DM, You L. PMID: 23651443; PMCID: PMC3729857.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    33. Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One. 2012; 7(6):e38996. Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L. PMID: 22768056; PMCID: PMC3387212.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    34. The expression of Dishevelled-3 and glutamine metabolism in malignant pleural mesothelioma. J Clin Pathol. 2012 Sep; 65(9):855-8. Li T, Hou SC, Mao JH, Wang YC, Lu XD, Tan JL, You B, Liu YP, Ni J, Au A, Jablons DM, Xu Z, You L. PMID: 22569537; PMCID: PMC3422606.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. Transgenic mice for cre-inducible overexpression of the Cul4A gene. Genesis. 2011 Mar; 49(3):134-41. Li T, Hung MS, Wang Y, Mao JH, Tan JL, Jahan K, Roos H, Xu Z, Jablons DM, You L. PMID: 21381181; PMCID: PMC3285554.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    36. Cul4A is an oncogene in malignant pleural mesothelioma. J Cell Mol Med. 2011 Feb; 15(2):350-8. Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons DM, You L. PMID: 19929949; PMCID: PMC3355981.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    37. The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma. J Pathol. 2011 Mar; 223(4):519-30. Li T, Li H, Wang Y, Harvard C, Tan JL, Au A, Xu Z, Jablons DM, You L. PMID: 21294125; PMCID: PMC3085597.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    38. Adenovirus-mediated SOCS3 gene transfer inhibits the growth and enhances the radiosensitivity of human non-small cell lung cancer cells. Oncol Rep. 2010 Dec; 24(6):1605-12. Lin YC, Lin CK, Tsai YH, Weng HH, Li YC, You L, Chen JK, Jablons DM, Yang CT. PMID: 21042758.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    39. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS One. 2010 Jul 02; 5(7):e11418. Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons DM, You L. PMID: 20625391; PMCID: PMC2896393.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    40. Procaine and procainamide inhibit the Wnt canonical pathway by promoter demethylation of WIF-1 in lung cancer cells. Oncol Rep. 2009 Dec; 22(6):1479-84. Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablons DM, You L. PMID: 19885602.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    41. Promoter demethylation of WIF-1 by epigallocatechin-3-gallate in lung cancer cells. Anticancer Res. 2009 Jun; 29(6):2025-30. Gao Z, Xu Z, Hung MS, Lin YC, Wang T, Gong M, Zhi X, Jablon DM, You L. PMID: 19528461.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    42. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. BMC Cancer. 2009 May 06; 9:135. Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L. PMID: 19419583; PMCID: PMC2696466.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    43. Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis. Head Neck. 2008 Jul; 30(7):946-63. Chou J, Lin YC, Kim J, You L, Xu Z, He B, Jablons DM. PMID: 18446839; PMCID: PMC3046044.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansCells
    44. Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription. Mol Cancer Ther. 2008 Jun; 7(6):1633-8. You L, Xu Z, Punchihewa C, Jablons DM, Fujii N. PMID: 18566234.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    45. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus. Cancer Sci. 2008 Jan; 99(1):46-53. Clément G, Guilleret I, He B, Yagui-Beltrán A, Lin YC, You L, Xu Z, Shi Y, Okamoto J, Benhattar J, Jablons D. PMID: 18005197.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    46. Targeting the Wnt signaling pathway with dishevelled and cisplatin synergistically suppresses mesothelioma cell growth. Anticancer Res. 2007 Nov-Dec; 27(6B):4239-42. Uematsu K, Seki N, Seto T, Isoe C, Tsukamoto H, Mikami I, You L, He B, Xu Z, Jablons DM, Eguchi K. PMID: 18225596.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    47. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. Int J Cancer. 2007 Sep 15; 121(6):1175-81. Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui-Beltran A, Clement G, Lin YC, Okamoto J, Bravo DT, Jablons DM. PMID: 17534895.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    48. Roles of secreted frizzled-related proteins in cancer. Acta Pharmacol Sin. 2007 Sep; 28(9):1499-504. Shi Y, He B, You L, Jablons DM. PMID: 17723183.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    49. Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Hum Gene Ther. 2007 Apr; 18(4):379-86. Lin YC, You L, Xu Z, He B, Yang CT, Chen JK, Mikami I, Clément G, Shi Y, Kuchenbecker K, Okamoto J, Kashani-Sabet M, Jablons DM. PMID: 17472570.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    50. Wnt inhibitory factor inhibits lung cancer cell growth. J Thorac Cardiovasc Surg. 2007 Mar; 133(3):733-7. Kim J, You L, Xu Z, Kuchenbecker K, Raz D, He B, Jablons D. PMID: 17320573.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    51. An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth. Cancer Res. 2007 Jan 15; 67(2):573-9. Fujii N, You L, Xu Z, Uematsu K, Shan J, He B, Mikami I, Edmondson LR, Neale G, Zheng J, Guy RK, Jablons DM. PMID: 17234765.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    52. Stathmin is overexpressed in malignant mesothelioma. Anticancer Res. 2007 Jan-Feb; 27(1A):39-44. Kim JY, Harvard C, You L, Xu Z, Kuchenbecker K, Baehner R, Jablons D. PMID: 17352214.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    53. Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1228-32. Batra S, Shi Y, Kuchenbecker KM, He B, Reguart N, Mikami I, You L, Xu Z, Lin YC, Clément G, Jablons DM. PMID: 16516163.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    54. Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun. 2006 Mar 10; 341(2):635-40. Lin YC, You L, Xu Z, He B, Mikami I, Thung E, Chou J, Kuchenbecker K, Kim J, Raz D, Yang CT, Chen JK, Jablons DM. PMID: 16427602.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    55. Wnt-1 signal as a potential cancer therapeutic target. Drug News Perspect. 2006 Jan-Feb; 19(1):27-31. You L, Kim J, He B, Xu Z, McCormick F, Jablons DM. PMID: 16550254.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    56. The role of Wnt signaling in cancer and stem cells. Future Oncol. 2005 Dec; 1(6):787-97. Reguart N, He B, Taron M, You L, Jablons DM, Rosell R. PMID: 16556058.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    57. Wnt2 as a new therapeutic target in malignant pleural mesothelioma. Int J Cancer. 2005 Nov 01; 117(2):326-32. Mazieres J, You L, He B, Xu Z, Twogood S, Lee AY, Reguart N, Batra S, Mikami I, Jablons DM. PMID: 15900580.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    58. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene. 2005 Aug 11; 24(34):5396-400. Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM. PMID: 16007226.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    59. Wnt signaling in stem cells and non-small-cell lung cancer. Clin Lung Cancer. 2005 Jul; 7(1):54-60. He B, Barg RN, You L, Xu Z, Reguart N, Mikami I, Batra S, Rosell R, Jablons DM. PMID: 16098245.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    60. Efficacy of Wnt-1 monoclonal antibody in sarcoma cells. BMC Cancer. 2005 May 24; 5:53. Mikami I, You L, He B, Xu Z, Batra S, Lee AY, Mazieres J, Reguart N, Uematsu K, Koizumi K, Jablons DM. PMID: 15913453; PMCID: PMC1164405.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    61. Wnt signaling in lung cancer. Cancer Lett. 2005 May 10; 222(1):1-10. Mazieres J, He B, You L, Xu Z, Jablons DM. PMID: 15837535.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    62. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene. 2005 Apr 21; 24(18):3054-8. He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM. PMID: 15735684.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    63. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res. 2005 Feb 01; 65(3):743-8. He B, Lee AY, Dadfarmay S, You L, Xu Z, Reguart N, Mazieres J, Mikami I, McCormick F, Jablons DM. PMID: 15705870.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    64. Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. Biochem Biophys Res Commun. 2004 Oct 29; 323(4):1246-50. Lee AY, He B, You L, Xu Z, Mazieres J, Reguart N, Mikami I, Batra S, Jablons DM. PMID: 15451431.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    65. Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochem Biophys Res Commun. 2004 Oct 08; 323(1):229-34. Reguart N, He B, Xu Z, You L, Lee AY, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F, Jablons DM. PMID: 15351726.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    66. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene. 2004 Aug 26; 23(39):6672-6. Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, Jablons DM. PMID: 15221014.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    67. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene. 2004 Aug 12; 23(36):6170-4. You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, Jablons DM. PMID: 15208662.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    68. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res. 2004 Aug 01; 64(15):5385-9. You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F, Jablons DM. PMID: 15289346.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    69. Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts. Ann Thorac Surg. 2004 Aug; 78(2):436-43; discussion 436-43. Beseth BD, Cameron RB, Leland P, You L, Varricchio F, Kreitman RJ, Maki RA, Jablons DM, Husain SR, Puri RK. PMID: 15276492.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    70. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res. 2004 Jul 15; 64(14):4717-20. Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F, Jablons DM. PMID: 15256437.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    71. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. Cancer Res. 2004 May 15; 64(10):3474-8. You L, He B, Uematsu K, Xu Z, Mazieres J, Lee A, McCormick F, Jablons DM. PMID: 15150100.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    72. Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer. Clin Lung Cancer. 2004 May; 5(6):366-70. He B, You L, Xu Z, Mazieres J, Lee AY, Jablons DM. PMID: 15217536.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    73. Future directions: oncolytic viruses. Clin Lung Cancer. 2004 Jan; 5(4):226-30. You L, He B, Xu Z, McCormick F, Jablons DM. PMID: 14967074.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    74. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia. 2004 Jan-Feb; 6(1):7-14. He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, McCormick F, Jablons DM. PMID: 15068666; PMCID: PMC1508626.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    75. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14133-8. He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM. PMID: 14617776; PMCID: PMC283558.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    76. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene. 2003 Oct 16; 22(46):7218-21. Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM. PMID: 14562050.
      View in: PubMed   Mentions: 133     Fields:    Translation:Humans
    77. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res. 2003 Aug 01; 63(15):4547-51. Uematsu K, Kanazawa S, You L, He B, Xu Z, Li K, Peterlin BM, McCormick F, Jablons DM. PMID: 12907630.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    78. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q. Anticancer Res. 2003 May-Jun; 23(3B):2281-9. Jensen RH, Tiirikainen M, You L, Ginzinger D, He B, Uematsu K, Xu Z, Treseler P, McCormick F, Jablons DM. PMID: 12894504.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    79. Cloning and characterization of a functional promoter of the human SOCS-3 gene. Biochem Biophys Res Commun. 2003 Feb 07; 301(2):386-91. He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F, Jablons DM. PMID: 12565872.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    80. A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells. Anticancer Res. 2003 Jan-Feb; 23(1A):33-8. Yang CT, You L, Lin YC, Lin CL, Mccormick F, Jablons DM. PMID: 12680192.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    81. Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides. Mol Cancer Ther. 2002 Jul; 1(9):687-94. Xia C, Xu Z, Yuan X, Uematsu K, You L, Li K, Li L, McCormick F, Jablons DM. PMID: 12479365.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    82. p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53. Cancer Res. 2001 Aug 15; 61(16):5959-63. Yang CT, You L, Uematsu K, Yeh CC, McCormick F, Jablons DM. PMID: 11507034.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    83. A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens. Cancer Epidemiol Biomarkers Prev. 2001 May; 10(5):523-32. Strickler HD, International SV40 Working Group. PMID: 11352864.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    84. Indomethacin reduces lung adenoma number in A/J mice. Anticancer Res. 2001 May-Jun; 21(3B):1749-55. Moody TW, Leyton J, Zakowicz H, Hida T, Kang Y, Jakowlew S, You L, Ozbun L, Zia H, Youngberg J, Malkinson A. PMID: 11497255.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    85. Identification of differentially expressed nucleolar TGF-beta1 target (DENTT) in human lung cancer cells that is a new member of the TSPY/SET/NAP-1 superfamily. Genomics. 2001 Apr 15; 73(2):179-93. Ozbun LL, You L, Kiang S, Angdisen J, Martinez A, Jakowlew SB. PMID: 11318608.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    86. Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Lung Cancer. 2001 Feb-Mar; 31(2-3):203-12. Casibang M, Purdom S, Jakowlew S, Neckers L, Zia F, Ben-Av P, Hla T, You L, Jablons DM, Moody TW. PMID: 11165399.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    87. Stage II (N1) lung cancer. Chest Surg Clin N Am. 2001 Feb; 11(1):39-59, viii. Choy O, Jahan T, Roach M, You L, Jablons D. PMID: 11253600.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    88. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. J Natl Cancer Inst. 2000 Apr 19; 92(8):636-41. Yang CT, You L, Yeh CC, Chang JW, Zhang F, McCormick F, Jablons DM. PMID: 10772681.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    89. ONYX-015 works synergistically with chemotherapy in lung cancer cell lines and primary cultures freshly made from lung cancer patients. Cancer Res. 2000 Feb 15; 60(4):1009-13. You L, Yang CT, Jablons DM. PMID: 10706117.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    90. Transforming growth factor-beta expression in mouse lung carcinogenesis. Exp Lung Res. 1998 Jul-Aug; 24(4):579-93. Jakowlew SB, Moody TW, You L, Mariano JM. PMID: 9659584.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    91. Reduction in transforming growth factor-beta type II receptor in mouse lung carcinogenesis. Mol Carcinog. 1998 May; 22(1):46-56. Jakowlew SB, Moody TW, You L, Mariano JM. PMID: 9609100.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    92. Identification of early growth response gene-1 (Egr-1) as a phorbol myristate acetate-induced gene in lung cancer cells by differential mRNA display. Am J Respir Cell Mol Biol. 1997 Nov; 17(5):617-24. You L, Jakowlew SB. PMID: 9374113.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    93. Differential regulation of protease and extracellular matrix protein expression by transforming growth factor-beta 1 in non-small cell lung cancer cells and normal human bronchial epithelial cells. Biochim Biophys Acta. 1997 Aug 07; 1353(2):157-70. Jakowlew SB, Mariano JM, You L, Mathias A. PMID: 9294010.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    94. Effects of transforming growth factor-beta 1 and phorbol ester on PAI-1 and PA genes in human lung cells. Growth Factors. 1997; 14(2-3):177-97. Jakowlew SB, Mariano JM, You L. PMID: 9255608.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    95. Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c,g]carbazole in strain A/J mouse lung. Carcinogenesis. 1996 Apr; 17(4):865-71. Warshawsky D, Talaska G, Jaeger M, Collins T, Galati A, You L, Stoner G. PMID: 8625502.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    96. Frameshift mutation in codon 176 of the p53 gene in rat esophageal epithelial cells transformed by benzo[a]pyrene dihydrodiol. Mol Carcinog. 1995 Oct; 14(2):84-93. Wang D, You L, Sneddon J, Cheng SJ, Jamasbi R, Stoner GD. PMID: 7576103.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    97. Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung. Carcinogenesis. 1994 Nov; 15(11):2613-8. You L, Wang D, Galati AJ, Ross JA, Mass MJ, Nelson GB, Wilson KH, Amin S, Stoner JC, Nesnow S, et al. PMID: 7955114.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    98. Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens. Carcinogenesis. 1994 Sep; 15(9):2031-5. Chen B, You L, Wang Y, Stoner GD, You M. PMID: 7923598.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    99. Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5804-8. You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH, Anderson M. PMID: 1352876; PMCID: PMC402106.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    100. Activation of protooncogenes in mouse lung tumors. Exp Lung Res. 1991 Mar-Apr; 17(2):389-400. You M, Wang Y, Lineen A, Stoner GD, You LA, Maronpot RR, Anderson MW. PMID: 2050038.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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