Marc Shuman, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-476-2125
EmailMarc.Shuman@ucsf.edu
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    Collapse Biography 
    Collapse Awards and Honors
    Peking Union Medical College Hospital2011Honorary Professor
    Univ. of Wisconsin-Madison1959  - 1960Phi Eta Sigma Freshman Honor Society(1 of 25 students and only one elected after one semester)

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    UCSF PROSTATE CANCER SPORE
    NIH P50CA089520Sep 25, 2000 - Jun 30, 2010
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Investigator
    SPORE in Breast Cancer
    NIH P50CA058207Aug 1, 1997 - Nov 30, 2013
    Role: Co-Investigator
    Proteases in Cancer Biology and Drug Development
    NIH P01CA072006Jun 10, 1997 - Jun 30, 2010
    Role: Co-Principal Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Principal Investigator
    UROKINASE RECEPTOR IN PROSTATE DEVELOPMENT AND CANCER
    NIH R01CA059545Aug 15, 1993 - Jul 31, 1997
    Role: Principal Investigator
    BIOSYNTHESIS AND GENETICS OF GLYCOPROTEINS IIB AND IIIA
    NIH R01HL033277Dec 1, 1984 - Nov 30, 1993
    Role: Principal Investigator
    Basic Research in Hematology and Oncology
    NIH T32DK007636May 1, 1984 - Mar 31, 2014
    Role: Principal Investigator
    PROTEINASE-INHIBITOR REACTIONS IN CORNEAL ENDOTHELIUM
    NIH R01EY004882Jul 1, 1983 - Sep 29, 1989
    Role: Principal Investigator
    CELLULAR REGULATION OF BLOOD CLOTTING
    NIH R01HL021403Dec 1, 1981 - Nov 30, 1992
    Role: Principal Investigator
    MECHANISM OF ACTIVATION OF COAGULATION AND PLATELETS
    NIH K04HL000802Dec 1, 1980 - Nov 30, 1985
    Role: Principal Investigator
    BLOOD BANKING SCIENCES AND RELATED PROGRAMS
    NIH T32HL007100Jul 1, 1975 - Jun 30, 1996
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer. JCI Insight. 2018 09 06; 3(17). Su Y, Liu Y, Behrens CR, Bidlingmaier S, Lee NK, Aggarwal R, Sherbenou DW, Burlingame AL, Hann BC, Simko JP, Premasekharan G, Paris PL, Shuman MA, Seo Y, Small EJ, Liu B. PMID: 30185663.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    2. Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells. J Clin Invest. 2016 12 01; 126(12):4640-4653. Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B. PMID: 27841764.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    3. EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci. 2015 Sep; 18(9):1236-46. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S, Barshow S, Zhu S, Cooper MK, Peacock J, Ramaswamy V, Garzia L, Wu X, Remke M, Forester CM, Kim CC, Weiss WA, James CD, Shuman MA, Bader GD, Mueller S, Taylor MD, Jan YN, Jan LY. PMID: 26258683.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    4. WITHDRAWN: Enhanced Detection and Phenotypic and Karyotypic in Situ Characterization of Circulating Tumor Cells. Am J Pathol. 2014 Oct 17. Ge F, Wang DD, Li L, Lin PP, Shuman MA. PMID: 25451150.
      View in: PubMed   Mentions:    Fields:    
    5. Complement activation and intraventricular rituximab distribution in recurrent central nervous system lymphoma. Clin Cancer Res. 2014 Feb 15; 20(4):1029-41. Kadoch C, Li J, Wong VS, Chen L, Cha S, Munster P, Lowell CA, Shuman MA, Rubenstein JL. PMID: 24190981.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    6. Multicenter phase 1 trial of intraventricular immunochemotherapy in recurrent CNS lymphoma. Blood. 2013 Jan 31; 121(5):745-51. Rubenstein JL, Li J, Chen L, Advani R, Drappatz J, Gerstner E, Batchelor T, Krouwer H, Hwang J, Auerback G, Kadoch C, Lowell C, Munster P, Cha S, Shuman MA, Damon LE. PMID: 23197589.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCTClinical Trials
    7. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. PMID: 22855790.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    8. Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. Clin Cancer Res. 2012 Feb 15; 18(4):1146-55. Wieduwilt MJ, Valles F, Issa S, Behler CM, Hwang J, McDermott M, Treseler P, O'Brien J, Shuman MA, Cha S, Damon LE, Rubenstein JL. PMID: 22228634.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCTClinical Trials
    9. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res. 2012 Feb; 40(4):1695-707. Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. PMID: 22053081.
      View in: PubMed   Mentions: 133     Fields:    Translation:AnimalsCells
    10. Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors. ACS Nano. 2010 Feb 23; 4(2):978-84. Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X. PMID: 20121209.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    11. The unfolded protein response during prostate cancer development. Cancer Metastasis Rev. 2009 Jun; 28(1-2):219-23. So AY, de la Fuente E, Walter P, Shuman M, Bernales S. PMID: 19172382.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    12. Pathologic correlates of primary central nervous system lymphoma defined in an orthotopic xenograft model. Clin Cancer Res. 2009 Mar 15; 15(6):1989-97. Kadoch C, Dinca EB, Voicu R, Chen L, Nguyen D, Parikh S, Karrim J, Shuman MA, Lowell CA, Treseler PA, James CD, Rubenstein JL. PMID: 19276270.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. Differential gene expression in central nervous system lymphoma. Blood. 2009 Jan 01; 113(1):266-7; author reply 267-8. Rubenstein JL, Shen A, Batchelor TT, Kadoch C, Treseler P, Shuman MA. PMID: 19122120.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    14. Protein biomarker identification in the CSF of patients with CNS lymphoma. J Clin Oncol. 2008 Jan 01; 26(1):96-105. Roy S, Josephson SA, Fridlyand J, Karch J, Kadoch C, Karrim J, Damon L, Treseler P, Kunwar S, Shuman MA, Jones T, Becker CH, Schulman H, Rubenstein JL. PMID: 18056677.
      View in: PubMed   Mentions: 58     Fields:    Translation:Humans
    15. Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. J Clin Oncol. 2007 Apr 10; 25(11):1350-6. Rubenstein JL, Fridlyand J, Abrey L, Shen A, Karch J, Wang E, Issa S, Damon L, Prados M, McDermott M, O'Brien J, Haqq C, Shuman M. PMID: 17312328.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCTClinical Trials
    16. The epidemiology of prostate cancer--with a focus on nonsteroidal anti-inflammatory drugs. Hematol Oncol Clin North Am. 2006 Aug; 20(4):797-809. Chan JM, Feraco A, Shuman M, Hernández-Díaz S. PMID: 16861115.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Gene expression and angiotropism in primary CNS lymphoma. Blood. 2006 May 01; 107(9):3716-23. Rubenstein JL, Fridlyand J, Shen A, Aldape K, Ginzinger D, Batchelor T, Treseler P, Berger M, McDermott M, Prados M, Karch J, Okada C, Hyun W, Parikh S, Haqq C, Shuman M. PMID: 16418334.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    18. Quinine/quinidine-induced thrombocytopenia: a great imitator. Arch Intern Med. 2004 Jan 26; 164(2):218-20. Reddy JC, Shuman MA, Aster RH. PMID: 14744847.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    19. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells. Biol Chem. 2003 Feb; 384(2):257-66. Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS. PMID: 12675519.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    20. Rituximab therapy for CNS lymphomas: targeting the leptomeningeal compartment. Blood. 2003 Jan 15; 101(2):466-8. Rubenstein JL, Combs D, Rosenberg J, Levy A, McDermott M, Damon L, Ignoffo R, Aldape K, Shen A, Lee D, Grillo-Lopez A, Shuman MA. PMID: 12393404.
      View in: PubMed   Mentions: 121     Fields:    Translation:Animals
    21. Hemorrhage and VEGF expression in a case of primary CNS lymphoma. J Neurooncol. 2002 May; 58(1):53-6. Rubenstein J, Fischbein N, Aldape K, Burton E, Shuman M. PMID: 12160141.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans