Marco Conti

InstitutionUniversity of California San Francisco
DepartmentOb/Gyn, Reproductive Sciences
Address513 Parnassus Ave
San Francisco CA 94143
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    Other Positions
    TitleDirector, Center for Reproductive Sciences

    Collapse Research 
    Collapse Research Activities and Funding
    RNA binding protein networks and translational control in mammalian oocytes
    NIH/NIGMS R01GM116926May 6, 2016 - Jan 31, 2020
    Role: Principal Investigator
    Wee Kinases and the Control of the Meiotic Cell Cycle
    NIH/NIGMS R01GM115241Apr 13, 2015 - Jan 31, 2019
    Role: Principal Investigator
    The translational program in oocyte and early embryo development
    NIH/NIGMS R01GM097165Sep 15, 2011 - Jun 30, 2015
    Role: Principal Investigator
    Cyclic nucleotide signaling and the modulation of asthma inflammatory responses
    NIH/NIAID R56AI073705Jun 21, 2010 - Mar 1, 2012
    Role: Principal Investigator
    Hormonal Regulation of Phosphodiestrases
    NIH/NHLBI R01HL092788Jul 15, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Cyclic AMP and the Control of the Meiotic Cell Cycle
    NIH/NIGMS R01GM080527Jun 1, 2007 - May 31, 2011
    Role: Principal Investigator
    Origins and Biological Consequences of Human Infertility
    NIH/NICHD U54HD055764May 3, 2007 - Mar 31, 2017
    Role: Co-Investigator
    Center for Research, Innovation and Training in Reproduction and Infertility
    NIH/NICHD P50HD055764Apr 1, 2007 - Mar 31, 2023
    Role: Co-Investigator
    Role of the EGF Network in Ovulation
    NIH/NICHD R01HD052909Apr 1, 2007 - Mar 31, 2013
    Role: Principal Investigator
    SCOR in Cellular and Molecular Mechanisms of Asthma
    NIH P50HL067674Sep 30, 2001 - Aug 31, 2006
    Role: Co-Investigator
    Gonadal and Endometrial Function in Human Reproduction
    NIH/NICHD U54HD031398Apr 7, 1997 - Mar 31, 2008
    Role: Co-Principal Investigator
    Role of Cyclic Nucleotides in Sperm Function
    NIH/NICHD R01HD031544May 1, 1994 - Feb 28, 2011
    Role: Principal Investigator
    NIH/NICHD R01HD021722Apr 1, 1986 - Nov 30, 1989
    Role: Principal Investigator
    Hormonal Regulation of Phosphodiesterases
    NIH/NICHD R01HD020788Feb 1, 1985 - Aug 31, 2008
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Conti M, Franciosi F. Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events. Hum Reprod Update. 2018 Feb 08. PMID: 29432538.
      View in: PubMed
    2. Martins JPS, Conti M. Profiling Maternal mRNA Translation During Oocyte Development. Methods Mol Biol. 2018; 1818:43-50. PMID: 29961254.
      View in: PubMed
    3. Han SJ, Martins JPS, Yang Y, Kang MK, Daldello EM, Conti M. The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle. Sci Rep. 2017 Oct 26; 7(1):14077. PMID: 29074977.
      View in: PubMed
    4. Zhang QH, Yuen WS, Adhikari D, Flegg JA, FitzHarris G, Conti M, Sicinski P, Nabti I, Marangos P, Carroll J. Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II. J Cell Biol. 2017 10 02; 216(10):3133-3143. PMID: 28819014.
      View in: PubMed
    5. Rinaudo PF, Conti M. Report from the 2016 University of California, San Francisco, Center for Reproductive Sciences retreat. Mol Reprod Dev. 2017 Oct; 84(10):1024-1026. PMID: 28736970.
      View in: PubMed
    6. Yang Y, Yang CR, Han SJ, Daldello EM, Cho A, Martins JPS, Xia G, Conti M. Maternal mRNAs with distinct 3' UTRs define the temporal pattern of Ccnb1 synthesis during mouse oocyte meiotic maturation. Genes Dev. 2017 07 01; 31(13):1302-1307. PMID: 28808066.
      View in: PubMed
    7. Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M. Functional selectivity of GPCR-directed drug action through location bias. Nat Chem Biol. 2017 Jul; 13(7):799-806. PMID: 28553949.
      View in: PubMed
    8. Yang JX, Hsieh KC, Chen YL, Lee CK, Conti M, Chuang TH, Wu CP, Jin SC. Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages. Sci Rep. 2017 Apr 06; 7:46165. PMID: 28383060.
      View in: PubMed
    9. Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev. 2017 Apr; 69(2):93-139. PMID: 28255005.
      View in: PubMed
    10. Cakmak H, Franciosi F, Zamah AM, Cedars MI, Conti M. Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2424-9. PMID: 26864200; PMCID: PMC4780620.
    11. Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016 Mar 15; 129(6):1271-82. PMID: 26826184; PMCID: PMC4813292 [Available on 03/15/17].
    12. Franciosi F, Manandhar S, Conti M. FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence. Endocrinology. 2016 Feb; 157(2):872-82. PMID: 26653334; PMCID: PMC4733122 [Available on 02/01/17].
    13. Mika D, Conti M. PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways. Cell Signal. 2016 07; 28(7):719-24. PMID: 26562185.
      View in: PubMed
    14. Mika D, Richter W, Conti M. A CaMKII/PDE4D negative feedback regulates cAMP signaling. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2023-8. PMID: 25646485; PMCID: PMC4343159.
    15. Lin CJ, Koh FM, Wong P, Conti M, Ramalho-Santos M. Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote. Dev Cell. 2014 Aug 11; 30(3):268-79. PMID: 25087892; PMCID: PMC4134436.
    16. Xie M, Blackman B, Scheitrum C, Mika D, Blanchard E, Lei T, Conti M, Richter W. The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s). Biochem J. 2014 May 01; 459(3):539-50. PMID: 24555506; PMCID: PMC4315173.
    17. Liu X, Xie F, Zamah AM, Cao B, Conti M. Multiple pathways mediate luteinizing hormone regulation of cGMP signaling in the mouse ovarian follicle. Biol Reprod. 2014 Jul; 91(1):9. PMID: 24740605; PMCID: PMC4434964.
    18. Hansen RT, Conti M, Zhang HT. Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. Psychopharmacology (Berl). 2014 Aug; 231(15):2941-54. PMID: 24563185.
      View in: PubMed
    19. Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovasc Res. 2014 Apr 01; 102(1):97-106. PMID: 24550350; PMCID: PMC3958623.
    20. Mika D, Richter W, Westenbroek RE, Catterall WA, Conti M. PDE4B mediates local feedback regulation of ß1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes. J Cell Sci. 2014 Mar 01; 127(Pt 5):1033-42. PMID: 24413164; PMCID: PMC3937773.
    21. Conti M, Mika D, Richter W. Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases. J Gen Physiol. 2014 Jan; 143(1):29-38. PMID: 24378905; PMCID: PMC3874571.
    22. Chen J, Torcia S, Xie F, Lin CJ, Cakmak H, Franciosi F, Horner K, Onodera C, Song JS, Cedars MI, Ramalho-Santos M, Conti M. Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol. 2013 Dec; 15(12):1415-23. PMID: 24270888; PMCID: PMC4066669.
    23. Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W. Anchored PDE4 regulates chloride conductance in wild-type and ?F508-CFTR human airway epithelia. FASEB J. 2014 Feb; 28(2):791-801. PMID: 24200884; PMCID: PMC3898646.
    24. Lin CJ, Conti M, Ramalho-Santos M. Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development. Development. 2013 Sep; 140(17):3624-34. PMID: 23903189; PMCID: PMC3742145.
    25. Richter W, Menniti FS, Zhang HT, Conti M. PDE4 as a target for cognition enhancement. Expert Opin Ther Targets. 2013 Sep; 17(9):1011-27. PMID: 23883342; PMCID: PMC4066988.
    26. Richter W, Mika D, Blanchard E, Day P, Conti M. ß1-adrenergic receptor antagonists signal via PDE4 translocation. EMBO Rep. 2013 Mar 01; 14(3):276-83. PMID: 23381222; PMCID: PMC3589095.
    27. Oh JS, Susor A, Schindler K, Schultz RM, Conti M. Cdc25A activity is required for the metaphase II arrest in mouse oocytes. J Cell Sci. 2013 Mar 01; 126(Pt 5):1081-5. PMID: 23345398; PMCID: PMC3635459.
    28. Xie F, Eddy EM, Conti M. Analysis of signaling pathways controlling flagellar movements in mammalian spermatozoa. Methods Enzymol. 2013; 524:91-104. PMID: 23498736.
      View in: PubMed
    29. Geister KA, Brinkmeier ML, Hsieh M, Faust SM, Karolyi IJ, Perosky JE, Kozloff KM, Conti M, Camper SA. A novel loss-of-function mutation in Npr2 clarifies primary role in female reproduction and reveals a potential therapy for acromesomelic dysplasia, Maroteaux type. Hum Mol Genet. 2013 Jan 15; 22(2):345-57. PMID: 23065701; PMCID: PMC4817088.
    30. Ghigo A, Perino A, Mehel H, Zahradníková A, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G, Hirsch E, Fischmeister R. Phosphoinositide 3-kinase ? protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation. 2012 Oct 23; 126(17):2073-83. PMID: 23008439; PMCID: PMC3913165.
    31. Molina CE, Leroy J, Richter W, Xie M, Scheitrum C, Lee IO, Maack C, Rucker-Martin C, Donzeau-Gouge P, Verde I, Llach A, Hove-Madsen L, Conti M, Vandecasteele G, Fischmeister R. Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias. J Am Coll Cardiol. 2012 Jun 12; 59(24):2182-90. PMID: 22676938.
      View in: PubMed
    32. Peluffo MC, Ting AY, Zamah AM, Conti M, Stouffer RL, Zelinski MB, Hennebold JD. Amphiregulin promotes the maturation of oocytes isolated from the small antral follicles of the rhesus macaque. Hum Reprod. 2012 Aug; 27(8):2430-7. PMID: 22593432; PMCID: PMC3398676.
    33. Conti M, Hsieh M, Zamah AM, Oh JS. Novel signaling mechanisms in the ovary during oocyte maturation and ovulation. Mol Cell Endocrinol. 2012 Jun 05; 356(1-2):65-73. PMID: 22101318; PMCID: PMC4104635.
    34. Conti M. Phosphodiesterases and regulation of female reproductive function. Curr Opin Pharmacol. 2011 Dec; 11(6):665-9. PMID: 22019564.
      View in: PubMed
    35. Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones P, Tian X, Wilson LS, Ahmad F, Chen SRW, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH. Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current. Circ Res. 2011 Oct 14; 109(9):1024-1030. PMID: 21903937.
      View in: PubMed
    36. Hsieh M, Thao K, Conti M. Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation. PLoS One. 2011; 6(6):e21574. PMID: 21738714; PMCID: PMC3128061.
    37. Conti M. When an egg is not an egg: compromised maternal mRNA storage and stabilization. Biol Reprod. 2011 Sep; 85(3):429-30. PMID: 21677309.
      View in: PubMed
    38. Leroy J, Richter W, Mika D, Castro LR, Abi-Gerges A, Xie M, Scheitrum C, Lefebvre F, Schittl J, Mateo P, Westenbroek R, Catterall WA, Charpentier F, Conti M, Fischmeister R, Vandecasteele G. Phosphodiesterase 4B in the cardiac L-type Ca²? channel complex regulates Ca²? current and protects against ventricular arrhythmias in mice. J Clin Invest. 2011 Jul; 121(7):2651-61. PMID: 21670503; PMCID: PMC3223827.
    39. Xie M, Rich TC, Scheitrum C, Conti M, Richter W. Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP. Mol Pharmacol. 2011 Aug; 80(2):281-93. PMID: 21551375; PMCID: PMC3141887.
    40. Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M. Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev. 2011 Apr 01; 25(7):755-66. PMID: 21460039; PMCID: PMC3070937.
    41. Oh JS, Susor A, Conti M. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Science. 2011 Apr 22; 332(6028):462-5. PMID: 21454751; PMCID: PMC4104668.
    42. Blackman BE, Horner K, Heidmann J, Wang D, Richter W, Rich TC, Conti M. PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts. J Biol Chem. 2011 Apr 08; 286(14):12590-601. PMID: 21288894; PMCID: PMC3069460.
    43. Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnell JM, Zhang HT. Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci. 2011 Jan 05; 31(1):172-83. PMID: 21209202; PMCID: PMC3079568.
    44. Richter W, Xie M, Scheitrum C, Krall J, Movsesian MA, Conti M. Conserved expression and functions of PDE4 in rodent and human heart. Basic Res Cardiol. 2011 Mar; 106(2):249-62. PMID: 21161247; PMCID: PMC3032896.
    45. Jin SL, Goya S, Nakae S, Wang D, Bruss M, Hou C, Umetsu D, Conti M. Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol. 2010 Dec; 126(6):1252-9.e12. PMID: 21047676; PMCID: PMC3002752.
    46. Nyegaard M, Overgaard MT, Su YQ, Hamilton AE, Kwintkiewicz J, Hsieh M, Nayak NR, Conti M, Conover CA, Giudice LC. Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility. Biol Reprod. 2010 Jun; 82(6):1129-38. PMID: 20130263; PMCID: PMC2874498.
    47. Oh JS, Han SJ, Conti M. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol. 2010 Jan 25; 188(2):199-207. PMID: 20083600; PMCID: PMC2812522.
    48. Aghajanova L, Horcajadas JA, Weeks JL, Esteban FJ, Nezhat CN, Conti M, Giudice LC. The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis. Endocrinology. 2010 Mar; 151(3):1341-55. PMID: 20068008; PMCID: PMC2840687.
    49. Abi-Gerges A, Richter W, Lefebvre F, Mateo P, Varin A, Heymes C, Samuel JL, Lugnier C, Conti M, Fischmeister R, Vandecasteele G. Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. Circ Res. 2009 Oct 09; 105(8):784-92. PMID: 19745166; PMCID: PMC2792993.
    50. Vaccari S, Weeks JL, Hsieh M, Menniti FS, Conti M. Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes. Biol Reprod. 2009 Sep; 81(3):595-604. PMID: 19474061; PMCID: PMC2731981.
    51. Guidice LC, Conti M. Growth factors and the development and function of the reproductive organs. Semin Reprod Med. 2009 Jan; 27(1):3-4. PMID: 19197799.
      View in: PubMed
    52. Hsieh M, Zamah AM, Conti M. Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation. Semin Reprod Med. 2009 Jan; 27(1):52-61. PMID: 19197805; PMCID: PMC4624340.
    53. Conti M, Giudice L. From stem cells to germ cells and back again. Nat Med. 2008 Nov; 14(11):1188-90. PMID: 18989302.
      View in: PubMed
    54. Bruss MD, Richter W, Horner K, Jin SL, Conti M. Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. J Biol Chem. 2008 Aug 15; 283(33):22430-42. PMID: 18508768; PMCID: PMC2504879.
    55. Moore SW, Lai Wing Sun K, Xie F, Barker PA, Conti M, Kennedy TE. Soluble adenylyl cyclase is not required for axon guidance to netrin-1. J Neurosci. 2008 Apr 09; 28(15):3920-4. PMID: 18400890.
      View in: PubMed
    56. Fatemi SH, King DP, Reutiman TJ, Folsom TD, Laurence JA, Lee S, Fan YT, Paciga SA, Conti M, Menniti FS. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. Schizophr Res. 2008 Apr; 101(1-3):36-49. PMID: 18394866.
      View in: PubMed
    57. Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechêne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G. Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circ Res. 2008 May 09; 102(9):1091-100. PMID: 18369156.
      View in: PubMed
    58. Vaccari S, Horner K, Mehlmann LM, Conti M. Generation of mouse oocytes defective in cAMP synthesis and degradation: endogenous cyclic AMP is essential for meiotic arrest. Dev Biol. 2008 Apr 01; 316(1):124-34. PMID: 18280465; PMCID: PMC2755085.
    59. Panigone S, Hsieh M, Fu M, Persani L, Conti M. Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol. 2008 Apr; 22(4):924-36. PMID: 18187604; PMCID: PMC2276469.
    60. Richter W, Day P, Agrawal R, Bruss MD, Granier S, Wang YL, Rasmussen SG, Horner K, Wang P, Lei T, Patterson AJ, Kobilka B, Conti M. Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J. 2008 Jan 23; 27(2):384-93. PMID: 18188154; PMCID: PMC2196435.
    61. Ryu KY, Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, Kopito RR. The mouse polyubiquitin gene Ubb is essential for meiotic progression. Mol Cell Biol. 2008 Feb; 28(3):1136-46. PMID: 18070917; PMCID: PMC2223379.
    62. Zhang HT, Huang Y, Masood A, Stolinski LR, Li Y, Zhang L, Dlaboga D, Jin SL, Conti M, O'Donnell JM. Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B). Neuropsychopharmacology. 2008 Jun; 33(7):1611-23. PMID: 17700644; PMCID: PMC2728355.
    63. Peter D, Jin SL, Conti M, Hatzelmann A, Zitt C. Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D. J Immunol. 2007 Apr 15; 178(8):4820-31. PMID: 17404263.
      View in: PubMed
    64. Lee JH, Richter W, Namkung W, Kim KH, Kim E, Conti M, Lee MG. Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors. J Biol Chem. 2007 Apr 06; 282(14):10414-22. PMID: 17244609.
      View in: PubMed
    65. Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 2007; 76:481-511. PMID: 17376027.
      View in: PubMed
    66. Hsieh M, Lee D, Panigone S, Horner K, Chen R, Theologis A, Lee DC, Threadgill DW, Conti M. Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Mol Cell Biol. 2007 Mar; 27(5):1914-24. PMID: 17194751; PMCID: PMC1820474.
    67. Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, Conti M. Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation. EMBO J. 2006 Dec 13; 25(24):5716-25. PMID: 17124499; PMCID: PMC1698880.
    68. Rich TC, Xin W, Mehats C, Hassell KA, Piggott LA, Le X, Karpen JW, Conti M. Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C319-31. PMID: 16899551; PMCID: PMC4712347.
    69. Xie F, Garcia MA, Carlson AE, Schuh SM, Babcock DF, Jaiswal BS, Gossen JA, Esposito G, van Duin M, Conti M. Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev Biol. 2006 Aug 15; 296(2):353-62. PMID: 16842770.
      View in: PubMed
    70. Rochais F, Abi-Gerges A, Horner K, Lefebvre F, Cooper DM, Conti M, Fischmeister R, Vandecasteele G. A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ Res. 2006 Apr 28; 98(8):1081-8. PMID: 16556871; PMCID: PMC2099453.
    71. Han SJ, Conti M. New pathways from PKA to the Cdc2/cyclin B complex in oocytes: Wee1B as a potential PKA substrate. Cell Cycle. 2006 Feb; 5(3):227-31. PMID: 16418576.
      View in: PubMed
    72. Schuh SM, Carlson AE, McKnight GS, Conti M, Hille B, Babcock DF. Signaling pathways for modulation of mouse sperm motility by adenosine and catecholamine agonists. Biol Reprod. 2006 Mar; 74(3):492-500. PMID: 16291925.
      View in: PubMed
    73. Hinckley M, Vaccari S, Horner K, Chen R, Conti M. The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Dev Biol. 2005 Nov 15; 287(2):249-61. PMID: 16229830.
      View in: PubMed
    74. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35. PMID: 16213210; PMCID: PMC2901878.
    75. Bajpai M, Fiedler SE, Huang Z, Vijayaraghavan S, Olson GE, Livera G, Conti M, Carr DW. AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa. Biol Reprod. 2006 Jan; 74(1):109-18. PMID: 16177223; PMCID: PMC1352331.
    76. Han SJ, Chen R, Paronetto MP, Conti M. Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol. 2005 Sep 20; 15(18):1670-6. PMID: 16169490.
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    77. Hsieh M, Conti M. G-protein-coupled receptor signaling and the EGF network in endocrine systems. Trends Endocrinol Metab. 2005 Sep; 16(7):320-6. PMID: 16054836.
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    78. Jin SL, Lan L, Zoudilova M, Conti M. Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages. J Immunol. 2005 Aug 01; 175(3):1523-31. PMID: 16034090.
      View in: PubMed
    79. Conti M, Hsieh M, Park JY, Su YQ. Role of the epidermal growth factor network in ovarian follicles. Mol Endocrinol. 2006 Apr; 20(4):715-23. PMID: 16051667.
      View in: PubMed
    80. Richter W, Jin SL, Conti M. Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue. Biochem J. 2005 Jun 15; 388(Pt 3):803-11. PMID: 15717866; PMCID: PMC1183459.
    81. Xiang Y, Naro F, Zoudilova M, Jin SL, Conti M, Kobilka B. Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):909-14. PMID: 15644445; PMCID: PMC544184.
    82. Jin SL, Latour AM, Conti M. Generation of PDE4 knockout mice by gene targeting. Methods Mol Biol. 2005; 307:191-210. PMID: 15988065.
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    83. Barnes AP, Livera G, Huang P, Sun C, O'Neal WK, Conti M, Stutts MJ, Milgram SL. Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem. 2005 Mar 04; 280(9):7997-8003. PMID: 15611099.
      View in: PubMed
    84. Ariga M, Neitzert B, Nakae S, Mottin G, Bertrand C, Pruniaux MP, Jin SL, Conti M. Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation. J Immunol. 2004 Dec 15; 173(12):7531-8. PMID: 15585880.
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    85. Nedachi T, Conti M. Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation. Development. 2004 Oct; 131(20):4987-98. PMID: 15371306.
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    89. Esposito G, Jaiswal BS, Xie F, Krajnc-Franken MA, Robben TJ, Strik AM, Kuil C, Philipsen RL, van Duin M, Conti M, Gossen JA, Jaiswal BS. Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):2993-8. PMID: 14976244; PMCID: PMC365733.
    90. Park JY, Su YQ, Ariga M, Law E, Jin SL, Conti M. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science. 2004 Jan 30; 303(5658):682-4. PMID: 14726596.
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    91. Xie F, Conti M. Expression of the soluble adenylyl cyclase during rat spermatogenesis: evidence for cytoplasmic sites of cAMP production in germ cells. Dev Biol. 2004 Jan 01; 265(1):196-206. PMID: 14697363.
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    92. Méhats C, Jin SL, Wahlstrom J, Law E, Umetsu DT, Conti M. PDE4D plays a critical role in the control of airway smooth muscle contraction. FASEB J. 2003 Oct; 17(13):1831-41. PMID: 14519662.
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    93. Jaiswal BS, Conti M. Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10676-81. PMID: 12958208; PMCID: PMC196863.
    94. Yoshida H, Beltran-Parrazal L, Butler P, Conti M, Charles AC, Weiner RI. Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells. Mol Endocrinol. 2003 Oct; 17(10):1982-90. PMID: 12829807.
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    95. Horner K, Livera G, Hinckley M, Trinh K, Storm D, Conti M. Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Dev Biol. 2003 Jun 15; 258(2):385-96. PMID: 12798295.
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    96. De Arcangelis V, Coletti D, Conti M, Lagarde M, Molinaro M, Adamo S, Nemoz G, Naro F. IGF-I-induced differentiation of L6 myogenic cells requires the activity of cAMP-phosphodiesterase. Mol Biol Cell. 2003 Apr; 14(4):1392-404. PMID: 12686596; PMCID: PMC153109.
    97. Park JY, Richard F, Chun SY, Park JH, Law E, Horner K, Jin SL, Conti M. Phosphodiesterase regulation is critical for the differentiation and pattern of gene expression in granulosa cells of the ovarian follicle. Mol Endocrinol. 2003 Jun; 17(6):1117-30. PMID: 12649328.
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    98. Shinozaki H, Butnev V, Tao YX, Ang KL, Conti M, Segaloff DL. Desensitization of Gs-coupled receptor signaling by constitutively active mutants of the human lutropin/choriogonadotropin receptor. J Clin Endocrinol Metab. 2003 Mar; 88(3):1194-204. PMID: 12629106.
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    99. Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA. Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes. Biochem J. 2003 Jan 15; 369(Pt 2):227-38. PMID: 12374568; PMCID: PMC1223087.
    100. Conti M, Richter W, Mehats C, Livera G, Park JY, Jin C. Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling. J Biol Chem. 2003 Feb 21; 278(8):5493-6. PMID: 12493749.
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    101. Paruthiyil S, eL Majdoubi M, Conti M, Weiner RI. Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):17191-6. PMID: 12482943; PMCID: PMC139291.
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    103. Perry SJ, Baillie GS, Kohout TA, McPhee I, Magiera MM, Ang KL, Miller WE, McLean AJ, Conti M, Houslay MD, Lefkowitz RJ. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science. 2002 Oct 25; 298(5594):834-6. PMID: 12399592.
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    104. Robichaud A, Stamatiou PB, Jin SL, Lachance N, MacDonald D, Laliberté F, Liu S, Huang Z, Conti M, Chan CC. Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest. 2002 Oct; 110(7):1045-52. PMID: 12370283; PMCID: PMC151147.
    105. Zhang HT, Huang Y, Jin SL, Frith SA, Suvarna N, Conti M, O'Donnell JM. Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmacology. 2002 Oct; 27(4):587-95. PMID: 12377395.
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    106. Richter W, Conti M. Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs). J Biol Chem. 2002 Oct 25; 277(43):40212-21. PMID: 12177055.
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    107. Jin SL, Conti M. Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7628-33. PMID: 12032334; PMCID: PMC124305.
    108. D'Sa C, Tolbert LM, Conti M, Duman RS. Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons. J Neurochem. 2002 May; 81(4):745-57. PMID: 12065634.
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    109. Conti M, Andersen CB, Richard F, Mehats C, Chun SY, Horner K, Jin C, Tsafriri A. Role of cyclic nucleotide signaling in oocyte maturation. Mol Cell Endocrinol. 2002 Feb 22; 187(1-2):153-9. PMID: 11988323.
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    110. Mehats C, Andersen CB, Filopanti M, Jin SL, Conti M. Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrinol Metab. 2002 Jan-Feb; 13(1):29-35. PMID: 11750860.
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