Margaret Alexander, PhD

Title(s)Postdoctoral Scholar, Hooper Foundation
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-502-3264
ORCID ORCID Icon0000-0003-2972-7521 Additional info
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    Collapse Research 
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    Using diet to alter immune manipulation by Eggerthella lenta metabolites: eating away at autoimmunity
    NIH F32AI147456Sep 1, 2019 - Aug 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human gut bacterial metabolism drives Th17 activation and colitis. Cell Host Microbe. 2022 01 12; 30(1):17-30.e9. Alexander M, Ang QY, Nayak RR, Bustion AE, Sandy M, Zhang B, Upadhyay V, Pollard KS, Lynch SV, Turnbaugh PJ. PMID: 34822777; PMCID: PMC8785648.
      View in: PubMed   Mentions:
    2. Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome. Cell Rep. 2021 11 02; 37(5):109930. Lam KN, Spanogiannopoulos P, Soto-Perez P, Alexander M, Nalley MJ, Bisanz JE, Nayak RR, Weakley AM, Yu FB, Turnbaugh PJ. PMID: 34731631; PMCID: PMC8591988.
      View in: PubMed   Mentions:
    3. The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis. Arthritis Rheumatol. 2021 06; 73(6):931-942. Artacho A, Isaac S, Nayak R, Flor-Duro A, Alexander M, Koo I, Manasson J, Smith PB, Rosenthal P, Homsi Y, Gulko P, Pons J, Puchades-Carrasco L, Izmirly P, Patterson A, Abramson SB, Pineda-Lucena A, Turnbaugh PJ, Ubeda C, Scher JU. PMID: 33314800.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. Cell Host Microbe. 2021 03 10; 29(3):362-377.e11. Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ. PMID: 33440172; PMCID: PMC7954989.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    5. Stressed-out gut bacteria are pterin up gut inflammation. Nat Microbiol. 2020 11; 5(11):1316-1318. Alexander M, Turnbaugh PJ. PMID: 33087901.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions. Immunity. 2020 08 18; 53(2):264-276. Alexander M, Turnbaugh PJ. PMID: 32814025; PMCID: PMC7441819.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells. Cell. 2020 06 11; 181(6):1263-1275.e16. Ang QY, Alexander M, Newman JC, Tian Y, Cai J, Upadhyay V, Turnbaugh JA, Verdin E, Hall KD, Leibel RL, Ravussin E, Rosenbaum M, Patterson AD, Turnbaugh PJ. PMID: 32437658; PMCID: PMC7293577.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    8. Precision Medicine Goes Microscopic: Engineering the Microbiome to Improve Drug Outcomes. Cell Host Microbe. 2019 Jul 10; 26(1):22-34. Lam KN, Alexander M, Turnbaugh PJ. PMID: 31295421; PMCID: PMC6709864.
      View in: PubMed   Mentions: 17  Translation:Humans
    9. Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease. PLoS Genet. 2019 02; 15(2):e1007970. Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM. PMID: 30768595; PMCID: PMC6395003.
      View in: PubMed   Mentions:
    10. Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli. J Immunol. 2017 11 15; 199(10):3559-3570. Alexander M, Ramstead AG, Bauer KM, Lee SH, Runtsch MC, Wallace J, Huffaker TB, Larsen DK, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM. PMID: 28978688; PMCID: PMC5821227.
      View in: PubMed   Mentions:
    11. Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade. J Biol Chem. 2017 11 10; 292(45):18530-18541. Huffaker TB, Lee SH, Tang WW, Wallace JA, Alexander M, Runtsch MC, Larsen DK, Thompson J, Ramstead AG, Voth WP, Hu R, Round JL, Williams MA, O'Connell RM. PMID: 28912267; PMCID: PMC5682963.
      View in: PubMed   Mentions:
    12. miR-155 promotes FLT3-ITD-induced myeloproliferative disease through inhibition of the interferon response. Blood. 2017 06 08; 129(23):3074-3086. Wallace JA, Kagele DA, Eiring AM, Kim CN, Hu R, Runtsch MC, Alexander M, Huffaker TB, Lee SH, Patel AB, Mosbruger TL, Voth WP, Rao DS, Miles RR, Round JL, Deininger MW, O'Connell RM. PMID: 28432220; PMCID: PMC5465836.
      View in: PubMed   Mentions:
    13. MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis. Oncotarget. 2015 Oct 06; 6(30):28556-72. Runtsch MC, Hu R, Alexander M, Wallace J, Kagele D, Petersen C, Valentine JF, Welker NC, Bronner MP, Chen X, Smith DP, Ajami NJ, Petrosino JF, Round JL, O'Connell RM. PMID: 26456940; PMCID: PMC4745677.
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    14. Noncoding RNAs and chronic inflammation: Micro-managing the fire within. Bioessays. 2015 Sep; 37(9):1005-15. Alexander M, O'Connell RM. PMID: 26249326; PMCID: PMC5054901.
      View in: PubMed   Mentions:
    15. Exosome-delivered microRNAs modulate the inflammatory response to endotoxin. Nat Commun. 2015 Jun 18; 6:7321. Alexander M, Hu R, Runtsch MC, Kagele DA, Mosbruger TL, Tolmachova T, Seabra MC, Round JL, Ward DM, O'Connell RM. PMID: 26084661; PMCID: PMC4557301.
      View in: PubMed   Mentions:
    16. Defective apical extrusion signaling contributes to aggressive tumor hallmarks. Elife. 2015 Jan 26; 4:e04069. Gu Y, Shea J, Slattum G, Firpo MA, Alexander M, Mulvihill SJ, Golubovskaya VM, Rosenblatt J. PMID: 25621765; PMCID: PMC4337653.
      View in: PubMed   Mentions:
    17. miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity. 2014 Oct 16; 41(4):605-19. Hu R, Kagele DA, Huffaker TB, Runtsch MC, Alexander M, Liu J, Bake E, Su W, Williams MA, Rao DS, Möller T, Garden GA, Round JL, O'Connell RM. PMID: 25367574; PMCID: PMC4657560.
      View in: PubMed   Mentions:
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