Margaret Feeney, MD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address1001 Potrero Avenue
San Francisco CA 94110
Phone628-206-8218
ORCID ORCID Icon0000-0002-2515-2989 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Dartmouth CollegeB.A.1992
    University of PennsylvaniaM.D.1996
    UCSFResidency in Pediatrics1996-99
    Boston Children's HospitalFellowship in Pediatric Infectious Diseases1999-02
    Harvard Medical School M.Sc. in Clinical Investigation2002
    Collapse Awards and Honors
    2011William F. Friedman, M.D. Pediatric Research Award
    Pediatric AIDS Foundation: 2006Elizabeth Glaser Scientist Award
    Massachusetts Infectious Disease Society:2002Edward H. Kass Award for Clinical Excellence
    2016American Society for Clinical Ingestigation

    Collapse Overview 
    Collapse Overview
    Dr. Feeney is a Professor of Pediatrics in the Division of Pediatric Infectious Diseases and Global Health at UCSF. She is the Principal Investigator of several NIH-funded projects focused on the immune response to malaria and CMV in infants and children. Dr. Feeney is board certified in Pediatric Infectious Diseases and provides clinical care for children with complex infections at UCSF Benioff Children’s Hospital, where she also teaches students and housestaff. She holds a secondary appointment in the Department of Medicine (Division of Experimental Medicine) where her laboratory is based. She is active in mentoring programs for medical students, residents, and junior faculty, and is the recipient of an NIH K24 Mentoring Award entitled “Mentoring Translational Researchers for Careers in Pediatric Global Health”.

    Dr. Feeney’s research interests encompass the host response to infection and age-based differences in the immune response during early life. Her laboratory conducted key studies of the infant antiviral immune response following mother-to-child transmission of HIV, in collaboration with pediatric clinicians South Africa and Jamaica. More recently, her lab has focused on understanding natural immunity to malaria, identifying correlates of protective antimalarial immunity to guide vaccine design, and investigating the impact of in utero antigen exposure on the fetal immune response to malaria and other perinatal pathogens. A major current emphasis in the lab is the role of gamma delta T cells (gdT), a unique population of semi-innate cells that play a major role in immunity in the fetus and infant. Gamma delta T cells have been shown to play a role in protective immunity to both P. falciparum and CMV.

    Dr. Feeney is a member of the NIH IDEaL (Immune Development in Early Life) consortium and leads an ImmunoX Co-Project. Dr. Feeney was elected to the American Society for Clinical Investigation in 2016 and has received several research awards including the Elizabeth Glaser Scientist Award from the Pediatric AIDS Foundation and the William F. Friedman Pediatric Research Award. She holds the Edward B. Shaw Chair in Pediatrics.
    Collapse Global Health Equity

    Collapse Research 
    Collapse Research Activities and Funding
    T cell immunity to CMV in utero and in early childhood
    NIAID U01 AI168390Feb 18, 2022 - Feb 17, 2027
    Mentoring Translational Researchers for Careers in Pediatric Global Health
    NIH K24AI113002Jun 3, 2014 - Jun 30, 2024
    Role: Principal Investigator
    The role of ?? T cells in fetal and infant immune defense against malaria
    NIH R01AI093615Mar 15, 2011 - May 31, 2026
    Role: Principal Investigator
    Description: The role of gamma delta T cells in fetal and infant immune defense against malaria
    Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda
    NIH U19AI089674Jul 1, 2010 - Jun 30, 2017
    Role: Co-Investigator
    The impact of CD8 T cells on viral control and evolution in HIV-infected infants
    NIH R01AI068497Feb 15, 2007 - Jan 31, 2013
    Role: Principal Investigator
    Immune Control of HIV in Children
    NIH K23AI052078Apr 15, 2002 - Mar 31, 2007
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection. J Infect Dis. 2022 09 04; 226(4):566-575. Vaaben AV, Levan J, Nguyen CBT, Callaway PC, Prahl M, Warrier L, Nankya F, Musinguzi K, Kakuru A, Muhindo MK, Dorsey G, Kamya MR, Feeney ME. PMID: 35876164; PMCID: PMC9441208.
      View in: PubMed   Mentions:    Fields:    
    2. Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children. Nat Commun. 2022 07 18; 13(1):4159. Chan JA, Loughland JR, de la Parte L, Okano S, Ssewanyana I, Nalubega M, Nankya F, Musinguzi K, Rek J, Arinaitwe E, Tipping P, Bourke P, Andrew D, Dooley N, SheelaNair A, Wines BD, Hogarth PM, Beeson JG, Greenhouse B, Dorsey G, Kamya M, Hartel G, Minigo G, Feeney M, Jagannathan P, Boyle MJ. PMID: 35851033; PMCID: PMC9293980.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner. Proc Natl Acad Sci U S A. 2022 07 19; 119(29):e2205498119. Walker-Sperling V, Digitale JC, Viard M, Martin MP, Bashirova A, Yuki Y, Ramsuran V, Kulkarni S, Naranbhai V, Li H, Anderson SK, Yum L, Clifford R, Kibuuka H, Ake J, Thomas R, Rowland-Jones S, Rek J, Arinaitwe E, Kamya M, Rodriguez-Barraquer I, Feeney ME, Carrington M. PMID: 35858344; PMCID: PMC9303992.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis. Lancet Infect Dis. 2022 09; 22(9):1321-1328. Girometti N, Byrne R, Bracchi M, Heskin J, McOwan A, Tittle V, Gedela K, Scott C, Patel S, Gohil J, Nugent D, Suchak T, Dickinson M, Feeney M, Mora-Peris B, Stegmann K, Plaha K, Davies G, Moore LSP, Mughal N, Asboe D, Boffito M, Jones R, Whitlock G. PMID: 35785793; PMCID: PMC9534773.
      View in: PubMed   Mentions:    Fields:    
    5. A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection. Cell Rep. 2022 05 17; 39(7):110815. McCarthy EE, Odorizzi PM, Lutz E, Smullin CP, Tenvooren I, Stone M, Simmons G, Hunt PW, Feeney ME, Norris PJ, Busch MP, Spitzer MH, Rutishauser RL. PMID: 35584677; PMCID: PMC9151348.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    6. Peripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated With Increased Maternal Microchimerism in the Offspring. J Infect Dis. 2021 12 15; 224(12):2105-2112. Simon N, Shallat J, Houck J, Jagannathan P, Prahl M, Muhindo MK, Kakuru A, Olwoch P, Feeney ME, Harrington WE. PMID: 34010401; PMCID: PMC8672744.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Association of Inhibitory Killer Cell Immunoglobulin-like Receptor Ligands With Higher Plasmodium falciparum Parasite Prevalence. J Infect Dis. 2021 07 02; 224(1):175-183. Digitale JC, Callaway PC, Martin M, Nelson G, Viard M, Rek J, Arinaitwe E, Dorsey G, Kamya M, Carrington M, Rodriguez-Barraquer I, Feeney ME. PMID: 33165540; PMCID: PMC8491837.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. HLA Alleles B*53:01 and C*06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda. Front Immunol. 2021; 12:650028. Digitale JC, Callaway PC, Martin M, Nelson G, Viard M, Rek J, Arinaitwe E, Dorsey G, Kamya M, Carrington M, Rodriguez-Barraquer I, Feeney ME. PMID: 33815410; PMCID: PMC8017319.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Malaria and Early Life Immunity: Competence in Context. Front Immunol. 2021; 12:634749. Callaway PC, Farrington LA, Feeney ME. PMID: 33679787; PMCID: PMC7933008.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    10. Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy. Nat Commun. 2021 01 08; 12(1):132. Prahl M, Odorizzi P, Gingrich D, Muhindo M, McIntyre T, Budker R, Jagannathan P, Farrington L, Nalubega M, Nankya F, Sikyomu E, Musinguzi K, Naluwu K, Auma A, Kakuru A, Kamya MR, Dorsey G, Aweeka F, Feeney ME. PMID: 33420104; PMCID: PMC7794579.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    11. Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure. PLoS Pathog. 2020 10; 16(10):e1008997. Farrington LA, Callaway PC, Vance HM, Baskevitch K, Lutz E, Warrier L, McIntyre TI, Budker R, Jagannathan P, Nankya F, Musinguzi K, Nalubega M, Sikyomu E, Naluwu K, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. PMID: 33085728; PMCID: PMC7605717.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    12. Gravidity-dependent associations between interferon response and birth weight in placental malaria. Malar J. 2020 Aug 05; 19(1):280. Quanquin NM, Barres LG, Aliyari SR, Day NT, Gerami H, Fisher SJ, Kakuru A, Kamya MR, Havlir DV, Feeney M, Dorsey G, Cheng G, Gaw SL. PMID: 32758231; PMCID: PMC7409479.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. The impact of gravidity, symptomatology and timing of infection on placental malaria. Malar J. 2020 Jun 24; 19(1):227. Tran EE, Cheeks ML, Kakuru A, Muhindo MK, Natureeba P, Nakalembe M, Ategeka J, Nayebare P, Kamya M, Havlir D, Feeney ME, Dorsey G, Gaw SL. PMID: 32580739; PMCID: PMC7315526.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. The immune response to malaria in utero. Immunol Rev. 2020 01; 293(1):216-229. Feeney ME. PMID: 31553066; PMCID: PMC6944753.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    15. miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival. Cell Rep. 2019 08 20; 28(8):2169-2181.e4. Gagnon JD, Kageyama R, Shehata HM, Fassett MS, Mar DJ, Wigton EJ, Johansson K, Litterman AJ, Odorizzi P, Simeonov D, Laidlaw BJ, Panduro M, Patel S, Jeker LT, Feeney ME, McManus MT, Marson A, Matloubian M, Sanjabi S, Ansel KM. PMID: 31433990; PMCID: PMC6715152.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    16. Intermittent preventive treatment with dihydroartemisinin-piperaquine and risk of malaria following cessation in young Ugandan children: a double-blind, randomised, controlled trial. Lancet Infect Dis. 2019 09; 19(9):962-972. Muhindo MK, Jagannathan P, Kakuru A, Opira B, Olwoch P, Okiring J, Nalugo N, Clark TD, Ruel T, Charlebois E, Feeney ME, Havlir DV, Dorsey G, Kamya MR. PMID: 31307883; PMCID: PMC6722008.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCTClinical Trials
    17. In utero priming of highly functional effector T cell responses to human malaria. Sci Transl Med. 2018 10 17; 10(463). Odorizzi PM, Jagannathan P, McIntyre TI, Budker R, Prahl M, Auma A, Burt TD, Nankya F, Nalubega M, Sikyomu E, Musinguzi K, Naluwu K, Kakuru A, Dorsey G, Kamya MR, Feeney ME. PMID: 30333241; PMCID: PMC6321770.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    18. Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. PLoS Med. 2018 07; 15(7):e1002606. Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G. PMID: 30016328; PMCID: PMC6049882.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    19. 865: Malaria exposure in pregnancy: birth outcomes with placental and non-placental malaria infection. American Journal of Obstetrics and Gynecology. 2018 Jan 1; 218(1):s515-s516. Washburn WE, Kakuru KA, Muhindo MM, Natureeba NP, Nakalembe NM, Ategeka AJ, Nayebare NP, Feeney FM, Dorsey DG, Gaw GS. .
      View in: Publisher Site   Mentions:
    20. 862: Gene expression profiling of fetal Hofbauer cells and maternal intervillous macrophages in placental malaria. American Journal of Obstetrics and Gynecology. 2018 Jan 1; 218(1):s513-s514. Gaw GS, Ozarslan ON, Montoya MD, Robinson RJ, Dorsey DG, Feeney FM, Cheng CG, Fisher FS. .
      View in: Publisher Site   Mentions:
    21. Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children. Malar J. 2017 12 29; 16(1):499. Farrington L, Vance H, Rek J, Prahl M, Jagannathan P, Katureebe A, Arinaitwe E, Kamya MR, Dorsey G, Feeney ME. PMID: 29284469; PMCID: PMC5747142.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    22. The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission. Front Immunol. 2017; 8:1329. Boyle MJ, Jagannathan P, Bowen K, McIntyre TI, Vance HM, Farrington LA, Schwartz A, Nankya F, Naluwu K, Wamala S, Sikyomu E, Rek J, Greenhouse B, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. PMID: 29097996; PMCID: PMC5653696.
      View in: PubMed   Mentions: 14     Fields:    
    23. Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. Sci Rep. 2017 09 13; 7(1):11487. Jagannathan P, Lutwama F, Boyle MJ, Nankya F, Farrington LA, McIntyre TI, Bowen K, Naluwu K, Nalubega M, Musinguzi K, Sikyomu E, Budker R, Katureebe A, Rek J, Greenhouse B, Dorsey G, Kamya MR, Feeney ME. PMID: 28904345; PMCID: PMC5597587.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    24. Sex Disparity in Cord Blood FoxP3+ CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero. Open Forum Infect Dis. 2017; 4(1):ofx022. Prahl M, Jagannathan P, McIntyre TI, Auma A, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Odorizzi P, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME. PMID: 28480292; PMCID: PMC5414097.
      View in: PubMed   Mentions: 7  
    25. Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation. Malar J. 2016 10 07; 15(1):497. Prahl M, Jagannathan P, McIntyre TI, Auma A, Farrington L, Wamala S, Nalubega M, Musinguzi K, Naluwu K, Sikyoma E, Budker R, Vance H, Odorizzi P, Nayebare P, Ategeka J, Kakuru A, Havlir DV, Kamya MR, Dorsey G, Feeney ME. PMID: 27717402; PMCID: PMC5055709.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    26. Impact of In Utero Exposure to Malaria on Fetal T Cell Immunity. Trends Mol Med. 2016 Oct; 22(10):877-888. Odorizzi PM, Feeney ME. PMID: 27614925; PMCID: PMC5048621.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    27. A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection. PLoS One. 2016; 11(9):e0162132. Fontana MF, Baccarella A, Craft JF, Boyle MJ, McIntyre TI, Wood MD, Thorn KS, Anidi C, Bayat A, Chung MR, Hamburger R, Kim CY, Pearman E, Pham J, Tang JJ, Boon L, Kamya MR, Dorsey G, Feeney ME, Kim CC. PMID: 27583554; PMCID: PMC5008831.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    28. Effective Antimalarial Chemoprevention in Childhood Enhances the Quality of CD4+ T Cells and Limits Their Production of Immunoregulatory Interleukin 10. J Infect Dis. 2016 07 15; 214(2):329-38. Jagannathan P, Bowen K, Nankya F, McIntyre TI, Auma A, Wamala S, Sikyomu E, Naluwu K, Nalubega M, Boyle MJ, Farrington LA, Bigira V, Kapisi J, Aweeka F, Greenhouse B, Kamya M, Dorsey G, Feeney ME. PMID: 27067196; PMCID: PMC4918829.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Erratum to: B cell sub-types following acute malaria and associations with clinical immunity. Malar J. 2016 Mar 31; 15:188. Sullivan RT, Ssewanyana I, Wamala S, Nankya F, Jagannathan P, Tappero JW, Mayanja-Kizza H, Muhindo MK, Arinaitwe E, Kamya M, Dorsey G, Feeney ME, Riley EM, Drakeley CJ, Greenhouse B. PMID: 27036294; PMCID: PMC4818512.
      View in: PubMed   Mentions: 2     Fields:    
    30. Dihydroartemisinin-Piperaquine for the Prevention of Malaria in Pregnancy. N Engl J Med. 2016 Mar 10; 374(10):928-39. Kakuru A, Jagannathan P, Muhindo MK, Natureeba P, Awori P, Nakalembe M, Opira B, Olwoch P, Ategeka J, Nayebare P, Clark TD, Feeney ME, Charlebois ED, Rizzuto G, Muehlenbachs A, Havlir DV, Kamya MR, Dorsey G. PMID: 26962728; PMCID: PMC4847718.
      View in: PubMed   Mentions: 101     Fields:    Translation:Humans
    31. B cell sub-types following acute malaria and associations with clinical immunity. Malar J. 2016 Mar 03; 15:139. Sullivan RT, Ssewanyana I, Wamala S, Nankya F, Jagannathan P, Tappero JW, Mayanja-Kizza H, Muhindo MK, Arinaitwe E, Kamya M, Dorsey G, Feeney ME, Riley EM, Drakeley CJ, Greenhouse B, Sullivan R. PMID: 26939776; PMCID: PMC4778296.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Frequent Malaria Drives Progressive Vδ2 T-Cell Loss, Dysfunction, and CD16 Up-regulation During Early Childhood. J Infect Dis. 2016 May 01; 213(9):1483-90. Farrington LA, Jagannathan P, McIntyre TI, Vance HM, Bowen K, Boyle MJ, Nankya F, Wamala S, Auma A, Nalubega M, Sikyomu E, Naluwu K, Bigira V, Kapisi J, Dorsey G, Kamya MR, Feeney ME. PMID: 26667315; PMCID: PMC4813738.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    33. Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria. PLoS Pathog. 2015 Jul; 11(7):e1005041. Boyle MJ, Jagannathan P, Farrington LA, Eccles-James I, Wamala S, McIntyre TI, Vance HM, Bowen K, Nankya F, Auma A, Nalubega M, Sikyomu E, Naluwu K, Rek J, Katureebe A, Bigira V, Kapisi J, Tappero J, Muhindo MK, Greenhouse B, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. PMID: 26182204; PMCID: PMC4504515.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    34. FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. PLoS Pathog. 2015 May; 11(5):e1004894. Sullivan RT, Kim CC, Fontana MF, Feeney ME, Jagannathan P, Boyle MJ, Drakeley CJ, Ssewanyana I, Nankya F, Mayanja-Kizza H, Dorsey G, Greenhouse B. PMID: 25993340; PMCID: PMC4438005.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    35. Effector Phenotype of Plasmodium falciparum-Specific CD4+ T Cells Is Influenced by Both Age and Transmission Intensity in Naturally Exposed Populations. J Infect Dis. 2015 Aug 01; 212(3):416-25. Boyle MJ, Jagannathan P, Bowen K, McIntyre TI, Vance HM, Farrington LA, Greenhouse B, Nankya F, Rek J, Katureebe A, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. PMID: 25646355; PMCID: PMC4539911.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    36. IFNγ Responses to Pre-erythrocytic and Blood-stage Malaria Antigens Exhibit Differential Associations With Past Exposure and Subsequent Protection. J Infect Dis. 2015 Jun 15; 211(12):1987-96. Jagannathan P, Nankya F, Stoyanov C, Eccles-James I, Sikyomu E, Naluwu K, Wamala S, Nalubega M, Briggs J, Bowen K, Bigira V, Kapisi J, Kamya MR, Dorsey G, Feeney ME. PMID: 25520427; PMCID: PMC4836719.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    37. Loss and dysfunction of Vδ2⁺ γδ T cells are associated with clinical tolerance to malaria. Sci Transl Med. 2014 Aug 27; 6(251):251ra117. Jagannathan P, Kim CC, Greenhouse B, Nankya F, Bowen K, Eccles-James I, Muhindo MK, Arinaitwe E, Tappero JW, Kamya MR, Dorsey G, Feeney ME. PMID: 25163477; PMCID: PMC4198150.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    38. IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children. PLoS Pathog. 2014 Jan; 10(1):e1003864. Jagannathan P, Eccles-James I, Bowen K, Nankya F, Auma A, Wamala S, Ebusu C, Muhindo MK, Arinaitwe E, Briggs J, Greenhouse B, Tappero JW, Kamya MR, Dorsey G, Feeney ME. PMID: 24415936; PMCID: PMC3887092.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCellsCTClinical Trials
    39. Pediatric response to second-line antiretroviral therapy in South Africa. PLoS One. 2012; 7(11):e49591. Zanoni BC, Sunpath H, Feeney ME. PMID: 23185373; PMCID: PMC3502491.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    40. Predictors of poor CD4 and weight recovery in HIV-infected children initiating ART in South Africa. PLoS One. 2012; 7(3):e33611. Zanoni BC, Phungula T, Zanoni HM, France H, Cook EF, Feeney ME. PMID: 22438965; PMCID: PMC3306429.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    41. Sex differences in HIV RNA level and CD4 cell percentage during childhood. Clin Infect Dis. 2011 Sep; 53(6):592-9. Ruel TD, Zanoni BC, Ssewanyana I, Cao H, Havlir DV, Kamya M, Achan J, Charlebois ED, Feeney ME. PMID: 21840929; PMCID: PMC3160805.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    42. Risk factors associated with increased mortality among HIV infected children initiating antiretroviral therapy (ART) in South Africa. PLoS One. 2011; 6(7):e22706. Zanoni BC, Phungula T, Zanoni HM, France H, Feeney ME. PMID: 21829487; PMCID: PMC3146475.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    43. Impact of tuberculosis cotreatment on viral suppression rates among HIV-positive children initiating HAART. AIDS. 2011 Jan 02; 25(1):49-55. Zanoni BC, Phungula T, Zanoni HM, France H, Feeney ME. PMID: 20935555.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    44. Sequence evolution of HIV-1 following mother-to-child transmission. J Virol. 2010 Dec; 84(23):12437-44. Ryland EG, Tang Y, Christie CD, Feeney ME. PMID: 20861265; PMCID: PMC2976410.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    45. Correlates of spontaneous viral control among long-term survivors of perinatal HIV-1 infection expressing human leukocyte antigen-B57. AIDS. 2010 Jun 19; 24(10):1425-35. Tang Y, Huang S, Dunkley-Thompson J, Steel-Duncan JC, Ryland EG, St John MA, Hazra R, Christie CD, Feeney ME. PMID: 20539088; PMCID: PMC2903552.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    46. Maternal transmission of human immunodeficiency virus escape mutations subverts HLA-B57 immunodominance but facilitates viral control in the haploidentical infant. J Virol. 2009 Sep; 83(17):8616-27. Schneidewind A, Tang Y, Brockman MA, Ryland EG, Dunkley-Thompson J, Steel-Duncan JC, St John MA, Conrad JA, Kalams SA, Noel F, Allen TM, Christie CD, Feeney ME. PMID: 19515764; PMCID: PMC2738193.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    47. Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment. J Immunol. 2008 Dec 01; 181(11):8103-11. Huang S, Dunkley-Thompson J, Tang Y, Macklin EA, Steel-Duncan J, Singh-Minott I, Ryland EG, Smikle M, Walker BD, Christie CD, Feeney ME. PMID: 19018003; PMCID: PMC2714370.
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    48. A viral CTL escape mutation leading to immunoglobulin-like transcript 4-mediated functional inhibition of myelomonocytic cells. J Exp Med. 2007 Nov 26; 204(12):2813-24. Lichterfeld M, Kavanagh DG, Williams KL, Moza B, Mui SK, Miura T, Sivamurthy R, Allgaier R, Pereyra F, Trocha A, Feeney M, Gandhi RT, Rosenberg ES, Altfeld M, Allen TM, Allen R, Walker BD, Sundberg EJ, Yu XG. PMID: 18025130; PMCID: PMC2118510.
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    49. Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. J Virol. 2007 Feb; 81(4):1619-31. Yu XG, Lichterfeld M, Chetty S, Williams KL, Mui SK, Miura T, Frahm N, Feeney ME, Tang Y, Pereyra F, Labute MX, Pfafferott K, Leslie A, Crawford H, Allgaier R, Hildebrand W, Kaslow R, Brander C, Allen TM, Rosenberg ES, Kiepiela P, Vajpayee M, Goepfert PA, Altfeld M, Goulder PJ, Walker BD. PMID: 17121793; PMCID: PMC1797559.
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    50. Absence of detectable viremia in a perinatally HIV-1-infected teenager after discontinuation of antiretroviral therapy. J Allergy Clin Immunol. 2006 Aug; 118(2):324-30. Feeney ME, Tang Y, Rathod A, Kneut C, McIntosh K. PMID: 16890753.
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    51. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat Immunol. 2006 Feb; 7(2):173-8. Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, Marincola FM, Moore C, Mallal S, Carrington M, Heckerman D, Allen TM, Mullins JI, Korber BT, Goulder PJ, Walker BD, Brander C. PMID: 16369537.
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    52. Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol. 2005 Nov; 79(21):13239-49. Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, Brander C, Draenert R, Rockstroh JK, Jessen H, Rosenberg ES, Mallal SA, Walker BD. PMID: 16227247; PMCID: PMC1262562.
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    53. Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infection. J Virol. 2005 Sep; 79(18):12100-5. Pillay T, Zhang HT, Drijfhout JW, Robinson N, Brown H, Khan M, Moodley J, Adhikari M, Pfafferott K, Feeney ME, St John A, Holmes EC, Coovadia HM, Klenerman P, Goulder PJ, Phillips RE. PMID: 16140787; PMCID: PMC1212591.
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    54. HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. J Virol. 2005 Aug; 79(16):10218-25. Frahm N, Adams S, Kiepiela P, Linde CH, Hewitt HS, Lichterfeld M, Sango K, Brown NV, Pae E, Wurcel AG, Altfeld M, Feeney ME, Allen TM, Roach T, St John MA, Daar ES, Rosenberg E, Korber B, Marincola F, Walker BD, Goulder PJ, Brander C. PMID: 16051815; PMCID: PMC1182636.
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    55. HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response. J Immunol. 2005 Jun 15; 174(12):7524-30. Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, Yu XG, Verrill C, Allen T, Moore C, Mallal S, Burchett S, McIntosh K, Pelton SI, St John MA, Hazra R, Klenerman P, Altfeld M, Walker BD, Goulder PJ. PMID: 15944251.
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    56. HIV and children: the developing immune system fights back. West Indian Med J. 2004 Oct; 53(5):359-62. Feeney ME. PMID: 15675505.
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    57. Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing child. J Virol. 2004 Aug; 78(16):8927-30. Feeney ME, Tang Y, Roosevelt KA, Leslie AJ, McIntosh K, Karthas N, Walker BD, Goulder PJ. PMID: 15280502; PMCID: PMC479057.
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    58. Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels. AIDS. 2004 Apr 09; 18(6):871-6. Draenert R, Brander C, Yu XG, Altfeld M, Verrill CL, Feeney ME, Walker BD, Goulder PJ. PMID: 15060434.
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    59. Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med. 2004 Apr 05; 199(7):905-15. Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ. PMID: 15067030; PMCID: PMC2211885.
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    60. Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol. 2004 Mar; 78(5):2187-200. Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV, SenGupta D, Piechocka-Trocha A, Simonis T, Marincola FM, Wurcel AG, Stone DR, Russell CJ, Adolf P, Cohen D, Roach T, StJohn A, Khatri A, Davis K, Mullins J, Goulder PJ, Walker BD, Brander C. PMID: 14963115; PMCID: PMC369231.
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    61. HIV evolution: CTL escape mutation and reversion after transmission. Nat Med. 2004 Mar; 10(3):282-9. Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ. PMID: 14770175.
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    62. Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infection. J Immunol. 2003 Dec 15; 171(12):6968-75. Feeney ME, Draenert R, Roosevelt KA, Pelton SI, McIntosh K, Burchett SK, Mao C, Walker BD, Goulder PJ. PMID: 14662905.
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    63. Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection. AIDS. 2003 Dec 05; 17(18):2581-91. Altfeld M, Addo MM, Rosenberg ES, Hecht FM, Lee PK, Vogel M, Yu XG, Draenert R, Johnston MN, Strick D, Allen TM, Feeney ME, Kahn JO, Sekaly RP, Levy JA, Rockstroh JK, Goulder PJ, Walker BD. PMID: 14685052.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansCells
    64. Comprehensive screening reveals strong and broadly directed human immunodeficiency virus type 1-specific CD8 responses in perinatally infected children. J Virol. 2003 Jul; 77(13):7492-501. Feeney ME, Roosevelt KA, Tang Y, Pfafferott KJ, McIntosh K, Burchett SK, Mao C, Walker BD, Goulder PJ. PMID: 12805449; PMCID: PMC164781.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    65. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol. 2003 Feb; 77(3):2081-92. Addo MM, Yu XG, Rathod A, Cohen D, Eldridge RL, Strick D, Johnston MN, Corcoran C, Wurcel AG, Fitzpatrick CA, Feeney ME, Rodriguez WR, Basgoz N, Draenert R, Stone DR, Brander C, Goulder PJ, Rosenberg ES, Altfeld M, Walker BD. PMID: 12525643; PMCID: PMC140965.
      View in: PubMed   Mentions: 326     Fields:    Translation:HumansCells
    66. Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection. J Clin Invest. 2002 Mar; 109(6):837-43. Altfeld M, van Lunzen J, Frahm N, Yu XG, Schneider C, Eldridge RL, Feeney ME, Meyer-Olson D, Stellbrink HJ, Walker BD. PMID: 11901192; PMCID: PMC150914.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    67. Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses. AIDS. 2002 Feb 15; 16(3):321-8. Yu XG, Shang H, Addo MM, Eldridge RL, Phillips MN, Feeney ME, Strick D, Brander C, Goulder PJ, Rosenberg ES, Walker BD, Altfeld M, HIV Study Collaboration. PMID: 11834942.
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