Margaret Lowe

Title(s)	Assistant Professor, Dermatology
School	School of Medicine
Phone	--
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Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa. bioRxiv. 2023 Feb 15. Lowe MM, Cohen JN, Moss MI, Clancy S, Adler J, Yates A, Naik HB, Pauli M, Taylor I, McKay A, Harris H, Kim E, Hansen SL, Rosenblum MD, Moreau JM. PMID: 36824918; PMCID: PMC9949072.

View in: PubMed Mentions:
Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy. JCI Insight. 2022 10 24; 7(20). Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD. PMID: 36278491; PMCID: PMC9744256.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)
Translation:Humans
Xenograft Skin Model to Manipulate Human Immune Responses In Vivo. J Vis Exp. 2022 06 29; (184). Moss MI, Pauli M, Moreau JM, Cohen JN, Rosenblum MD, Lowe MM. PMID: 35848826.

View in: PubMed Mentions: 1 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals
Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin. Nature. 2021 11; 599(7886):667-672. Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD. PMID: 34707292; PMCID: PMC8906225.

View in: PubMed Mentions: 17 Fields:
Sci Science
Translation:Humans Animals Cells
Layilin Anchors Regulatory T Cells in Skin. J Immunol. 2021 10 01; 207(7):1763-1775. Mehta P, Gouirand V, Boda DP, Zhang J, Gearty SV, Zirak B, Lowe MM, Clancy S, Boothby I, Mahuron KM, Fries A, Krummel MF, Mankoo P, Chang HW, Liu J, Moreau JM, Scharschmidt TC, Daud A, Kim E, Neuhaus IM, Harris HW, Liao W, Rosenblum MD. PMID: 34470859; PMCID: PMC8489406.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Regulatory T cells promote innate inflammation after skin barrier breach via TGF-β activation. Sci Immunol. 2021 08 27; 6(62). Moreau JM, Dhariwala MO, Gouirand V, Boda DP, Boothby IC, Lowe MM, Cohen JN, Macon CE, Leech JM, Kalekar LA, Scharschmidt TC, Rosenblum MD. PMID: 34452925; PMCID: PMC8958044.

View in: PubMed Mentions: 13 Fields:
All Allergy and Immunology
Translation:Animals Cells
B Home or You Are In Trouble: B Cell Integrin-Mediated Recruitment Attenuates Skin Inflammation. J Invest Dermatol. 2021 08; 141(8):1885-1887. Moreau JM, Lowe MM. PMID: 34303469.

View in: PubMed Mentions: Fields:
Der Dermatology
Translation:Animals Cells
Single-cell analyses characterize circulating anti-tumor CD8+ T cells in mice and humans and identify markers for their enrichment. The Journal of Immunology. 2021 May 1; 206(1_Supplement):26.02-26.02. Pauken PK, Shahid SO, Lagattuta LK, Mahuron MK, Luber LJ, Lowe LM, Huang HL, Delaney DC, Long LJ, Fung FM, Newcomer NK, Tsai TK, Chow CM, Guinn GS, Kuchroo KJ, Burke BK, Schenkel SJ, Rosenblum RM, Daud DA, Sharpe SA, Singer SM. .

View in: Publisher Site Mentions:
Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment. J Exp Med. 2021 04 05; 218(4). Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, Burke KP, Schenkel JM, Rosenblum MD, Daud AI, Sharpe AH, Singer M. PMID: 33651880; PMCID: PMC7933992.

View in: PubMed Mentions: 37 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Humans Animals Cells
Abstract PO016: Single-cell analyses characterize circulating anti-tumor CD8 T cells and identify markers for their isolation. Cancer Immunology Research. 2021 Feb 1; 9(2_Supplement):po016-po016. Pauken PK, Shahid SO, Lagattuta LK, Mahuron MK, Luber LJ, Lowe LM, Huang HL, Delaney DC, Long LJ, Fung FM, Newcomer NK, Tsai TK, Chow CM, Guinn GS, Kuchroo KJ, Burke BK, Schenkel SJ, Rosenblum RM, Daud DA, Sharpe SA, Singer SM. .

View in: Publisher Site Mentions:
Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020 11 17; 1(8):100132. Dhariwala MO, Karthikeyan D, Vasquez KS, Farhat S, Weckel A, Taravati K, Leitner EG, Clancy S, Pauli M, Piper ML, Cohen JN, Ashouri JF, Lowe MM, Rosenblum MD, Scharschmidt TC. PMID: 33294857; PMCID: PMC7691438.

View in: PubMed Mentions: 11 Fields:
Med Medicine (General)
Translation:Humans Cells
Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy. JCI Insight. 2020 10 02; 5(19). Lowe MM, Naik HB, Clancy S, Pauli M, Smith KM, Bi Y, Dunstan R, Gudjonsson JE, Paul M, Harris H, Kim E, Shin US, Ahn R, Liao W, Hansen SL, Rosenblum MD. PMID: 32841223; PMCID: PMC7566733.

View in: PubMed Mentions: 27 Fields:
Med Medicine (General)
Translation:Humans Cells
Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis. JCI Insight. 2020 10 02; 5(19). Gudjonsson JE, Tsoi LC, Ma F, Billi AC, van Straalen KR, Vossen ARJV, van der Zee HH, Harms PW, Wasikowski R, Yee CM, Rizvi SM, Xing X, Xing E, Plazyo O, Zeng C, Patrick MT, Lowe MM, Burney RE, Kozlow JH, Cherry-Bukowiec JR, Jiang Y, Kirma J, Weidinger S, Cushing KC, Rosenblum MD, Berthier C, MacLeod AS, Voorhees JJ, Wen F, Kahlenberg JM, Maverakis E, Modlin RL, Prens EP. PMID: 32853177; PMCID: PMC7566715.

View in: PubMed Mentions: 40 Fields:
Med Medicine (General)
Translation:Humans Cells
Layilin augments integrin activation to promote antitumor immunity. J Exp Med. 2020 09 07; 217(9). Mahuron KM, Moreau JM, Glasgow JE, Boda DP, Pauli ML, Gouirand V, Panjabi L, Grewal R, Luber JM, Mathur AN, Feldman RM, Shifrut E, Mehta P, Lowe MM, Alvarado MD, Marson A, Singer M, Wells J, Jupp R, Daud AI, Rosenblum MD. PMID: 32539073; PMCID: PMC7478725.

View in: PubMed Mentions: 9 Fields:
All Allergy and Immunology Med Medicine (General)
Translation:Humans Animals Cells
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 12 19; 4(24). Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. PMID: 31852848; PMCID: PMC6975275.

View in: PubMed Mentions: 34 Fields:
Med Medicine (General)
Translation:Humans Animals Cells
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria. Cell Host Microbe. 2019 12 11; 26(6):795-809.e5. Leech JM, Dhariwala MO, Lowe MM, Chu K, Merana GR, Cornuot C, Weckel A, Ma JM, Leitner EG, Gonzalez JR, Vasquez KS, Diep BA, Scharschmidt TC. PMID: 31784259; PMCID: PMC6989301.

View in: PubMed Mentions: 31 Fields:
Mic Microbiology
Translation:Animals Cells
An Injectable Cytokine Trap for Local Treatment of Autoimmune Disease. Biomaterials. 2020 02; 230:119626. Zamecnik CR, Levy ES, Lowe MM, Zirak B, Rosenblum MD, Desai TA. PMID: 31753473; PMCID: PMC6930339.

View in: PubMed Mentions: 7 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Regulatory T cells in skin are uniquely poised to suppress profibrotic immune responses. Sci Immunol. 2019 09 06; 4(39). Kalekar LA, Cohen JN, Prevel N, Sandoval PM, Mathur AN, Moreau JM, Lowe MM, Nosbaum A, Wolters PJ, Haemel A, Boin F, Rosenblum MD. PMID: 31492709; PMCID: PMC6848056.

View in: PubMed Mentions: 45 Fields:
All Allergy and Immunology
Translation:Animals Cells
868 Histologic progression of hidradenitis suppurativa: Implications for future therapeutic intervention. Journal of Investigative Dermatology. 2019 May 1; 139(5):s150. Salte SK, Todorovic TV, Wetter WJ, Scott SV, Smith SK, Lowe LM, Rosenblum RM, Gudjonsson GJ, Honore HP, Dunstan DR. .

View in: Publisher Site Mentions:
Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair. Immunity. 2019 03 19; 50(3):655-667.e4. Mathur AN, Zirak B, Boothby IC, Tan M, Cohen JN, Mauro TM, Mehta P, Lowe MM, Abbas AK, Ali N, Rosenblum MD. PMID: 30893588; PMCID: PMC6507428.

View in: PubMed Mentions: 57 Fields:
All Allergy and Immunology
Translation:Animals Cells
The TNFRSF members CD27 and OX40 coordinately limit TH17 differentiation in regulatory T cells. Sci Immunol. 2018 12 21; 3(30). Remedios KA, Zirak B, Sandoval PM, Lowe MM, Boda D, Henley E, Bhattrai S, Scharschmidt TC, Liao W, Naik HB, Rosenblum MD. PMID: 30578350.

View in: PubMed Mentions: 20 Fields:
All Allergy and Immunology
Translation:Animals Cells
Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome. 2018 09 05; 6(1):154. Chang HW, Yan D, Singh R, Liu J, Lu X, Ucmak D, Lee K, Afifi L, Fadrosh D, Leech J, Vasquez KS, Lowe MM, Rosenblum MD, Scharschmidt TC, Lynch SV, Liao W. PMID: 30185226; PMCID: PMC6125946.

View in: PubMed Mentions: 89 Fields:
Gen Genetics Mic Microbiology
Translation:Humans Cells
Injectable Polymeric Cytokine-Binding Nanowires Are Effective Tissue-Specific Immunomodulators. ACS Nano. 2017 11 28; 11(11):11433-11440. Zamecnik CR, Lowe MM, Patterson DM, Rosenblum MD, Desai TA. PMID: 29124929; PMCID: PMC5709211.

View in: PubMed Mentions: 7 Fields:
Nan Nanotechnology
Translation:Humans Animals Cells
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 01; 169(6):1119-1129.e11. Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. PMID: 28552347; PMCID: PMC5504703.

View in: PubMed Mentions: 252 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
041 Regulatory T cells drive stem cell differentiation during skin barrier repair. Journal of Investigative Dermatology. 2017 May 1; 137(5):s7. Mathur MA, Zirak ZB, Lowe LM, Abbas AA, Rosenblum RM. .

View in: Publisher Site Mentions:
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe. 2017 Apr 12; 21(4):467-477.e5. Scharschmidt TC, Vasquez KS, Pauli ML, Leitner EG, Chu K, Truong HA, Lowe MM, Sanchez Rodriguez R, Ali N, Laszik ZG, Sonnenburg JL, Millar SE, Rosenblum MD. PMID: 28343820; PMCID: PMC5516645.

View in: PubMed Mentions: 102 Fields:
Mic Microbiology
Translation:Animals Cells
Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages. Viral Immunol. 2017 04; 30(3):142-148. Trang K, Raposo RA, Lowe MM, Krow-Lucal ER, Yonemoto W, Cabido VD, SenGupta D, McCune JM. PMID: 28151065; PMCID: PMC5393417.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology Vir Virology
Translation:Humans Cells
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One. 2014; 9(2):e87877. Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. PMID: 24498387; PMCID: PMC3912126.

View in: PubMed Mentions: 59 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
The catalytic subunit of human telomerase is a unique caspase-6 and caspase-7 substrate. Biochemistry. 2011 Oct 25; 50(42):9046-55. Soares J, Lowe MM, Jarstfer MB. PMID: 21936563.

View in: PubMed Mentions: 4 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med. 2010 May 19; 2(32):32ra36. Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM. PMID: 20484731; PMCID: PMC3034445.

View in: PubMed Mentions: 287 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells