Marielle Cavrois, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
Address1650 Owens St
San Francisco CA 94107
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Overview 
    Collapse Overview
    Mucosal transmission of HIV is a major force driving expansion of the global AIDS epidemic. Understanding the initial events in the establishment of infection in a new host is key to developing an effective vaccine and microbicides.

    Areas of Investigation
    Our main focus is to understand HIV transmission: what cells HIV initially infects in the genital mucosa and what HIV features are critical for viral transmission from one person to another. We are particularly interested in the envelope protein encoded by HIV and how it mediates fusion, the initial step of the viral life cycle. We developed a fluorometric assay to identify the most susceptible cells in vivo and characterize the strains of HIV circulating in the population.

    Collapse Research 
    Collapse Research Activities and Funding
    BD FACSAria II Flow Cytometer
    NIH/NCRR S10RR028962Jun 1, 2011 - May 31, 2012
    Role: Principal Investigator
    HIV Fusion to CD4 T Cells and Dendritic Cells
    NIH/NIAID R03AI062263Apr 15, 2005 - Mar 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 Jul 25; 20(4):984-998. PMID: 28746881.
      View in: PubMed
    2. Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC. Semen amyloids participate in spermatozoa selection and clearance. Elife. 2017 06 27; 6. PMID: 28653619.
      View in: PubMed
    3. Gesner M, Maiti M, Grant R, Cavrois M. Fluorescence-linked Antigen Quantification (FLAQ) Assay for Fast Quantification of HIV-1 p24Gag. Bio Protoc. 2014 Dec 20; 4(24). PMID: 27525295.
      View in: PubMed
    4. Cavrois M, Neidleman J, Greene WC. HIV-1 Fusion Assay. Bio Protoc. 2014 Aug 20; 4(16). PMID: 27525294.
      View in: PubMed
    5. Cavrois M, Neidleman J, Santiago ML, Derdeyn CA, Hunter E, Greene WC. Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains. J Virol. 2014 Feb; 88(4):2083-94. PMID: 24335304; PMCID: PMC3911571.
    6. Roan NR, Cavrois M, Greene WC. [Role of semen-derived amyloid fibrils as facilitators of HIV infection]. Med Sci (Paris). 2012 Apr; 28(4):358-60. PMID: 22549858.
      View in: PubMed
    7. Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbeler AM, Greene WC. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell. 2010 Nov 24; 143(5):789-801. PMID: 21111238; PMCID: PMC3026834.
    8. Cavrois M, Neidleman J, Galloway N, Derdeyn CA, Hunter E, Greene WC. Measuring HIV fusion mediated by envelopes from primary viral isolates. Methods. 2011 Jan; 53(1):34-8. PMID: 20554044; PMCID: PMC3563671.
    9. Cavrois M, Neidleman J, Greene WC. The achilles heel of the trojan horse model of HIV-1 trans-infection. PLoS Pathog. 2008 Jun 27; 4(6):e1000051. PMID: 18584030; PMCID: PMC2430767.
    10. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8718-23. PMID: 18562290; PMCID: PMC2438419.
    11. Cavrois M, Neidleman J, Kreisberg JF, Greene WC. In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Pathog. 2007 Jan; 3(1):e4. PMID: 17238285; PMCID: PMC1779297.
    12. Cavrois M, Neidleman J, Kreisberg JF, Fenard D, Callebaut C, Greene WC. Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J Virol. 2006 Feb; 80(4):1992-9. PMID: 16439555; PMCID: PMC1367165.
    13. Fenard D, Yonemoto W, de Noronha C, Cavrois M, Williams SA, Greene WC. Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. J Immunol. 2005 Nov 01; 175(9):6050-7. PMID: 16237100.
      View in: PubMed
    14. Yonezawa A, Cavrois M, Greene WC. Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha. J Virol. 2005 Jan; 79(2):918-26. PMID: 15613320; PMCID: PMC538559.
    15. Cavrois M, Neidleman J, Yonemoto W, Fenard D, Greene WC. HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion. Virology. 2004 Oct 10; 328(1):36-44. PMID: 15380356.
      View in: PubMed
    16. Cavrois M, Neidleman J, Bigos M, Greene WC. Fluorescence resonance energy transfer-based HIV-1 virion fusion assay. Methods Mol Biol. 2004; 263:333-44. PMID: 14976375.
      View in: PubMed
    17. Cavrois M, De Noronha C, Greene WC. A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes. Nat Biotechnol. 2002 Nov; 20(11):1151-4. PMID: 12355096.
      View in: PubMed
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