Mark Looney, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-9190
ORCID ORCID Icon0000-0003-0241-9190 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency 2001Internal Medicine
    University of TennesseeM.D.1998School of Medicine
    Collapse Awards and Honors
    University of Tennessee1997Alpha Omega Alpha
    American Thoracic Society2008Carl Booberg Research Award
    International Society of Blood Transfusion (ISBT)2010Jean Julliard Prize
    American Society for Clinical Investigation2013Elected Member
    Association of American Physicians2018Elected Member

    Collapse Overview 
    Collapse Overview
    Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

    Research Interests

    My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular traps
    NIH R01AI160167Sep 17, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Mechanisms of antibody-mediated lung Injury after blood transfusion
    NIH R01HL138673Jan 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Fine-tuning the Neutrophilic Response to Pneumonia
    NIH R01AI125445Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Innate Immune Mechanisms of Primary Graft Dysfunction after Lung Transplantation
    NIH R01HL130324Jan 1, 2016 - Dec 31, 2020
    Role: Principal Investigator
    Platelet and megakaryocyte biology in the normal and injured lung
    NIH R01HL107386Apr 1, 2011 - Apr 30, 2021
    Role: Principal Investigator
    Experimental transfusion-related acute lung injury
    NIH K08HL082742Dec 8, 2006 - Nov 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 Aug; 596(7872):E8. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 34341540.
      View in: PubMed   Mentions:    Fields:    
    2. Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. Proc Natl Acad Sci U S A. 2021 Jul 13; 118(28). Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S. PMID: 34244428.
      View in: PubMed   Mentions:    Fields:    
    3. Chewing the fat on TRALI. Blood. 2021 02 04; 137(5):586-587. Cleary SJ, Looney MR. PMID: 33538806.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. J Clin Invest. 2021 02 01; 131(3). Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR. PMID: 33290276.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction. Circ Res. 2021 03 05; 128(5):655-669. Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath KE, Morrell CN. PMID: 33508948.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 03; 591(7848):124-130. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33494096.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    7. Lung megakaryocytes are immune modulatory cells. J Clin Invest. 2021 01 04; 131(1). Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders J, Georas SN, Veazey J, Madere F, Santos LT, Arne A, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons C, Metcalf-Pate KA, McGrath KE, Palis J, Morrell CN. PMID: 33079726.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    8. Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation. Sci Adv. 2020 Nov; 6(45). Hyun YM, Seo SU, Choi WS, Kwon HJ, Kim DY, Jeong S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS. PMID: 33158867.
      View in: PubMed   Mentions: 3     Fields:    
    9. Complement activation on endothelium initiates antibody-mediated acute lung injury. J Clin Invest. 2020 11 02; 130(11):5909-5923. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR. PMID: 32730229.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Update on animal models for COVID-19 research. Br J Pharmacol. 2020 12; 177(24):5679-5681. Cleary SJ, Magnen M, Looney MR, Page CP. PMID: 33140409.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    11. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv. 2020 Oct 29. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140050.
      View in: PubMed   Mentions:
    12. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq. 2020 Oct 28. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140041.
      View in: PubMed   Mentions:
    13. Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose. Arch Toxicol. 2021 02; 95(2):693-701. Zhao Y, Magaña LC, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L. PMID: 33084937.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    14. NT-proBNP levels in the identification and classification of pulmonary transfusion reactions. Transfusion. 2020 11; 60(11):2548-2556. Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) . PMID: 32905629.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    15. Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology. Br J Pharmacol. 2020 11; 177(21):4851-4865. Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP. PMID: 32462701.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    16. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med. 2020 06 01; 217(6). Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M. PMID: 32302401.
      View in: PubMed   Mentions: 400     Fields:    Translation:HumansCellsPHPublic Health
    17. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020 04 01; 130(4):2041-2053. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR. PMID: 31961827.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    18. Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2020 03; 62(3):364-372. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. PMID: 31647878.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    19. Platelet Biogenesis in the Lung Circulation. Physiology (Bethesda). 2019 11 01; 34(6):392-401. Lefrançais E, Looney MR. PMID: 31577166.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Modulating Pathogenesis with Mobile-CRISPRi. J Bacteriol. 2019 11 15; 201(22). Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS. PMID: 31481541.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin. Am J Respir Cell Mol Biol. 2019 08; 61(2):232-243. Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC. PMID: 30768917.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    22. An update of the transfusion-related acute lung injury (TRALI) definition. Transfus Clin Biol. 2019 Nov; 26(4):354-356. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. PMID: 31221537.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 05 01; 199(9):1076-1085. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. PMID: 30888839.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    24. A consensus redefinition of transfusion-related acute lung injury. Transfusion. 2019 07; 59(7):2465-2476. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S. PMID: 30993745.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    25. Live imaging of the pulmonary immune environment. Cell Immunol. 2020 04; 350:103862. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Looney MR, Headley MB. PMID: 30336937; PMCID: PMC6742573.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. The incomparable platelet: holy alveoli! Blood. 2018 09 13; 132(11):1088-1089. Looney MR. PMID: 30213837.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis. Res Pract Thromb Haemost. 2018 Jul; 2(3):407-428. Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H. PMID: 30046746.
      View in: PubMed   Mentions:
    28. Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Crit Care Med. 2018 04; 46(4):577-585. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study- . PMID: 29300236.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    29. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI Insight. 2018 02 08; 3(3). Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR. PMID: 29415887.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    30. Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway. Am J Respir Crit Care Med. 2017 07 15; 196(2):122-124. Lefrançais E, Looney MR. PMID: 28707972.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    31. Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice. PLoS One. 2017; 12(6):e0178725. Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney MR. PMID: 28570672.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    32. Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI Insight. 2017 May 04; 2(9). Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR. PMID: 28469087.
      View in: PubMed   Mentions: 11     Fields:    
    33. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 07; 57(7):1684-1690. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL, TRALI Study Group . PMID: 28470756.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    34. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28; 2(10). Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P. PMID: 28626833.
      View in: PubMed   Mentions: 38     Fields:    
    35. Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training. Ann Am Thorac Soc. 2017 Apr; 14(4):565-568. Santhosh L, Babik J, Looney MR, Hollander H. PMID: 28362539.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. PMID: 28329764.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    37. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017 11; 72(11):971-980. Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. PMID: 28082531.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    38. Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock. 2017 01; 47(1):13-21. Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR. PMID: 27984533.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    39. Lung Imaging in Animal Models. Acute Lung Injury and Repair. 2017 Jan 1; 107-132. Lefrançais LE, Mallavia MB, Looney LM. .
      View in: Publisher Site   Mentions:
    40. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion. 2017 03; 57(3):709-713. Toy P, Kleinman SH, Looney MR. PMID: 28019007.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan; 112(1):56-63. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL, NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) . PMID: 28001313.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    42. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016 11 15; 7:13464. Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. PMID: 27845343.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    43. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 10 17; 213(11):2293-2314. Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. PMID: 27811056.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    44. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Ann Am Thorac Soc. 2016 Oct; 13(10):1858-1860. Henry TS, Naeger DM, Looney MR, Elicker BM. PMID: 27726440.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    45. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 09 08; 1(14):e86704. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ. PMID: 27699234.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    46. Reply to concerns regarding dropping the term "possible TRALI". Transfusion. 2016 09; 56(9):2394-5. Toy P, Kleinman SH, Looney MR. PMID: 27624212.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. PMID: 26982733.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimalsCells
    48. Inhibiting Integrin αvβ5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. Am J Transplant. 2016 Apr; 16(4):1306-11. Mallavia B, Liu F, Sheppard D, Looney MR. PMID: 26602748.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    49. Current concepts in TRALI pathogenesis. ISBT Science Series. 2016 Jan 1; 11(S1):206-210. Looney LM. .
      View in: Publisher Site   Mentions:
    50. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PLoS One. 2015; 10(7):e0133022. Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR. PMID: 26176623.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    51. Selectin' for NETs. Blood. 2015 Jul 09; 126(2):129-30. Looney MR. PMID: 26160186.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    52. Non-invasive Intratracheal Instillation in Mice. Bio Protoc. 2015; 5(12). Ortiz-Muñoz G, Looney MR. PMID: 27390765.
      View in: PubMed   Mentions:
    53. Two-event Transfusion-related Acute Lung Injury Mouse Model. Bio Protoc. 2015 Jun 20; 5(12). Ortiz-Muñoz G, Looney MR. PMID: 29104887.
      View in: PubMed   Mentions:
    54. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 May 01; 191(9):1089. Sayah DM, Mallavia B, Looney MR. PMID: 25932769.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    55. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. PMID: 25789765.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    56. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL, TRALI Study Group . PMID: 25702590.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    57. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):455-63. Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A, Lung Transplant Outcomes Group Investigators , Ware LB, Christie JD, Belperio JA, Looney MR. PMID: 25485813.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    58. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. PMID: 25533958.
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    59. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. PMID: 25488517.
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    60. Platelets Induce Neutrophil Extracellular Traps in Transfusion-Related Acute Lung Injury. Blood. 2014 Dec 6; 124(21):sci-18-sci-18. Looney LM. .
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    61. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Oct 23; 124(17):2625-34. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR. PMID: 25143486.
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    62. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res. 2014 Aug 13; 15:95. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH. PMID: 25115556.
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    63. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P, Transfusion-Related Acute Lung Injury Study Group . PMID: 24776608.
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    64. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. PMID: 24974157.
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    65. Live imaging of the lung. Annu Rev Physiol. 2014; 76:431-45. Looney MR, Bhattacharya J. PMID: 24245941.
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    66. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P, TRALI Study Group . PMID: 23357450.
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    67. Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Crit Care Clin. 2012 Jul; 28(3):363-72, v. Sayah DM, Looney MR, Toy P. PMID: 22713611.
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    68. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. PMID: 22684106.
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    69. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. PMID: 22585735.
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    70. Live imaging of the lung. Curr Protoc Cytom. 2012 Apr; Chapter 12:Unit12.28. Thornton EE, Krummel MF, Looney MR. PMID: 22470155.
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    71. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. PMID: 22262647.
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    72. Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des. 2012; 18(22):3260-6. Caudrillier A, Looney MR. PMID: 22621270.
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    73. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study Group . PMID: 22117051.
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    74. Reducing noninfectious risks of blood transfusion. Anesthesiology. 2011 Sep; 115(3):635-49. Gilliss BM, Looney MR, Gropper MA. PMID: 21792054.
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    75. The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion. 2011 Oct; 51(10):2078-91. Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM, National Heart, Lung, and Blood Institute Retrovirus Epidemiology Donor Study-II . PMID: 21446938.
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    76. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA. PMID: 21301926.
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    77. Experimental models of transfusion-related acute lung injury. Transfus Med Rev. 2011 Jan; 25(1):1-11. Gilliss BM, Looney MR. PMID: 21134622.
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    78. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. PMID: 21151136.
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    79. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. Looney MR, Gilliss BM, Matthay MA. PMID: 20601870.
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    80. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. . 2010 Feb; 298(2):L169-77. Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. PMID: 19933399.
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    81. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 19809160.
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    82. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. Liu KD, Looney MR, Matthay MA. PMID: 19519935.
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    83. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. . 2009 Jul; 297(1):L1-5. Su X, Looney MR, Gupta N, Matthay MA. PMID: 19411309.
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    84. Neutrophil sandwiches injure the microcirculation. Nat Med. 2009 Apr; 15(4):364-6. Looney MR, Matthay MA. PMID: 19350004.
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    85. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. Looney MR, Esmon CT, Matthay MA. PMID: 19008297.
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    86. Acute lung injury after blood product transfusion: are the times changing? Crit Care Med. 2008 Jun; 36(6):1968-70. Looney MR. PMID: 18520657.
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    87. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. PMID: 18453616.
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    88. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. Looney MR, Matthay MA. PMID: 24395479.
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    89. Microarray analysis of a mouse model of transfusion-related acute lung injury (TRALI) reveals prominent increased expression of neutrophil-derived chemokines. The FASEB Journal. 2007 Jan 1; 21(6):a1202-a1202. Looney LM, Barbeau BR, Barczak BA, Xiao XY, Lowell LC, Erle ED, Matthay MM. .
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    90. Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. Clin Chest Med. 2006 Dec; 27(4):591-600; abstract viii. Looney MR. PMID: 17085248.
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    91. Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature. Transfus Med. 2006 Oct; 16(5):343-8. Church GD, Price C, Sanchez R, Looney MR. PMID: 16999757.
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    92. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 16710475.
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    93. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6. Looney MR, Matthay MA. PMID: 16617257.
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    94. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. Looney MR, Matthay MA. PMID: 17169139.
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    95. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. . 2005 Jul; 289(1):L104-10. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. PMID: 15781423.
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    96. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. Su X, Looney M, Robriquet L, Fang X, Matthay MA. PMID: 15524406.
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    97. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. Looney MR, Gropper MA, Matthay MA. PMID: 15249468.
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    98. The Role of Protein C in Sepsis. Curr Infect Dis Rep. 2001 Oct; 3(5):413-418. Looney MR, Matthay MA. PMID: 11559461.
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