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Mark Looney, MD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-476-9563
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency 2001Internal Medicine
    University of TennesseeM.D.1998School of Medicine
    Collapse Awards and Honors
    University of Tennessee1997Alpha Omega Alpha
    American Thoracic Society2008Carl Booberg Research Award
    International Society of Blood Transfusion (ISBT)2010Jean Julliard Prize
    American Society for Clinical Investigation2013Elected Member
    Association of American Physicians2018Elected Member

    Collapse Overview 
    Collapse Overview
    Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

    Research Interests

    My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of antibody-mediated lung Injury after blood transfusion
    NIH/NHLBI R01HL138673Jan 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Fine-tuning the Neutrophilic Response to Pneumonia
    NIH/NIAID R01AI125445Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Innate Immune Mechanisms of Primary Graft Dysfunction after Lung Transplantation
    NIH/NHLBI R01HL130324Jan 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Platelet and megakaryocyte biology in the normal and injured lung
    NIH/NHLBI R01HL107386Apr 1, 2011 - Apr 30, 2021
    Role: Principal Investigator
    Experimental transfusion-related acute lung injury
    NIH/NHLBI K08HL082742Dec 8, 2006 - Nov 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV. Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma. Am J Respir Crit Care Med. 2019 May 01; 199(9):1076-1085. PMID: 30888839.
      View in: PubMed
    2. Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC. LPS-Induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-selectin. Am J Respir Cell Mol Biol. 2019 Feb 15. PMID: 30768917.
      View in: PubMed
    3. Looney MR, Headley MB. Live imaging of the pulmonary immune environment. Cell Immunol. 2018 Oct 09. PMID: 30336937.
      View in: PubMed
    4. Looney MR. The incomparable platelet: holy alveoli! Blood. 2018 Sep 13; 132(11):1088-1089. PMID: 30213837.
      View in: PubMed
    5. Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H. Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis. Res Pract Thromb Haemost. 2018 Jul; 2(3):407-428. PMID: 30046746.
      View in: PubMed
    6. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Crit Care Med. 2018 04; 46(4):577-585. PMID: 29300236.
      View in: PubMed
    7. Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR. Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury. JCI Insight. 2018 Feb 08; 3(3). PMID: 29415887.
      View in: PubMed
    8. Lefrançais E, Looney MR. Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway. Am J Respir Crit Care Med. 2017 07 15; 196(2):122-124. PMID: 28707972.
      View in: PubMed
    9. Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney MR. Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice. PLoS One. 2017; 12(6):e0178725. PMID: 28570672.
      View in: PubMed
    10. Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR. Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop. JCI Insight. 2017 May 04; 2(9). PMID: 28469087.
      View in: PubMed
    11. Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 07; 57(7):1684-1690. PMID: 28470756.
      View in: PubMed
    12. Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28; 2(10). PMID: 28626833.
      View in: PubMed
    13. Santhosh L, Babik J, Looney MR, Hollander H. Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training. Ann Am Thorac Soc. 2017 Apr; 14(4):565-568. PMID: 28362539.
      View in: PubMed
    14. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
      View in: PubMed
    15. Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017 11; 72(11):971-980. PMID: 28082531.
      View in: PubMed
    16. Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR. Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock. 2017 01; 47(1):13-21. PMID: 27984533.
      View in: PubMed
    17. Toy P, Kleinman SH, Looney MR. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion. 2017 03; 57(3):709-713. PMID: 28019007.
      View in: PubMed
    18. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan; 112(1):56-63. PMID: 28001313.
      View in: PubMed
    19. Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016 11 15; 7:13464. PMID: 27845343.
      View in: PubMed
    20. Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG. CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses. J Exp Med. 2016 10 17; 213(11):2293-2314. PMID: 27811056.
      View in: PubMed
    21. Henry TS, Naeger DM, Looney MR, Elicker BM. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Ann Am Thorac Soc. 2016 Oct; 13(10):1858-1860. PMID: 27726440.
      View in: PubMed
    22. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 09 08; 1(14):e86704. PMID: 27699234.
      View in: PubMed
    23. Toy P, Kleinman SH, Looney MR. Reply to concerns regarding dropping the term "possible TRALI". Transfusion. 2016 09; 56(9):2394-5. PMID: 27624212.
      View in: PubMed
    24. Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. PMID: 26982733; PMCID: PMC4892380.
    25. Mallavia B, Liu F, Sheppard D, Looney MR. Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. Am J Transplant. 2016 Apr; 16(4):1306-11. PMID: 26602748.
      View in: PubMed
    26. Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PLoS One. 2015; 10(7):e0133022. PMID: 26176623.
      View in: PubMed
    27. Looney MR. Selectin' for NETs. Blood. 2015 Jul 09; 126(2):129-30. PMID: 26160186.
      View in: PubMed
    28. Ortiz-Muñoz G, Looney MR. Non-invasive Intratracheal Instillation in Mice. Bio Protoc. 2015; 5(12). PMID: 27390765.
      View in: PubMed
    29. Ortiz-Muñoz G, Looney MR. Two-event Transfusion-related Acute Lung Injury Mouse Model. Bio Protoc. 2015 Jun 20; 5(12). PMID: 29104887.
      View in: PubMed
    30. Sayah DM, Mallavia B, Looney MR. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 May 01; 191(9):1089. PMID: 25932769.
      View in: PubMed
    31. Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
    32. Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135.
    33. Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney MR. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):455-63. PMID: 25485813; PMCID: PMC4351593.
    34. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958.
      View in: PubMed
    35. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517.
      View in: PubMed
    36. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Oct 23; 124(17):2625-34. PMID: 25143486; PMCID: PMC4208278.
    37. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res. 2014 Aug 13; 15:95. PMID: 25115556; PMCID: PMC4151192.
    38. Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. PMID: 24776608; PMCID: PMC4284060.
    39. Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. PMID: 24974157; PMCID: PMC4124173.
    40. Looney MR, Bhattacharya J. Live imaging of the lung. Annu Rev Physiol. 2014; 76:431-45. PMID: 24245941; PMCID: PMC4501380.
    41. Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450; PMCID: PMC3652681.
    42. Sayah DM, Looney MR, Toy P. Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Crit Care Clin. 2012 Jul; 28(3):363-72, v. PMID: 22713611; PMCID: PMC3380279.
    43. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. PMID: 22684106; PMCID: PMC3386815.
    44. Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. PMID: 22585735; PMCID: PMC3371730.
    45. Thornton EE, Krummel MF, Looney MR. Live imaging of the lung. Curr Protoc Cytom. 2012 Apr; Chapter 12:Unit12.28. PMID: 22470155.
      View in: PubMed
    46. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. PMID: 22262647; PMCID: PMC3927839.
    47. Caudrillier A, Looney MR. Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des. 2012; 18(22):3260-6. PMID: 22621270.
      View in: PubMed
    48. Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051; PMCID: PMC3286351.
    49. Gilliss BM, Looney MR, Gropper MA. Reducing noninfectious risks of blood transfusion. Anesthesiology. 2011 Sep; 115(3):635-49. PMID: 21792054; PMCID: PMC3162102.
    50. Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney MR, Kakaiya RM. The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion. 2011 Oct; 51(10):2078-91. PMID: 21446938.
      View in: PubMed
    51. Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. PMID: 21301926; PMCID: PMC3116128.
    52. Gilliss BM, Looney MR. Experimental models of transfusion-related acute lung injury. Transfus Med Rev. 2011 Jan; 25(1):1-11. PMID: 21134622; PMCID: PMC3011933.
    53. Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6. PMID: 21151136; PMCID: PMC3076005.
    54. Looney MR, Gilliss BM, Matthay MA. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
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    55. Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney MR, Wang RA. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L169-77. PMID: 19933399; PMCID: PMC2822562.
    56. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
      View in: PubMed
    57. Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935; PMCID: PMC2717421.
    58. Su X, Looney MR, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
    59. Looney MR, Matthay MA. Neutrophil sandwiches injure the microcirculation. Nat Med. 2009 Apr; 15(4):364-6. PMID: 19350004; PMCID: PMC2719794.
    60. Looney MR, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. PMID: 19008297; PMCID: PMC4459744.
    61. Looney MR. Acute lung injury after blood product transfusion: are the times changing? Crit Care Med. 2008 Jun; 36(6):1968-70. PMID: 18520657.
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    62. Su X, Johansen M, Looney MR, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616; PMCID: PMC2771449.
    63. Looney MR, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
      View in: PubMed
    64. Looney MR. Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. Clin Chest Med. 2006 Dec; 27(4):591-600; abstract viii. PMID: 17085248.
      View in: PubMed
    65. Church GD, Price C, Sanchez R, Looney MR. Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature. Transfus Med. 2006 Oct; 16(5):343-8. PMID: 16999757.
      View in: PubMed
    66. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
    67. Looney MR, Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6. PMID: 16617257.
      View in: PubMed
    68. Looney MR, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. PMID: 17169139; PMCID: PMC1794467.
    69. Looney MR, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
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    70. Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
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    71. Looney MR, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
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    72. Looney MR, Matthay MA. The Role of Protein C in Sepsis. Curr Infect Dis Rep. 2001 Oct; 3(5):413-418. PMID: 11559461.
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