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Mark Looney, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-9563
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoResidency 2001Internal Medicine
    University of TennesseeM.D.1998School of Medicine

    Collapse Overview 
    Collapse Overview
    Mark R. Looney, MD is a Professor of Medicine and Laboratory Medicine and Attending Physician on the Pulmonary Consult Service and the Intensive Care Units at UCSF. He received his undergraduate degree from Lipscomb University in Nashville, Tennessee in 1994 and his medical degree from the University of Tennessee, Memphis in 1998. He then came to UCSF where he completed his residency in Internal Medicine, a fellowship in Pulmonary and Critical Care Medicine, and research training in the Cardiovascular Research Institute.

    Research Interests

    My lab is broadly focused on innate immune biology in the lung. Thematic areas include neutrophil and platelet biology as applied to a variety of pulmonary disease states including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), primary graft dysfunction after lung transplantation, and cystic fibrosis. A major interest is the application of multiphoton intravital lung microscopy as a discovery tool to aid in the study of lung biology, including novel studies on the role of the pulmonary circulation in platelet biogenesis and the hematopoietic potential of the lung. Our overall goal is to identify new mechanisms responsible for lung inflammation and injury and to develop novel therapies to combat lung disease.


    Collapse Research 
    Collapse Research Activities and Funding
    Fine-tuning the Neutrophilic Response to Pneumonia
    NIH/NIAID R01AI125445Jun 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Innate Immune Mechanisms of Primary Graft Dysfunction after Lung Transplantation
    NIH/NHLBI R01HL130324Jan 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Mechanisms of acute lung injury from blood transfusions.
    NIH/NHLBI R01HL107386Apr 1, 2011 - Apr 30, 2021
    Role: Principal Investigator
    Experimental transfusion-related acute lung injury
    NIH/NHLBI K08HL082742Dec 8, 2006 - Nov 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Lefrançais E, Looney M. Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway. Am J Respir Crit Care Med. 2017 Jul 15; 196(2):122-124. PMID: 28707972.
      View in: PubMed
    2. Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney M. Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice. PLoS One. 2017; 12(6):e0178725. PMID: 28570672.
      View in: PubMed
    3. Roubinian NH, Looney M, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL. Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion. 2017 Jul; 57(7):1684-1690. PMID: 28470756.
      View in: PubMed
    4. Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney M, Krummel MF, Kubes P. The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection. Sci Immunol. 2017 Apr 28; 2(10). PMID: 28626833.
      View in: PubMed
    5. Santhosh L, Babik J, Looney M, Hollander H. Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training. Ann Am Thorac Soc. 2017 Apr; 14(4):565-568. PMID: 28362539.
      View in: PubMed
    6. Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney M. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature. 2017 04 06; 544(7648):105-109. PMID: 28329764.
      View in: PubMed
    7. Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney M, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS. Thorax. 2017 Jan 12. PMID: 28082531.
      View in: PubMed
    8. Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney M, Tuinman PR. Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies. Shock. 2017 Jan; 47(1):13-21. PMID: 27984533.
      View in: PubMed
    9. Toy P, Kleinman SH, Looney M. Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion. 2017 Mar; 57(3):709-713. PMID: 28019007.
      View in: PubMed
    10. Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney M, Matthay MA, Kleinman SH, Brambilla D, Murphy EL. Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan; 112(1):56-63. PMID: 28001313.
      View in: PubMed
    11. Rossaint J, Kühne K, Skupski J, Van Aken H, Looney M, Hidalgo A, Zarbock A. Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response. Nat Commun. 2016 Nov 15; 7:13464. PMID: 27845343.
      View in: PubMed
    12. Henry TS, Naeger DM, Looney M, Elicker BM. Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules. Ann Am Thorac Soc. 2016 Oct; 13(10):1858-1860. PMID: 27726440.
      View in: PubMed
    13. Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney M, Wolters PJ. Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis. JCI Insight. 2016 Sep 08; 1(14):e86704. PMID: 27699234.
      View in: PubMed
    14. Toy P, Kleinman SH, Looney M. Reply to concerns regarding dropping the term "possible TRALI". Transfusion. 2016 Sep; 56(9):2394-5. PMID: 27624212.
      View in: PubMed
    15. Headley MB, Bins A, Nip A, Roberts EW, Looney M, Gerard A, Krummel MF. Visualization of immediate immune responses to pioneer metastatic cells in the lung. Nature. 2016 Mar 24; 531(7595):513-7. PMID: 26982733; PMCID: PMC4892380.
    16. Mallavia B, Liu F, Sheppard D, Looney M. Inhibiting Integrin avß5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice. Am J Transplant. 2016 Apr; 16(4):1306-11. PMID: 26602748.
      View in: PubMed
    17. Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney M. Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice. PLoS One. 2015; 10(7):e0133022. PMID: 26176623; PMCID: PMC4503436.
    18. Looney M. Selectin' for NETs. Blood. 2015 Jul 09; 126(2):129-30. PMID: 26160186.
      View in: PubMed
    19. Ortiz-Muñoz G, Looney M. Non-invasive Intratracheal Instillation in Mice. Bio Protoc. 2015; 5(12). PMID: 27390765.
      View in: PubMed
    20. Sayah DM, Mallavia B, Looney M. Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 May 01; 191(9):1089. PMID: 25932769.
      View in: PubMed
    21. Bose O, Baluk P, Looney M, Cheng LE, McDonald DM, Caughey GH, Krummel MF. Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice. PLoS One. 2015; 10(3):e0118513. PMID: 25789765; PMCID: PMC4366375.
    22. Roubinian NH, Looney M, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL. Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion. 2015 Aug; 55(8):1838-46. PMID: 25702590; PMCID: PMC4536135.
    23. Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch Iii JP, Saggar R, Ardehali A, Ware LB, Christie JD, Belperio JA, Looney M. Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2015 Feb 15; 191(4):455-63. PMID: 25485813; PMCID: PMC4351593.
    24. Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney M, Matthay MA, Rock JR, Chapman HA. Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury. Nature. 2015 Jan 29; 517(7536):621-5. PMID: 25533958; PMCID: PMC4312207.
    25. Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney M. Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion. 2015 May; 55(5):947-52. PMID: 25488517; PMCID: PMC4428945.
    26. Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney M. Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice. Blood. 2014 Oct 23; 124(17):2625-34. PMID: 25143486; PMCID: PMC4208278.
    27. Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney M, Caughey GH. Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction. Respir Res. 2014 Aug 13; 15:95. PMID: 25115556; PMCID: PMC4151192.
    28. Looney M, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P. Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med. 2014 Jul; 42(7):1676-87. PMID: 24776608; PMCID: PMC4284060.
    29. Lelkes E, Headley MB, Thornton EE, Looney M, Krummel MF. The spatiotemporal cellular dynamics of lung immunity. Trends Immunol. 2014 Aug; 35(8):379-86. PMID: 24974157; PMCID: PMC4124173.
    30. Looney M, Bhattacharya J. Live imaging of the lung. Annu Rev Physiol. 2014; 76:431-45. PMID: 24245941; PMCID: PMC4501380.
    31. Murphy EL, Kwaan N, Looney M, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P. Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med. 2013 Apr; 126(4):357.e29-38. PMID: 23357450; PMCID: PMC3652681.
    32. Sayah DM, Looney M, Toy P. Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury. Crit Care Clin. 2012 Jul; 28(3):363-72, v. PMID: 22713611; PMCID: PMC3380279.
    33. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney M. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. PMID: 22684106; PMCID: PMC3386815.
    34. Thornton EE, Looney M, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF. Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med. 2012 Jun 04; 209(6):1183-99. PMID: 22585735; PMCID: PMC3371730.
    35. Thornton EE, Krummel MF, Looney M. Live imaging of the lung. Curr Protoc Cytom. 2012 Apr; Chapter 12:Unit12.28. PMID: 22470155.
      View in: PubMed
    36. Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney M, Lowell CA, Gropper MA. Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg. 2012 Mar; 114(3):511-9. PMID: 22262647; PMCID: PMC3927839.
    37. Caudrillier A, Looney M. Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury. Curr Pharm Des. 2012; 18(22):3260-6. PMID: 22621270.
      View in: PubMed
    38. Toy P, Gajic O, Bacchetti P, Looney M, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA. Transfusion-related acute lung injury: incidence and risk factors. Blood. 2012 Feb 16; 119(7):1757-67. PMID: 22117051; PMCID: PMC3286351.
    39. Gilliss BM, Looney M, Gropper MA. Reducing noninfectious risks of blood transfusion. Anesthesiology. 2011 Sep; 115(3):635-49. PMID: 21792054; PMCID: PMC3162102.
    40. Kleinman SH, Triulzi DJ, Murphy EL, Carey PM, Gottschall JL, Roback JD, Carrick D, Mathew S, Wright DJ, Cable R, Ness P, Gajic O, Hubmayr RD, Looney M, Kakaiya RM. The Leukocyte Antibody Prevalence Study-II (LAPS-II): a retrospective cohort study of transfusion-related acute lung injury in recipients of high-plasma-volume human leukocyte antigen antibody-positive or -negative components. Transfusion. 2011 Oct; 51(10):2078-91. PMID: 21446938; PMCID: PMC3606005.
    41. Su X, Looney M, Su HE, Lee JW, Song Y, Matthay MA. Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res. 2011 Jul; 60(7):619-32. PMID: 21301926; PMCID: PMC3116128.
    42. Gilliss BM, Looney M. Experimental models of transfusion-related acute lung injury. Transfus Med Rev. 2011 Jan; 25(1):1-11. PMID: 21134622; PMCID: PMC3011933.
    43. Looney M, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. Stabilized imaging of immune surveillance in the mouse lung. Nat Methods. 2011 Jan; 8(1):91-6. PMID: 21151136; PMCID: PMC3076005.
    44. Looney M, Gilliss BM, Matthay MA. Pathophysiology of transfusion-related acute lung injury. Curr Opin Hematol. 2010 Sep; 17(5):418-23. PMID: 20601870.
      View in: PubMed
    45. Miniati D, Jelin EB, Ng J, Wu J, Carlson TR, Wu X, Looney M, Wang RA. Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L169-77. PMID: 19933399; PMCID: PMC2822562.
    46. Looney M, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. PMID: 19809160.
      View in: PubMed
    47. Liu KD, Looney M, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Crit Care. 2009; 13(3):150. PMID: 19519935; PMCID: PMC2717421.
    48. Su X, Looney M, Gupta N, Matthay MA. Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury. Am J Physiol Lung Cell Mol Physiol. 2009 Jul; 297(1):L1-5. PMID: 19411309; PMCID: PMC2711813.
    49. Looney M, Matthay MA. Neutrophil sandwiches injure the microcirculation. Nat Med. 2009 Apr; 15(4):364-6. PMID: 19350004; PMCID: PMC2719794.
    50. Looney M, Esmon CT, Matthay MA. Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax. 2009 Feb; 64(2):114-20. PMID: 19008297; PMCID: PMC4459744.
    51. Looney M. Acute lung injury after blood product transfusion: are the times changing? Crit Care Med. 2008 Jun; 36(6):1968-70. PMID: 18520657.
      View in: PubMed
    52. Su X, Johansen M, Looney M, Brown EJ, Matthay MA. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008 May 15; 180(10):6947-53. PMID: 18453616; PMCID: PMC2771449.
    53. Looney M, Matthay MA. The role of protein C in sepsis. Curr Infect Dis Rep. 2007 Oct; 3(5):413-8. PMID: 24395479.
      View in: PubMed
    54. Looney M. Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza. Clin Chest Med. 2006 Dec; 27(4):591-600; abstract viii. PMID: 17085248.
      View in: PubMed
    55. Church GD, Price C, Sanchez R, Looney M. Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature. Transfus Med. 2006 Oct; 16(5):343-8. PMID: 16999757.
      View in: PubMed
    56. Looney M, Su X, Van Ziffle JA, Lowell CA, Matthay MA. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. PMID: 16710475; PMCID: PMC1462945.
    57. Looney M, Matthay MA. Animal models of transfusion-related acute lung injury. Crit Care Med. 2006 May; 34(5 Suppl):S132-6. PMID: 16617257.
      View in: PubMed
    58. Looney M, Matthay MA. Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. Crit Care. 2006; 10(6):239. PMID: 17169139; PMCID: PMC1794467.
    59. Looney M, Sartori C, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Jul; 289(1):L104-10. PMID: 15781423.
      View in: PubMed
    60. Su X, Looney M, Robriquet L, Fang X, Matthay MA. Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice. Exp Lung Res. 2004 Sep; 30(6):479-93. PMID: 15524406.
      View in: PubMed
    61. Looney M, Gropper MA, Matthay MA. Transfusion-related acute lung injury: a review. Chest. 2004 Jul; 126(1):249-58. PMID: 15249468.
      View in: PubMed
    62. Looney M, Matthay MA. The Role of Protein C in Sepsis. Curr Infect Dis Rep. 2001 Oct; 3(5):413-418. PMID: 11559461.
      View in: PubMed
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