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Matilda Chan, MD, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
DepartmentOphthalmology
Address1001 Potrero Ave
San Francisco CA 94110
Phone415-206-8854
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship School of Medicine
    Keck/University of Southern CaliforniaM.D., Ph.D.2002School of Medicine

    Collapse Overview 
    Collapse Overview
    Matilda Chan is a cornea specialist at the F.I. Proctor Foundation. Her clinical expertise is the diagnosis and management of patients with corneal and ocular surface diseases. Her basic and translational research program focuses on understanding the cellular and molecular responses to corneal injury.


    Collapse Research 
    Collapse Research Activities and Funding
    Research to Prevent Blindness (RPB) Physician-Scientist AwardJul 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Regulation of Corneal Repair by Metalloproteinases
    NIH/NEI R01EY022739Sep 1, 2013 - Aug 31, 2018
    Role: Principal Investigator
    The Role of Extracelluar Enzymes in Regulating Corneal Repair
    NIH/NEI K08EY018858Apr 1, 2008 - Mar 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wolf M, Maltseva I, Clay SM, Pan P, Gajjala A, Chan M. Effects of MMP12 on cell motility and inflammation during corneal epithelial repair. Exp Eye Res. 2017 Jul; 160:11-20. PMID: 28442300.
      View in: PubMed
    2. Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan M. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. PLoS One. 2017; 12(4):e0175112. PMID: 28384203.
      View in: PubMed
    3. Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan M, Healy KE. sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo. PLoS One. 2016; 11(6):e0155990. PMID: 27257918; PMCID: PMC4892585.
      View in: PubMed, PubMed Central
    4. Chou J, Chan M, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 Apr; 4(2). PMID: 27227311; PMCID: PMC4888795.
      View in: PubMed, PubMed Central
    5. Chan M, Werb Z. Animal Models of Corneal Injury. Bio Protoc. 2015 Jul 05; 5(13):e1516. PMID: 26191536.
      View in: PubMed
    6. Chan M, Werb Z. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio Protoc. 2015 Jul 05; 5(13):e1517. PMID: 26191537.
      View in: PubMed
    7. Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642. PMID: 23950901; PMCID: PMC3738537.
      View in: PubMed, PubMed Central
    8. Chan M, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 01; 126(Pt 17):3948-60. PMID: 23813962; PMCID: PMC3757333.
      View in: PubMed, PubMed Central
    9. Dalmon C, Porco TC, Lietman TM, Prajna NV, Prajna L, Das MR, Kumar JA, Mascarenhas J, Margolis TP, Whitcher JP, Jeng BH, Keenan JD, Chan M, McLeod SD, Acharya NR. The clinical differentiation of bacterial and fungal keratitis: a photographic survey. Invest Ophthalmol Vis Sci. 2012 Apr 02; 53(4):1787-91. PMID: 22395880; PMCID: PMC3342793.
      View in: PubMed, PubMed Central
    10. Chan M, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA. Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci. 2011 Aug; 88(8):1005-9. PMID: 21552176; PMCID: PMC3667701.
      View in: PubMed, PubMed Central
    11. Oldenburg CE, Keenan JD, Cevallos V, Chan M, Acharya NR, Gaynor BD, McLeod SD, Esterberg EJ, Porco TC, Lietman TM. Microbiological cure times in acanthamoeba keratitis. Eye (Lond). 2011 Sep; 25(9):1155-60. PMID: 21637300; PMCID: PMC3178241.
      View in: PubMed, PubMed Central
    12. Hu AY, Strauss EC, Holland GN, Chan M, Yu F, Margolis TP. Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol. 2010 Feb; 149(2):214-220.e3. PMID: 19909942; PMCID: PMC4507370.
      View in: PubMed, PubMed Central
    13. Rutar T, Chan M, Acharya NR, Naseri A. Cicatrising conjunctivitis due to paraneoplastic pemphigoid. Br J Ophthalmol. 2007 Nov; 91(11):1562-3. PMID: 17947274; PMCID: PMC2095435.
      View in: PubMed, PubMed Central
    14. Sappington RM, Chan M, Calkins DJ. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2932-42. PMID: 16799036.
      View in: PubMed
    15. Liang G, Chan M, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002 Jan; 22(2):480-91. PMID: 11756544; PMCID: PMC139739.
      View in: PubMed, PubMed Central
    16. Chan M, van Amerongen R, Nijjar T, Cuppen E, Jones PA, Laird PW. Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol. 2001 Nov; 21(22):7587-600. PMID: 11604495; PMCID: PMC99930.
      View in: PubMed, PubMed Central
    17. Chan M, Liang G, Jones PA. Relationship between transcription and DNA methylation. Curr Top Microbiol Immunol. 2000; 249:75-86. PMID: 10802939.
      View in: PubMed
    18. Simoneau AR, Spruck CH, Gonzalez-Zulueta M, Gonzalgo ML, Chan M, Tsai YC, Dean M, Steven K, Horn T, Jones PA. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res. 1996 Nov 01; 56(21):5039-43. PMID: 8895761.
      View in: PubMed
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