Matilda Chan, MD, PhD

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Potrero Avenue, #215
San Francisco CA 94110
Phone415-476-1442
PronounsShe/Her/Hers
ORCID ORCID Icon0000-0001-8679-6932 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship School of Medicine
    Keck/University of Southern CaliforniaM.D., Ph.D.2002School of Medicine
    University of California, San Francisco, CA2018Diversity, Equity, and Inclusion Champion Training

    Collapse Overview 
    Collapse Overview
    Matilda Chan is a cornea specialist at the F.I. Proctor Foundation. Her clinical expertise is the diagnosis and management of patients with corneal and ocular surface diseases. Her basic and translational research program focuses on understanding the cellular and molecular responses to corneal injury.

    Collapse Research 
    Collapse Research Activities and Funding
    Serum components to support corneal health
    NIH/NEI R21EY035829Jan 1, 2025 - Dec 31, 2026
    Role: PI
    Transcription Factor 4 (TCF4) Regulation of Corneal Health
    NIH R21EY035294Sep 1, 2023 - Aug 31, 2025
    Role: Principal Investigator
    Analysis of chemical modulators for corneal endothelial dystrophies
    NIH R01EY032161Sep 30, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Research to Prevent Blindness (RPB) Physician-Scientist AwardJul 1, 2016 - Dec 31, 2019
    Role: Principal Investigator
    Regulation of Corneal Repair by Metalloproteinases
    NIH R01EY022739Sep 1, 2013 - Aug 31, 2019
    Role: Principal Investigator
    The Role of Extracelluar Enzymes in Regulating Corneal Repair
    NIH K08EY018858Apr 1, 2008 - Mar 30, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Peer Review in Ophthalmology: A Collaborative Approach to Training the Next Generation of Reviewers. Invest Ophthalmol Vis Sci. 2024 Aug 01; 65(10):1. Chan MF, Council of Vision Editors. PMID: 39087935; PMCID: PMC11305435.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Calcium-sensing receptor (CaSR) modulates ocular surface chloride transport and its inhibition promotes ocular surface hydration. Ocul Surf. 2024 Oct; 34:30-37. Pasricha ND, Lindgren ES, Yan R, Kuo YM, Chan M, Verkman AS, Chu T, Yottasan P, de Souza Goncalves L, Cil O. PMID: 38871216.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Incidence and Mitigation of Corneal Pseudomicrocysts Induced by Antibody-Drug Conjugates (ADCs). Curr Ophthalmol Rep. 2024 Jun; 12(2):13-22. Lindgren ES, Yan R, Cil O, Verkman AS, Chan MF, Seitzman GD, Farooq AV, Huppert LA, Rugo HS, Pohlmann PR, Lu J, Esserman LJ, Pasricha ND. PMID: 38756824; PMCID: PMC11095972.
      View in: PubMed   Mentions: 1  
    4. Characterization of Polymicrobial and Antibiotic-Resistant Infectious Keratitis in a County Hospital Setting. Cornea Open. 2023 Sep; 2(3). Chan L, Lopez JB, Saifee M, Padmanabhan S, Chan MF, Yung M. PMID: 38516051; PMCID: PMC10957133.
      View in: PubMed   Mentions:
    5. Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy. Cornea. 2023 Aug 01; 42(8):929-933. Chan MF, Pan P, Wolfreys FD. PMID: 37318135; PMCID: PMC10313750.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Isolated Ocular Mpox without Skin Lesions, United States. Emerg Infect Dis. 2023 06; 29(6):1285-1288. Nguyen MT, Mentreddy A, Schallhorn J, Chan M, Aung S, Doernberg SB, Babik J, Miles K, Yang K, Lydon E, Minter DJ, Gonzales J, Shantha J, Doan T, Seitzman GD. PMID: 37130504; PMCID: PMC10202873.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Disrupting autorepression circuitry generates ''open-loop lethality'' to yield escape-resistant antiviral agents. Cell. 2023 Apr 27; 186(9):2036-2037. Chaturvedi S, Pablo M, Wolf M, Rosas-Rivera D, Calia G, Kumar AJ, Vardi N, Du K, Glazier J, Ke R, Chan MF, Perelson AS, Weinberger LS. PMID: 37116472; PMCID: PMC10134482.
      View in: PubMed   Mentions:    Fields:    
    8. Characterization of Infectious Keratitis in Opioid Users in a County Hospital Setting. Cornea Open. 2023 Mar; 2(1). Lopez JB, Chan L, Saifee M, Seitzman GD, Yung M, Chan MF. PMID: 37637189; PMCID: PMC10449330.
      View in: PubMed   Mentions:
    9. Ocular Rosacea microBiome Study (ORBS)-sub-microbial versus antibiotic dosing of doxycycline versus placebo in treatment of symptomatic ocular rosacea: study protocol for a parallel-arm randomized clinical trial. Trials. 2022 Dec 20; 23(1):1033. Mahmud H, Keenan JD, Gonzales J, Schallhorn J, Chan M, Arnold B, Cavallino V, Lietman TM, Doan T, Seitzman GD. PMID: 36539810; PMCID: PMC9769060.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    10. Risk Factors Predicting Loss to Follow-Up, Medication Noncompliance, and Poor Visual Outcomes Among Patients With Infectious Keratitis at a Public County Hospital. Cornea. 2023 Sep 01; 42(9):1069-1073. Lopez JB, Chan L, Saifee M, Padmanabhan S, Yung M, Chan MF. PMID: 36036690; PMCID: PMC9958267.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Oxytocin and secretin receptors - implications for dry eye syndrome and ocular pain. Front Ophthalmol (Lausanne). 2022; 2:948481. Lopez JB, Chang CC, Kuo YM, Chan MF, Winn BJ. PMID: 38983562; PMCID: PMC11182124.
      View in: PubMed   Mentions:
    12. Disrupting autorepression circuitry generates "open-loop lethality" to yield escape-resistant antiviral agents. Cell. 2022 06 09; 185(12):2086-2102.e22. Chaturvedi S, Pablo M, Wolf M, Rosas-Rivera D, Calia G, Kumar AJ, Vardi N, Du K, Glazier J, Ke R, Chan MF, Perelson AS, Weinberger LS. PMID: 35561685; PMCID: PMC9097017.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Characterization of Recruited Mononuclear Phagocytes following Corneal Chemical Injury. Int J Mol Sci. 2022 Feb 25; 23(5). Lamy R, Wolf M, Bispo C, Clay SM, Zheng S, Wolfreys F, Pan P, Chan MF. PMID: 35269717; PMCID: PMC8910730.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Spontaneous hyphema in the setting of COVID-19 pneumonia. Am J Ophthalmol Case Rep. 2022 Jun; 26:101447. Chiang J, Chan L, Stallworth JY, Chan MF. PMID: 35224286; PMCID: PMC8855609.
      View in: PubMed   Mentions:
    15. Pulsating Cilioretinal Artery From Ocular Hypertension. JAMA Ophthalmol. 2021 02 01; 139(2):e204108. Liu Y, Chan MF, Stewart JM. PMID: 33595610.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Corneal Repair Models in Mice: Epithelial/Mechanical Versus Stromal/Chemical Injuries. Methods Mol Biol. 2021; 2193:149-158. Pan P, Chan MF. PMID: 32808267; PMCID: PMC10448794.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    17. Author Correction: Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy. Sci Rep. 2020 Feb 06; 10(1):2395. Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF. PMID: 32024933; PMCID: PMC7002491.
      View in: PubMed   Mentions:    Fields:    
    18. Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy. Sci Rep. 2019 11 08; 9(1):16385. Pan P, Weisenberger DJ, Zheng S, Wolf M, Hwang DG, Rose-Nussbaumer JR, Jurkunas UV, Chan MF. PMID: 31705138; PMCID: PMC6841734.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2. Sci Rep. 2019 08 09; 9(1):11579. Wolf M, Clay SM, Zheng S, Pan P, Chan MF. PMID: 31399604; PMCID: PMC6689067.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    20. Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1734-1747. Wolf M, Clay SM, Oldenburg CE, Rose-Nussbaumer J, Hwang DG, Chan MF. PMID: 31022731; PMCID: PMC6485316.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Epidemiology of uveitis in a US population-based study. J Ophthalmic Inflamm Infect. 2018 Apr 17; 8(1):6. González MM, Solano MM, Porco TC, Oldenburg CE, Acharya NR, Lin SC, Chan MF. PMID: 29666980; PMCID: PMC5904090.
      View in: PubMed   Mentions: 31  
    22. Effects of MMP12 on cell motility and inflammation during corneal epithelial repair. Exp Eye Res. 2017 07; 160:11-20. Wolf M, Maltseva I, Clay SM, Pan P, Gajjala A, Chan MF. PMID: 28442300; PMCID: PMC5502814.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    23. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. PLoS One. 2017; 12(4):e0175112. Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan MF. PMID: 28384203; PMCID: PMC5383226.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    24. sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo. PLoS One. 2016; 11(6):e0155990. Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan MF, Healy KE. PMID: 27257918; PMCID: PMC4892585.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    25. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). Chou J, Chan MF, Werb Z. PMID: 27227311; PMCID: PMC4888795.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    26. Animal Models of Corneal Injury. Bio Protoc. 2015 Jul 05; 5(13):e1516. Chan MF, Werb Z. PMID: 26191536; PMCID: PMC4505371.
      View in: PubMed   Mentions: 7  
    27. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio Protoc. 2015 Jul 05; 5(13):e1517. Chan MF, Werb Z. PMID: 26191537; PMCID: PMC4505377.
      View in: PubMed   Mentions: 1  
    28. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642. Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD. PMID: 23950901; PMCID: PMC3738537.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    29. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 01; 126(Pt 17):3948-60. Chan MF, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. PMID: 23813962; PMCID: PMC3757333.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    30. The clinical differentiation of bacterial and fungal keratitis: a photographic survey. Invest Ophthalmol Vis Sci. 2012 Apr 02; 53(4):1787-91. Dalmon C, Porco TC, Lietman TM, Prajna NV, Prajna L, Das MR, Kumar JA, Mascarenhas J, Margolis TP, Whitcher JP, Jeng BH, Keenan JD, Chan MF, McLeod SD, Acharya NR. PMID: 22395880; PMCID: PMC3342793.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    31. Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci. 2011 Aug; 88(8):1005-9. Chan MF, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA. PMID: 21552176; PMCID: PMC3667701.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Microbiological cure times in acanthamoeba keratitis. Eye (Lond). 2011 Sep; 25(9):1155-60. Oldenburg CE, Keenan JD, Cevallos V, Chan MF, Acharya NR, Gaynor BD, McLeod SD, Esterberg EJ, Porco TC, Lietman TM. PMID: 21637300; PMCID: PMC3178241.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    33. Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol. 2010 Feb; 149(2):214-220.e3. Hu AY, Strauss EC, Holland GN, Chan MF, Yu F, Margolis TP. PMID: 19909942; PMCID: PMC4507370.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    34. Cicatrising conjunctivitis due to paraneoplastic pemphigoid. Br J Ophthalmol. 2007 Nov; 91(11):1562-3. Rutar T, Chan MF, Acharya NR, Naseri A. PMID: 17947274; PMCID: PMC2095435.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    35. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2932-42. Sappington RM, Chan M, Calkins DJ. PMID: 16799036.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    36. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002 Jan; 22(2):480-91. Liang G, Chan MF, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA. PMID: 11756544; PMCID: PMC139739.
      View in: PubMed   Mentions: 209     Fields:    Translation:AnimalsCells
    37. Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol. 2001 Nov; 21(22):7587-600. Chan MF, van Amerongen R, Nijjar T, Cuppen E, Jones PA, Laird PW. PMID: 11604495; PMCID: PMC99930.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    38. Relationship between transcription and DNA methylation. Curr Top Microbiol Immunol. 2000; 249:75-86. Chan MF, Liang G, Jones PA. PMID: 10802939.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    39. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res. 1996 Nov 01; 56(21):5039-43. Simoneau AR, Spruck CH, Gonzalez-Zulueta M, Gonzalgo ML, Chan MF, Tsai YC, Dean M, Steven K, Horn T, Jones PA. PMID: 8895761.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
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