Matilda Chan | UCSF Profiles

Matilda Chan, MD, PhD

Title	Associate Professor
Institution	University of California San Francisco
Department	Ophthalmology
Address	1001 Potrero Ave San Francisco CA 94110
Phone	415-206-8854
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Biography

Education and Training

University of California, San Francisco	Clinical Fellowship		School of Medicine
Keck/University of Southern California	M.D., Ph.D.	2002	School of Medicine

Overview

Matilda Chan is a cornea specialist at the F.I. Proctor Foundation. Her clinical expertise is the diagnosis and management of patients with corneal and ocular surface diseases. Her basic and translational research program focuses on understanding the cellular and molecular responses to corneal injury.

Research

Research Activities and Funding

Research to Prevent Blindness (RPB) Physician-Scientist AwardJul 1, 2016 - Dec 31, 2019
Role: Principal Investigator

Regulation of Corneal Repair by Metalloproteinases
NIH/NEI R01EY022739Sep 1, 2013 - Aug 31, 2018
Role: Principal Investigator

The Role of Extracelluar Enzymes in Regulating Corneal Repair
NIH/NEI K08EY018858Apr 1, 2008 - Mar 30, 2014
Role: Principal Investigator

ORNG Applications

Websites

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

List All | Timeline

GonzÃ¡lez MM, Solano MM, Porco TC, Oldenburg CE, Acharya NR, Lin SC, Chan M. Epidemiology of uveitis in a US population-based study. J Ophthalmic Inflamm Infect. 2018 Apr 17; 8(1):6. PMID: 29666980.

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Wolf M, Maltseva I, Clay SM, Pan P, Gajjala A, Chan M. Effects of MMP12 on cell motility and inflammation during corneal epithelial repair. Exp Eye Res. 2017 07; 160:11-20. PMID: 28442300.

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Khuc E, Bainer R, Wolf M, Clay SM, Weisenberger DJ, Kemmer J, Weaver VM, Hwang DG, Chan M. Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy. PLoS One. 2017; 12(4):e0175112. PMID: 28384203.

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Altiok EI, Browne S, Khuc E, Moran EP, Qiu F, Zhou K, Santiago-Ortiz JL, Ma JX, Chan M, Healy KE. sFlt Multivalent Conjugates Inhibit Angiogenesis and Improve Half-Life In Vivo. PLoS One. 2016; 11(6):e0155990. PMID: 27257918; PMCID: PMC4892585.

View in: PubMed, PubMed Central
Chou J, Chan M, Werb Z. Metalloproteinases: a Functional Pathway for Myeloid Cells. Microbiol Spectr. 2016 04; 4(2). PMID: 27227311; PMCID: PMC4888795.

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Chan M, Werb Z. Animal Models of Corneal Injury. Bio Protoc. 2015 Jul 05; 5(13):e1516. PMID: 26191536.

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Chan M, Werb Z. Confocal Imaging of Myeloid Cells in the Corneal Stroma of Live Mice. Bio Protoc. 2015 Jul 05; 5(13):e1517. PMID: 26191537.

View in: PubMed
Maltseva I, Chan M, Kalus I, Dierks T, Rosen SD. The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013; 8(8):e69642. PMID: 23950901; PMCID: PMC3738537.

View in: PubMed, PubMed Central
Chan M, Li J, Bertrand A, Casbon AJ, Lin JH, Maltseva I, Werb Z. Protective effects of matrix metalloproteinase-12 following corneal injury. J Cell Sci. 2013 Sep 01; 126(Pt 17):3948-60. PMID: 23813962; PMCID: PMC3757333.

View in: PubMed, PubMed Central
Dalmon C, Porco TC, Lietman TM, Prajna NV, Prajna L, Das MR, Kumar JA, Mascarenhas J, Margolis TP, Whitcher JP, Jeng BH, Keenan JD, Chan M, McLeod SD, Acharya NR. The clinical differentiation of bacterial and fungal keratitis: a photographic survey. Invest Ophthalmol Vis Sci. 2012 Apr 02; 53(4):1787-91. PMID: 22395880; PMCID: PMC3342793.

View in: PubMed, PubMed Central
Chan M, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA. Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci. 2011 Aug; 88(8):1005-9. PMID: 21552176; PMCID: PMC3667701.

View in: PubMed, PubMed Central
Oldenburg CE, Keenan JD, Cevallos V, Chan M, Acharya NR, Gaynor BD, McLeod SD, Esterberg EJ, Porco TC, Lietman TM. Microbiological cure times in acanthamoeba keratitis. Eye (Lond). 2011 Sep; 25(9):1155-60. PMID: 21637300; PMCID: PMC3178241.

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Hu AY, Strauss EC, Holland GN, Chan M, Yu F, Margolis TP. Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol. 2010 Feb; 149(2):214-220.e3. PMID: 19909942; PMCID: PMC4507370.

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Rutar T, Chan M, Acharya NR, Naseri A. Cicatrising conjunctivitis due to paraneoplastic pemphigoid. Br J Ophthalmol. 2007 Nov; 91(11):1562-3. PMID: 17947274; PMCID: PMC2095435.

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Sappington RM, Chan M, Calkins DJ. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2932-42. PMID: 16799036.

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Liang G, Chan M, Tomigahara Y, Tsai YC, Gonzales FA, Li E, Laird PW, Jones PA. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol. 2002 Jan; 22(2):480-91. PMID: 11756544; PMCID: PMC139739.

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Chan M, van Amerongen R, Nijjar T, Cuppen E, Jones PA, Laird PW. Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol. 2001 Nov; 21(22):7587-600. PMID: 11604495; PMCID: PMC99930.

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Chan M, Liang G, Jones PA. Relationship between transcription and DNA methylation. Curr Top Microbiol Immunol. 2000; 249:75-86. PMID: 10802939.

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Simoneau AR, Spruck CH, Gonzalez-Zulueta M, Gonzalgo ML, Chan M, Tsai YC, Dean M, Steven K, Horn T, Jones PA. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res. 1996 Nov 01; 56(21):5039-43. PMID: 8895761.

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