Matthew Chalkley, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address555 Mission Bay Blvd South
San Francisco CA 94158
ORCID ORCID Icon0000-0002-0484-7335 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTB.S.05/2009Chemistry
    University of Erlangen-Nuremberg, GermanyN/A06/2014Chemistry
    California Institute of Technology, Pasadena, CAPh.D.02/2020Chemistry
    Collapse Awards and Honors
    Yale University2012  - 2013Barry Goldwater Scholar
    University of Erlangen-Nuremberg2013  - 2014Fulbright Fellowship
    Caltech2014  - 2017NSF Graduate Research Fellowship
    Caltech2017  - 2018CEMI Graduate Research Fellowship
    Caltech2018  - 2020Resnick Sustainability Institute Fellow
    UCSF2020  - 2023NIH Postdoctoral Fellowship (F32)

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Light Alters the NH3 vs N2H4 Product Profile in Iron-catalyzed Nitrogen Reduction via Dual Reactivity from an Iron Hydrazido (Fe=NNH2) Intermediate. Angew. Chem. Int. Ed. 2023. Pablo Garrido-Barros Matthew Chalkley Jonas Peters. . View Publication.
    2. Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments. BioRxiv. 2022. Gregory E. Merz, Matthew J. Chalkley, Sophia Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado, Daniel R. Southworth. View Publication.
    3. Tandem electrocatalytic N2 fixation via proton-coupled electron transfer. Nature. 2022; 609:71-76. Garrido-Barros P, Derosa J, Chalkley MJ, Peters JC. View Publication.
    4. De novo metalloprotein design. Nat Rev Chem. 2022 Jan; 6(1):31-50. Chalkley MJ, Mann SI, DeGrado WF. PMID: 35811759; PMCID: PMC9264687.
      View in: PubMed   Mentions:
    5. Elucidation of the molecular interactions that enable stable assembly and structural diversity in multicomponent immune receptors. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). Fong LK, Chalkley MJ, Tan SK, Grabe M, DeGrado WF. PMID: 34155106; PMCID: PMC8256006.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. Exploring the Limits of Dative Boratrane Bonding: Iron as a Strong Lewis Base in Low-Valent Non-Heme Iron-Nitrosyl Complexes. Inorg Chem. 2020 Oct 19; 59(20):14967-14982. Dong HT, Chalkley MJ, Oyala PH, Zhao J, Alp EE, Hu MY, Peters JC, Lehnert N. PMID: 32989992; PMCID: PMC7640944.
      View in: PubMed   Mentions: 2     Fields:    
    7. A molecular mediator for reductive concerted proton-electron transfers via electrocatalysis. Science. 2020 08 14; 369(6505):850-854. Chalkley MJ, Garrido-Barros P, Peters JC. PMID: 32792399.
      View in: PubMed   Mentions: 7     Fields:    
    8. Catalytic N2-to-NH3 (or -N2H4) Conversion by Well-Defined Molecular Coordination Complexes. Chem Rev. 2020 06 24; 120(12):5582-5636. Chalkley MJ, Drover MW, Peters JC. PMID: 32352271; PMCID: PMC7493999.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    9. Relating N–H Bond Strengths to the Overpotential for Catalytic Nitrogen Fixation. Eur. J. Inorg. Chem. 2020. Chalkley MJ, Peters JC . View Publication.
    10. Relating N-H Bond Strengths to the Overpotential for Catalytic Nitrogen Fixation. Eur J Inorg Chem. 2020 Apr 30; 2020(15-16):1353-1357. Chalkley MJ, Peters JC. PMID: 33071628; PMCID: PMC7566871.
      View in: PubMed   Mentions: 2  
    11. Cp* Noninnocence Leads to a Remarkably Weak C-H Bond via Metallocene Protonation. J Am Chem Soc. 2019 03 20; 141(11):4721-4729. Chalkley MJ, Oyala PH, Peters JC. PMID: 30789720.
      View in: PubMed   Mentions: 6     Fields:    
    12. Electronic Structures of an [Fe(NNR2)]+/0/- Redox Series: Ligand Noninnocence and Implications for Catalytic Nitrogen Fixation. Inorg Chem. 2019 Mar 04; 58(5):3535-3549. Thompson NB, Oyala PH, Dong HT, Chalkley MJ, Zhao J, Alp EE, Hu M, Lehnert N, Peters JC. PMID: 30762355; PMCID: PMC6598684.
      View in: PubMed   Mentions: 5     Fields:    
    13. Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase. Proc Natl Acad Sci U S A. 2018 07 10; 115(28):7308-7313. Lewis RD, Garcia-Borràs M, Chalkley MJ, Buller AR, Houk KN, Kan SBJ, Arnold FH. PMID: 29946033; PMCID: PMC6048479.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    14. Fe-Mediated Nitrogen Fixation with a Metallocene Mediator: Exploring p Ka Effects and Demonstrating Electrocatalysis. J Am Chem Soc. 2018 05 16; 140(19):6122-6129. Chalkley MJ, Del Castillo TJ, Matson BD, Peters JC. PMID: 29669205; PMCID: PMC6071328.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    15. A Thermodynamic Model for Redox-Dependent Binding of Carbon Monoxide at Site-Differentiated, High Spin Iron Clusters. J Am Chem Soc. 2018 04 25; 140(16):5569-5578. Arnett CH, Chalkley MJ, Agapie T. PMID: 29589921; PMCID: PMC6452638.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    16. Catalytic N2-to-NH3 Conversion by Fe at Lower Driving Force: A Proposed Role for Metallocene-Mediated PCET. ACS Cent Sci. 2017 Mar 22; 3(3):217-223. Chalkley MJ, Del Castillo TJ, Matson BD, Roddy JP, Peters JC. PMID: 28386599; PMCID: PMC5364448.
      View in: PubMed   Mentions: 30  
    17. A Triad of Highly Reduced, Linear Iron Nitrosyl Complexes: {FeNO}(8-10). Angew Chem Int Ed Engl. 2016 09 19; 55(39):11995-8. Chalkley MJ, Peters JC. PMID: 27560776; PMCID: PMC5079689.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    18. Synthesis and characterization of iron trisphenolate complexes with hydrogen-bonding cavities. Inorg Chem. 2014 Mar 17; 53(6):2763-5. Adelhardt M, Chalkley MJ, Heinemann FW, Sutter J, Scheurer A, Meyer K. PMID: 24588682.
      View in: PubMed   Mentions:    Fields:    
    19. Synthesis and properties of NHC-supported palladium (I) dimers with bridging allyl, cyclopentadienyl, and indenyl ligands. Organometallics. 2013; 32(18):5114-5127. Wei Dai, Matthew J. Chalkley, Gary W. Brudvig, Nilay Hazari, Patrick R. Melvin, Ravi Pokhrel, Michael K. Takase. View Publication.
    20. Synthesis, electronic structure, and reactivity of palladium (I) dimers with bridging allyl, cyclopentadienyl, and indenyl ligands. Organometallics. 2013; 32(15):4223-4238. Matthew J. Chalkley, Louise M. Guard, Nilay Hazari, Peter Hofmann, Damian P. Hruszkewycz, Timothy J. Schmeier, Michael K. Takase. View Publication.
    21. Photoelectron Spectroscopy of Palladium (I) Dimers with Bridging Allyl Ligands. Organometallics. 2012; 31(24):8571-8576. Phuong Diem Dau, Damian P. Hruszkewycz, Dao-Ling Huang, Matthew J. Chalkley, Hong-Tao Liu, Jennifer C. Green, Nilay Hazari, Lai-Sheng Wang. View Publication.
    22. New Bidentate Trans-Chelating N-Heterocyclic Carbene Ligands for Palladium. Organometallics. 2011; 30(7):1818-1829. James D. Blakemore, Matthew J. Chalkley, Joy H. Farnaby, Louise M. Guard, Nilay Hazari, Christopher D. Incarvito, Eddie D. Luzik Jr., Hee Won Suh. View Publication.
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