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Matthew Gruner, PhD

Title(s)Postdoctoral Scholar, Cell and Tissue Biology
SchoolSchool of Dentistry
ORCID ORCID Icon0000-0001-5175-4177 Additional info
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    Collapse Biography 
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    University of Nevada, Reno, Reno, NVPhD2017Cell Molecular Biology

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    Collapse Overview
    I am interested in understanding what RNA can tell us about how cells work and what happens during disease. Many RNAs are transcribed and not translated into protein but rather regulate protein production. Recently circRNAs were shown to regulate cell division during development and cancer via interactions with microRNAs, transcription factors and RNA binding proteins. As a PhD student at the University of Nevada in Reno I helped identify new circRNAs in the nematode C. elegans that accumulate throughout its lifespan. During my postdoc at UCSF I hopes to identify a circRNA signature for specific oncogenes such as Myc then dissect the pathways necessary for circRNA-dependent oncogenesis.

    Collapse Research 
    Collapse Research Activities and Funding
    Identification of functional non-coding RNAs in Human Breast Cancer
    NIH/NCI F32CA236411Dec 3, 2018 - Dec 2, 2021
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cortés-López M, Gruner MR, Cooper DA, Gruner HN, Voda AI, van der Linden AM, Miura P. Global accumulation of circRNAs during aging in Caenorhabditis elegans. BMC Genomics. 2018 01 03; 19(1):8. PMID: 29298683.
      View in: PubMed
    2. Gruner M, Grubbs J, McDonagh A, Valdes D, Winbush A, van der Linden AM. Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors. PLoS Genet. 2016 08; 12(8):e1006237. PMID: 27487365.
      View in: PubMed
    3. Winbush A, Gruner M, Hennig GW, van der Linden AM. Long-term imaging of circadian locomotor rhythms of a freely crawling C. elegans population. J Neurosci Methods. 2015 Jul 15; 249:66-74. PMID: 25911068.
      View in: PubMed
    4. Gruner M, van der Linden AM. Plasticity of chemoreceptor gene expression: Sensory and circuit inputs modulate state-dependent chemoreceptors. Worm. 2015 Apr-Jun; 4(2):e1023497. PMID: 26430563.
      View in: PubMed
    5. Gruner M, Nelson D, Winbush A, Hintz R, Ryu L, Chung SH, Kim K, Gabel CV, van der Linden AM. Feeding state, insulin and NPR-1 modulate chemoreceptor gene expression via integration of sensory and circuit inputs. PLoS Genet. 2014 Oct; 10(10):e1004707. PMID: 25357003.
      View in: PubMed
    6. Burnham-Marusich AR, Snodgrass CJ, Johnson AM, Kiyoshi CM, Buzby SE, Gruner MR, Berninsone PM. Metabolic labeling of Caenorhabditis elegans primary embryonic cells with azido-sugars as a tool for glycoprotein discovery. PLoS One. 2012; 7(11):e49020. PMID: 23152843.
      View in: PubMed