Matthew Kan, MD, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Phone415-476-5001
ORCID ORCID Icon0000-0003-4840-2917 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard UniversityB.A.2007Biology
    Duke UniversityM.D.2016School of Medicine
    Duke UniversityPh.D.2016Department of Immunology
    UCSF2021Pediatrics Residency
    UCSF, San Francisco2023Allergy and Immunology Fellowship
    Collapse Awards and Honors
    Pediatric Scientist Development Program2021  - 2023PSDP Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Targeted gene correction in Artemis-deficient Severe Combined Immunodeficiency Syndrome
    Pediatric Scientist Development Program/Eunice Kennedy Shriver National Institute of Child Health and Human Development PSDP Fellowship (K12)Jul 1, 2021 - Jun 30, 2023
    Role: Principal Investigator
    Sequencing T-cell receptor diversity after hematopoietic stem cell transplantation in Severe Combined Immunodeficiency (SCID) as an early biomarker for failure of bone marrow reconstitution
    UCSF Benioff Children's Hospital President's Innovation FundJul 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    Sequence-based lymphocyte receptor diversity: a biomarker of immune reconstitution after hematopoietic cell transplantation for SCID
    Primary Immune Deficiency Treatment Consortium Fellow Research Training GrantMay 1, 2020 - Aug 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic Acids Res. 2024 Jan 05; 52(D1):D590-D596. Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, Tsuchida CA, Tran RV, Hofman L, Shi H, Wasko KM, Zhou Z, Xia C, Al-Shimary MJ, Patel JR, Thomas VCJX, Pattali R, Kan MJ, Vardapetyan A, Yang A, Lahiri A, Maxwell MF, Murdock AG, Ramit GC, Henderson HR, Calvert RW, Bamert RS, Knott GJ, Lapinaite A, Pausch P, Cofsky JC, Sontheimer EJ, Wiedenheft B, Fineran PC, Brouns SJJ, Sashital DG, Thomas BC, Brown CT, Goltsman DSA, Barrangou R, Siksnys V, Banfield JF, Savage DF, Doudna JA. PMID: 37889041; PMCID: PMC10767948.
      View in: PubMed   Mentions: 1     Fields:    
    2. Treatment of Genetic Diseases With CRISPR Genome Editing. JAMA. 2022 09 13; 328(10):980-981. Kan MJ, Doudna JA. PMID: 36098733.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    3. Fever Without a Source in an Infant Due to Severe Acute Respiratory Syndrome Coronavirus-2. J Pediatric Infect Dis Soc. 2021 Feb 13; 10(1):49-51. Kan MJ, Grant LMC, Muña MA, Greenhow TL. PMID: 32318729; PMCID: PMC7188112.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    4. Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension. J Immunol. 2020 03 15; 204(6):1474-1485. Yu YA, Malakhau Y, Yu CA, Phelan SJ, Cumming RI, Kan MJ, Mao L, Rajagopal S, Piantadosi CA, Gunn MD. PMID: 31996456; PMCID: PMC7065976.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    5. Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia. Sci Data. 2019 10 15; 6(1):201. Paik H, Kan MJ, Rappoport N, Hadley D, Sirota M, Chen B, Manber U, Cho SB, Butte AJ. PMID: 31615985; PMCID: PMC6794302.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    6. Removal of microglial-specific MyD88 signaling alters dentate gyrus doublecortin and enhances opioid addiction-like behaviors. Brain Behav Immun. 2019 02; 76:104-115. Rivera PD, Hanamsagar R, Kan MJ, Tran PK, Stewart D, Jo YC, Gunn M, Bilbo SD. PMID: 30447281; PMCID: PMC6348129.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    7. The 10,000 Immunomes Project: Building a Resource for Human Immunology. Cell Rep. 2018 Nov 13; 25(7):1995. Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ. PMID: 30428364; PMCID: PMC6362995.
      View in: PubMed   Mentions: 8     Fields:    
    8. The 10,000 Immunomes Project: Building a Resource for Human Immunology. Cell Rep. 2018 10 09; 25(2):513-522.e3. Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ. PMID: 30304689; PMCID: PMC6263160.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    9. Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia. Genome Res. 2018 04; 28(4):423-431. Bhattacharya S, Li J, Sockell A, Kan MJ, Bava FA, Chen SC, Ávila-Arcos MC, Ji X, Smith E, Asadi NB, Lachman RS, Lam HYK, Bustamante CD, Butte AJ, Nolan GP. PMID: 29567674; PMCID: PMC5880234.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    10. The 10,000 Immunomes Project: A Resource for Human Immunology. Journal of Allergy and Clinical Immunology. 2018 Feb 1; 141(2):ab269. Kan KM, Zalocusky ZK, Hu HZ, Dunn DP, Thomson TE, Wiser WJ, Bhattacharya BS, Butte BA. .
      View in: Publisher Site   Mentions:
    11. Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity. J Control Release. 2018 01 10; 269:364-373. Mastria EM, Cai LY, Kan MJ, Li X, Schaal JL, Fiering S, Gunn MD, Dewhirst MW, Nair SK, Chilkoti A. PMID: 29146246; PMCID: PMC6475912.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    12. C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. Am J Pathol. 2016 11; 186(11):2846-2856. Rudemiller NP, Patel MB, Zhang JD, Jeffs AD, Karlovich NS, Griffiths R, Kan MJ, Buckley AF, Gunn MD, Crowley SD. PMID: 27640148; PMCID: PMC5222967.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    13. IMMUNE-MEDIATED NUTRIENT DEPRIVATION AND METABOLIC DISRUPTION IN AN ALZHEIMER'S DISEASE MOUSE MODEL. Alzheimer's & Dementia. 2016 Jul 1; 12(7):p660. Colton CC, Puranam PR, Vitek VM, Kan KM. .
      View in: Publisher Site   Mentions:
    14. A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. PLoS One. 2016; 11(3):e0150606. Yu YR, O'Koren EG, Hotten DF, Kan MJ, Kopin D, Nelson ER, Que L, Gunn MD. PMID: 26938654; PMCID: PMC4777539.
      View in: PubMed   Mentions: 182     Fields:    Translation:AnimalsCells
    15. Macrophages Contribute to the Spermatogonial Niche in the Adult Testis. Cell Rep. 2015 Aug 18; 12(7):1107-19. DeFalco T, Potter SJ, Williams AV, Waller B, Kan MJ, Capel B. PMID: 26257171; PMCID: PMC4545310.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    16. Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. J Neurosci. 2015 Apr 15; 35(15):5969-82. Kan MJ, Lee JE, Wilson JG, Everhart AL, Brown CM, Hoofnagle AN, Jansen M, Vitek MP, Gunn MD, Colton CA. PMID: 25878270; PMCID: PMC4397598.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    17. Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke. PLoS Genet. 2013; 9(10):e1003807. Keum S, Lee HK, Chu PL, Kan MJ, Huang MN, Gallione CJ, Gunn MD, Lo DC, Marchuk DA. PMID: 24130503; PMCID: PMC3794904.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    18. Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. J Immunol. 2013 Nov 01; 191(9):4665-75. Cain DW, O'Koren EG, Kan MJ, Womble M, Sempowski GD, Hopper K, Gunn MD, Kelsoe G. PMID: 24078688; PMCID: PMC3808250.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    19. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J Immunol. 2007 Oct 01; 179(7):4661-71. Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT. PMID: 17878364; PMCID: PMC2564604.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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